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Volumn 105, Issue 51, 2008, Pages 20072-20076

How the Dorsal gradient works: Insights from postgenome technologies

Author keywords

Drosophila; Embryo; Morphogen; Regulatory code

Indexed keywords

DNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DORSAL; UNCLASSIFIED DRUG;

EID: 58149500204     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0806476105     Document Type: Review
Times cited : (106)

References (50)
  • 1
    • 0024839859 scopus 로고
    • The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila
    • Rushlow CA, Han K, Manley JL, Levine M (1989) The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila. Cell 59:1165-1177.
    • (1989) Cell , vol.59 , pp. 1165-1177
    • Rushlow, C.A.1    Han, K.2    Manley, J.L.3    Levine, M.4
  • 2
    • 0024834128 scopus 로고
    • A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo
    • Roth S, Stein D, Nüsslein-Volhard C (1989) A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo. Cell 59:1189-1202.
    • (1989) Cell , vol.59 , pp. 1189-1202
    • Roth, S.1    Stein, D.2    Nüsslein-Volhard, C.3
  • 3
    • 0026089246 scopus 로고
    • The dorsal morphogen is a sequence-specific DNA-binding protein that interacts with a long-range repression element in Drosophila
    • Ip YT, Kraut R, Levine M, Rushlow CA (1991) The dorsal morphogen is a sequence-specific DNA-binding protein that interacts with a long-range repression element in Drosophila. Cell 64:439-446.
    • (1991) Cell , vol.64 , pp. 439-446
    • Ip, Y.T.1    Kraut, R.2    Levine, M.3    Rushlow, C.A.4
  • 4
    • 0022189558 scopus 로고
    • Establishment of dorsal-ventral polarity in the Drosophila embryo: The induction of polarity by the Toll gene product
    • Anderson KV, Bokla L, Nüsslein-Volhard C (1985) Establishment of dorsal-ventral polarity in the Drosophila embryo: The induction of polarity by the Toll gene product. Cell 42:791-798.
    • (1985) Cell , vol.42 , pp. 791-798
    • Anderson, K.V.1    Bokla, L.2    Nüsslein-Volhard, C.3
  • 5
    • 0022230197 scopus 로고
    • Establishment of dorsal-ventral polarity in the Drosophila embryo: Genetic studies on the role of the Toll gene product
    • Anderson KV, Jürgens G, Nüsslein-Volhard C (1985) Establishment of dorsal-ventral polarity in the Drosophila embryo: Genetic studies on the role of the Toll gene product. Cell 42:779-789.
    • (1985) Cell , vol.42 , pp. 779-789
    • Anderson, K.V.1    Jürgens, G.2    Nüsslein-Volhard, C.3
  • 6
    • 0037184519 scopus 로고    scopus 로고
    • Whole-genome analysis of dorsal-ventral patterning in the Drosophila embryo
    • Stathopoulos A, Van Drenth M, Erives A, Markstein M, Levine M (2002) Whole-genome analysis of dorsal-ventral patterning in the Drosophila embryo. Cell 111:687-701.
    • (2002) Cell , vol.111 , pp. 687-701
    • Stathopoulos, A.1    Van Drenth, M.2    Erives, A.3    Markstein, M.4    Levine, M.5
  • 7
    • 33847189172 scopus 로고    scopus 로고
    • Whole-genome ChIP-chip analysis of Dorsal, Twist, and Snail suggests integration of diverse patterning processes in the Drosophila embryo
    • Zeitlinger J, et al. (2007) Whole-genome ChIP-chip analysis of Dorsal, Twist, and Snail suggests integration of diverse patterning processes in the Drosophila embryo. Genes Dev 21:385-390.
    • (2007) Genes Dev , vol.21 , pp. 385-390
    • Zeitlinger, J.1
  • 8
    • 0036607116 scopus 로고    scopus 로고
    • Dorsal gradient networks in the Drosophila embryo
    • Stathopoulos A, Levine M (2002) Dorsal gradient networks in the Drosophila embryo. Dev Biol 246:57-67.
