Novel therapies for the prevention of malaria

Expert Opinion on Investigational Drugs

Volumn 17, Issue 12, 2008, Pages 1839-1847

  Bojang, Kalifa A ^a  

^a MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

Author keywords

Artemisinin based combination therapy; Chemotherapy; Home based management of malaria; Intermittent preventive treatment; Malaria; Mass drug administration

Indexed keywords

AMODIAQUINE; AMODIAQUINE PLUS ARTESUNATE; ANTIMALARIAL AGENT; ARTEMETHER PLUS BENFLUMETOL; ARTEMISININ; ARTESUNATE; AZITHROMYCIN; CHLOROQUINE; DIHYDROARTEMISININ PLUS PIPERAQUINE; FANSIDAR; IRON; MALOPRIM; MEFLOQUINE; PIPERAQUINE; PRIMAQUINE; PYRIMETHAMINE; SULFALENE;

ANEMIA; CHEMOPROPHYLAXIS; CHEMOTHERAPY; CLINICAL TRIAL; COST EFFECTIVENESS ANALYSIS; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; ENDEMIC DISEASE; HEALTH CARE DELIVERY; HOME CARE; HUMAN; MALARIA; MALARIA CONTROL; REVIEW; SINGLE DRUG DOSE; SYSTEMATIC REVIEW; ANIMAL; INFECTION CONTROL;

ANIMALS; ANTIMALARIALS; CHEMOPREVENTION; COMMUNICABLE DISEASE CONTROL; HUMANS; MALARIA;

EID: 58149392577     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543780802514039     Document Type: Review

References (67)

