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Volumn 336, Issue 4, 2005, Pages 1241-1250

CYP2D7 splice variants in human liver and brain: Does CYP2D7 encode functional protein?

Author keywords

Alternative splicing; Brain; CYP2D6; CYP2D7; Liver; mRNA

Indexed keywords

CODEINE; CYTOCHROME P450 2D6; CYTOCHROME P450 2D7; CYTOCHROME P450 ISOENZYME; UNCLASSIFIED DRUG;

EID: 25644444404     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.08.255     Document Type: Article
Times cited : (30)

References (24)
  • 1
    • 3142519666 scopus 로고    scopus 로고
    • Pharmacogenetics of antidepressants and antipsychotics: The contribution of allelic variations to the phenotype of drug response
    • J. Kirchheiner, K. Nickchen, M. Bauer, M.L. Wong, J. Licinio, I. Roots, and J. Brockmoller Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response Mol. Psychiatry 9 2004 442 473
    • (2004) Mol. Psychiatry , vol.9 , pp. 442-473
    • Kirchheiner, J.1    Nickchen, K.2    Bauer, M.3    Wong, M.L.4    Licinio, J.5    Roots, I.6    Brockmoller, J.7
  • 2
    • 0038240578 scopus 로고    scopus 로고
    • Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase
    • A.M. Yu, J.R. Idle, T. Herraiz, A. Kupfer, and F.J. Gonzalez Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase Pharmacogenetics 13 2003 307 319
    • (2003) Pharmacogenetics , vol.13 , pp. 307-319
    • Yu, A.M.1    Idle, J.R.2    Herraiz, T.3    Kupfer, A.4    Gonzalez, F.J.5
  • 3
    • 3042641834 scopus 로고    scopus 로고
    • A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine
    • H.V. Pai, R.P. Kommaddi, S.J. Chinta, T. Mori, M.R. Boyd, and V. Ravindranath A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine J. Biol. Chem. 279 2004 27383 27389
    • (2004) J. Biol. Chem. , vol.279 , pp. 27383-27389
    • Pai, H.V.1    Kommaddi, R.P.2    Chinta, S.J.3    Mori, T.4    Boyd, M.R.5    Ravindranath, V.6
  • 4
    • 0024796958 scopus 로고
    • The human debrisoquine 4-hydroxylase (CYP2D) locus: Sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene
    • S. Kimura, M. Umeno, R.C. Skoda, U.A. Meyer, and F.J. Gonzalez The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene Am. J. Hum. Genet. 45 1989 889 904
    • (1989) Am. J. Hum. Genet. , vol.45 , pp. 889-904
    • Kimura, S.1    Umeno, M.2    Skoda, R.C.3    Meyer, U.A.4    Gonzalez, F.J.5
  • 5
    • 0037081031 scopus 로고    scopus 로고
    • Discriminative quantification of cytochrome P4502D6 and 2D7/8 pseudogene expression by TaqMan real-time reverse transcriptase polymerase chain reaction
    • K. Endrizzi, J. Fischer, K. Klein, M. Schwab, A. Nüssler, P. Neuhaus, M. Eichelbaum, and U.M. Zanger Discriminative quantification of cytochrome P4502D6 and 2D7/8 pseudogene expression by TaqMan real-time reverse transcriptase polymerase chain reaction Anal. Biochem. 300 2002 121 131
    • (2002) Anal. Biochem. , vol.300 , pp. 121-131
    • Endrizzi, K.1    Fischer, J.2    Klein, K.3    Schwab, M.4    Nüssler, A.5    Neuhaus, P.6    Eichelbaum, M.7    Zanger, U.M.8
  • 7
    • 0031195277 scopus 로고    scopus 로고
    • Alternative splicing of CYP2D mRNA in human breast tissue
    • Z. Huang, M.J. Fasco, and L.S. Kaminsky Alternative splicing of CYP2D mRNA in human breast tissue Arch. Biochem. Biophys. 343 1997 101 108
    • (1997) Arch. Biochem. Biophys. , vol.343 , pp. 101-108
    • Huang, Z.1    Fasco, M.J.2    Kaminsky, L.S.3
  • 8