    • (2002) Dev Biol , vol.246 , pp. 57-67
    • Stathopoulos, A.1    Levine, M.2
  • 9
    • 0037154218 scopus 로고    scopus 로고
    • Genomewide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryo
    • Markstein M, Markstein P, Markstein V, Levine MS (2002) Genomewide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryo. Proc Natl Acad Sci USA 99:763-768.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 763-768
    • Markstein, M.1    Markstein, P.2    Markstein, V.3    Levine, M.S.4
  • 10
    • 17044380888 scopus 로고    scopus 로고
    • Quantitative analysis of binding motifs mediating diverse spatial readouts of the Dorsal gradient in the Drosophila embryo
    • Papatsenko D, Levine M (2005) Quantitative analysis of binding motifs mediating diverse spatial readouts of the Dorsal gradient in the Drosophila embryo. Proc Natl Acad Sci USA 102:4966-4971.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 4966-4971
    • Papatsenko, D.1    Levine, M.2
  • 11
    • 33748049810 scopus 로고    scopus 로고
    • Comprehensive identification of Drosophila dorsal-ventral patterning genes using a whole-genome tiling array
    • Biemar F, et al. (2006) Comprehensive identification of Drosophila dorsal-ventral patterning genes using a whole-genome tiling array. Proc Natl Acad Sci USA 103:12763-12768.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 12763-12768
    • Biemar, F.1
  • 12
    • 17044368752 scopus 로고    scopus 로고
    • Gene regulatory networks for development
    • Levine M, Davidson E (2005) Gene regulatory networks for development. Proc Ntal Acad Sci USA 102:4936-4942.
    • (2005) Proc Ntal Acad Sci USA , vol.102 , pp. 4936-4942
    • Levine, M.1    Davidson, E.2
  • 13
    • 26444591973 scopus 로고    scopus 로고
    • Genomic regulatory networks and animal development
    • Stathopoulos A, Levine M (2005) Genomic regulatory networks and animal development. Dev Cell 9:449-462.
    • (2005) Dev Cell , vol.9 , pp. 449-462
    • Stathopoulos, A.1    Levine, M.2
  • 14
    • 31744445880 scopus 로고    scopus 로고
    • Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila
    • Bardin AJ, Schweisguth F (2006) Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila. Dev Cell 10:245-255.
    • (2006) Dev Cell , vol.10 , pp. 245-255
    • Bardin, A.J.1    Schweisguth, F.2
  • 15
    • 31744431546 scopus 로고    scopus 로고
    • Dorsal-ventral pattern of Delta trafficking is established by a Snail-Tom-Neuralized pathway
    • De Renzis S, Yu J, Zinzen R, Wieschaus E (2006) Dorsal-ventral pattern of Delta trafficking is established by a Snail-Tom-Neuralized pathway. Dev Cell 10:257-264.
    • (2006) Dev Cell , vol.10 , pp. 257-264
    • De Renzis, S.1    Yu, J.2    Zinzen, R.3    Wieschaus, E.4
  • 16
    • 0036339989 scopus 로고    scopus 로고
    • The Snail repressor positions Notch signaling in the Drosophila embryo
    • Cowden J, Levine M (2002) The Snail repressor positions Notch signaling in the Drosophila embryo. Development 129:1785-1793.
    • (2002) Development , vol.129 , pp. 1785-1793
    • Cowden, J.1    Levine, M.2
  • 17
    • 0037357248 scopus 로고    scopus 로고
    • Snail is required for Delta endocytosis and Notch-dependent activation of single-minded expression
    • Morel V, Le Borgne R, Schweisguth F (2003) Snail is required for Delta endocytosis and Notch-dependent activation of single-minded expression. Dev Genes Evol 213:65-72.
    • (2003) Dev Genes Evol , vol.213 , pp. 65-72
    • Morel, V.1    Le Borgne, R.2    Schweisguth, F.3
  • 18
    • 0029744895 scopus 로고    scopus 로고
    • Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins
    • Schnepp B, Grumbling G, Donaldson T, Simcox A (1996) Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins. Genes Dev 10:2302-2313.
