Fasting plasma total ghrelin concentrations in monozygotic twins discordant for obesity

Metabolism: Clinical and Experimental

Volumn 58, Issue 2, 2009, Pages 174-179

  Leskelä, Piia ^a   Ukkola, Olavi ^a   Vartiainen, Johanna ^a   Rönnemaa, Tapani ^b   Kaprio, Jaakko ^c,d   Bouchard, Claude ^e   Kesäniemi, Y Antero ^a  

^a UNIVERSITY OF OULU   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^e PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN;

ADULT; ARTICLE; BODY WEIGHT; CLINICAL ARTICLE; FEMALE; FOOD INTAKE; GENETIC POLYMORPHISM; GENOTYPE; HORMONAL REGULATION; HORMONE BLOOD LEVEL; HUMAN; MALE; MONOZYGOTIC TWINS; OBESITY; PRIORITY JOURNAL;

ADULT; BODY WEIGHT; ENERGY METABOLISM; FASTING; FEMALE; GENE FREQUENCY; GENETIC VARIATION; GENOTYPE; GHRELIN; HUMANS; MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, GENETIC; TWINS, MONOZYGOTIC;

EID: 58249092179     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2008.09.010     Document Type: Article

References (38)

1. Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., and Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999) 656-660
2. Nakazato M., Murakami N., Date Y., Kojima M., Matsuo H., Kangawa K., et al. A role for ghrelin in the central regulation of feeding. Nature 409 (2001) 194-198
3. Wren A.M., Seal L.J., Cohen M.A., Brymes A.E., Frost G.S., Murphy K.G., et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86 (2001) 5992-5995
4. Cummings D.E., Purnell J.Q., Frayo R.S., Schmidova K., Wisse B.E., and Weigle D.S. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50 (2001) 1714-1719
5. Tschöp M., Viswanath D., Weyer C., Tataranni P.A., Ravussin E., and Heiman M.L. Circulating ghrelin levels are decreased in human obesity. Diabetes 50 (2001) 707-709
6. Pöykkö S., Kellokoski E., Hörkkö S., Kauma H., Kesaniemi Y.A., and Ukkola O. Low plasma ghrelin is associated with insulin resistance, hypertension and the prevalence of type 2 diabetes. Diabetes 52 (2003) 2546-2553
7. Ravussin E., Tschöp M., Morales S., Bouchard C., and Heiman M.L. Plasma ghrelin concentration and energy balance: overfeeding and negative energy balance studies in twins. J Clin Endocrinol Metab 86 (2001) 4547-4551
8. Ukkola O., Ravussin E., Jacobson P., Snyder E.E., Chagnon M., Sjöström L., et al. Mutations in preproghrelin/ghrelin gene associated with obesity in humans. J Clin Endocrinol Metab 86 (2001) 3996-3999
9. Miraglia del Giudice E., Santoro N., Cirillo G., Raimondo P., Grandone A., D'Aniello A., et al. Molecular screening of the ghrelin gene in Italian obese children: the Leu72Met variant is associated with an earlier onset of obesity. Int J Obes Relat Metab Disord 28 (2004) 447-450
10. Korbonits M., Gueorguiev M., O'Grady E., Lecoeur C., Swan D.C., Mein C.A., et al. A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children. J Clin Endocrinol Metab 87 (2002) 4005-4008
11. Hinney A., Hoch A., Geller F., Schäfer H., Siegfried W., Goldschmidt H., et al. Ghrelin gene: identification of missense variants and a frameshift mutation in extremely obese children and adolescents and healthy normal weight students. J Clin Endocrinol Metab 87 (2002) 2716-2719
12. Berg K., Kondo I., Drayna D., and Lawn R. "Variability gene" effect of cholesteryl ester transfer protein (CETP) genes. Clin Genet 35 (1989) 437-445
13. Berg K. Variability gene effect on cholesterol at the Kidd blood group locus. Clin Genet 33 (1988) 102-107
14. Berg K. Genetics of coronary heart disease and its risk factors. Ciba Found Symp 130 (1987) 14-33
15. Bouchard C., Tremblay A., Després J.P., Nadeau A., Lupien P.J., Thériault G., et al. The response to long-term overfeeding in identical twins. N Engl J Med 322 (1990) 1477-1482
16. Fraga M.F., Ballestar E., Paz M.F., Ropero S., Setien F., Ballestar M.L., et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A 102 (2005) 10604-10609
17. Martin N., Boomsma D., and Machin G. A twin-pronged attack on complex traits. Nat Genet 17 (1997) 387-392
18. Gottesman I.I., and Hanson D.R. Human development: biological and genetic processes. Annu Rev Psychol 56 (2005) 263-286
