Modulation of neurotoxicant-induced increases in intracellular calcium by phytoestrogens differ for amyloid beta peptide (Aβ) and 1-methyl-4-phenyl-pyridine (MPP+)

Journal of Applied Toxicology

Volumn 29, Issue 1, 2009, Pages 84-89

  Sørensen, Izel Fourie ^b   Purup, Stig ^b   Ehrich, Marion ^a  

^a VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

1 methyl 4 phenylpyridine (MPP+); Amyloid beta peptide; Intracellular calcium; Phytoestrogens; SH SY5Y human neuroblastoma cells

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; AMYLOID BETA PROTEIN; APIGENIN; CALCIUM; CARBACHOL; COUMESTROL; DAIDZEIN; EQUOL; ESTRADIOL; FORMONONETIN; GENISTEIN; LACTATE DEHYDROGENASE; NIFEDIPINE; PHYTOESTROGEN; QUERCETIN; RESVERATROL;

ARTICLE; CALCIUM CELL LEVEL; CELL CULTURE; CELL DEATH; CELL VIABILITY; CYTOTOXICITY; ENZYME RELEASE; HUMAN; HUMAN CELL; IN VITRO STUDY; NEUROBLASTOMA; NEUROMODULATION; PRIORITY JOURNAL;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; AMYLOID BETA-PROTEIN; CALCIUM; CALCIUM SIGNALING; CELL LINE, TUMOR; CELL SURVIVAL; DRUG ANTAGONISM; GENISTEIN; HUMANS; ISOFLAVONES; L-LACTATE DEHYDROGENASE; NEUROBLASTOMA; NEUROTOXINS; NIFEDIPINE; PHYTOESTROGENS;

EID: 58149461408     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1376     Document Type: Article

References (43)