1. World Health Organization, Ninth world health assembly, Int Organ 1956;10:642-644
2. Greenwood B. Progress in malaria control in endemic areas. Travel Med Infect Dis 2008;6:173-176
3. Greenwood BM, Bojang K, Whitty CJ, et al. Malaria. Lancet 2005;365:1487-1498
4. Guyatt HL, Snow RW. Malaria in pregnancy as an indirect cause of infant mortality in sub-Saharan Africa. Trans R Soc Trop Med Hyg 2001;95:569-576 (Pubitemid 34202243)
5. Snow RW, Guerra CA, Noor AM, et al. The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature 2005;434:214-217 (Pubitemid 40388051)
6. Sabatinelli G, Ejov M, Joergensen P. Malaria in the WHO European Region (1971-1999). Eur Surveill 2001;6:61-65
7. Sunstrum J, Elliott LJ, Barat LM, et al. Probable autochthonous Plasmodium vivax malaria transmission in Michigan: case report and epidemiological investigation. Am J Trop Med Hyg 2001;65:949-953 (Pubitemid 34049502)
8. Schellenberg D, Cissé B, Menendez C. The IPTi Consortium: research for policy and action. Trends Parasitol 2006;22:296-300 •• Describes the policy-making process required for deploying IPT as a malaria control tool. (Pubitemid 43964897)
9. Cissé B, Sokhna C, Boulanger D, et al. Seasonal intermittent preventive treatment with artesunate and sulfadoxine-pyrimethamine for prevention of malaria in Senegalese children: a randomised, placebo-controlled, double blind trial. Lancet 2006;367:659-667 •• A trial which demonstrates that IPT provides significant protection against malaria in children in an area of seasonal transmission. (Pubitemid 43289156)
10. Baird K. Effectiveness of Antimalarial drugs. N Engl J Med 2005;352:1565-1577
11. Nosten F, van Vugt M, Price R, et al. Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study. Lancet 2000;356:297-302 (Pubitemid 30459588)
12. Barnes KI, Durrheim DN, Little F, et al. Effect of artemether- lumefantrine policy and improved vector control on malaria burden in KwaZulu-Natal, South Africa. PLoS Med 2005;2:e330 (Pubitemid 41735780)
13. World-Health-Organization. Guidelines for the treatment of malaria WHO/HTM/MAL/2006.1108
14. Denis MB, Tsuyuoka R, Poravuth Y, et al. Surveillance of the efficacy of artesunate and mefloquine combination for the treatment of uncomplicated falciparum malaria in Cambodia. Trop Med Int Health 2006;11:1360-1366 (Pubitemid 44289723)
15. Available from: www.mmv.org
16. Ro DK, Paradise EM, Ouellet M, et al. Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 2006;440:940-943
17. WHO: The Roll Back Malaria strategy for improving access to treatment through home management for malaria. World Health Organization; 2005
18. WHO: Scaling up home-based management of malaria: from research to implementation. Geneva, World Health Organization; 2004
19. Kidane G, Morrow RH. Teaching mothers to provide home treatment of malaria in Tigray, Ethiopia: a randomized trial. Lancet 2001;356:550-555
20. Sirima SB, Konate A, Tiono AB. Early treatment of childhood fevers with pre-packaged antimalarial drugs in the home reduces severe malaria morbidity in Burkina Faso. Trop Med Int Health 2003;8:133-139 (Pubitemid 36269364)
21. Gomes M, Ribeiro I, Warsame M, et al. Rectal artemisinins for malaria: a review of efficacy and safety from individual patient data in clinical studies. BMC Infect Dis 2008;28:8:39 (Pubitemid 351634257)
22. Dondorp A, Nosten F, Stepniewska K, et al; South East Asian Quinine Artesunate Malaria Trial (SEAQUAMAT) Group. Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial. Lancet 2005;366:717-725
23. Snow RW, Omumbo JA, Lowe B, et al. Relation between severe malaria morbidity in children and level of P. falciparum transmission in Africa. Lancet 1997;349:1650-1654 (Pubitemid 27234806)
24. Von Seidlein L, Greenwood BM. Mass administration of antimalarial drugs. Trends Parasitol 2003;19:452-460
25. Molineaux L, Gramiccia G. The Garki Project. Geneva: World Health Organization; 1980
26. Garfield R. Changes in malaria incidence after mass drug administration in Nicaragua. Lancet 1983;2:500-503
27. Von Seidlein L, Walraven G, Milligan PLM, et al. The effect of mass administration of pyrimethamine/sulphadoxine combined with artesunate on malaria transmission: a double blind, community randomised, placebo controlled trial in The Gambia. Trans R Soc Trop Med Hyg 2003;97:217-225 (Pubitemid 37265637)
