-
1
-
-
0025870797
-
Assessment of the mouse as an experimental model for studying polymorphic oxidation of the sparteine/debrisoquine type
-
Adams M, Lennard MS, Otton SV, Tucker GT, and Woods HF (1991) Assessment of the mouse as an experimental model for studying polymorphic oxidation of the sparteine/debrisoquine type. Biochem Pharmacol 42:947-949.
-
(1991)
Biochem Pharmacol
, vol.42
, pp. 947-949
-
-
Adams, M.1
Lennard, M.S.2
Otton, S.V.3
Tucker, G.T.4
Woods, H.F.5
-
2
-
-
0019492928
-
Animal modelling of human polymorphic drug oxidation - The metabolism of debrisoquine and phenacetin in rat inbred strains
-
Al-Dabbagh SG, Idle JR, and Smith RL (1981) Animal modelling of human polymorphic drug oxidation - the metabolism of debrisoquine and phenacetin in rat inbred strains. J Pharm Pharmacol 33:161-164.
-
(1981)
J Pharm Pharmacol
, vol.33
, pp. 161-164
-
-
Al-Dabbagh, S.G.1
Idle, J.R.2
Smith, R.L.3
-
3
-
-
0030960653
-
Cytochrome P450 4A and 2E1 expression in human kidney microsomes
-
Amet Y, Berthou F, Fournier G, Dreano Y, Bardou L, Cledes J, and Menez JF (1997) Cytochrome P450 4A and 2E1 expression in human kidney microsomes. Biochem Pharmacol 53:765-771.
-
(1997)
Biochem Pharmacol
, vol.53
, pp. 765-771
-
-
Amet, Y.1
Berthou, F.2
Fournier, G.3
Dreano, Y.4
Bardou, L.5
Cledes, J.6
Menez, J.F.7
-
4
-
-
0028273879
-
An evaluation of cytochrome P450 isoform activities in the female dark agouti (DA) rat: Relevance to its use as a model of the CYP2D6 poor metaboliser phenotype
-
Barham HM, Lennard MS, and Tucker GT (1994) An evaluation of cytochrome P450 isoform activities in the female dark agouti (DA) rat: relevance to its use as a model of the CYP2D6 poor metaboliser phenotype. Biochem Pharmacol 47:1295-1307.
-
(1994)
Biochem Pharmacol
, vol.47
, pp. 1295-1307
-
-
Barham, H.M.1
Lennard, M.S.2
Tucker, G.T.3
-
5
-
-
0034664679
-
Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells
-
Blume N, Leonard J, Xu ZJ, Watanabe O, Remotti H, and Fishman J (2000) Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells. Arch Biochem Biophys 381:191-204.
-
(2000)
Arch Biochem Biophys
, vol.381
, pp. 191-204
-
-
Blume, N.1
Leonard, J.2
Xu, Z.J.3
Watanabe, O.4
Remotti, H.5
Fishman, J.6
-
6
-
-
0029680208
-
Microsomal codeine N-demethylation: Cosegregation with cytochrome P4503A4 activity
-
Caraco Y, Tateishi T, Guengerich FP, and Wood AJ (1996) Microsomal codeine N-demethylation: cosegregation with cytochrome P4503A4 activity. Drug Metab Dispos 24:761-764.
-
(1996)
Drug Metab Dispos
, vol.24
, pp. 761-764
-
-
Caraco, Y.1
Tateishi, T.2
Guengerich, F.P.3
Wood, A.J.4
-
7
-
-
0029965231
-
Dextromethorphan as an in vivo probe for the simultaneous determination of CYP2D6 and CYP3A activity
-
Ducharme J, Abdullah S, and Wainer IW (1996) Dextromethorphan as an in vivo probe for the simultaneous determination of CYP2D6 and CYP3A activity. J Chromatogr B Biomed Appl 678:113-128.
-
(1996)
J Chromatogr B Biomed Appl
, vol.678
, pp. 113-128
-
-
Ducharme, J.1
Abdullah, S.2
Wainer, I.W.3
-
8
-
-
0023568113
-
MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation
-
Fonne P-R, Bargetzi MJ, and Meyer UA (1987) MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation. Biochem Biophys Res Commun 148:1144-1150.
