DIDS protects against neuronal injury by blocking Toll-like receptor 2 activated-mechanisms

Journal of Neurochemistry

Volumn 108, Issue 3, 2009, Pages 835-846

  Yao, Hang ^b   Felfly, Hady ^b   Wang, Juan ^b   Zhou, Dan ^b   Haddad, Gabriel G ^a,b,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c RADY CHILDREN'S HOSPITAL   (United States)

Author keywords

Gene expression; Ischemia; Penumbra; Slice culture

Indexed keywords

4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; INTERLEUKIN 1BETA; NEUTRALIZING ANTIBODY; PROPIDIUM IODIDE; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TOLL LIKE RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CELL DAMAGE; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; GENE EXPRESSION PROFILING; HIPPOCAMPUS; ISCHEMIA; MOUSE; NERVE CELL; NERVE INJURY; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; ANIMALS; BLOTTING, WESTERN; CELL DEATH; DOSE-RESPONSE RELATIONSHIP, DRUG; INTERLEUKIN-1BETA; ISCHEMIA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUROPROTECTIVE AGENTS; TOLL-LIKE RECEPTORS; UP-REGULATION;

EID: 58149347179     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05838.x     Document Type: Article

References (52)

1. Anwer M. S., Nolan K. Hardison W. G. (1988) Role of bicarbonate in biliary excretion of diisothiocyanostilbene disulfonate. Am. J. Physiol. 255, G713 G722.
2. Araki T., Hayashi M., Watanabe N., Kanuka H., Yoshino J., Miura M. Saruta T. (2002) Down-regulation of Mcl-1 by inhibition of the PI3-K/Akt pathway is required for cell shrinkage-dependent cell death. Biochem. Biophys. Res. Commun. 290, 1275 1281.
3. Babcock A. A., Wirenfeldt M., Holm T. et al. (2006) Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation. J. Neurosci. 26, 12826 12837.
4. Back T., Hemmen T. Schuler O. G. (2004) Lesion evolution in cerebral ischemia. J. Neurol. 251, 388 397.
5. Baird A. E., Benfield A., Schlaug G., Siewert B., Lovblad K. O., Edelman R. R. Warach S. (1997) Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging. Ann. Neurol. 41, 581 589.
6. Bates S., Read S. J., Harrison D. C., Topp S., Morrow R., Gale D., Murdock P., Barone F. C., Parsons A. A. Gloger I. S. (2001) Characterisation of gene expression changes following permanent MCAO in the rat using subtractive hybridisation. Brain Res. Mol. Brain Res. 93, 70 80.
7. Beg A. A. (2002) Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses. Trends Immunol 23, 509 512.
8. Boutin H., LeFeuvre R. A., Horai R., Asano M., Iwakura Y. Rothwell N. J. (2001) Role of IL-1alpha and IL-1beta in ischemic brain damage. J. Neurosci. 21, 5528 5534.
9. Buttini M., Sauter A. Boddeke H. W. (1994) Induction of interleukin-1 beta mRNA after focal cerebral ischaemia in the rat. Brain Res. Mol. Brain Res. 23, 126 134.
10. Calvano S. E., Xiao W., Richards D. R. et al. (2005) A network-based analysis of systemic inflammation in humans. Nature 437, 1032 1037.
11. Chu H. W., Campbell J. A., Rino J. G., Harbeck R. J. Martin R. J. (2004) Inhaled fluticasone propionate reduces concentration of Mycoplasma pneumoniae, inflammation, and bronchial hyperresponsiveness in lungs of mice. J. Infect. Dis. 189, 1119 1127.
12. Fisher M. (2006) The ischemic penumbra: a new opportunity for neuroprotection. Cerebrovasc. Dis. 21 (Suppl. 2 64 70.
13. Fisher M. Ratan R. (2003) New perspectives on developing acute stroke therapy. Ann. Neurol. 53, 10 20.