1. Atkinson C, Frankenfeld CL, Lampe JW. 2005. Gut bacterial metabolism of the soy isoflavone daidzein: exploring the relevance to human health. Exp. Biol. Med. 230: 155-170.
2. 2+ channel modulation in the neuroprotective actions of estrogen in beta-amyloid protein and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) cytotoxic models. Neurochem. Int. 45: 31-38.
3. Bang OY, Hong HS, Kim DH, Kim H, Boo JH, Huh K, Mook-Jung I. 2004. Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity. Neurobiol. Dis. 16: 21-28.
4. Beresford SA, Weiss NS, Voigt LF, McKnight B. 1997. Risk of endometrial cancer in relation to use of oestrogen combined with cyclic progestogen therapy in postmenopausal women. Lancet 349: 458-461.
5. Braak H, Braak E. 1998. Evolution of neuronal changes in the course of Alzheimer's disease. J. Neural Transm. 53S: 127-140.
6. Butterfield DA, Drake J, Pocernich C, Castegna A. 2001. Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid beta-peptide. Trends Mol. Med. 7: 548-554.
7. Cao G, Sofic E, Prior RL. 1997. Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships. Free Radical Biol. Med. 22: 749-760.
8. Cavaletti G, Oggioni N, Sala F, Pezzoni G, Cavaletti P, Marmiroli P, Petruccioli MG, Frattola L, Tredici G. 2000. Effect on the peripheral nervous system of systemically administered dimethylsulfoxide in the rat: a neurophysiological and pathological study. Toxicol. Lett. 118: 103-107.
9. Collaborative Group on Hormonal Factors in Breast Cancer. 1997. Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast cancer and 108,411 women without breast cancer. Lancet 350: 1047-1059.
10. Demuro A, Mina E, Kayed R, Milton SC, Parker I, Glabe CG. 2005. Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. J. Biol. Chem. 280: 17294-17300.
11. Ekinci FJ, Malik KU, Shea TB. 1999. Activation of the L voltage-sensitive calcium channel by mitogen-activated protein (MAP) kinase following exposure of neuronal cells to beta-amyloid. MAP kinase mediates beta-amyloid-induced neurodegeneration. J. Biol. Chem. 274: 30322-30327.
12. Henneberry RC, Novelli A, Cox JA, Lysko PG. 1989. Neurotoxicity at the N-methyl-D-aspartate receptor in energy-compromised neurons. An hypothesis for cell death in aging and disease. Ann. NY Acad. Sci. 568: 225-233.
13. Ho KP, Li L, Zhao L, Qian ZM. 2003. Genistein protects primary cortical neurons from iron-induced lipid peroxidation. Molec. Cell. Biochem. 247: 219-222.
14. Huang HM, Ou HC, Hsieh SJ. 2000a. Amyloid beta peptide impaired carbachol but not glutamate-mediated phosphoinositide pathways in cultured rat cortical neurons. Neurochem. Res. 25: 303-312.
15. Huang HM, Ou HC, Hsieh SJ. 2000b. Antioxidants prevent amyloid peptide-induced apoptosis and alteration of calcium homeostasis in cultured cortical neurons. Life Sci. 66: 1879-1892.
16. Kelly JF, Furukawa K, Barger SW, Rengen MR, Mark RJ, Blanc EM, Roth GS, Mattson MP. 1996. Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons. Proc. Natl Acad. Sci. USA 93: 6753-6758.
17. Kilbourn MR, Charalambous A, Frey KA, Sherman P, Higgins DS Jr, Greenamyre JT. 1997. Intrastriatal neurotoxin injections reduce in vitro and in vivo binding of radiolabeled rotenoids to mitochondrial complex I. J. Cerebral Blood Flow Metab. 17: 265-272.
18. LaFerla FM. 2002. Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease. Nat. Rev. Neurosci. 3: 862-872.
19. Lambert DG, Nahorski SR. 1992. Carbachol-stimulated calcium entry in SH-SY5Y human neuroblastoma cells: which route? J. Physiol. Paris 86: 77-82.
20. 2+ in 1-methyl-4-phenylpyridinium- or 6-hydroxydopamine-induced cell viability loss in PC12 cells. Neurochem. Res. 31: 851-860.
21. Leist M, Volbracht C, Fava E, Nicotera P. 1998. 1-Methyl-4- phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis. Mol. Pharmac. 54: 789-801.
22. Li YP, Bushnell AF, Lee CM, Perlmutter LS, Wong SK. 1996. Beta-amyloid induces apoptosis in human-derived neurotypic SH-SY5Y cells. Brain Res. 738: 196-204.
23. Linford NJ, Dorsa DM. 2002. 17beta-Estradiol and the phytoestrogen genistein attenuate neuronal apoptosis induced by the endoplasmic reticulum calcium-ATPase inhibitor thapsigargin. Steroids 67: 1029-1040.
24. Lyden P, Wahlgren NG. 2000. Mechanisms of action of neuroprotectants in stroke. J. Stroke Cerebrovasc. Dis. 9: 9-14.
25. Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE. 1992. beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12: 376-389.
26. Miksicek RJ. 1993. Commonly occurring plant flavonoids have estrogenic activity. Mol. Pharmac. 44: 37-43.
27. Miranda CL, Stevens JF, Helmrich A, Henderson MC, Rodriguez RJ, Yang Y-H, Deinzer ML, Barnes DW, Buhler DR. 1999. Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines. Food Chem. Toxicol. 37: 271-285.
28. Nicklas WJ, Vyas I, Heikkila RE. 1985. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci. 36: 2503-2508.
29. Obata T. 2002. Dopamine efflux by MPTP and hydroxyl radicalgeneration. J. Neural Transm. 109: 1159-1180.
30. Orrenius S, Zhivotovsky B, Nicotera P. 2003. Regulation of cell death: the calcium-apoptosis link. Nat. Rev. Mol. Cell Biol. 4: 552-565.
31. Patisaul HB, Melby M, Whitten PL, Young LJ. 2002. Genistein affects ER beta- but not ER alpha-dependent gene expression in the hypothalamus. Endocrinology 143: 2189-2197.
32. Pierrot N, Ghisdal P, Caumont AS, Octave JN. 2004. Intraneuronal amyloidbeta1-42 production triggered by sustained increase of cytosolic calcium concentration induces neuronal death. J. Neurochem. 88: 1140-1150.
33. SAS. 1999. Release 8.2. SAS Institute Inc.: Cary, NC.
34. Schreihofer DA. 2005. Transcriptional regulation by phytoestrogens in neuronal cell lines. Mol. Cell. Endocrinol. 231: 13-22.
35. Selkoe DJ. 1997. Alzheimer's disease: genotypes, phenotypes, and treatments. Science 275: 630-631.
36. Singh J, Kaur G. 2007. Transcriptional regulation of polysialylated neural cell adhesion molecule expression by NMDA receptor activation in retinoic acid-differentiated SH-SY5Y neuroblastoma cultures. Brain Res. 1154: 8-21.
37. Sonee M, Sum T, Wang C, Mukherjee SK. 2004. The soy isoflavone, genistein, protects human cortical neuronal cells from oxidative stress. Neurotoxicol. 25: 885-891.
38. +) nigral toxicity in the rat by prior decortication or MK-801 treatment: a stereological estimate of neuronal loss. Neurobiol. Aging 14: 295-301.
39. 2+ channels: a possible involvement of free radicals. J. Neurochem. 68: 265-271.
40. Wang CN, Chi CW, Lin YL, Chen CF, Shiao YJ. 2001. The neuroprotective effects of phytoestrogens on amyloid beta protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons. J. Biol. Chem. 276: 5287-5295.
41. Wise PM, Dubal DB, Rau SW, Brown CM, Suzuki S. 2005. Are estrogens protective or risk factors in brain injury and neurodegeneration? Reevaluation after the Women's Health Initiative. Endocrine Rev. 26: 308-312.
42. Zeng H, Chen Q, Zhao B. 2004. Genistein ameliorates beta-amyloid peptide (25-35)-induced hippocampal neuronal apoptosis. Free Radical Biol. Med. 36: 180-188.
43. Zhao L, Chen Q, Brinton RD. 2002. Neuroprotective and neurotrophic efficacy of phytoestrogens in cultured hippocampal neurons. Exp. Biol. Med. 227: 509-519.