-
(1987)
Biochem Biophys Res Commun
, vol.148
, pp. 1144-1150
-
-
Fonne, P.-R.1
Bargetzi, M.J.2
Meyer, U.A.3
-
9
-
-
0031014344
-
Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization
-
Gilham DE, Cairns W, Paine MJ, Modi S, Poulsom R, Roberts GC, and Wolf CR (1997) Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization. Xenobiotica 27:111-125.
-
(1997)
Xenobiotica
, vol.27
, pp. 111-125
-
-
Gilham, D.E.1
Cairns, W.2
Paine, M.J.3
Modi, S.4
Poulsom, R.5
Roberts, G.C.6
Wolf, C.R.7
-
10
-
-
0027983085
-
Pharmacogenetic phenotyping and genotyping. Present status and future potential
-
Gonzalez FJ and Idle JR (1994) Pharmacogenetic phenotyping and genotyping. Present status and future potential. Clin Pharmacokinet 26:59-70.
-
(1994)
Clin Pharmacokinet
, vol.26
, pp. 59-70
-
-
Gonzalez, F.J.1
Idle, J.R.2
-
11
-
-
0023154962
-
Debrisoquine 4-hydroxylase: Characterization of a new P450 gene subfamily, regulation, chromosomal mapping and molecular analysis of the DA rat polymorphism
-
Gonzalez FJ, Matsunaga T, Nagata K, Meyer UA, Nebert DW, Pastewka J, Kozak CA, Gillette J, Gelboin HV, and Hardwick JP (1987) Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping and molecular analysis of the DA rat polymorphism. DNA 6:149-161.
-
(1987)
DNA
, vol.6
, pp. 149-161
-
-
Gonzalez, F.J.1
Matsunaga, T.2
Nagata, K.3
Meyer, U.A.4
Nebert, D.W.5
Pastewka, J.6
Kozak, C.A.7
Gillette, J.8
Gelboin, H.V.9
Hardwick, J.P.10
-
12
-
-
0023854270
-
Characterization of the common genetic defect in humans deficient in debrisoquine metabolism
-
Gonzalez FJ, Skoda RC, Kimura S, Umeno M, Zanger UM, Nebert DW, Gelboin HV, Hardwick JP, and Meyer UA (1988) Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature (Lond) 331:442-446.
-
(1988)
Nature (Lond)
, vol.331
, pp. 442-446
-
-
Gonzalez, F.J.1
Skoda, R.C.2
Kimura, S.3
Umeno, M.4
Zanger, U.M.5
Nebert, D.W.6
Gelboin, H.V.7
Hardwick, J.P.8
Meyer, U.A.9
-
13
-
-
0027956791
-
Characterization of dextromethorphan N-demethylation by human liver microsomes. Contribution of the cytochrome P450 3A (CYP3A) subfamily
-
Gorski JC, Jones DR, Wrighton SA, and Hall SD (1994) Characterization of dextromethorphan N-demethylation by human liver microsomes. Contribution of the cytochrome P450 3A (CYP3A) subfamily. Biochem Pharmacol 48:173-182.
-
(1994)
Biochem Pharmacol
, vol.48
, pp. 173-182
-
-
Gorski, J.C.1
Jones, D.R.2
Wrighton, S.A.3
Hall, S.D.4
-
14
-
-
33745277866
-
Cytochrome P450 pharmacogenetics
-
Lee J ed, FontisMedia, Lausanne, Switzerland
-
Haining R and Yu A (2003) Cytochrome P450 pharmacogenetics, in Cytochrome P450 and Drug Metabolism (Lee J ed), pp 343-387, FontisMedia, Lausanne, Switzerland.
