메뉴 건너뛰기




Volumn 20, Issue 5, 2008, Pages 1047-1052

DNA damage sensor protein hRad9, a novel molecular target for lung cancer treatment

Author keywords

Cell cycle checkpoint; Chk1; DNA damage; hRad9; Non small cell lung cancer

Indexed keywords

CHECKPOINT KINASE 1; PROTEIN RAD9; SMALL INTERFERING RNA; CELL CYCLE PROTEIN; PROTEIN KINASE;

EID: 58149340190     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000108     Document Type: Article
Times cited : (11)

References (26)
  • 2
    • 0035854804 scopus 로고    scopus 로고
    • Reconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complex
    • Burtelow MA, Roos-Mattjus PM, Rauen M, Babendure JR and Karnitz LM: Reconstitution and molecular analysis of the hRad9-hHus1-hRad1 (9-1-1) DNA damage responsive checkpoint complex. J Biol Chem 276: 25903-25909, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 25903-25909
    • Burtelow, M.A.1    Roos-Mattjus, P.M.2    Rauen, M.3    Babendure, J.R.4    Karnitz, L.M.5
  • 3
    • 0036668474 scopus 로고    scopus 로고
    • Clamp and clamp loader structures of the human checkpoint protein complexes, Rad9-1-1 and Rad17-RFC
    • Shiomi Y, Shinozaki A, Nakada D, Sugimoto K, Usukura J, Obuse C and Tsurimoto T: Clamp and clamp loader structures of the human checkpoint protein complexes, Rad9-1-1 and Rad17-RFC. Genes Cells 7: 861-868, 2002.
    • (2002) Genes Cells , vol.7 , pp. 861-868
    • Shiomi, Y.1    Shinozaki, A.2    Nakada, D.3    Sugimoto, K.4    Usukura, J.5    Obuse, C.6    Tsurimoto, T.7
  • 4
    • 0033534613 scopus 로고    scopus 로고
    • Human homologs of Schizosaccharomyces pombe rad1, hus1 and hRad9 form a DNA damage-responsive protein complex
    • Volkmer E and Karnitz LM: Human homologs of Schizosaccharomyces pombe rad1, hus1 and hRad9 form a DNA damage-responsive protein complex. J Biol Chem 274: 567-570, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 567-570
    • Volkmer, E.1    Karnitz, L.M.2
  • 5
    • 0034235463 scopus 로고    scopus 로고
    • Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes
    • Venclovas C and Thelen MP: Structure-based predictions of Rad1, Rad9, Hus1 and Rad17 participation in sliding clamp and clamp-loading complexes. Nucleic Acids Res 28: 2481-2493, 2000.
    • (2000) Nucleic Acids Res , vol.28 , pp. 2481-2493
    • Venclovas, C.1    Thelen, M.P.2
  • 6
    • 0033965418 scopus 로고    scopus 로고
    • A novel Rad24 checkpoint protein complex closely related to replication factor C
    • Green CM, Erdjument-Bromage H, Tempst P and Lowndes NF: A novel Rad24 checkpoint protein complex closely related to replication factor C. Curr Biol 10: 39-42, 2000.
    • (2000) Curr Biol , vol.10 , pp. 39-42
    • Green, C.M.1    Erdjument-Bromage, H.2    Tempst, P.3    Lowndes, N.F.4
  • 7
    • 0035949503 scopus 로고    scopus 로고
    • Purification and characterization of human DNA damage checkpoint Rad complexes
    • Lindsey-Boltz LA, Bermudez VP, Hurwitz J and Sancar A: Purification and characterization of human DNA damage checkpoint Rad complexes. Proc Natl Acad Sci USA 98: 11236-11241, 2001.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11236-11241
    • Lindsey-Boltz, L.A.1    Bermudez, V.P.2    Hurwitz, J.3    Sancar, A.4
  • 8
    • 0032962928 scopus 로고    scopus 로고
    • Role of a complex containing Rad17, Mec3 and Ddc1 in the yeast DNA damage checkpoint pathway
    • Kondo T, Matsumoto K and Sugimoto K: Role of a complex containing Rad17, Mec3 and Ddc1 in the yeast DNA damage checkpoint pathway. Mol Cell Biol 19: 1136-1143, 1999.
    • (1999) Mol Cell Biol , vol.19 , pp. 1136-1143
    • Kondo, T.1    Matsumoto, K.2    Sugimoto, K.3
  • 9
    • 0037452605 scopus 로고    scopus 로고
    • Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
    • Bermudez VP, Lindsey-Boltz LA, Cesare AJ, Maniwa Y, Griffith JD, Hurwitz J and Sancar A: Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro. Proc Natl Acad Sci USA 100: 1633-1638, 2003.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1633-1638
    • Bermudez, V.P.1    Lindsey-Boltz, L.A.2    Cesare, A.J.3    Maniwa, Y.4    Griffith, J.D.5    Hurwitz, J.6    Sancar, A.7
  • 10
    • 0034703051 scopus 로고    scopus 로고
    • The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1 and hRad9
    • Rauen M, Burtelow MA, Dufault VM and Karnitz LM: The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1 and hRad9. J Biol Chem 275: 29767-29771, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 29767-29771