19. Petronis A. The origin of schizophrenia: genetic thesis, epigenetic antithesis, and resolving synthesis. Biol Psychiatry 55 (2004) 965-970
20. Rönnemaa T., Marniemi J., Savolainen M.J., Kesäniemi Y.A., Ehnholm C., Bouchard C., et al. Serum lipids, lipoproteins, and lipid metabolizing enzymes in identical twins discordant for obesity. J Clin Endocrinol Metab 83 (1998) 2792-2799
21. Ronnemaa T., Karonen S.L., Rissanen A., Koskenvuo M., and Koivisto V.A. Relation between plasma leptin levels and measures of body fat in identical twins discordant for obesity. Ann intern Med 126 (1997) 26-31
22. Pietilainen K.H., Rissanen A., Laamanen M., Lindholm A.K., Markkula H., Yki-Jarvinen H., et al. Growth patterns in young adult monozygotic twin pairs discordant and concordant for obesity. Twin Res 7 (2004) 421-429
23. Pietiläinen K.H., Rissanen A., Kaprio J., Makimattila S., Hakkinen A.M., Westerbacka J., et al. Acquired obesity is associated with increased liver fat, intra-abdominal fat, and insulin resistance in young adult monozygotic twins. Am J Physiol Endocrinol Metab 288 (2005) E768-E774
24. Pietiläinen K.H., Kannisto K., Korsheninnikova E., Rissanen A., Kaprio J., Ehrenborg E., et al. Acquired obesity increases CD68 and TNF-{alpha} and decreases adiponectin gene expression in adipose tissue. A study in monozygotic twins. J Clin Endocrinol Metab 91 (2006) 2776-2781
25. Kannisto K., Pietiläinen K.H., Ehrenborg E., Rissanen A., Kaprio J., Hamsten A., et al. Overexpression of 11beta-hydroxysteroid dehydrogenase-1 in adipose tissue is associated with acquired obesity and features of insulin resistance: studies in young adult monozygotic twins. J Clin Endocrinol Metab 89 (2004) 4414-4421
26. Gertow K., Pietiläinen K.H., Yki-Järvinen H., Kaprio J., Rissanen A., Eriksson P., et al. Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance. Diabetologia 47 (2004) 1118-1125
27. Pietiläinen K.H., Bergholm R., Rissanen A., Kaprio J., Hakkinen A.M., Sattar N., et al. Effects of acquired obesity on endothelial function in monozygotic twins. Obesity 14 (2006) 826-837
28. Siri W.E. The gross composition of the body. In: Lawrence J.H., and Tobias C.A. (Eds). Advances in biological and medical physics Vol. 4 (1956), Academic, New York 239-280
29. Staten M.A., Totty W.G., and Kohrt W.M. Measurement of fat distribution by magnetic resonance imaging. Invest Radiol 24 (1989) 345-349
30. Siedel J., Schlumberger H., Klose S., Ziegenhorn J., and Wahlefeld A.W. Improved reagent for the enzymatic determination of serum cholesterol. J Clin Chem Clin Biochem 19 (1981) 83-89
31. Kostner G.M. Enzymatic determination of high density lipoprotein fractions prepared by polyanion precipitation. Clin Chem 22 (1976) 695
32. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334 (1996) 292-295
33. Rönnemaa T., Koskenvuo M., Marniemi J., Koivunen T., Sajantila A., Rissanen A., et al. Glucose metabolism in identical twins discordant for obesity. The critical role of visceral fat. J Clin Endocrinol Metab 82 (1997) 383-387
34. Hakala P., Rissanen A., Koskenvuo M., Kaprio J., and Rönnemaa T. Environmental factors in the development of obesity in identical twins. Int J Obes Relat Metab Disord 23 (1999) 746-753
35. Rönnemaa T., Pulkki K., and Kaprio J. Serum soluble tumor necrosis factor-alpha receptor 2 is elevated in obesity but is not related to insulin sensitivity: a study in identical twins discordant for obesity. J Clin Endocrinol Metab 85 (2000) 2728-2732
36. Utermann G., Pruin N., and Steinmetz A. Polymorphism of apolipoprotein E. III. Effect of a single polymorphic gene locus on plasma lipid levels in man. Clin Genet 15 (1979) 63-72
37. Fabsitz R.R., Sholinsky P., and Carmelli D. Genetic influences on adult weight gain and maximum body mass index in male twins. Am J of Epidemiol 140 (1994) 711-720
38. Fox C.S., Heard-Costa N.L., Vasan R.S., Murabito J.M., D'Agostino R.B., and Atwood L.D. Genomewide linkage analysis of weight change in the Framingham Heart Study. J Clin Endocrinol Metab 90 (2005) 3197-3201