-
(2003)
Cytochrome P450 and Drug Metabolism
, pp. 343-387
-
-
Haining, R.1
Yu, A.2
-
15
-
-
0030587544
-
Allelic variants of human cytochrome P450 2C9: Baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity and prochiral selectivity of the wild-type and I359L mutant forms
-
Haining RL, Hunter AP, Veronese ME, Trager WF, and Rettie AE (1996) Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity and prochiral selectivity of the wild-type and I359L mutant forms. Arch Biochem Biophys 333:447-458.
-
(1996)
Arch Biochem Biophys
, vol.333
, pp. 447-458
-
-
Haining, R.L.1
Hunter, A.P.2
Veronese, M.E.3
Trager, W.F.4
Rettie, A.E.5
-
18
-
-
0034602396
-
Porcine microsomal vitamin D(3) 25-hydroxylase (CYP2D25). Catalytic properties, tissue distribution and comparison with human CYP2D6
-
Hosseinpour F and Wikvall K (2000) Porcine microsomal vitamin D(3) 25-hydroxylase (CYP2D25). Catalytic properties, tissue distribution and comparison with human CYP2D6. J Biol Chem 275:34650-34655.
-
(2000)
J Biol Chem
, vol.275
, pp. 34650-34655
-
-
Hosseinpour, F.1
Wikvall, K.2
-
19
-
-
0029944684
-
Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes
-
Iribarne C, Berthou F, Baird S, Dreano Y, Picart D, Bail JP, Beaune P, and Menez JF (1996) Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes. Chem Res Toxicol 9:365-373.
-
(1996)
Chem Res Toxicol
, vol.9
, pp. 365-373
-
-
Iribarne, C.1
Berthou, F.2
Baird, S.3
Dreano, Y.4
Picart, D.5
Bail, J.P.6
Beaune, P.7
Menez, J.F.8
-
20
-
-
0029906605
-
Determination of cytochrome P450 3A4/5 activity in vivo with dextromethorphan N-demethylation
-
Jones DR, Gorski JC, Haehner BD, O'Mara EM Jr, and Hall SD (1996) Determination of cytochrome P450 3A4/5 activity in vivo with dextromethorphan N-demethylation. Clin Pharmacol Ther 60:374-384.
-
(1996)
Clin Pharmacol Ther
, vol.60
, pp. 374-384
-
-
Jones, D.R.1
Gorski, J.C.2
Haehner, B.D.3
O'Mara Jr., E.M.4
Hall, S.D.5
-
21
-
-
0022362531
-
Sex and strain differences in hepatic debrisoquine 4-hydroxylase activity of the rat
-
Kahn GC, Rubenfield M, Davies DS, Murray S, and Boobis AR (1985) Sex and strain differences in hepatic debrisoquine 4-hydroxylase activity of the rat. Drug Metab Dispos 13:510-516.
-
(1985)
Drug Metab Dispos
, vol.13
, pp. 510-516
-
-
Kahn, G.C.1
Rubenfield, M.2
Davies, D.S.3
Murray, S.4
Boobis, A.R.5
-
22
-
-
0029959286
-
Genomic cloning and protein expression of a novel rat brain cytochrome P-450 CYP2D18* catalyzing imipramine Ndemethylation
-
Kawashima H, Sequeira DJ, Nelson DR, and Strobel HW (1996) Genomic cloning and protein expression of a novel rat brain cytochrome P-450 CYP2D18* catalyzing imipramine Ndemethylation. J Biol Chem 271:28176-28180.
-
(1996)
J Biol Chem
, vol.271
, pp. 28176-28180
-
-
Kawashima, H.1
Sequeira, D.J.2
Nelson, D.R.3
Strobel, H.W.4
-
23
-
-
0024796958
-
The human debrisoquine 4-hydroxylase (CYP2D) locus: Sequence and identification of the polymorphic CYP2D6 gene, a related gene and a pseudogene
-
Kimura S, Umeno M, Skoda RC, Meyer UA, and Gonzalez FJ (1989) The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene and a pseudogene. Am J Hum Genet 45:889-904.
