Angiogenesis inhibitor TNP-470 inhibits murine cutaneous wound healing

Journal of Surgical Research

Volumn 82, Issue 2, 1999, Pages 268-274

  Klein, Scott A ^a   Bond, Sheldon J ^a   Gupta, Subhas C ^b   Yacoub, Oraib A ^a   Anderson, Gary L ^a  

^a University of Louisville School of Medicine   (United States)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

AGM 1470; Angiogenesis inhibitor; Basic fibroblast growth factor (bFGF); TNP 470; Wound healing

Indexed keywords

ANGIOGENESIS INHIBITOR; BASIC FIBROBLAST GROWTH FACTOR; FUMAGILLOL CHLOROACETYLCARBAMATE; MINOCYCLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG RESPONSE; DRUG SCREENING; HISTOPATHOLOGY; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SKIN INJURY; WOUND HEALING;

EID: 0032864848     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1998.5551     Document Type: Article

References (22)

1. Rudolph R., Vande Berg J., Ehrlich H. P. Wound contraction and scar contracture. Wound Healing: Biochemical & Clinical Aspects. 1992;Saunders, Philadelphia. p. 96-114.
2. Arbiser J. L. Angiogenesis and the skin: A primer. J. Am. Acad. Dermatol. 34:1996;486.
3. Yamamoto T., Sudo K., Fujita T. Significant inhibition of endothelial cell growth in tumor vasculature by an angiogenesis inhibitor, AGM-1470 (TNP-470). Anticancer Res. 14:1994;1.
4. O'Reilly M. S., Brem H., Folkman J. Treatment of murine hemangioendotheliomas with the angiogenesis inhibitor TNP-470. J. Pediatr. Surg. 30:1995;325.
5. Brem H., Ingber D., Blood C. H., Bradley D., Urioste S., Folkman J. Suppression of tumor metastasis by angiogenesis inhibition. Surg. Forum. 42:1994;439.
6. Ingber D., Fujita T., Kishimoto S. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumor growth. Nature. 348:1990;555.
7. Kusaka M., Sudo K., Fujita T. Potent anti-angiogenic action of TNP-470: Comparison to the fumagillin parent. Biochem. Biophys. Res. Commun. 174:1991;1070.
8. Gonzalez E. M., Adamis A. P., Folkman J. Systematic administration of an angiogenesis inhibitor (TNP-470) inhibits bFGF-induced corneal neovascularization. Invest. Ophthalmol. Vis. Sci. 33:1992;777.
9. Brem H., Gresser I., Grosfeld J. The combination of antiangiogenic agents to inhibit primary tumor growth and metastasis. J. Pediatr. Surg. 28:1993;1253.
10. Teicher B. A., Dupuis N. P., Robinson M. F. Antiangiogenic treatment (TNP-470/Minocycline) increases tissue levels of anticancer drugs in mice bearing Lewis lung carcinoma. Oncol. Res. 7:1995;237.
11. Brem H., Folkman J. Analysis of experimental antiangiogenic therapy. J. Pediatr. Surg. 28:1993;445.
12. Lorenz H. P., Adzick N. S. Wound Healing: The biological and clinical essentials. Sabiston D. C., Lyerly H. K. Sabiston Essentials of Surgery. 1994;86-90 Saunders, Philadelphia.
13. Ksander G. A. Exogenous growth factors in dermal wound healing. Ann. Rep. Med. Chem. 24:1989;223.
14. Lawrence W. T., Diegelmann R. F. Growth factors in wound healing. Clin. Dermatol. 17:1994;157.
15. Mustoe T. A., Pierce G. F., Morishima C., Deuel T. F. Growth factor-induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal ulcer model. J. Clin. Invest. 87:1991;694.
16. Pierce G. F., Tarpley J. E., Yanagihara D., Mustoe T. A., Fox G. M., Thomas A. Platelet-derived growth factor (BB Homodimer), transforming growth factor-β1, and basic fibroblast growth factor in dermal wound healing. Am. J. Pathol. 140:1992;1375.
17. Slavin J. Fibroblast growth factors: At the heart of angiogenesis. Cell. Biol. Int. 19:1995;431.
18. Toi M., Takayanagi T., Toumna R., Tominaga T. Inhibition of vascular endothelial growth factor induced by an angiogenesis inhibitor TNP-470 in capillary endothelial cells. Oncol. Rep. 1:1994;423.
19. McLeskey S. W., Zhang L., Trock B. J., Kharbanda S., Liu Y., Gottardis M. M., Lippman M. E., Kern F. G. Effects of TNP-470 and pentosan polysulphate on tumorigenicity and metastasis of FGF-transfected MCF-7 cells. Br. J. Cancer. 73:1996;1053.
20. McKleskey S. W., Zhang L., Kharbanda S., Kurebayashi J., Lippman M. E., Dickson R. B., Kern F. G. Fibroblast growth factor overexpressing breast carcinoma cells as models of angiogenesis and metastasis. Breast Cancer Res. Treat. 39:1996;103.
21. Griffith E. C., Su Z., Turk B. E., Chen S., Chan Y. H., Wu Z., Biemann K., Liu J. O. Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors TNP-470 and ovalicin. Chem. Biol. 4:1997;461.
22. Sin N., Meng L., Wang M. Q. W., Wen J. J., Bornmann W. G., Crews C. M. The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2. Proc. Natl. Acad. Sci. USA. 94:1997;6099.