-
1
-
-
34547154407
-
Frequency of the frame-shifting CYP2D7 138deIT polymorphism in a large, ethnically diverse sample population
-
Bhathena A, Mueller T, Grimm DR, Idler K, Tsurutani A, Spear BB, and Katz DA (2007) Frequency of the frame-shifting CYP2D7 138deIT polymorphism in a large, ethnically diverse sample population. Drug Metab Dispos 35:1251-1253.
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 1251-1253
-
-
Bhathena, A.1
Mueller, T.2
Grimm, D.R.3
Idler, K.4
Tsurutani, A.5
Spear, B.B.6
Katz, D.A.7
-
2
-
-
38749088304
-
Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice
-
Felmlee MA, Lon HK, Gonzalez FJ, and Yu AM (2008) Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice. Drug Metab Dispos 36:435-441.
-
(2008)
Drug Metab Dispos
, vol.36
, pp. 435-441
-
-
Felmlee, M.A.1
Lon, H.K.2
Gonzalez, F.J.3
Yu, A.M.4
-
4
-
-
25644444404
-
CYP2D7 splice variants in human liver and brain: Does CYP2D7 encode functional protein?
-
Gaedigk A, Gaedigk R, and Leeder JS (2005) CYP2D7 splice variants in human liver and brain: does CYP2D7 encode functional protein? Biochem Biophys Res Commun 336:1241-1250.
-
(2005)
Biochem Biophys Res Commun
, vol.336
, pp. 1241-1250
-
-
Gaedigk, A.1
Gaedigk, R.2
Leeder, J.S.3
-
5
-
-
38349132802
-
The CYP2D6 activity score: Translating genotype information into a qualitative measure of phenotype
-
Gaedigk A, Simon SD, Pearce RE, Bradford LD, Kennedy MJ, and Leeder JS (2008) The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype. Clin Pharmacol Ther 83:234-242.
-
(2008)
Clin Pharmacol Ther
, vol.83
, pp. 234-242
-
-
Gaedigk, A.1
Simon, S.D.2
Pearce, R.E.3
Bradford, L.D.4
Kennedy, M.J.5
Leeder, J.S.6
-
6
-
-
0023854270
-
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism
-
Gonzalez FJ, Skoda RC, Kimura S, Umeno M, Zanger UM, Nebert DW, Gelboin HV, Hardwick JP, and Meyer UA (1988) Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature 331:442-446.
-
(1988)
Nature
, vol.331
, pp. 442-446
-
-
Gonzalez, F.J.1
Skoda, R.C.2
Kimura, S.3
Umeno, M.4
Zanger, U.M.5
Nebert, D.W.6
Gelboin, H.V.7
Hardwick, J.P.8
Meyer, U.A.9
-
7
-
-
33144459032
-
Cytochrome P450 and xenobiotic receptor humanized mice
-
Gonzalez FJ and Yu AM (2006) Cytochrome P450 and xenobiotic receptor humanized mice. Annu Rev Pharmacol Toxicol 46:41-64.
-
(2006)
Annu Rev Pharmacol Toxicol
, vol.46
, pp. 41-64
-
-
Gonzalez, F.J.1
Yu, A.M.2
-
8
-
-
0030587544
-
Allelic variants of human cytochrome P450 2C9: Baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms
-
Haining RL, Hunter AP, Veronese ME, Trager WF, and Rettie AE (1996) Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms. Arch Biochem Biophys 333:447-458.
-
(1996)
Arch Biochem Biophys
, vol.333
, pp. 447-458
-
-
Haining, R.L.1
Hunter, A.P.2
Veronese, M.E.3
Trager, W.F.4
Rettie, A.E.5
-
9
-
-
0027965620
-
Genetic analysis of the Chinese cytochrome P4502D locus: Characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation
-
Johansson I, Oscarson M, Yue QY, Bertilsson L, Sjöqvist F, and Ingelman-Sundberg M (1994) Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation. Mol Pharmacol 46:452-459.