-
(1989)
Am J Hum Genet
, vol.45
, pp. 889-904
-
-
Kimura, S.1
Umeno, M.2
Skoda, R.C.3
Meyer, U.A.4
Gonzalez, F.J.5
-
24
-
-
0032797812
-
In vivo comparison of putative probes of CYP3A4/5 activity: Erythromycin, dextromethorphan and verapamil
-
Krecic-Shepard ME, Barnas CR, Slimko J, Gorski JC, Wainer IW, and Schwartz JB (1999) In vivo comparison of putative probes of CYP3A4/5 activity: erythromycin, dextromethorphan and verapamil. Clin Pharmacol Ther 66:40-50.
-
(1999)
Clin Pharmacol Ther
, vol.66
, pp. 40-50
-
-
Krecic-Shepard, M.E.1
Barnas, C.R.2
Slimko, J.3
Gorski, J.C.4
Wainer, I.W.5
Schwartz, J.B.6
-
25
-
-
9144249651
-
Metabolism of human cytochrome P450 marker substrates in mouse: A strain and gender comparison
-
Lofgren S, Hagbjork AL, Ekman S, Fransson-Steen R, and Terelius Y (2004) Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison. Xenobiotica 34:811-834.
-
(2004)
Xenobiotica
, vol.34
, pp. 811-834
-
-
Lofgren, S.1
Hagbjork, A.L.2
Ekman, S.3
Fransson-Steen, R.4
Terelius, Y.5
-
26
-
-
0033485965
-
Molecular cloning, expression and characterization of CYP2D17 from cynomolgus monkey liver
-
Mankowski DC, Laddison KJ, Christopherson PA, Ekins S, Tweedie DJ, and Lawton MP (1999) Molecular cloning, expression and characterization of CYP2D17 from cynomolgus monkey liver. Arch Biochem Biophys 372:189-196.
-
(1999)
Arch Biochem Biophys
, vol.372
, pp. 189-196
-
-
Mankowski, D.C.1
Laddison, K.J.2
Christopherson, P.A.3
Ekins, S.4
Tweedie, D.J.5
Lawton, M.P.6
-
27
-
-
0030885306
-
Selective deficiency of debrisoquine 4-hydroxylase activity in mouse liver microsomes
-
Masubuchi Y, Iwasa T, Hosokawa S, Suzuki T, Horie T, Imaoka S, Funae Y, and Narimatsu S (1997) Selective deficiency of debrisoquine 4-hydroxylase activity in mouse liver microsomes. J Pharmacol Exp Ther 282:1435-1441.
-
(1997)
J Pharmacol Exp Ther
, vol.282
, pp. 1435-1441
-
-
Masubuchi, Y.1
Iwasa, T.2
Hosokawa, S.3
Suzuki, T.4
Horie, T.5
Imaoka, S.6
Funae, Y.7
Narimatsu, S.8
-
28
-
-
0024416946
-
The CYP2D gene subfamily: Analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats
-
Matsunaga E, Zanger UM, Hardwick JP, Gelboin HV, Meyer UA, and Gonzalez FJ (1989) The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats. Biochemistry 28:7349-7355.
-
(1989)
Biochemistry
, vol.28
, pp. 7349-7355
-
-
Matsunaga, E.1
Zanger, U.M.2
Hardwick, J.P.3
Gelboin, H.V.4
Meyer, U.A.5
Gonzalez, F.J.6
-
29
-
-
0031472072
-
The association between polymorphisms in the cytochrome P-450 2D6 gene and Parkinson's disease: A case-control study and meta-analysis
-
McCann SJ, Pond SM, James KM, and Le Couteur DG (1997) The association between polymorphisms in the cytochrome P-450 2D6 gene and Parkinson's disease: a case-control study and meta-analysis. J Neurol Sci 153:50-53.
-
(1997)
J Neurol Sci
, vol.153
, pp. 50-53
-
-
McCann, S.J.1
Pond, S.M.2
James, K.M.3
Le Couteur, D.G.4
-
30
-
-
0031448854
-
The involvement of cytochrome P450 3A4 in the N-demethylation of L-alpha-acetylmethadol (LAAM), nor-LAAM, and methadone
-
Moody DE, Alburges ME, Parker RJ, Collins JM, and Strong JM (1997) The involvement of cytochrome P450 3A4 in the N-demethylation of L-alpha-acetylmethadol (LAAM), nor-LAAM, and methadone. Drug Metab Dispos 25:1347-1353.
