Drug-target identification from total cellular lysate by drug-induced conformational changes

Analytical Biochemistry

Volumn 385, Issue 2, 2009, Pages 314-320

  Nishiya, Yoichi ^a   Shibata, Kenji ^a   Saito, Seiji ^a   Yano, Keiichi ^a   Oneyama, Chitose ^a   Nakano, Hirofumi ^a   Sharma, Sreenath V ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Drug target identification; Protease; Protein conformation; Proteolysis

Indexed keywords

CONFORMATIONS; PROTEOLYSIS;

CONFORMATIONAL CHANGE; DRUG TARGET IDENTIFICATION; PROTEASE; PROTECTIVE EFFECTS; PROTEIN CONFORMATION; PROTEIN PHOSPHATASE 2A; SIGNALING INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIPS;

PROTEINS;

FKBP12 PROTEIN; HEAT SHOCK PROTEIN 90; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN; PROTEIN DERIVATIVE; PROTEIN SAM68; PROTEINASE; RADICICOL; TACROLIMUS; UCS15A PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CELL LYSATE; CONFORMATIONAL TRANSITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTECTION; PROTEIN DEGRADATION; STRUCTURE ACTIVITY RELATION; TECHNOLOGY; VALIDATION STUDY;

EID: 58149398274     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2008.11.034     Document Type: Article

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