14. Fortunato S. J. Menon R. (2003) IL-1 beta is a better inducer of apoptosis in human fetal membranes than IL-6. Placenta 24, 922 928.
15. Garcia J. H., Yoshida Y., Chen H., Li Y., Zhang Z. G., Lian J., Chen S. Chopp M. (1993) Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat. Am. J. Pathol. 142, 623 635.
16. Gibson R. M., Rothwell N. J. Le Feuvre R. A. (2004) CNS injury: the role of the cytokine IL-1. Vet. J 168, 230 237.
17. Gonzalez R. G. (2006) Imaging-guided acute ischemic stroke therapy: from "time is brain" to "physiology is brain". Am. J. Neuroradiol. 27, 728 735.
18. Han D., Antunes F., Canali R., Rettori D. Cadenas E. (2003) Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol. J. Biol. Chem. 278, 5557 5563.
19. + flux associated with hepatic exocrine secretion. Can. J. Physiol. Pharmacol. 77, 268 275.
20. Himi T., Ishizaki Y. Murota S. I. (2002) 4,4′-Diisothiocyano-2, 2′-stilbenedisulfonate protects cultured cerebellar granule neurons from death. Life Sci. 70, 1235 1249.
21. Hsiao A., Ideker T., Olefsky J. M. Subramaniam S. (2005) VAMPIRE microarray suite: a web-based platform for the interpretation of gene expression data. Nucleic Acids Res. 33, W627 W632.
22. Huang J., Upadhyay U. M. Tamargo R. J. (2006) Inflammation in stroke and focal cerebral ischemia. Surg. Neurol. 66, 232 245.
23. Huyton T., Rossjohn J. Wilce M. (2007) Toll-like receptors: structural pieces of a curve-shaped puzzle. Immunol. Cell Biol. 85, 406 410.
24. Inoue H., Ohtaki H., Nakamachi T., Shioda S. Okada Y. (2007) Anion channel blockers attenuate delayed neuronal cell death induced by transient forebrain ischemia. J. Neurosci. Res. 85, 1427 1435.
25. Karonen J. O., Vanninen R. L., Liu Y. et al. (1999) Combined diffusion and perfusion MRI with correlation to single-photon emission CT in acute ischemic stroke. Ischemic penumbra predicts infarct growth. Stroke 30, 1583 1590.
26. Kigerl K. A., Lai W., Rivest S., Hart R. P., Satoskar A. R. Popovich P. G. (2007) Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injury. J. Neurochem. 102, 37 50.
27. Konat G. W., Kielian T. Marriott I. (2006) The role of Toll-like receptors in CNS response to microbial challenge. J. Neurochem. 99, 1 12.
28. Laver D. R. Bradley K. M. (2006) Disulfonic stilbene permeation and block of the anion channel from the sarcoplasmic reticulum of rabbit skeletal muscle. Am. J. Physiol. Cell Physiol. 290, C1666 C1677.
29. Lehnardt S., Lehmann S., Kaul D., Tschimmel K., Hoffmann O., Cho S., Krueger C., Nitsch R., Meisel A. Weber J. R. (2007) Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia. J. Neuroimmunol. 190, 28 33.
30. Liu T., Clark R. K., McDonnell P. C., Young P. R., White R. F., Barone F. C. Feuerstein G. Z. (1994) Tumor necrosis factor-alpha expression in ischemic neurons. Stroke 25, 1481 1488.
31. Liu J., Lai Z. F., Wang X. D., Tokutomi N. Nishi K. (1998) Inhibition of sodium current by chloride channel blocker 4,4′-diisothiocyanatostilbene- 2,2′-disulfonic acid (DIDS) in guinea pig cardiac ventricular cells. J. Cardiovasc. Pharmacol. 31, 558 567.
32. Lo E. H., Moskowitz M. A. Jacobs T. P. (2005) Exciting, radical, suicidal: how brain cells die after stroke. Stroke 36, 189 192.
