Amyloid beta peptide impaired carbachol but not glutamate-mediated phosphoinositide pathways in cultured rat cortical neurons

Neurochemical Research

Volumn 25, Issue 2, 2000, Pages 303-312

  Huang, Hsueh Meei ^a   Ou, Hsio Chung ^a   Hsieh, Shon Jean ^a  

^a TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Amyloid peptide; Antioxidants; B27 supplement; Carbachol; Cortical neuronal culture; Cytosolic free calcium concentration; Ins(1,4,5)P3; Neurodegeneration; Trans ACPD

Indexed keywords

ALPHA TOCOPHEROL; AMYLOID BETA PROTEIN; CALCIUM; CARBACHOL; GLUTAMIC ACID; INOSITOL 1,4,5 TRISPHOSPHATE; LACTATE DEHYDROGENASE; PHOSPHATIDYLINOSITIDE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BRAIN CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME RELEASE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

AMYLOID BETA-PROTEIN; ANIMALS; CALCIUM; CARBACHOL; CELLS, CULTURED; CEREBRAL CORTEX; GLUTAMIC ACID; INOSITOL 1,4,5-TRISPHOSPHATE; NEURONS; PEPTIDE FRAGMENTS; PHOSPHATIDYLINOSITOLS; RATS;

ANIMALIA;

EID: 0034081045     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007592007956     Document Type: Article

References (56)

