The role of HBV genotype core promoter and precore mutations in advanced liver disease in renal transplant recipients

Journal of Hepatology

Volumn 50, Issue 2, 2009, Pages 281-288

  Tsai, Ming Chao ^a   Chen, Chien Hung ^a   Lee, Chuan Mo ^a   Chen, Yen Ta ^a   Chien, Yu Shu ^a   Hung, Chao Hung ^a   Wang, Jing Houng ^a   Lu, Sheng Nan ^a   Yen, Yi Hao ^a   Changchien, Chi Sin ^a   Hu, Tsung Hui ^a  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Core promoter and precore mutations; HBV genotype; Hepatitis B virus; Liver cirrhosis; Renal transplantation

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA FETOPROTEIN; CYCLOSPORIN; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIBODY; HEPATITIS B(E) ANTIGEN; LAMIVUDINE; PREDNISOLONE; TACROLIMUS; VIRUS DNA;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTIVIRAL THERAPY; ARTICLE; CONTROLLED STUDY; DISEASE DURATION; DNA REPLICATION; FEMALE; FOLLOW UP; GENE MUTATION; GENE SEQUENCE; GENOTYPE; GRAFT RECIPIENT; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; KIDNEY GRAFT; KIDNEY GRAFT REJECTION; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SAMPLE SIZE; VIRUS REPLICATION;

ADULT; ALANINE TRANSAMINASE; DNA, VIRAL; FEMALE; FOLLOW-UP STUDIES; GENOTYPE; HEPATITIS B CORE ANTIGENS; HEPATITIS B VIRUS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; LIVER CIRRHOSIS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MUTATION; PROMOTER REGIONS, GENETIC; RETROSPECTIVE STUDIES;

EID: 58149460908     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2008.09.013     Document Type: Article

References (40)