33. Lu J. Boron W. F. (2007) Reversible and irreversible interactions of DIDS with the human electrogenic Na/HCO3 cotransporter NBCe1-A: role of lysines in the KKMIK motif of TM5. Am. J. Physiol. Cell Physiol. 292, C1787 C1798.
34. Maeno E., Ishizaki Y., Kanaseki T., Hazama A. Okada Y. (2000) Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis. Proc. Natl Acad. Sci. USA 97, 9487 9492.
35. Matzinger P. (2002) The danger model: a renewed sense of self. Science 296, 301 305.
36. Nguyen M. D., Julien J. P. Rivest S. (2002) Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat. Rev. Neurosci. 3, 216 227.
37. Parsons M. W., Barber P. A., Chalk J. et al. (2002) Diffusion- and perfusion-weighted MRI response to thrombolysis in stroke. Ann. Neurol. 51, 28 37.
38. - cotransporter. Nature 387, 409 413.
39. Rozen S. Skaletsky H. (2000) Primer3 on the WWW for general users and for biologist programmers. Methods Mol. Biol. 132, 365 386.
40. Schmidt-Kastner R., Zhang B., Belayev L., Khoutorova L., Amin R., Busto R. Ginsberg M. D. (2002) DNA microarray analysis of cortical gene expression during early recirculation after focal brain ischemia in rat. Brain Res. Mol. Brain Res. 108, 81 93.
41. Sharp F. R., Lu A., Tang Y. Millhorn D. E. (2000) Multiple molecular penumbras after focal cerebral ischemia. J. Cereb. Blood Flow Metab. 20, 1011 1032.
42. Tauskela J. S., Mealing G., Comas T., Brunette E., Monette R., Small D. L. Morley P. (2003) Protection of cortical neurons against oxygen-glucose deprivation and N-methyl-D-aspartate by DIDS and SITS. Eur. J. Pharmacol. 464, 17 25.
43. Thornton P., Pinteaux E., Gibson R. M., Allan S. M. Rothwell N. J. (2006) Interleukin-1-induced neurotoxicity is mediated by glia and requires caspase activation and free radical release. J. Neurochem. 98, 258 266.
44. Tsuboi M., Kawakami A., Nakashima T. et al. (1999) Tumor necrosis factor-alpha and interleukin-1beta increase the Fas-mediated apoptosis of human osteoblasts. J. Lab. Clin. Med. 134, 222 231.
45. Verstak B., Hertzog P. Mansell A. (2007) Toll-like receptor signalling and the clinical benefits that lie within. Inflamm. Res. 56, 1 10.
46. Wangemann P., Wittner M., Di Stefano A., Englert H. C., Lang H. J., Schlatter E. Greger R. (1986) Cl(-)-channel blockers in the thick ascending limb of the loop of Henle. Structure activity relationship. Pflugers Arch. 407 (Suppl. 2 S128 S141.
47. + conductance via uptake through the bilirubin pathway. J. Physiol. 471, 617 635.
48. Xue J., Zhou D., Yao H. Haddad G. G. (2008) Role of transporters and ion channels in neuronal injury under hypoxia. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294, R451 R457.
49. Yao H., Shu Y., Wang J., Brinkman B. C. Haddad G. G. (2007a) Factors influencing cell fate in the infarct rim. J. Neurochem. 100, 1224 1233.
50. Yao H., Sun X., Gu X., Wang J. Haddad G. G. (2007b) Cell death in an ischemic infarct rim model. J. Neurochem. 103, 1644 1653.
51. Zhang H., Bailey J. S., Coss D., Lin B., Tsutsumi R., Lawson M. A., Mellon P. L. Webster N. J. (2006) Activin modulates the transcriptional response of LbetaT2 cells to gonadotropin-releasing hormone and alters cellular proliferation. Mol. Endocrinol. 20, 2909 2930.
52. Ziegler G., Harhausen D., Schepers C., Hoffmann O., Rohr C., Prinz V., Konig J., Lehrach H., Nietfeld W. Trendelenburg G. (2007) TLR2 has a detrimental role in mouse transient focal cerebral ischemia. Biochem. Biophys. Res. Commun. 359, 574 579.