Rapid detection of genotypes and mutations in the pre-core promoter and the pre-core region of hepatitis B virus genome: Correlation with viral persistence and disease severity

Journal of Hepatology

Volumn 33, Issue 3, 2000, Pages 430-439

  Grandjacques, Cécile ^a   Pradat, Pierre ^a   Stuyver, Lieven ^b   Chevallier, Michèle ^c   Chevallier, Philippe ^d   Pichoud, Christian ^e   Maisonnas, Mireille ^e   Trépo, Christian ^a,e   Zoulim, Fabien ^a,e  

^a Liver Unit   (Belgium)

^b INNOGENETICS   (Belgium)

^c Laboratoire Mérieux   (France)

^d HOSPICES CIVILS DE LYON   (France)

^e INSERM   (France)

Author keywords

Chronic hepatitis; Genetic variability; Hepatitis B virus; Pre core mutants

Indexed keywords

VIRUS DNA;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CHRONIC HEPATITIS; DISEASE SEVERITY; FEMALE; GENE MUTATION; GENETIC VARIABILITY; GENOTYPE; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MUTATION RATE; NONHUMAN; PERSISTENT VIRUS INFECTION; PREVALENCE; PRIORITY JOURNAL; PROMOTER REGION; VIRUS GENOME; VIRUS REPLICATION;

EID: 0033844989     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(00)80279-2     Document Type: Article

References (48)

1. Hepatitis B virus infection
2. Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate
3. Complete genomes, phylogenetic relatedness, and structural proteins of six strains of the hepatitis B virus, four of which represent two new genotypes
4. The clinical significance of molecular variation within the hepatitis B virus genome
5. Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection
6. Expression of the precore region of an avian hepatitis B virus is not required for viral replication
7. The duck hepatitis B virus pre-C region encodes a signal sequence which is essential for synthesis and secretion of processed core proteins but not for virus formation
8. The secretory core protein of human hepatitis B virus is expressed on the cell surface
9. Antibodies in anti-HBe-positive patient sera bind to an HBe protein expressed on the cell surface of human hepatoma cells: Implications for virus clearance
10. Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis
11. Frequent and rapid emergence of mutated pre-C sequences in HBV from e-antigen positive carriers who seroconvert to anti-HBe during interferon treatment
12. Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen
13. Changes in the prevalence of HBeAg-negative mutant hepatitis B virus during the course of chronic hepatitis B
14. Active hepatitis B virus replication in the presence of anti-HBe is associated with viral variants containing an inactive pre-C region
15. Rapid detection and further characterization of infection with hepatitis B virus variants containing a stop codon in the distal pre-C region
16. Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pregenome encapsidation signal
17. Replication capacities of natural and artificial precore stop codon mutants of hepatitis B virus: Relevance of pregenome encapsidation signal
18. The stem-loop structure of the cisencapsidation signal is highly conserved in naturally occurring hepatitis B virus variants
19. Evidence for a base-paired region of hepatitis B virus pregenoma encapsidation signal which influences the patterns of precore mutations abolishing HBe protein expression
20. Hepatitis B virus genotype A rarely circulates as an HBe-minus mutant: Possible contribution of a single nucleotide in the precore region
21. Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen
22. Wild-type levels of pregenomic RNA and replication but reduced pre-C RNA and e-antigen synthesis of hepatitis B virus with C(1653)→T, A(1762)→T and G(1764)→A mutations in the core promoter
23. Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication
24. Naturally occurring variants of hepatitis B virus
25. Long-term follow-up of anti-HBe-positive chronic active hepatitis B
26. Chronic hepatitis in HBsAg carriers with serum HBV DNA and anti-HBe
27. Comparison of anti-HBe-positive and HBe-antigen-positive chronic hepatitis B in France
28. Predictive value of precore hepatitis B virus mutations in spontaneous and interferon-induced hepatitis B e antigen clearance
29. Different hepatitis B virus genotypes are associated with different mutations in the core promoter and precore regions during hepatitis B e antigen seroconversion
30. High prevalence of 1762(T) 1764(A) mutations in the basic core promoter of hepatitis B virus isolated from black Africans with hepatocellular carcinoma compared with asymptomatic carriers
31. Analysis of hepatitis B virus genotypes and pre-core region variability during interferon treatment of HBe antigen negative chronic hepatitis B
32. Hepatitis B virus infection: Precore mutants and its relation to viral genotypes and core mutations
33. A line probe assay for hepatitis B virus genotypes
34. Comparison of methods for detection of hepatitis B virus DNA
35. Clinical evaluation of the branched DNA assay for hepatitis B virus DNA detection in patients with chronic hepatitis B lacking hepatitis B e antigen and treated with interferon alpha
36. Three cases of severe subfulminant hepatitis in heart-transplanted patients after nosocomial transmission of a mutant hepatitis B virus
37. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis
38. Classification of chronic hepatitis: Diagnosis, grading and staging
39. Early and frequent detection of HBx Ag and/or anti-HBx in hepatitis B virus infection
40. A second generation line probe assay for hepatitis C virus
41. Hepatitis B virus carriers without precore mutations in hepatitis B e antigen-negative stage show more severe liver damage
42. Low frequency of precore hepatitis B virus mutants in anti-hepatitis B e-positive reactivation after loss of hepatitis B e antigen in patients with chronic hepatitis B
43. Enhanced replication of a hepatitis B virus mutant associated with an epidemic of fulminant hepatitis
44. Biologic properties of hepatitis B viral genomes with mutations in the precore promoter and precore open reading frame
45. Analysis of hepatitis B virus populations in an interferon-alpha-treated patient reveals predominant mutations in the C-gene and changing e-antigenicity
46. The precore sequence of hepatitis B virus is required for nuclear localization of the core protein
47. Hepatitis B virus nucleocapsid particles do not cross the hepatocyte nuclear membrane in transgenic mice
48. Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carriers