-
(1997)
Drug Metab Dispos
, vol.25
, pp. 1347-1353
-
-
Moody, D.E.1
Alburges, M.E.2
Parker, R.J.3
Collins, J.M.4
Strong, J.M.5
-
31
-
-
0031035007
-
Polymorphisms in drug-metabolizing enzymes: What is their clinical relevance and why do they exist?
-
Nebert DW (1997) Polymorphisms in drug-metabolizing enzymes: what is their clinical relevance and why do they exist? Am J Hum Genet 60:265-271.
-
(1997)
Am J Hum Genet
, vol.60
, pp. 265-271
-
-
Nebert, D.W.1
-
32
-
-
9044254525
-
P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature
-
Nelson DR, Koymans L, Kamataki T, Stegeman JJ, Feyereisen R, Waxman DJ, Waterman MR, Gotoh O, Coon MJ, Estabrook RW, et al. (1996) P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 6:1-42.
-
(1996)
Pharmacogenetics
, vol.6
, pp. 1-42
-
-
Nelson, D.R.1
Koymans, L.2
Kamataki, T.3
Stegeman, J.J.4
Feyereisen, R.5
Waxman, D.J.6
Waterman, M.R.7
Gotoh, O.8
Coon, M.J.9
Estabrook, R.W.10
-
33
-
-
0027499341
-
Relationship between antidepressant response and plasma concentrations of fluoxetine and norfluoxetine
-
Norman TR, Gupta RK, Burrows GD, Parker G, and Judd FK (1993) Relationship between antidepressant response and plasma concentrations of fluoxetine and norfluoxetine. Int Clin Psychopharmacol 8:25-29.
-
(1993)
Int Clin Psychopharmacol
, vol.8
, pp. 25-29
-
-
Norman, T.R.1
Gupta, R.K.2
Burrows, G.D.3
Parker, G.4
Judd, F.K.5
-
34
-
-
0034893705
-
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): Potential contribution of intestinal metabolism to presystemic clearance and bioactivation
-
Oda Y and Kharasch ED (2001) Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation. J Pharmacol Exp Ther 298:1021-1032.
-
(2001)
J Pharmacol Exp Ther
, vol.298
, pp. 1021-1032
-
-
Oda, Y.1
Kharasch, E.D.2
-
35
-
-
0025136874
-
Metabolism and brain accumulation of tetrahydroisoquinoline (TIQ) a possible parkinsonism inducing substance, in an animal model of a poor debrisoquine metabolizer
-
Ohta S, Tachikawa O, Makino Y, Tasaki Y, and Hirobe M (1990) Metabolism and brain accumulation of tetrahydroisoquinoline (TIQ) a possible parkinsonism inducing substance, in an animal model of a poor debrisoquine metabolizer. Life Sci 46:599-605.
-
(1990)
Life Sci
, vol.46
, pp. 599-605
-
-
Ohta, S.1
Tachikawa, O.2
Makino, Y.3
Tasaki, Y.4
Hirobe, M.5
-
36
-
-
78651165715
-
The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
-
Omura T and Sato R (1964) The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J Biol Chem 239:2370-2378.
-
(1964)
J Biol Chem
, vol.239
, pp. 2370-2378
-
-
Omura, T.1
Sato, R.2
-
39
-
-
85034892163
-
Glutathione S-transferase, cytochrome P450 and uridine 5′-diphosphate-glucuronosyltransferase in human small intestine and liver
-
Peters WH, Nagengast FM, and van Tongeren JH (1989) Glutathione S-transferase, cytochrome P450 and uridine 5′-diphosphate- glucuronosyltransferase in human small intestine and liver. Gastroenterology 96:783-789.