    • 0030789095 scopus 로고    scopus 로고
    • Comparison of CYP2D messenger RNA splice variant profiles in human lung tumors and normal tissues
    • Z. Huang, M.J. Fasco, S. Spivak, and L.S. Kaminsky Comparison of CYP2D messenger RNA splice variant profiles in human lung tumors and normal tissues Cancer Res. 57 1997 2589 2592
    • (1997) Cancer Res. , vol.57 , pp. 2589-2592
    • Huang, Z.1    Fasco, M.J.2    Spivak, S.3    Kaminsky, L.S.4
  • 9
    • 0030741819 scopus 로고    scopus 로고
    • Analysis of CYP2D6 expression in human lung: Implications for the association between CYP2D6 activity and susceptibility to lung cancer
    • K.T. Kivistö, E.-U. Griese, T. Stüven, P. Fritz, G. Friedel, H.K. Kroemer, and U.M. Zanger Analysis of CYP2D6 expression in human lung: implications for the association between CYP2D6 activity and susceptibility to lung cancer Pharmacogenetics 7 1997 295 302
    • (1997) Pharmacogenetics , vol.7 , pp. 295-302
    • Kivistö, K.T.1    Griese, E.-U.2    Stüven, T.3    Fritz, P.4    Friedel, G.5    Kroemer, H.K.6    Zanger, U.M.7
  • 10
    • 0042357513 scopus 로고    scopus 로고
    • Only truncated, not complete cytochrome P450 2D6 RNA transcript and no detectable enzyme activity are expressed in human lymphocytes
    • L. McConnachie, B. Phillips, M. Bajpai, D.D. Shen, and R.J. Ho Only truncated, not complete cytochrome P450 2D6 RNA transcript and no detectable enzyme activity are expressed in human lymphocytes Drug Metab. Dispos. 31 2003 1103 1107
    • (2003) Drug Metab. Dispos. , vol.31 , pp. 1103-1107
    • McConnachie, L.1    Phillips, B.2    Bajpai, M.3    Shen, D.D.4    Ho, R.J.5
  • 11
    • 15744393886 scopus 로고    scopus 로고
    • Inter-individual variation of several cytochrome P450 2D6 splice variants in human liver
    • J. Denson, Y. Wu, W. Yang, and J. Zhang Inter-individual variation of several cytochrome P450 2D6 splice variants in human liver Biochem. Biophys. Res. Commun. 330 2005 498 504
    • (2005) Biochem. Biophys. Res. Commun. , vol.330 , pp. 498-504
    • Denson, J.1    Wu, Y.2    Yang, W.3    Zhang, J.4
  • 12
    • 0009503375 scopus 로고    scopus 로고
    • Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: A role for the CYP2D6*35 allele in ultrarapid metabolism?
    • R. Løvlie, A.K. Daly, G.E. Matre, A. Molven, and V.M. Steen Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism? Pharmacogenetics 11 2001 45 55
    • (2001) Pharmacogenetics , vol.11 , pp. 45-55
    • Løvlie, R.1    Daly, A.K.2    Matre, G.E.3    Molven, A.4    Steen, V.M.5
  • 13
    • 0033461165 scopus 로고    scopus 로고
    • Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data
    • A. Gaedigk, R.R. Gotschall, N.S. Forbes, S.D. Simon, and J.S. Leeder Optimization of cytochrome P4502D6 (CYP2D6) phenotype assignment using a genotyping algorithm based on allele frequency data Pharmacogenetics 9 1999 669 682
    • (1999) Pharmacogenetics , vol.9 , pp. 669-682
    • Gaedigk, A.1    Gotschall, R.R.2    Forbes, N.S.3    Simon, S.D.4    Leeder, J.S.5
  • 15
    • 0036339071 scopus 로고    scopus 로고
    • Unique CYP2D6 activity distribution and genotype-phenotype discordance in African Americans
    • A. Gaedigk, L.D. Bradford, K.A. Marcucci, and J.S. Leeder Unique CYP2D6 activity distribution and genotype-phenotype discordance in African Americans Clin. Pharmacol. Ther. 72 2002 76 89
    • (2002) Clin. Pharmacol. Ther. , vol.72 , pp. 76-89
