Surveillance of the efficacy of artesunate and mefloquine combination for the treatment of uncomplicated falciparum malaria in Cambodia

Tropical Medicine and International Health

Volumn 11, Issue 9, 2006, Pages 1360-1366

  Denis, Mey Bouth ^a,b   Tsuyuoka, Reiko ^b   Poravuth, Yi ^a   Narann, Top Sophoan ^a   Seila, Suon ^a   Lim, Chim ^a   Incardona, Sandra ^c   Lim, Pharath ^c   Sem, Rithy ^c   Socheat, Duong ^a   Christophel, Eva Maria ^b   Ringwald, Pascal ^b  

^a National Center for Parasitology Entomology and Malaria Control   (Cambodia)

^b WORLD HEALTH ORGANIZATION   (Switzerland)

^c INSTITUT PASTEUR DU CAMBODGE   (Cambodia)

Author keywords

Artesunate; Cambodia; Efficacy; Mefloquine; Plasmodium falciparum

Indexed keywords

ARTESUNATE; MEFLOQUINE;

DISEASE TREATMENT; DRUG; MALARIA;

ABDOMINAL PAIN; ADOLESCENT; ADULT; ARTICLE; BODY WEIGHT; CAMBODIA; CHILD; DIARRHEA; DISEASE SEVERITY; DIZZINESS; DRUG EFFICACY; DRUG INDUCED HEADACHE; FOLLOW UP; HEART PALPITATION; HUMAN; INSOMNIA; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; NAUSEA; PLASMODIUM FALCIPARUM; PRURITUS; TACHYCARDIA; TINNITUS; TREATMENT OUTCOME; VOMITING;

ADOLESCENT; ADULT; ANTIMALARIALS; ARTEMISININS; CAMBODIA; CHILD; CHILD, PRESCHOOL; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; HUMANS; MALARIA, FALCIPARUM; MEFLOQUINE; SESQUITERPENES; TREATMENT OUTCOME;

ASIA; CAMBODIA; EURASIA; SOUTHEAST ASIA;

ARTESUNATE; PLASMODIUM FALCIPARUM;

EID: 33747880765     PISSN: 13602276     EISSN: 13653156     Source Type: Journal    
DOI: 10.1111/j.1365-3156.2006.01690.x     Document Type: Article

References (13)

1. Boudreau EF, Webster HK, Pavanand K & Thosingha L (1982) Type II mefloquine resistance in Thailand. Lancet 2, 1335.
2. Denis MB, Davis TM, Hewitt S et al. (2002) Efficacy and safety of dihydroartemisinin-piperaquine (Artekin) in Cambodian children and adults with uncomplicated falciparum malaria. Clinical Infectious Diseases 35, 1469-1476.
3. Eyles DE, Hoo CC, Warren MC & Sandosham AA (1963) Plasmodium falciparum resistant to chloroquine in Cambodia. American Journal of Tropical Medicine and Hygiene 12, 840-843.
4. Farnert A, Arez AP, Babiker HA et al. (2001) Genotyping of Plasmodium falciparum infections by PCR: a comparative multicentre study. Transaction of the Royal Society of Tropical Medicine and Hygiene 95, 225-232.
5. Giboda M & Denis MB (1988) Response of Kampuchean strains of Plasmodium falciparum to antimalarials: in vivo assessment of quinine and quinine plus tetracycline; multiple drug resistance in vitro. Journal of Tropical Medicine and Hygiene 91, 205-211.
6. ter Kuile FO, Nosten F, Luxemburger C et al. (1995) Mefloquine treatment of acute falciparum malaria: a prospective study of non-serious adverse effects in 3673 patients. Bulletin of the World Health Organization 73, 631-642.
7. Meek SR, Doberstyn EB, Gauzère BA, Thanapanich C, Nordlander E & Phuphaisan S (1986) Treatment of falciparum malaria with quinine and tetracycline or combined mefloquine/sulfadoxine/pyrimethamine on the Thai-Kampuchean Border. American Journal of Tropical Medicine and Hygiene 35, 246-250.
8. Nosten F, van Vugt M, Price R et al. (2000) Effects of artesunatemefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study. Lancet 356, 297-302.
9. Nosten F, Mc Gready R, Ashley E & White NJ (2005) Malaria misconceptions. Lancet 365, 653.
10. Rojanawatsirivej C, Vijaykadga S, Amklad I, Wilairatna P & Looreesuwan S (2003) Monitoring the therapeutic efficacy of antimalarials against uncomplicated falciparum malaria in Thailand. Southeast Asian Journal of Tropical Medicine and Public Health 34, 536-541.
11. Simpson JA, Watkins ER, Price RN, Aarons L, Kyle DE & White NJ (2000) Mefloquine pharmacokinetic-pharmacodynamic models: implications for dosing and resistance. Antimicrobial Agents and Chemotherapy 44, 3414-3424.
12. Smithuis FM, van Woensel JB, Nordlander E, Yantha WS & ter Kuile FO (1993) Comparison of two mefloquine regimens for treatment of Plasmodium falciparum malaria on the northeastern Thai-Cambodian border. Antimicrobial Agents and Chemotherapy 37, 1977-1981.
13. WHO (2003) Assessment and Monitoring of Antimalarial Drug Efficacy for the Treatment of Uncomplicated falciparum Malaria. WHO/RBM/HTM/2003.50, World Health Organization, Geneva.