-
(1989)
Gastroenterology
, vol.96
, pp. 783-789
-
-
Peters, W.H.1
Nagengast, F.M.2
Van Tongeren, J.H.3
-
40
-
-
0026947330
-
Determination of methadone and its metabolites by high performance liquid chromatography following solid-phase extraction in rat plasma
-
Pierce TL, Murray AG, and Hope W (1992) Determination of methadone and its metabolites by high performance liquid chromatography following solid-phase extraction in rat plasma. J Chromatogr Sci 30:443-447.
-
(1992)
J Chromatogr Sci
, vol.30
, pp. 443-447
-
-
Pierce, T.L.1
Murray, A.G.2
Hope, W.3
-
41
-
-
0030918659
-
Improved high-performance liquid chromatographic procedure for the separation and quantification of hydroxytestosterone metabolites
-
Purdon MP and Lehman-McKeeman LD (1997) Improved high-performance liquid chromatographic procedure for the separation and quantification of hydroxytestosterone metabolites. J Pharmacol Toxicol Methods 37:67-73.
-
(1997)
J Pharmacol Toxicol Methods
, vol.37
, pp. 67-73
-
-
Purdon, M.P.1
Lehman-McKeeman, L.D.2
-
42
-
-
0028921457
-
The CYP2D6B mutant allele is overrepresented in the Lewy body variant of Alzheimer's disease
-
Saitoh T, Xia Y, Chen X, Masliah E, Galasko D, Shults C, Thal LJ, Hansen LA, and Katzman R (1995) The CYP2D6B mutant allele is overrepresented in the Lewy body variant of Alzheimer's disease. Ann Neurol 37:110-112.
-
(1995)
Ann Neurol
, vol.37
, pp. 110-112
-
-
Saitoh, T.1
Xia, Y.2
Chen, X.3
Masliah, E.4
Galasko, D.5
Shults, C.6
Thal, L.J.7
Hansen, L.A.8
Katzman, R.9
-
44
-
-
0025885546
-
NADPH-cytochrome P-450 oxidoreductase. the role of cysteine 566 in catalysis and cofactor binding
-
Shen AL, Christensen MJ, and Kasper CB (1991) NADPH-cytochrome P-450 oxidoreductase. The role of cysteine 566 in catalysis and cofactor binding. J Biol Chem 266:19976-19980.
-
(1991)
J Biol Chem
, vol.266
, pp. 19976-19980
-
-
Shen, A.L.1
Christensen, M.J.2
Kasper, C.B.3
-
45
-
-
0035049437
-
Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain
-
Siegle I, Fritz P, Eckhardt K, Zanger UM, and Eichelbaum M (2001) Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain. Pharmacogenetics 11:237-245.
-
(2001)
Pharmacogenetics
, vol.11
, pp. 237-245
-
-
Siegle, I.1
Fritz, P.2
Eckhardt, K.3
Zanger, U.M.4
Eichelbaum, M.5
-
46
-
-
0345638787
-
Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs
-
Skoda RC, Gonzalez FJ, Demierre A, and Meyer UA (1988) Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs. Proc Natl Acad Sci USA 85:5240-5243.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 5240-5243
-
-
Skoda, R.C.1
Gonzalez, F.J.2
Demierre, A.3
Meyer, U.A.4
-
47
-
-
0033846716
-
Recombinant cytochrome P450 2D18 metabolism of dopamine and arachidonic acid
-
Thompson CM, Capdevila JH, and Strobel HW (2000) Recombinant cytochrome P450 2D18 metabolism of dopamine and arachidonic acid. J Pharmacol Exp Ther 294:1120-1130.
-
(2000)
J Pharmacol Exp Ther
, vol.294
, pp. 1120-1130
-
-
Thompson, C.M.1
Capdevila, J.H.2
Strobel, H.W.3
-
48
-
-
0025021645
-
Fast reliable assay for morphine and its metabolites using high-performance liquid chromatography and native fluorescence detection
-
Venn RF and Michalkiewicz A (1990) Fast reliable assay for morphine and its metabolites using high-performance liquid chromatography and native fluorescence detection. J Chromatogr 525:379-388.