    • Rauen, M.1    Burtelow, M.A.2    Dufault, V.M.3    Karnitz, L.M.4
  • 11
    • 0035834690 scopus 로고    scopus 로고
    • DNA damage-dependent and -independent phosphorylation of the hRad9 checkpoint protein
    • St Onge RP, Besley BD, Park M, Casselman R and Davey S: DNA damage-dependent and -independent phosphorylation of the hRad9 checkpoint protein. J Biol Chem 276: 41898-41905, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 41898-41905
    • St Onge, R.P.1    Besley, B.D.2    Park, M.3    Casselman, R.4    Davey, S.5
  • 13
    • 0037698170 scopus 로고    scopus 로고
    • A role for the phosphorylation of hRad9 in checkpoint signaling
    • St Onge RP, Besley BD, Pelley JL and Davey S: A role for the phosphorylation of hRad9 in checkpoint signaling. J Biol Chem 278: 26620-26628, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 26620-26628
    • St Onge, R.P.1    Besley, B.D.2    Pelley, J.L.3    Davey, S.4
  • 14
    • 0033018634 scopus 로고    scopus 로고
    • The human G2 checkpoint control protein hRad9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1
    • St. Onge RP, Udell CM, Casselman R and Davey S: The human G2 checkpoint control protein hRad9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1. Mol Biol Cell 10: 1985-1995, 1999.
    • (1999) Mol Biol Cell , vol.10 , pp. 1985-1995
    • St. Onge, R.P.1    Udell, C.M.2    Casselman, R.3    Davey, S.4
  • 15
    • 0035844130 scopus 로고    scopus 로고
    • ATM-dependent phosphorylation of human HRad9 is required for ionizing radiation-induced checkpoint activation
    • Chen MJ, Lin YT, Lieberman HB, Chen G and Lee EY: ATM-dependent phosphorylation of human HRad9 is required for ionizing radiation-induced checkpoint activation. J Biol Chem 276: 16580-16586, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 16580-16586
    • Chen, M.J.1    Lin, Y.T.2    Lieberman, H.B.3    Chen, G.4    Lee, E.Y.5
  • 16
    • 0037067776 scopus 로고    scopus 로고
    • A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex
    • Hirai I and Wang HG: A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex. J Biol Chem 277: 25722-25727, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 25722-25727
    • Hirai, I.1    Wang, H.G.2
  • 17
    • 2442646547 scopus 로고    scopus 로고
    • Chk1 activation requires hRad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1
    • Furuya K, Poitelea M, Guo L, Caspari T and Carr AM: Chk1 activation requires hRad9 S/TQ-site phosphorylation to promote association with C-terminal BRCT domains of Rad4TOPBP1. Genes Dev 18: 1154-1164, 2004.
    • (2004) Genes Dev , vol.18 , pp. 1154-1164
    • Furuya, K.1    Poitelea, M.2    Guo, L.3    Caspari, T.4    Carr, A.M.5
  • 22
    • 0034472434 scopus 로고    scopus 로고
    • Chk1 and Cds1: Linchpins of the DNA damage and replication checkpoint pathways
    • Rhind N and Russell P: Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways. J Cell Sci 113: 3889-3896, 2000.
    • (2000) J Cell Sci , vol.113 , pp. 3889-3896
    • Rhind, N.1    Russell, P.2
  • 23
    • 0038418869 scopus 로고    scopus 로고
    • Chk1 and Chk2 kinases in checkpoint control and cancer
    • Bartek J and Lukas J: Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 3: 421-429, 2003.
    • (2003) Cancer Cell , vol.3 , pp. 421-429
    • Bartek, J.1    Lukas, J.2
  • 24
    • 25444478299 scopus 로고    scopus 로고
    • The cell cycle checkpoint gene hRad9 is a novel oncogene activated by 11q13 amplification and DNA methylation in breast cancer
    • Cheng CK, Chow LW, Loo WT, Chan TK and Chan V: The cell cycle checkpoint gene hRad9 is a novel oncogene activated by 11q13 amplification and DNA methylation in breast cancer. Cancer Res 65: 8646-8654, 2005.
    • (2005) Cancer Res , vol.65 , pp. 8646-8654
    • Cheng, C.K.1    Chow, L.W.2    Loo, W.T.3    Chan, T.K.4    Chan, V.5
  • 25
    • 33745744063 scopus 로고    scopus 로고
    • The hRad9 protein enhances survival and promotes DNA repair following exposure to ionizing radiation
    • Brandt PD, Helt CE, Keng PC and Bambara RA: The hRad9 protein enhances survival and promotes DNA repair following exposure to ionizing radiation. Biochem Biophys Res Commun 347: 232-237, 2006.
    • (2006) Biochem Biophys Res Commun , vol.347 , pp. 232-237
    • Brandt, P.D.1    Helt, C.E.2    Keng, P.C.3    Bambara, R.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.