1. Glenner, G. G., and Wong, C. W. 1984. Alzheimer's disease: Initial report of the purification and characteristics of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 122:885-890.
2. Kang, J., LeMaire, H. G., Unterceck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K. H., Multhaup, G. H., Beyreuther, K., and Muller-Hill, B. 1987. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325:733-736.
3. Kitaguchi, N., Takahashi, Y., Tokushima, Y., Shiojiri, S., and Ito, H. 1988. Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity. Nature 325:733-736.
4. Ponte, P., Gonzales-DeWhitt, P., Schilling, J., Miller, J., Hsu, D., Greenberg, B., Davis, K., Wallace, W., Lieberburg, I., Fuller, F., and Cordell B. 1988. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature 331:525-527.
5. Selkoe, D. J. 1989. Biochemistry of altered brain proteins in Alzheimer's disease. Annu. Rev. Neurosci. 12:463-490.
6. Selkoe, D. J. 1996. Amyloid beta-protein and the genetics of Alzheimer's disease. J. Biol. Chem. 271:18295-18298.
7. 2+ accumulation. Proc. Natl. Acad. Sci. 92:9328-9332.
8. Mattson, M. P., Cheng, B., Davis, D., Bryant, K., Lieberburg, I., and Rydel, R. E. 1992. β-amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12:376-389.
9. Behl, C., Davis, J., Cole, G. M., and Schubert, D. 1992. Vitamin E protects nerve cells from amyloid protein toxicity. Biochem. Biophys. Res. Commun. 186:944-952.
10. Behl, C., Davis, J., Lesley, R., and Schubert, D. 1994. Hydrogen peroxide mediates amyloid β protein toxicity. Cell 77: 817-827.
11. Cafe, C., Torri, C., Bertorelli, L., Angeretti, N., Lucca, E., Forloni, G., and Marzatico, F. 1996. Oxidative stress after acute and chronic application of beta-amyloid fragment 25-35 in cortical cultures. Neurosci. Lett. 203:61-65.
12. Hensley, K., Butterfield, D. A., Hall, N., Cole, P., Subramaniam, R., Mark, R., Mattson, M. P., Markesbery, W. R., Harris, M. E., Aksenova, M., Wu, J. F., and Carney, J. M. 1996. Reactive oxygen species as causal agents in the neurotoxicity of the Alzheimer's disease-associated amyloid beta peptide. Ann. N. Y. Acad. Sci. 786:120-134.
13. Zamani, M. R., Allen, Y. S., Owen, G. P., and Gray, J. A. 1997. Nicotine modulates the neurotoxic effect of beta-amyloid protein (25-35) in hippocampal cultures. NeuroReport 8:513-517.
14. Takashima, A., Noguchi, K., Michel, G., Mercken, M., Hoshi, M., Ishiguro, K., and Imahori, K. 1996. Exposure of rat hippocampal neurons to amyloid beta peptide (25-35) induces the inactivation of phosphatidyl inositol-3 kinase and the activation of tau protein kinase I/glycogen synthase kinase-3 beta. Neurosci. Lett. 203:33-36.
15. Luo, Y., Hiroshima, N., Li, Y. H., Alkon, D. L., Sunderland, T., Etcherrigaray, R., and Wolozin, B. 1995. Physiological levels of β-amyloid increased tyrosine phosphorylation and cytosolic calcium. Brain Res. 681:65-74.
16. Luo, Y., Sunderland, T., and Wolozin, B. 1996. Physiological levels of β-amyloid activate phosphatidylinositol 3-kinase with involvement of tyrosine phosphorylation. J. Neurochem. 67: 978-987.
17. Zhang, C., Lambert, M., Bunch, C., Barber, K., Wade, W., Krafft, G., and Klein, W. 1994. Focal adhesion kinase expressed by nerve cell lines shows increased tyrosine phosphorylation in response to Alzheimer's β peptide. J. Biochem. Chem. 269: 25247-25250.
18. Zhang, C., Qiu, H. E., Krafft, G. A., and Klein, W. L. 1996. Beta peptide enhances focal adhesion kinase/Fyn association in a rat CNS nerve cell line. Neurosci. Lett. 211:187-190.
19. Etcheberrigaray, R., Ito, E., Kim, C. S., and Alkon, D. L. 1994. Soluble β-amyloid induction of Alzheimer's phenotype for human fibroblast K+ channels. Science 264:276-279.
20. Fowler, C. J., Garlind, A., O'Neill, C., and Cowburn, R. F. 1996. Receptor-effector coupling dysfunctions in Alzheimer's disease. Ann. N. Y. Acad. Sci. 786:294-304.
21. Nordberg, A. 1992. Neuroreceptor changes in Alzheimer's disease. Cerebrovasc. Brain Metab. Rev. 4:303-328.
22. Huang, H.-M., Martins, R., Gandy, S., Etcheberrigaray, R., Ito, E., Alkon, D. L., Blass, J. P., and Gibson, G. E. 1994. Use of cultured fibroblasts in elucidating the pathophysiology and diagnosis of Alzheimer's disease. N. Y. Acad. Sci. 747:225-244.
23. Ferrari, DiLeo-G. and Flynn, D. D. 1993. Diminished muscarinic receptor-stimulated [3H]-PIP2 hydrolysis in Alzheimer's disease. Life Sci. 53:439-444.
24. Warpman, U., Alafuzoff, I., and Nordberg, A. 1993. Coupling of muscarinic receptors to GTP proteins in postmortem human brain-alterations in Alzheimer's disease. Neurosci. Lett. 150: 39-43
25. Ferrari, DiLeo-G., Mash, D. C., and Flynn, D. D. 1995. Attenuation of muscarinic receptor-G-protein interaction in Alzheimer disease. Mol. Chem. Neuropathol. 24:69-91.
26. Storga, D., Vrecko, K., Birkmayer, J. G., and Reibnegger, G. 1996. Monoaminergic neurotransmitters, their precursors and metabolites in brains of Alzheimer patients. Neurosci. Lett. 203:29-32.
27. DeKeyser, J., Ebinger, G., and Vauquelin, G. 1990. D1-dopamine receptor abnormality in frontal cortex points to a functional alteration of cortical cell membranes in Alzheimer's disease. Arch. Neurol. 47:761-763.
28. Cowburn, R. F., Vestling, M., Fowler, C. J., Ravid, R., Winblad, B., and O'Neill, C. 1993. Disrupted beta 1-adrenoceptor-G protein coupling in the temporal cortex of patients with Alzheimer's disease. Neurosci. Lett. 155:163-166.
29. O'Neill, C., Wiehager, B., Fowler, J., Ravid, R., Winblad, B., and Cowburn, R. F. 1994. Regionally selective alterations in G protein subunit levels in the Alzheimer's disease brain. Brain Res. 636:193-201