-
(1990)
J Chromatogr
, vol.525
, pp. 379-388
-
-
Venn, R.F.1
Michalkiewicz, A.2
-
49
-
-
0034645927
-
Cytochrome P-450 activities in human and rat brain microsomes
-
Voirol P, Jonzier-Perey M, Porchet F, Reymond MJ, Janzer RC, Bouras C, Strobel HW, Kosel M, Eap CB, and Baumann P (2000) Cytochrome P-450 activities in human and rat brain microsomes. Brain Res 855:235-243.
-
(2000)
Brain Res
, vol.855
, pp. 235-243
-
-
Voirol, P.1
Jonzier-Perey, M.2
Porchet, F.3
Reymond, M.J.4
Janzer, R.C.5
Bouras, C.6
Strobel, H.W.7
Kosel, M.8
Eap, C.B.9
Baumann, P.10
-
50
-
-
0031866703
-
Covalent binding of carbamazepine reactive metabolites to P450 isoforms present in the skin
-
Wolkenstein P, Tan C, Lecoeur S, Wechsler J, Garcia-Martin N, Charue D, Bagot M, and Beaune P (1998) Covalent binding of carbamazepine reactive metabolites to P450 isoforms present in the skin. Chem-Biol Interact 113:39-50.
-
(1998)
Chem-Biol Interact
, vol.113
, pp. 39-50
-
-
Wolkenstein, P.1
Tan, C.2
Lecoeur, S.3
Wechsler, J.4
Garcia-Martin, N.5
Charue, D.6
Bagot, M.7
Beaune, P.8
-
51
-
-
0034771887
-
Characterization of dextromethorphan O- and N-demethylation catalyzed by highly purified recombinant human CYP2D6
-
Yu A, Dong H, Lang D, and Haining RL (2001) Characterization of dextromethorphan O- and N-demethylation catalyzed by highly purified recombinant human CYP2D6. Drug Metab Dispos 29:1362-1365.
-
(2001)
Drug Metab Dispos
, vol.29
, pp. 1362-1365
-
-
Yu, A.1
Dong, H.2
Lang, D.3
Haining, R.L.4
-
52
-
-
0034782996
-
Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: Can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities?
-
Yu A and Haining RL (2001) Comparative contribution to dextromethorphan metabolism by cytochrome P450 isoforms in vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities? Drug Metab Dispos 29:1514-1520.
-
(2001)
Drug Metab Dispos
, vol.29
, pp. 1514-1520
-
-
Yu, A.1
Haining, R.L.2
-
53
-
-
0036897469
-
Expression, purification, biochemical characterization, and comparative function of human cytochrome P450 2D6.1, 2D6.2, 2D6.10 and 2D6.17 allelic isoforms
-
Yu A, Kneller BM, Rettie AE, and Haining RL (2002) Expression, purification, biochemical characterization, and comparative function of human cytochrome P450 2D6.1, 2D6.2, 2D6.10 and 2D6.17 allelic isoforms. J Pharmacol Exp Ther 303:1291-1300.
-
(2002)
J Pharmacol Exp Ther
, vol.303
, pp. 1291-1300
-
-
Yu, A.1
Kneller, B.M.2
Rettie, A.E.3
Haining, R.L.4
-
54
-
-
0038240578
-
Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase
-
Yu AM, Idle JR, Herraiz T, Kupfer A, and Gonzalez FJ (2003) Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase. Pharmacogenetics 13:307-319.
-
(2003)
Pharmacogenetics
, vol.13
, pp. 307-319
-
-
Yu, A.M.1
Idle, J.R.2
Herraiz, T.3
Kupfer, A.4
Gonzalez, F.J.5
-
55
-
-
0030887069
-
Different effects of inhibitors on the O- and N-demethylation of codeine in human liver microsomes
-
Yue QY and Sawe J (1997) Different effects of inhibitors on the O- and N-demethylation of codeine in human liver microsomes. Eur J Clin Pharmacol 52:41-47.
-
(1997)
Eur J Clin Pharmacol
, vol.52
, pp. 41-47
-
-
Yue, Q.Y.1
Sawe, J.2
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