Acquired obesity is associated with increased liver fat, intra-abdominal fat, and insulin resistance in young adult monozygotic twins

American Journal of Physiology - Endocrinology and Metabolism

Volumn 288, Issue 4 51-4, 2005, Pages

  Pietiläinen, Kirsi Hannele ^a,b   Rissanen, Aila ^b   Kaprio, Jaakko ^a,c   Mäkimattila, Sari ^b   Häkkinen, Anna Maija ^b   Westerbacka, Jukka ^b   Sutinen, Jussi ^b   Vehkavaara, Satu ^b   Yki Järvinen, Hannele ^b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Body composition; Environment; Fatty liver; Genes; Magnetic resonance imaging; Spectroscopy

Indexed keywords

INSULIN;

ADIPOSE TISSUE; ADULT; ARTICLE; BODY COMPOSITION; BODY MASS; BODY WEIGHT; CLAMP; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; HEREDITY; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; LIVER FAT; MALE; MONOZYGOTIC TWINS; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PRIORITY JOURNAL; SPECTROSCOPY; TISSUE DISTRIBUTION;

ADIPOSE TISSUE; ADULT; BLOOD GLUCOSE; BODY COMPOSITION; BODY MASS INDEX; DENSITOMETRY, X-RAY; FATTY LIVER; FEMALE; GLUCOSE CLAMP TECHNIQUE; HUMANS; INSULIN RESISTANCE; MAGNETIC RESONANCE IMAGING; MALE; OBESITY; STATISTICS, NONPARAMETRIC; TWINS, MONOZYGOTIC;

EID: 15444364990     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.00381.2004     Document Type: Article

References (50)

1. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, and Matsuzawa Y. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257: 79-83, 1999.
2. Barak Y, Nelson MC, Ong ES, Jones YZ, Ruiz-Lozano P, Chien KR, Koder A, and Evans RM. PPAR gamma is required for placental, cardiac, and adipose tissue development, Mol Cell 4: 585-595, 1999.
3. Barsh GS, Farooqi IS, and O'Rahilly S. Genetics of body-weight regulation. Nature 404: 644-651, 2000.
4. Bouchard C, Tremblay A, Despres JP, Nadeau A, Lupien PJ, Theriault G, Dussault J, Moorjani S, Pinault S, and Fournier G. The response to long-term overfeeding in identical twins. N Engl J Med 322: 1477-1482, 1990.
5. Burant CF, Sreenan S, Hirano K, Tai TA, Lohmiller J, Lukens J, Davidson NO, Ross S, and Graves RA. Troglitazone action is independent of adipose tissue. J Clin Invest 100: 2900-2908, 1997.
6. Carey DG, Jenkins AB, Campbell LV, Freund J, and Chisholm DJ. Abdominal fat and insulin resistance in normal and overweight women: direct measurements reveal a strong relationship in subjects at both low and high risk of NIDDM. Diabetes 45: 633-638, 1996.
7. Clark JM. Nonalcoholic fatty liver disease and the risk of type 2 diabetes in the United States (Abstract). Diabetes 50, Suppl 2: A38, 2001.
8. DeFronzo RA, Tobin JD, and Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol Endocrinol Metab Gastrointest Physiol 237: E214-E223, 1979.
9. Desbuquois B and Aurbach GD. Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays. J Clin Endocrinol Metab 33: 732-738, 1971.
10. Frayn KN. Visceral fat and insulin resistance-causative or correlative? Br J Nutr 83. Suppl 1: S71-S77, 2000.
11. Goris AH, Westerterp-Plantenga MS, and Westerterp KR. Undereating and underrecording of habitual food intake in obese men: selective underreporting of fat intake. Am J Clin Nutr 71: 130-134, 2000.
12. Kadish AH, Little RL, and Sternberg JC. A new and rapid method for the determination of glucose by measurement of rate of oxygen consumption. Clin Chem 14: 116-131, 1968.
13. Kaprio J, Pulkkinen L, and Rose RJ. Genetic and environmental factors in health-related behaviors: studies on Finnish twins and twin families. Twin Res 5: 366-371, 2002.
14. Kelley DE, Thaete FL, Troost F, Huwe T, and Goodpaster BH. Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance. Am J Physiol Endocrinol Metab 278: E941-E948, 2000.
15. Kim JK, Gavrilova O, Chen Y, Reitman ML, and Shulman GI. Mechanism of insulin resistance in A-ZIP/F-1 fatless mice. J Biol Chem 275: 8456-8460, 2000.
16. Kim SP, Ellmerer M, Van Citters GW, and Bergman RN. Primacy of hepatic insulin resistance in the development of the metabolic syndrome induced by an isocaloric moderate-fat diet in the dog. Diabetes 52: 2453-2460, 2003.
17. Longo R, Pollesello P, Ricci C, Masutti F, Kvam BJ, Bereich L, Croce LS, Grigolato P, Paoletti S, and de Bernard B. Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis. J Magn Reson Imaging 5: 281-285, 1995.
18. Marti B, Tuomilehto J, Salomaa V, Kartovaara L, Korhonen HJ, and Pietinen P. Body fat distribution in the Finnish population: environmental determinants and predictive power for cardiovascular risk factor levels. J Epidemiol Community Health 45: 131-137, 1991.
19. Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, and Flier JS. A transgenic model of visceral obesity and the metabolic syndrome. Science 294: 2166-2170, 2001.
20. Mazess RB, Barden HS, Bisek JP, and Hanson J. Dual-energy x-ray absorptiometry for total-body and regional bone-mineral and soft-tissue composition. Am J Clin Nutr 51: 1106-1112, 1990.
21. McGuire EA, Helderman JH, Tobin JD, Andres R, and Berman M. Effects of arterial versus venous sampling on analysis of glucose kinetics in man. J Appl Physiol 41: 565-573, 1976.
22. Miles J, Glasscock R, Aikens J, Gerich J, and Raymond M. A microfluorometric method for the determination of free fatty acids in plasma. J Lipid Res 24: 96-99, 1983.
23. Miles JM, Park YS, Walewicz D, Russell-Lopez C, Windsor S, Isley WL, Coppack SW, and Harris WS. Systemic and forearm triglyceride metabolism: fate of lipoprotein lipase-generated glycerol and free fatty acids. Diabetes 53: 521-527, 2004.
24. Neschen S, Moore I, Regittnig W, Yu CL, Wang Y, Pypaert M, Petersen KF, and Shulman GI. Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content. Am J Physiol Endocrinol Metab 282: E395-E401, 2002.
25. Nguyen-Duy TB, Nichaman MZ, Church TS, Blair SN, and Ross R. Visceral fat and liver fat are independent predictors of metabolic risk factors in men. Am J Physiol Endocrinol Metab 284: E1065-E1071, 2003.
26. Nielsen S, Guo Z, Johnson CM, Hensrud DD, and Jensen MD. Splanchnic lipolysis in human obesity. J Clin Invest 113: 1582-1588, 2004.