-
(1994)
Mol Pharmacol
, vol.46
, pp. 452-459
-
-
Johansson, I.1
Oscarson, M.2
Yue, Q.Y.3
Bertilsson, L.4
Sjöqvist, F.5
Ingelman-Sundberg, M.6
-
10
-
-
0024796958
-
The human debrisoquine 4-hydroxylase (CYP2D) locus: Sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene
-
Kimura S, Umeno M, Skoda RC, Meyer UA, and Gonzalez FJ (1989) The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene. Am J Hum Genet 45:889-904.
-
(1989)
Am J Hum Genet
, vol.45
, pp. 889-904
-
-
Kimura, S.1
Umeno, M.2
Skoda, R.C.3
Meyer, U.A.4
Gonzalez, F.J.5
-
11
-
-
34547209907
-
A natural variant of the heme-binding signature (R441C) resulting in complete loss of function of CYP2D6
-
Klein K, Tatzel S, Raimundo S, Saussele T, Hustert E, Pleiss J, Eichelbaum M, and Zanger UM (2007) A natural variant of the heme-binding signature (R441C) resulting in complete loss of function of CYP2D6. Drug Metab Dispos 35:1247-1250.
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 1247-1250
-
-
Klein, K.1
Tatzel, S.2
Raimundo, S.3
Saussele, T.4
Hustert, E.5
Pleiss, J.6
Eichelbaum, M.7
Zanger, U.M.8
-
12
-
-
33746041490
-
*56 allele identified by genotype/phenotype analysis of cryopreserved human hepatocytes
-
*56 allele identified by genotype/phenotype analysis of cryopreserved human hepatocytes. Drug Metab Dispos 34:1411-1416.
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 1411-1416
-
-
Li, L.1
Pan, R.M.2
Porter, T.D.3
Jensen, N.S.4
Silber, P.5
Russo, G.6
Tine, J.A.7
Heim, J.8
Ring, B.9
Wedlund, P.J.10
-
14
-
-
0030860004
-
Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: Characterization of 48 mutations and 53 alleles, their frequencies and evolution
-
Marez D, Legrand M, Sabbagh N, Guidice JM, Spire C, Lafltte JJ, Meyer UA, and Broly F (1997) Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogeneucs 7:193-202.
-
(1997)
Pharmacogeneucs
, vol.7
, pp. 193-202
-
-
Marez, D.1
Legrand, M.2
Sabbagh, N.3
Guidice, J.M.4
Spire, C.5
Lafltte, J.J.6
Meyer, U.A.7
Broly, F.8
-
15
-
-
78651165715
-
The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
-
Omura T and Sato R (1964) The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J Biol Chem 239:2370-2378.
-
(1964)
J Biol Chem
, vol.239
, pp. 2370-2378
-
-
Omura, T.1
Sato, R.2
-
16
-
-
3042641834
-
A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine
-
Pai HV, Kommaddi RP, Chinta SJ, Mori T, Boyd MR, and Ravindranath V (2004) A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine. J Biol Chem 279:27383-27389.
-
(2004)
J Biol Chem
, vol.279
, pp. 27383-27389
-
-
Pai, H.V.1
Kommaddi, R.P.2
Chinta, S.J.3
Mori, T.4
Boyd, M.R.5
Ravindranath, V.6
-
17
-
-
34547165040
-
Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17
-
Shen H, He MM, Liu H, Wrighton SA, Wang L, Guo B, and Li C (2007) Comparative metabolic capabilities and inhibitory profiles of CYP2D6.1, CYP2D6.10, and CYP2D6.17. Drug Metab Dispos 35:1292-1300.
-
(2007)
Drug Metab Dispos
, vol.35
, pp. 1292-1300
-
-
Shen, H.1
He, M.M.2
Liu, H.3
Wrighton, S.A.4
Wang, L.5
Guo, B.6
Li, C.7
-
18
-
-
54349118188
-
The endocanuabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6
-
Snider NT, Sikora MJ, Sridar C, Feuerstein TJ, Rae JM, and Hollenberg PF (2008) The endocanuabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6. J Pharmacol Exp Ther 327:538-545.
