Teratogenicity of the class III antiarrhythmic drug almokalant. Role of hypoxia and reactive oxygen species

Reproductive Toxicology

Volumn 13, Issue 2, 1999, Pages 93-101

  Wellfelt, Katrin ^a,b   Sköld, Anna Carin ^a,b   Wallin, Alf ^b   Danielsson, Bengt R ^a,b  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Almokalant; Class III antiarrhythmics; OTC; PBN; Protection by antioxidants; Reactive oxygen species; ROS; Teratogenicity

Indexed keywords

2 OXO 4 THIAZOLIDINECARBOXYLIC ACID; 2-OXOTHIAZOLIDINE-4-CARBOXYLIC ACID; ALMOKALANT; ANTIARRHYTHMIC AGENT; ANTIOXIDANT; N TERT BUTYL ALPHA PHENYLNITRONE; NITROGEN OXIDE; PHENYL-N-TERT-BUTYLNITRONE; PROPANOLAMINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; THIAZOLE DERIVATIVE;

ANIMAL; ANIMAL MODEL; ANOXIA; ARTICLE; BIRTH DEFECT; BODY WEIGHT; CARDIOVASCULAR MALFORMATION; CONGENITAL HEART MALFORMATION; CONGENITAL MALFORMATION; CONTROLLED STUDY; DRUG EFFECT; EMBRYO; FEMALE; FETUS DEATH; FETUS MALFORMATION; HEART ARRHYTHMIA; HYPOXIA; IATROGENIC DISEASE; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; METABOLISM; NONHUMAN; ORAL DRUG ADMINISTRATION; PATHOPHYSIOLOGY; PREGNANCY; RAT; RAT STRAIN; SPIN LABELING; SUBCUTANEOUS DRUG ADMINISTRATION; TERATOGENICITY;

EID: 0344286481     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(98)00066-5     Document Type: Article

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