28. Greenwood B. The use of anti-malarial drugs to prevent malaria in the population ofmalaria-endemic areas. Am J Trop Med Hyg 2004;70:1-7 • A good review of the IPT concept in infants and children. (Pubitemid 39220508)
29. Greenwood B. Review: intermittent preventive treatment - a new approach to the prevention of malaria in children in areas with seasonal malaria transmission. Trop Med Int Health 2006;11:983-991 • A good review of the IPT concept in areas of seasonal transmission. (Pubitemid 44015237)
30. Available from: http://www.who.int/ith/en/index.html
31. Available from: http://www.nathnac.org/travel/index.htm
32. Available from: http://www.cdc.gov/travel/
33. Garner P, Gulmezoglu AM. Prevention versus treatment for malaria in pregnant women. Cochrane Database Syst Rev, 2000;2:CD000169
34. Geerlins PD, Brabin BJ, Eggelte TA. Analysis of the effects of malaria chemoprophylaxis in children on haematological responses, morbidity and mortality. Bull World Health Organ 2003;81:205-216 (Pubitemid 36372959)
35. McGregor IA, Gilles HM, Walters JH, et al. Effects of heavy and repeated malarial infections on Gambian infants and children; effects of erythrocytic parasitisation. Br Med J 1956;ii:686-692
36. Greenwood BM, Greenwood AM, Bradley AK, et al. Comparison of two strategies for control of malaria within a primary health care programme in the Gambia. Lancet 1988;1:1121-1127 (Pubitemid 18120679)
37. Allen SJ, Snow RW, Menon A, Greenwood BM. Compliance with malaria chemoprophylaxis over a five year period among children in a rural area of the Gambia. J Trop Med Hyg 1990;93:313-322 (Pubitemid 20366309)
38. Greenwood BM. Malaria chemoprophylaxis in endemic regions. In: Targett GA, editor, Waiting for the vaccine. Wiley; 1991. p. 83-102
39. Schultz LJ, Steketee RW, Macheso A, et al. The efficacy of antimalarial regimens containing sulfadoxine-pyrimethamine and/or chloroquine in preventing peripheral and placental Plasmodium falciparum infection among pregnant women in Malawi. Am J Trop Med Hyg 1994;51:515-522 (Pubitemid 24378544)
40. Shulman CE, Dorman EK, Cutts F, et al. Intermittent sulphadoxine- pyrimethamine to prevent severe anaemia secondary to malaria in pregnancy: a randomised placebo-controlled trial. Lancet 1999;353:632-636 (Pubitemid 29087984)
41. Rogerson SJ, Chaluluka E, Kanjala M, et al. Intermittent sulphadoxine-pyrimethamine in pregnancy: effectiveness against malaria morbidity in Blantyre, Malawi, in 1997-1999. Trans R Soc Trop Med Hyg 2000;94:549-553
42. Van Eijk AM, Ayisi JG, ter Kuile FO, et al. Effectiveness of intermittent preventive treatment with sulphadoxine-pyrimethamine for control of malaria in pregnancy in western Kenya: a hospital-based study. Trop Med Int Health 2004;9:351-360
43. ter Kuile FO, van Eijk AM, Filler SJ. Effect of sulfadoxine-pyrimethamine resistance on the efficacy of intermittent preventive therapy for malaria control during pregnancy: a systematic review. J AM 2007;297:2603-2616 (Pubitemid 46961032)
44. Hamer DH, Mwanakasale V, MacLeod WB, et al. Two-dose versus monthly intermittent preventive treatment of malaria with sulfadoxine-pyrimethamine in HIV-seropositive pregnant Zambian women. J Infect Dis 2007;196:1585-1594
45. WHO: a strategic framework for malaria prevention and control during pregnancy in the Africa Region. World Health Organization, Geneva. AFR/MAL/04/01, 2004
46. National Institutes of Health USA: intermittent preventive treatment during pregnancy in Benin: a randomized, open, and equivalent trial comparing sulfadoxine-pyrimethamine with mefloquine 2006 . Available from: http://www.clinicaltrials.gov/ct/show/ NCT00274235?order=59
47. National Institutes of Health USA: efficacy of intermittent sulfadoxine pyrimethamine and sulfadoxine-pyrimethamine + artesunate treatment in the prevention of malaria in pregnancy in an area with chloroquine-resistant Plasmodium falciparum 2006. Available from: http://www.clinicaltrials.gov/ct/ show/ NCT00164255?order=38
48. National Institutes of Health USA: Lungwena Antenatal Intervention Study. A single-centre intervention trial in rural Malawi, testing maternal and infant health effects of presumptive intermittent treatment of pregnant women with sulfadoxine-pyrimethamine and azithromycin. 2006. Available from: http://www.clinicaltrials.gov/ct/show/NCT00131235?order=2
49. Schellenberg D, Menendez C, Kahigwa E, et al. Intermittent treatment for malaria and anaemia control at time of routine vaccinations in Tanzanian infants: a randomised, placebo controlled trial. Lancet 2001;357:1471-1477 •• The first demonstration in infants of the efficacy of IPT against malaria and anaemia. (Pubitemid 32488855)