    • (1996) Genes Dev , vol.10 , pp. 2302-2313
    • Schnepp, B.1    Grumbling, G.2    Donaldson, T.3    Simcox, A.4
  • 19
    • 0030827861 scopus 로고    scopus 로고
    • The Drosophila neuregulin homolog Vein mediates inductive interactions between myotubes and their epidermal attachment cells
    • Yarnitzky T, Min L, Volk T (1997) The Drosophila neuregulin homolog Vein mediates inductive interactions between myotubes and their epidermal attachment cells. Genes Dev 11:2691-2700.
    • (1997) Genes Dev , vol.11 , pp. 2691-2700
    • Yarnitzky, T.1    Min, L.2    Volk, T.3
  • 20
    • 0027176294 scopus 로고
    • The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway
    • Sturtevant MA, Roark M, Bier E (1993) The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway. Genes Dev 7:961-973.
    • (1993) Genes Dev , vol.7 , pp. 961-973
    • Sturtevant, M.A.1    Roark, M.2    Bier, E.3
  • 21
    • 0035913908 scopus 로고    scopus 로고
    • Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases
    • Urban S, Lee JR, Freeman M (2001) Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases. Cell 107:173-182.
    • (2001) Cell , vol.107 , pp. 173-182
    • Urban, S.1    Lee, J.R.2    Freeman, M.3
  • 22
    • 0030866482 scopus 로고    scopus 로고
    • In situ activation pattern of Drosophila EGF receptor pathway during development
    • Gabay L, Seger R, Shilo BZ (1997) In situ activation pattern of Drosophila EGF receptor pathway during development. Science 277:1103-1106.
    • (1997) Science , vol.277 , pp. 1103-1106
    • Gabay, L.1    Seger, R.2    Shilo, B.Z.3
  • 23
    • 0031666418 scopus 로고    scopus 로고
    • The Drosophila EGF receptor controls the formation and specification of neuroblasts along the dorsal-ventral axis of the Drosophila embryo
    • Skeath JB (1998) The Drosophila EGF receptor controls the formation and specification of neuroblasts along the dorsal-ventral axis of the Drosophila embryo. Development 125:3301-3312.
    • (1998) Development , vol.125 , pp. 3301-3312
    • Skeath, J.B.1
  • 24
    • 0037453058 scopus 로고    scopus 로고
    • Mutations that affect the ability of the vnd/NK-2 homeoprotein to regulate gene expression: Transgenic alterations and tertiary structure
    • Koizumi K et al. (2003) Mutations that affect the ability of the vnd/NK-2 homeoprotein to regulate gene expression: Transgenic alterations and tertiary structure. Proc Natl Acad Sci USA 100:3119-3124.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 3119-3124
    • Koizumi, K.1
  • 25
    • 0141615090 scopus 로고    scopus 로고
    • Ventral dominance governs sequential patterns of gene expression across the dorsal-ventral axis of the neuroectoderm in the Drosophila embryo
    • Cowden J, Levine M (2003) Ventral dominance governs sequential patterns of gene expression across the dorsal-ventral axis of the neuroectoderm in the Drosophila embryo. Dev Biol 262:335-349.
    • (2003) Dev Biol , vol.262 , pp. 335-349
    • Cowden, J.1    Levine, M.2
  • 26
    • 0026654687 scopus 로고
    • Individual dorsal morphogen binding sites mediate activation and repression in the Drosophila embryo
    • Jiang J, Rushlow CA, Zhou Q, Small S, Levine M (1992) Individual dorsal morphogen binding sites mediate activation and repression in the Drosophila embryo. EMBO J 11:3147-3154.
    • (1992) EMBO J , vol.11 , pp. 3147-3154
    • Jiang, J.1    Rushlow, C.A.2    Zhou, Q.3    Small, S.4    Levine, M.5
  • 27
    • 0026045994 scopus 로고
    • The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos
    • Jiang J, Kosman D, Ip YT, Levine M (1991) The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos. Genes Dev 5:1881-1891.
    • (1991) Genes Dev , vol.5 , pp. 1881-1891
    • Jiang, J.1    Kosman, D.2    Ip, Y.T.3    Levine, M.4
  • 28
    • 0027511507 scopus 로고
    • Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen
    • Jiang J, Levine M (1993) Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen. Cell 72:741-752.
    • (1993) Cell , vol.72 , pp. 741-752
    • Jiang, J.1    Levine, M.2
  • 29
    • 0026722283 scopus 로고
    • dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo
    • Ip YT, Park RE, Kosman D, Yazdanbakhsh K, Levine M (1992) dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo. Genes Dev 6:1518-1530.