30. Wang, S. Z., Zhu, S. Z., Mash, D. C., and el-Fakahany, E. E. 1992. Comparison of the concentration of messenger RNA encoding four muscarinic receptor subtypes in control and Alzheimer brains. Brain Res. Mol. Brain Res. 16:64-70.
31. Claus, J. J., Dubois, E. A., Booij, J., Habraken, J., de-Munck, J. C., van-Herk, M., Verbeeten, B. Jr., and van-Royen, E. A. 1997. Demonstration of a reduction in muscarinic receptor binding in early Alzheimer's disease using iodine-123 dexetimide single-photon emission tomography. Eur. J. Nucl. Med. 24: 602-608.
32. Huang, H.-M., and Gibson, G. E. 1993. Altered -adrenergic receptor-stimulated cAMP formation in cultured skin fibroblasts from Alzheimer's donors. J. Biol. Chem. 268:14616-14621.
33. Huang, H.-M., Lin, T.-A., Sun, G. Y., and Gibson, G. E. 1995. Increased inositol (1,4,5) trisphosphate accumulation correlates with upregulation of bradykinin receptors in Alzheimer's disease. J. Neurochem. 64:761-766.
34. Berridge, M. J. 1995. Inositol trisphosphate and calcium signaling. Ann. NY Acad. Sci. 766:31-43.
35. Blass, J. P. and Gibson, G. E. 1991. The role of oxidative abnormalities in the pathophysiology of Alzheimer's Disease. Rev. Neurol. 148:513-525.
36. Kelly, J. F., Furukawa, K., Barger, S. W., Rengen, M. R., Mark, R. J., Blanc, E. M., Roth, G. S., and Mattson, M. P. 1996. Amyloid peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons. Proc. Natl. Acad. Sci. 93:6753-6758.
37. Huang, H.-M., Ou, H.-C., and Hsueh, S.-J. 1998. Amyloid protein enhanced bradykinin-mediated inositol (1,4,5)trisphosphate formation and cytosolic free calcium. Life Sci. 63:195-203.
38. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
39. Kim, K. S., Huang, H.-M., Zhang, H., Wagner, J., Joh, T., and Gibson, G. E. 1995. The relation of cell density induced changes in gene expression to signal transduction systems. Molecular Brain Res. 33:254-260.
40. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260:3440-3450.
41. Muller, W. E., Eckert, G. P., Scheuer, K., Cairns, N. J., Maras, A., and Gattaz, W. F. 1998. Effects of beta-amyloid peptides on the fluidity of membranes from frontal and parietal lobes of human brain. High potencies of A beta 1-42 and A beta 1-43. Amyloid. 5:10.5
42. Muller, W. E., Koch, S., Eckert, A., Hartmann, H., and Scheuer, K. 1995. Beta-amyloid peptide decreases membrane fluidity. Brain Res. 674:133-136.
43. Li, X., Song, L., and Jope, R. S. 1996. Cholinergic stimulation of AP-1 and NFkB Transcription factors differentially sensitive to oxidative stress in SH-SY5Y neuroblastoma: relationship to phosphoinositide hydrolysis. J Neurosci. 16:5914-5922.
44. q/11. J Neurochem. 69:570-580.
45. Puttfarcken, P. S., Manelli, A. M., Falduto, M. T., Getz, G. S., and LaDu, M. J. 1997. Beta 25-35 alters calcium homeostasis and induces neurotoxicity in cerebellar granule cells. J. Neurochem. 68:760-769.
46. Goodman, Y. and Mattson, M. P. 1994. Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury. Exp. Neurobiol. 128:1-12.
47. Perry, E. K., Court, J. A., Lloyd, S., Johnson, M., Griffiths, M. H., Spurden, D., Piggott, M. A., Turner, J., and Perry, R. H. 1996. Beta-amyloidosis in normal aging and transmitter signaling in the human temporal lobe. Ann. N. Y. Acad. Sci. 777: 388-392
48. Buxbaum, J. D., Gandy, S. E., Cicchetti, P., Ehrlich, M. E., Czernik, A. J., Fracasso, R. P., Ramabhadran, T. V., Unterbeck, A. J., and Greengard, P. 1990. Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate proteins phosphorylation. Proc. Natl. Acad. Sci. USA 87:6003-6006.
49. Buxbaum, J. D., Oishi, M., Chen, H. I., Pinkas-Kramarski, R., Jaffe, E. A., Gandy, S. E., and Greengard, P. 1992. Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer's beta/A4 amyloid protein precursor. Proc. Natl. Acad. Sci. USA 89:10075-10078.
50. Wolf, B. A., Wertkin, A. M., Jolly, Y. C., Yasuda, R. P., Wolfe, B. B., Konrad, R. J., Manning, D., Ravi, S., Williamson, J. R., and Lee, V. M. 1995. Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells. J. Biol. Chem. 270:4916-4922.
51. Nitsch, R. M., Wurtman, R. J., and Growdon, J. H. 1996. Regulation of APP processing. Potential for the therapeutical reduction of brain amyloid burden. Ann. N. Y. Acad. Sci. 777: 175-182
52. Slack, B. E., Breu, J., Petryniak, M. A., Srivastava, K., and Wurtman, R. J. 1995. Tyrosine phosphorylation-dependent stimulation of amyloid precursor protein secretion by the m3 muscarinic acetylcholine receptor. J. Biol. Chem. 270:8337-8344.
53. Slack, B. E., Breu, J., Muchnicki, L., and Wurtman, R. J. 1997. Rapid stimulation of amyloid precursor protein release by epidermal growth factor: role of protein kinase C. Biochem. J. 327:245-249
54. Emmerling, M. R., Dudley, D. T., Dyer, R. D., Carroll, R. T., Doyle, P. D., and Davis, R. E. 1996. The role of arachidonic acid in the secretion of the amyloid precursor protein (APP). Ann. N. Y. Acad. Sci. 777:310-315.
55. Danenberg, D., Haring, R., Heldman, E., Gurwitz, D., Ben-Nathan, D., Pittel, Z., Zuckerman, A., and Fisher, A. 1995. Dehydroepiandrosterone augments M1-muscarinic receptor-stimulated amyloid precursor protein secretion in desensitized PC12M1 cells. Ann. N.Y. Acad. Sci. 774:300-303
56. Masliah, E., Westland, C. E., Rockenstein, E. M., Abraham, C. R., Mallory, M., Veinberg, I., Sheldon, E., and Mucke, L. 1997. Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo. Neuroscience. 78:135-146