1. Fabrizi F., Lunghi G., Poordad F.F., and Martin P. Management of hepatitis B after renal transplantation: an update. J Nephrol 15 (2002) 113-122
2. Fabrizi F., Martin P., Dixit V., Kanwal F., and Dulai G. HBsAg seropositive status and survival after renal transplantation: meta-analysis of observational studies. Am J Transplant 5 (2005) 2913-2921
3. Mathurin P., Mouquet C., Poynard T., Sylla C., Benalia H., Fretz C., et al. Impact of hepatitis B and C virus on kidney transplantation outcome. Hepatology 29 (1999) 257-263
4. Lee W.C., Shu K.H., Cheng C.H., Wu M.J., Chen C.H., and Lian J.C. Long-term impact of hepatitis B, C virus infection on renal transplantation. Am J Nephrol 21 (2001) 300-306
5. Fabrizi F., Martin P., and Ponticelli C. Hepatitis B virus and renal transplantation. Nephron 90 (2002) 241-251
6. Hu R.H., Lee P.H., Chung Y.C., Huang M.T., and Lee C.S. Hepatitis B and C in renal transplantation in Taiwan. Transplant Proc 26 (1994) 2059-2061
7. Fornairon S., Pol S., Legendre C., Carnot F., Mamzer-Bruneel M.F., Brechot C., et al. The long-term virologic and pathologic impact of renal transplantation on chronic hepatitis B virus infection. Transplantation 62 (1996) 297-299
8. Fairley C.K., Mijch A., Gust I.D., Nichilson S., Dimitrakakis M., and Lucas C.R. The increased risk of fatal liver disease in renal transplant patients who are hepatitis B e antigen and/or HBV DNA positive. Transplantation 52 (1991) 497-500
9. Behzad-Behbahani A., Mojiri A., Tabei S.Z., Farhadi-Andarabi A., Pouransari R., Yaghobi R., et al. Outcome of hepatitis B and C virus infection on graft function after renal transplantation. Transplant Proc 37 (2005) 3045-3047
10. Lee C.M., Lu S.N., Changchien C.S., Yeh C.T., Hsu T.T., Tang J.H., et al. Age, gender, and local geographic variations of viral etiology of hepatocellular carcinoma in a hyperendemic area for hepatitis B virus infection. Cancer 86 (1999) 1143-1150
11. Okamoto H., Tsuda F., Sakugawa H., Sastrosoewignjo R.I., Imai M., Miyakawa Y., et al. Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. J Gen Virol 69 (1988) 2575-2583
12. Norder H., Courouce A.M., and Magnius L.O. Molecular basis of hepatitis B virus serotype variations within the four major subtypes. J Gen Virol 73 (1992) 3141-3145
13. Stuyver L., De Gendt S., Van Geyt C., Zoulim F., Fried M., Schinazi R.F., et al. A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness. J Gen Virol 81 (2000) 67-74
14. Lindh M., Andersson A.S., and Gusdal A. Genotypes, nt 1858 variants, and geographic origin of hepatitis B virus - large-scale analysis using a new genotyping method. J Infect Dis 175 (1997) 1285-1293
15. Kao J.H., Chen P.J., Lai M.Y., and Chen D.S. Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology 118 (2000) 554-559
16. Lee C.M., Chen C.H., Lu S.N., Tung H.D., Chou W.J., Wang J.H., et al. Prevalence and clinical implications of hepatitis B virus genotypes in southern Taiwan. Scand J Gastroenterol 38 (2003) 95-101
17. Carman W.F., Jacyna M.R., Hadziyannis S., Karayiannis P., McGarvey M.J., Makris A., et al. Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet 2 (1989) 588-591
18. Okamoto H., Yotsumoto S., Akahane Y., Yamanaka T., Miyazaki Y., Sugai Y., et al. Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. J Virol 64 (1990) 1298-1303
19. Okamoto H., Tsuda F., Akahane Y., Sugai Y., Yoshiba M., Moriyama K., et al. Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen. J Virol 68 (1994) 8102-8110
20. Chen C.H., Lee C.M., Lu S.N., Changchien C.S., Eng H.L., Huang C.M., et al. Clinical significance of hepatitis B virus (HBV) genotypes and precore and core promoter mutations affecting HBV e antigen expression in Taiwan. J Clin Microbiol 43 (2005) 6000-6006
21. Kao J.H., Chen P.J., Lai M.Y., and Chen D.S. Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers. Gastroenterology 124 (2003) 327-334
22. Lindh M., Hannoun C., Dhillon A.P., Norkrans G., and Horal P. Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carriers. J Infect Dis 179 (1999) 775-782
23. Chan H.L., Leung N.W., Hussain M., Wong M.L., and Lok A.S. Hepatitis B e antigen-negative chronic hepatitis B in Hong Kong. Hepatology 31 (2000) 763-768
24. Kidd-Ljunggren K., Oberg M., and Kidd A.H. Hepatitis B virus X gene 1751 to 1764 mutations: implications for HBeAg status and disease. J Gen Virol 78 (1997) 1469-1478
25. Naoumov N.V., Schneider R., Grotzinger T., Jung M.C., Miska S., Pape G.R., et al. Precore mutant hepatitis B virus infection and liver disease. Gastroenterology 102 (1992) 538-543
26. Funk M.L., Rosenberg D.M., and Lok A.S. World-wide epidemiology of HBeAg-negative chronic hepatitis B and associated precore and core promoter variants. J Viral Hepat 9 (2002) 52-61
27. Grandjacques C., Pradat P., Stuyver L., Chevallier M., Chevallier P., Pichoud C., et al. Rapid detection of genotypes and mutations in the pre-core promoter and the pre-core region of hepatitis B virus genome: correlation with viral persistence and disease severity. J Hepatol 33 (2000) 430-439
28. Chan H.L., Hussain M., and Lok A.S. Different hepatitis B virus genotypes are associated with different mutations in the core promoter and precore regions during hepatitis B e antigen seroconversion. Hepatology 29 (1999) 976-984
29. Orito E., Mizokami M., Sakugawa H., Michitaka K., Ishikawa K., Ichida T., et al. A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C. Japan HBV Genotype Research Group. Hepatology 33 (2001) 218-223
30. Iloeje U.H., Yang H.I., Su J., Jen C.L., You S.L., and Chen C.J. Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 130 (2006) 678-686
31. Chen C.J., Yang H.I., Su J., Jen C.L., You S.L., Lu S.N., et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 295 (2006) 65-73
32. Lin D.Y., Sheen I.S., Chiu C.T., Lin S.M., Kuo Y.C., and Liaw Y.F. Ultrasonographic changes of early liver cirrhosis in chronic hepatitis B: a longitudinal study. J Clin Ultrasound 21 (1993) 303-308
33. Desmet V.J., Gerber M., Hoofnagle J.H., Manns M., and Scheuer P.J. Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 19 (1994) 1513-1520
34. Hung C.H., Lu S.N., Wang J.H., Lee C.M., Chen T.M., Tung H.D., et al. Correlation between ultrasonographic and pathologic diagnoses of hepatitis B and C virus-related cirrhosis. J Gastroenterol 38 (2003) 153-157
35. Rao K.V., Kasiske B.L., and Anderson W.R. Variability in the morphological spectrum and clinical outcome of chronic liver disease in hepatitis B-positive and B-negative renal transplant recipients. Transplantation 51 (1991) 391-396
36. Okamoto H., Imai M., Kametani M., Nakamura T., and Mayumi M. Genomic heterogeneity of hepatitis B virus in a 54-year-old woman who contracted the infection through materno-fetal transmission. Jpn J Exp Med 57 (1987) 231-236
37. Girones R., and Miller R.H. Mutation rate of the hepadnavirus genome. Virology 170 (1989) 595-597
38. Gunther S., Fischer L., Pult I., Sterneck M., and Will H. Naturally occurring variants of hepatitis B virus. Adv Virus Res 52 (1999) 25-137
39. Chen C.H., Lee C.M., Hung C.H., Hu T.H., Wang J.H., Wang J.C., et al. Clinical significance and evolution of core promoter and precore mutations in HBeAg-positive patients with HBV genotype B and C: a longitudinal study. Liver Int 27 (2007) 806-815
40. Hussain M., Chu C.J., Sablon E., and Lok A.S. Rapid and sensitive assays for determination of hepatitis B virus (HBV) genotypes and detection of HBV precore and core promoter variants. J Clin Microbiol 41 (2003) 3699-3705