-
(2008)
J Pharmacol Exp Ther
, vol.327
, pp. 538-545
-
-
Snider, N.T.1
Sikora, M.J.2
Sridar, C.3
Feuerstein, T.J.4
Rae, J.M.5
Hollenberg, P.F.6
-
20
-
-
0034771887
-
Characterization of dextromethorphan O- and N-demethylation catalyzed by highly purified recolnbinant human CYP2D6
-
Yu A, Dong H, Lang D, and Haining RL (2001) Characterization of dextromethorphan O- and N-demethylation catalyzed by highly purified recolnbinant human CYP2D6. Drug Metab Dispos 29:1362-1365.
-
(2001)
Drug Metab Dispos
, vol.29
, pp. 1362-1365
-
-
Yu, A.1
Dong, H.2
Lang, D.3
Haining, R.L.4
-
21
-
-
0036897469
-
Expression, purification, biochemical characterization, and comparative function of human cytochrome P450 2D6.1, 2D6.2, 2D6.10, and 2D6.17 allelic isoforms
-
Yu A, Kneller BM, Rettie AE, and Haining RL (2002) Expression, purification, biochemical characterization, and comparative function of human cytochrome P450 2D6.1, 2D6.2, 2D6.10, and 2D6.17 allelic isoforms. J Pharmacol Exp Ther 303:1291-1300.
-
(2002)
J Pharmacol Exp Ther
, vol.303
, pp. 1291-1300
-
-
Yu, A.1
Kneller, B.M.2
Rettie, A.E.3
Haining, R.L.4
-
22
-
-
33745245269
-
Expression, purification, and characterization of mouse CYP2d22
-
Yu AM and Haining RL (2006) Expression, purification, and characterization of mouse CYP2d22. Drug Metab Dispos 34:1167-1174.
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 1167-1174
-
-
Yu, A.M.1
Haining, R.L.2
-
23
-
-
0037342251
-
Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYT2D6
-
Yu AM, Idle JR. Byrd LG, Krausz KW, Kupfer A, and Gonzalez FJ (2003a) Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYT2D6. Pharmacogenetics 13:173-181.
-
(2003)
Pharmacogenetics
, vol.13
, pp. 173-181
-
-
Yu, A.M.1
Idle, J.R.2
Byrd, L.G.3
Krausz, K.W.4
Kupfer, A.5
Gonzalez, F.J.6
-
24
-
-
3042515935
-
Polymorphic cytochrome P450 2D6: Humanized mouse model and endogenous substrates
-
Yu AM, Idle JR, and Gonzalez FJ (2004) Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates. Drug Metab Rev 36:243-277.
-
(2004)
Drug Metab Rev
, vol.36
, pp. 243-277
-
-
Yu, A.M.1
Idle, J.R.2
Gonzalez, F.J.3
-
25
-
-
0038240578
-
Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase
-
Yu AM, Idle JR, Herraiz T, Kupfer A, and Gonzalez FJ (2003b) Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase. Pharmacogenetics 13:307-319.
-
(2003)
Pharmacogenetics
, vol.13
, pp. 307-319
-
-
Yu, A.M.1
Idle, J.R.2
Herraiz, T.3
Kupfer, A.4
Gonzalez, F.J.5
-
26
-
-
0742286803
-
Cytochrome P450 2D6: Overview and update on pharmacology, genetics, biochemistry
-
Zanger UM, Raimundo S, and Eichelbaum M (2004) Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry. Naunyn Schmiedebergs Arch Pharmacol 369:23-37.
-
(2004)
Naunyn Schmiedebergs Arch Pharmacol
, vol.369
, pp. 23-37
-
-
Zanger, U.M.1
Raimundo, S.2
Eichelbaum, M.3
|