    • (1992) Genes Dev , vol.6 , pp. 1518-1530
    • Ip, Y.T.1    Park, R.E.2    Kosman, D.3    Yazdanbakhsh, K.4    Levine, M.5
  • 30
    • 0026010224 scopus 로고
    • Establishment of the mesoderm-neuroectoderm boundary in the Drosophila embryo
    • Kosman D, Ip YT, Levine M, Arora K (1991) Establishment of the mesoderm-neuroectoderm boundary in the Drosophila embryo. Science 254:118-122.
    • (1991) Science , vol.254 , pp. 118-122
    • Kosman, D.1    Ip, Y.T.2    Levine, M.3    Arora, K.4
  • 31
    • 0026009094 scopus 로고
    • twist and snail as positive and negative regulators during Drosophila mesoderm development
    • Leptin M (1991) twist and snail as positive and negative regulators during Drosophila mesoderm development. Genes Dev 5:1568-1576.
    • (1991) Genes Dev , vol.5 , pp. 1568-1576
    • Leptin, M.1
  • 32
    • 0025804653 scopus 로고
    • Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo
    • Schneider DS, Hudson KL, Lin TY, Anderson KV (1991) Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo. Genes Dev 5:797-807.
    • (1991) Genes Dev , vol.5 , pp. 797-807
    • Schneider, D.S.1    Hudson, K.L.2    Lin, T.Y.3    Anderson, K.V.4
  • 33
    • 51149097760 scopus 로고    scopus 로고
    • Shadow enhancers as a source of evolutionary novelty
    • Hong JW, Hendrix DA, Levine M (2008) Shadow enhancers as a source of evolutionary novelty. Science 321:1314.
    • (2008) Science , vol.321 , pp. 1314
    • Hong, J.W.1    Hendrix, D.A.2    Levine, M.3
  • 34
    • 3042710549 scopus 로고    scopus 로고
    • A regulatory code for neurogenic gene expression in the Drosophila embryo
    • Markstein M, et al. (2004) A regulatory code for neurogenic gene expression in the Drosophila embryo. Development 131:2387-2394.
    • (2004) Development , vol.131 , pp. 2387-2394
    • Markstein, M.1
  • 35
    • 33745658106 scopus 로고    scopus 로고
    • Computational models for neurogenic gene expression in the Drosophila embryo
    • Zinzen RP, Senger K, Levine M, Papatsenko D (2006) Computational models for neurogenic gene expression in the Drosophila embryo. Curr Biol 16:1358-1365.
    • (2006) Curr Biol , vol.16 , pp. 1358-1365
    • Zinzen, R.P.1    Senger, K.2    Levine, M.3    Papatsenko, D.4
  • 36
    • 36048995970 scopus 로고    scopus 로고
    • A rationale for the enhanceosome and other evolutionarily constrained enhancers
    • Papatsenko D, Levine M (2007) A rationale for the enhanceosome and other evolutionarily constrained enhancers. Curr Biol 17:R955-R957.
    • (2007) Curr Biol , vol.17
    • Papatsenko, D.1    Levine, M.2
  • 37
    • 47149117454 scopus 로고    scopus 로고
    • Evolution of genes and genomes on the Drosophila phylogeny
    • Clark AG, et al. (2007) Evolution of genes and genomes on the Drosophila phylogeny. Nature 450:203-218.
    • (2007) Nature , vol.450 , pp. 203-218
    • Clark, A.G.1
  • 38
    • 27544442994 scopus 로고    scopus 로고
    • Helix-loop-helix proteins and lymphocyte development
    • Murre C (2005) Helix-loop-helix proteins and lymphocyte development. Nat Immunol 6:1079-1086.
    • (2005) Nat Immunol , vol.6 , pp. 1079-1086
    • Murre, C.1
  • 39
    • 0025301470 scopus 로고
    • Molecular analysis of a cellular decision during embryonic development of Drosophila melanogaster: Epidermogenesis or neurogenesis
    • Campos-Ortega JA, Knust E (1990) Molecular analysis of a cellular decision during embryonic development of Drosophila melanogaster: Epidermogenesis or neurogenesis. Eur J Biochem 190:1-10.