27. Pietiläinen KH, Rissanen A, Laamanen M, Lindholm AK, Markkula H, Yki-Järvinen H, and Kaprio J. Growth patterns in young adult monozygotic twins discordant and concordant for obesity. Twin Res 7: 421-429, 2004.
28. Reitman ML, Arioglu E, Gavrilova O, and Taylor SI. Lipoatrophy revisited. Trends Endocrinol Metab 11: 410-416, 2000.
29. Reue K, Xu P, Wang XP, and Slavin BG. Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene. J Lipid Res 41: 1067-1076, 2000.
30. Rönnemaa T, Koskenvuo M, Marniemi J, Koivunen T, Sajantila A, Rissanen A, Kaitsaari M, Bouchard C, and Kaprio J. Glucose metabolism in identical twins discordant for obesity. The critical role of visceral fat. J Clin Endocrinol Metab 82: 383-387, 1997.
31. Rose RJ, Dick DM, Viken RJ, and Kaprio J. Gene-environment interaction in patterns of adolescent drinking: regional residency moderates longitudinal influences on alcohol use. Alcohol Clin Exp Res 25: 637-643, 2001.
32. Ryysy L, Häkkinen AM, Goto T, Vehkavaara S, Westerbacka J, Halavaara J, and Yki-Järvinen H. Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients. Diabetes 49: 749-758, 2000.
33. Samuel VT, Liu ZX, Qu X, Elder BD, Bilz S, Befroy D, Romanelli AJ, and Shulman GI. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 279: 32345-32353, 2004.
34. Sarna S, Kaprio J, Sistonen P, and Koskenvuo M. Diagnosis of twin zygosity by mailed questionnaire. Hum Hered 28: 241-254, 1978.
35. Seppälä-Lindroos A, Vehkavaara S, Häkkinen AM, Goto T, Wester-backa J, Sovijärvi A, Halavaara J, and Yki-Järvinen H. Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 87: 3023-3028, 2002.
36. Shimomura I, Hammer RE, Richardson JA, Ikemoto S, Bashmakov Y, Goldstein JL, and Brown MS. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-Ic in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev 12: 3182-3194, 1998.
37. Smith SR, Lovejoy JC, Greenway F, Ryan D, dejonge L, de la BJ, Volafova J, and Bray GA. Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity. Metabolism 50: 425-435, 2001.
38. Summers LK, Fielding BA, Bradshaw HA, Ilic V, Beysen C, Clark ML, Moore NR, and Frayn KN. Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity. Diabetologia 45: 369-377, 2002.
39. Sutinen J, Häkkinen AM, Westerbacka J, Seppälä-Lindroos A, Vehkavaara S, Halavaara J, Järvinen A, Ristola M, and Yki-Järvinen H. Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy. AIDS 16: 2183-2193, 2002.
40. Sutinen J, Kannisto K, Korsheninnikova E, Nyman T, Ehrenborg E, Andrew R, Wake DJ, Hamsten A, Walker BR, and Yki-Järvinen H. In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue. Diabetologia 47: 1668-1671, 2004.
41. Sutinen J, Korsheninnikova E, Funahashi T, Matsuzawa Y, Nyman T, and Yki-Järvinen H. Circulating concentration of adiponectin and its expression in subcutaneous adipose tissue in patients with highly active antiretroviral therapy-associated lipodystrophy. J Clin Endocrinol Metab 88: 1907-1910, 2003.
42. Thomas EL, Saeed N, Hajnal JV, Brynes A, Goldstone AP, Frost G, and Bell JD. Magnetic resonance imaging of total body fat. J Appl Physiol 85: 1778-1785, 1998.
43. Thomsen C, Becker U, Winkler K, Christoffersen P, Jensen M, and Henriksen O. Quantification of liver fat using magnetic resonance spectroscopy. Magn Reson Imaging 12: 487-495, 1994.
44. Tiikkainen M, Bergholm R, Vehkavaara S, Rissanen A, Häkkinen AM, Tamminen M, Teramo K, and Yki-Järvinen H. Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content. Diabetes 52: 701-707, 2003.
45. Tiikkainen M, Tamminen M, Häkkinen AM, Bergholm R, Vehkavaara S, Halavaara J, Teramo K, Rissanen A, and Yki-Järvinen H. Liver-fat accumulation and insulin resistance in obese women with previous gestational diabetes. Obes Res 10: 859-867, 2002.
46. Vessby B, Unsitupa M, Hermansen K, Riccardi G, Rivellese AA, Tapsell LC, Nalsen C, Berglund L, Louheranta A, Rasmussen BM, Calvert GD, Maffetone A, Pedersen E, Gustafsson IB, and Storlien LH. Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: the KANWU Study. Diabetologia 44: 312-319, 2001.
47. Vozarova B, Stefan N, Lindsay RS, Saremi A, Pratley RE, Bogardus C, and Tataranni PA. High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes. Diabetes 51: 1889-1895, 2002.
48. Wake DJ, Rask E, Livingstone DE, Soderberg S, Olsson T, and Walker BR. Local and systemic impact of transcriptional up-regulation of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue in human obesity. J Clin Endocrinol Metab 88: 3983-3988, 2003.
49. Westerbacka J, Yki-Järvinen H, Vehkavaara S, Häkkinen AM, Andrew R, Wake DJ, Seckl JR, and Walker BR. Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver. J Clin Endocrinol Metab 88: 4924-4931, 2003.
50. Yki-Järvinen H, Young AA, Lamkin C, and Foley JE. Kinetics of glucose disposal in whole body and across the forearm in man. J Clin Invest 79: 1713-1719, 1987.