50. Schellenberg D, Menendez C, Aponte JJ, et al. Intermittent preventive antimalarial treatment for Tanzanian infants: follow-up to age 2 years of a randomised, placebo-controlled trial. Lancet 2005;365:1481-1483 (Pubitemid 40591693)
51. Massaga JJ, Kitua AY, Lemnge MM, et al. Effect of intermittent treatment with amodiaquine on anaemia and malarial fevers in infants in Tanzania: a randomised placebo-controlled trial. Lancet 2003;361:1853-1860 (Pubitemid 36645180)
52. Available from: www.ipti-malaria.org
53. Grobusch MP, Lell B, Schwarz NG, et al. Intermittent preventive treatment against malaria in infants in Gabon - a randomized, double-blind, placebo-controlled trial. J Infect Dis 2007;196:1595-1602 • One of the recent IPTi-sulfadoxine-pyrimethamine trials demonstrating protective efficacy against malaria.
54. Chandramohan D, Owusu-Agyei S, Carneiro I, et al. Cluster randomised trial of intermittent preventive treatment for malaria in infants in area of high, seasonal transmission in Ghana. Br Med J 2005;331:727-733 • One of the recent IPTi-sulfadoxine-pyrimethamine trials demonstrating protective efficacy against malaria. (Pubitemid 41414939)
55. Kobbe R, Kreuzberg C, Adjei S, et al. A randomized controlled trial of intermittent preventive antimalarial treatment in infants. Clin Infect Dis 200745:16-25 • One of the recent IPTi-sulfadoxine-pyrimethamine trials demonstrating protective efficacy against malaria. (Pubitemid 46984610)
56. Mockenhaupt FP, Reither K, Zanger P, et al. Intermittent preventive treatment in infants as a mean of malaria control: a randomized, double-blind, and placebo-controlled trial in northern Ghana. Antimicrob Agents Chemother 2007;51:3273-3281 • One of the recent IPTi-sulfadoxine-pyrimethamine trials demonstrating protective efficacy against malaria. (Pubitemid 350067540)
57. Macete E, Aide P, Aponte JJ, et al. Intermittent preventive treatment for malaria control administered at the time of routine vaccinations in Mozambican infants: a randomized, placebo-controlled trial. J Infect Dis 2006;194:276-285 • One of the recent IPTi-sulfadoxine-pyrimethamine trials demonstrating protective efficacy against malaria. (Pubitemid 44116968)
58. ter Kuile FO, Terlouw DJ, Kariuki SK, et al. Impact of permethrin-treated bed nets on malaria, anemia, and growth in infants in an area of intense perennial malaria transmission in western Kenya. Am J Trop Med Hyg 2003;68:68-77 (Pubitemid 38240684)
59. Greenwood B. Intermittent preventive antimalarial treatment in infants. Clin Infect Dis 2007;45:26-28 (Pubitemid 46984611)
60. IOM (Institute of Medicine). Assessment of the role of intermittent preventive treatment for malaria in infants. Letter Report. Washington DC: The National Academies Press; 2008
61. Dicko A, Sagara I, Sissoko MS, et al. Impact of intermittent preventive treatment with sulphadoxine-pyrimethamine targeting the transmission season on the incidence of clinical malaria in children in Mali. Malar J 2008;7:123 • One of the earliest trials demonstrating PE efficacy of IPT against malaria in an area of seasonal transmission.
62. Sokhna C, CisséB, Bâ el H, et al. A trial of the efficacy, safety and impact on drug resistance of four drug regimens for seasonal intermittent preventive treatment for malaria in Senegalese children. PLoS One 2008;3:e1471
63. Verhoef H, West CE, Nzyuko SM, et al. Intermittent administration of iron and sulfadoxine-pyrimethamine to control anaemia in Kenyan children: a randomised controlled trial. Lancet 2002;360:908-914 (Pubitemid 35283835)
64. Desai MR, Mei JV, Kariuki SK, et al. Randomized, controlled trial of daily iron supplementation and intermittent sulfadoxine-pyrimethamine for the treatment of mild childhood anemia in western Kenya. J Infect Dis 2003;187:658-666 (Pubitemid 36250030)
65. Clarke SE, Jukes MC, Njagi JK, et al. Effect of intermittent preventive treatment of malaria on health and education in schoolchildren: a cluster-randomised, double-blind, placebo-controlled trial. Lancet 2008;372:127-138 (Pubitemid 351952258)
66. White NJ. Intermittent presumptive treatment for malaria. PLoS Med 2005;2:e3
67. Greenwood B. Intermittent preventive antimalarial treatment in infants. Clin Infect Dis 2007;45:26-28 (Pubitemid 46984611)