    • (1990) Eur J Biochem , vol.190 , pp. 1-10
    • Campos-Ortega, J.A.1    Knust, E.2
  • 40
    • 34249722123 scopus 로고    scopus 로고
    • Enhancer responses to similarly distributed antagonistic gradients in development
    • Zinzen RP, Papatsenko D (2007) Enhancer responses to similarly distributed antagonistic gradients in development. PLoS Comput Biol 3:e84.
    • (2007) PLoS Comput Biol , vol.3
    • Zinzen, R.P.1    Papatsenko, D.2
  • 41
    • 33745106890 scopus 로고    scopus 로고
    • The TAGteam DNA motif controls the timing of Drosophila preblastoderm transcription
    • ten Bosch JR, Benavides JA, Cline TW (2006) The TAGteam DNA motif controls the timing of Drosophila preblastoderm transcription. Development 133:1967-1977.
    • (2006) Development , vol.133 , pp. 1967-1977
    • ten Bosch, J.R.1    Benavides, J.A.2    Cline, T.W.3
  • 42
    • 0030697514 scopus 로고    scopus 로고
    • Conversion of dorsal from an activator to a repressor by the global corepressor Groucho
    • Dubnicoff T, et al. (1997) Conversion of dorsal from an activator to a repressor by the global corepressor Groucho. Genes Dev 11:2952-2957.
    • (1997) Genes Dev , vol.11 , pp. 2952-2957
    • Dubnicoff, T.1
  • 43
    • 33845881156 scopus 로고    scopus 로고
    • Uncoupling dorsal-mediated activation from dorsal-mediated repression in the Drosophila embryo
    • Ratnaparkhi GS, Jia S, Courey AJ (2006) Uncoupling dorsal-mediated activation from dorsal-mediated repression in the Drosophila embryo. Development 133:4409-4414.
    • (2006) Development , vol.133 , pp. 4409-4414
    • Ratnaparkhi, G.S.1    Jia, S.2    Courey, A.J.3
  • 45
    • 0026489365 scopus 로고
    • The high mobility group protein HMGI(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene
    • Thanos D, Maniatis T (1992) The high mobility group protein HMGI(Y) is required for NF-κB-dependent virus induction of the human IFN-β gene. Cell 71:777-789.
    • (1992) Cell , vol.71 , pp. 777-789
    • Thanos, D.1    Maniatis, T.2
  • 46
    • 0027509952 scopus 로고
    • A short, disordered protein region mediates interactions between the homeodomain of the yeast α2 protein and the MCM1 protein
    • Vershon AK, Johnson AD (1993) A short, disordered protein region mediates interactions between the homeodomain of the yeast α2 protein and the MCM1 protein. Cell 72:105-112.
    • (1993) Cell , vol.72 , pp. 105-112
    • Vershon, A.K.1    Johnson, A.D.2
  • 47
    • 0027714828 scopus 로고
    • DNA bending and orientation-dependent function of YY1 in the c-fos promoter
    • Natesan S, Gilman MZ (1993) DNA bending and orientation-dependent function of YY1 in the c-fos promoter. Genes Dev 7:2497-2509.
    • (1993) Genes Dev , vol.7 , pp. 2497-2509
    • Natesan, S.1    Gilman, M.Z.2
  • 49
    • 0027760995 scopus 로고
    • Sonic hedgehog mediates the polarizing activity of the ZPA
    • Riddle RD, Johnson RL, Laufer E, Tabin C (1993) Sonic hedgehog mediates the polarizing activity of the ZPA. Cell 75:1401-1416.
    • (1993) Cell , vol.75 , pp. 1401-1416
    • Riddle, R.D.1    Johnson, R.L.2    Laufer, E.3    Tabin, C.4
  • 50
    • 5444257285 scopus 로고    scopus 로고
    • Whole-genome analysis of Drosophila gastrulation
    • Stathopoulos A, Levine M (2004) Whole-genome analysis of Drosophila gastrulation. Curr Opin Genet Dev 14:477-484.
    • (2004) Curr Opin Genet Dev , vol.14 , pp. 477-484
    • Stathopoulos, A.1    Levine, M.2


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