    • Gaedigk, A.1    Bradford, L.D.2    Marcucci, K.A.3    Leeder, J.S.4
  • 16
    • 0007293059 scopus 로고    scopus 로고
    • Ultrarapid metabolizers of debrisoquine: Characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene
    • R. Løvlie, A.K. Daly, A. Molven, J.R. Idle, and V.M. Steen Ultrarapid metabolizers of debrisoquine: characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene FEBS Lett. 392 1996 30 34
    • (1996) FEBS Lett. , vol.392 , pp. 30-34
    • Løvlie, R.1    Daly, A.K.2    Molven, A.3    Idle, J.R.4    Steen, V.M.5
  • 17
    • 17144362174 scopus 로고    scopus 로고
    • Automated splicing mutation analysis by information theory
    • V.K. Nalla, and P.K. Rogan Automated splicing mutation analysis by information theory Hum. Mutat. 25 2005 334 342
    • (2005) Hum. Mutat. , vol.25 , pp. 334-342
    • Nalla, V.K.1    Rogan, P.K.2
  • 18
    • 0031880376 scopus 로고    scopus 로고
    • Information analysis of human splice site mutations
    • P.K. Rogan, B.M. Faux, and T.D. Schneider Information analysis of human splice site mutations Hum. Mutat. 12 1998 153 171
    • (1998) Hum. Mutat. , vol.12 , pp. 153-171
    • Rogan, P.K.1    Faux, B.M.2    Schneider, T.D.3
  • 19
    • 0027464041 scopus 로고
    • Relationship between personality and debrisoquine hydroxylation capacity. Suggestion of an endogenous neuroactive substrate or product of the cytochrome P4502D6
    • A. Llerena, G. Edman, J. Cobaleda, J. Benitez, D. Schalling, and L. Bertilsson Relationship between personality and debrisoquine hydroxylation capacity. Suggestion of an endogenous neuroactive substrate or product of the cytochrome P4502D6 Acta Psychiatr. Scand. 87 1993 23 28
    • (1993) Acta Psychiatr. Scand. , vol.87 , pp. 23-28
    • Llerena, A.1    Edman, G.2    Cobaleda, J.3    Benitez, J.4    Schalling, D.5    Bertilsson, L.6
  • 20
    • 0038070292 scopus 로고    scopus 로고
    • Information theory-based analysis of CYP2C19, CYP2D6 and CYP3A5 splicing mutations
    • P.K. Rogan, S. Svojanovsky, and J.S. Leeder Information theory-based analysis of CYP2C19, CYP2D6 and CYP3A5 splicing mutations Pharmacogenetics 13 2003 207 218
    • (2003) Pharmacogenetics , vol.13 , pp. 207-218
    • Rogan, P.K.1    Svojanovsky, S.2    Leeder, J.S.3
  • 21
    • 0013394889 scopus 로고    scopus 로고
    • Mechanisms of alternative pre-messenger RNA splicing
    • D.L. Black Mechanisms of alternative pre-messenger RNA splicing Annu. Rev. Biochem. 72 2003 291 336
    • (2003) Annu. Rev. Biochem. , vol.72 , pp. 291-336
    • Black, D.L.1
  • 22
    • 0036736195 scopus 로고    scopus 로고
    • Regional and cellular expression of CYP2D6 in human brain: Higher levels in alcoholics
    • S. Miksys, Y. Rao, E. Hoffmann, D.C. Mash, and R.F. Tyndale Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics J. Neurochem. 82 2002 1376 1387
    • (2002) J. Neurochem. , vol.82 , pp. 1376-1387
    • Miksys, S.1    Rao, Y.2    Hoffmann, E.3    Mash, D.C.4    Tyndale, R.F.5
  • 23
    • 0035049437 scopus 로고    scopus 로고
    • Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain
    • I. Siegle, P. Fritz, K. Eckhardt, U.M. Zanger, and M. Eichelbaum Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain Pharmacogenetics 11 2001 237 245
    • (2001) Pharmacogenetics , vol.11 , pp. 237-245
    • Siegle, I.1    Fritz, P.2    Eckhardt, K.3    Zanger, U.M.4    Eichelbaum, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.