Chordoma and chondrosarcoma gene profile: Implications for immunotherapy

Cancer Immunology, Immunotherapy

Volumn 58, Issue 3, 2009, Pages 339-349

  Schwab, Joseph H ^a   Boland, Patrick J ^a   Agaram, Narasimhan P ^a   Socci, Nicholas D ^a   Guo, Tianhua ^a   O'Toole, Gary C ^a   Wang, Xinhui ^b   Ostroumov, Elena ^c   Hunter, Christopher J ^c   Block, Joel A ^d   Doty, Stephen ^e   Ferrone, Soldano ^b   Healey, John H ^a   Antonescu, Cristina R ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^c UNIVERSITY OF CALGARY   (Canada)

^d RUSH UNIVERSITY MEDICAL CENTER   (United States)

^e HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

Chondrosarcoma; Chordoma; Extracellular matrix; Gene expression; HMW MAA

Indexed keywords

AGGRECAN; CD24 ANTIGEN; COLLAGEN; COLLAGEN 11; COLLAGEN 9; COLLAGEN TYPE 10; COLLAGEN TYPE 2; CYTOKERATIN 13; CYTOKERATIN 15; CYTOKERATIN 18; CYTOKERATIN 19; CYTOKERATIN 8; FIBRONECTIN; GELATINASE B; HIGH MOLECULAR WEIGHT MELANOMA ASSOCIATED ANTIGEN; MATRILIN 3; MATRIX METALLOPROTEINASE 19; MELANOMA ANTIGEN; SCLEROPROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CHONDROSARCOMA; CHORDOMA; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE CLUSTER; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC SELECTION; GENOMICS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOTHERAPY; MALE; MALIGNANT TRANSFORMATION; MELANOMA CELL; MESENCHYME; MICROARRAY ANALYSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SARCOMA; TUMOR CELL LINE; UPREGULATION; WESTERN BLOTTING;

ANTIBODIES, MONOCLONAL; BONE NEOPLASMS; CELL LINE, TUMOR; CHONDROSARCOMA; CHORDOMA; COLLAGEN; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOTHERAPY; MODELS, BIOLOGICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 58149301551     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-008-0557-7     Document Type: Article

References (46)

1. CR Antonescu A Viale L Sarran SJ Tschernyavsky M Gonen NH Segal RG Maki ND Socci RP DeMatteo P Besmer 2004 Gene expression in gastrointestinal stromal tumors is distinguished by KIT genotype and anatomic site Clin Cancer Res 10 3282 3290
2. NP Agaram P Besmer GC Wong T Guo ND Socci RG Maki D DeSantis MF Brennan S Singer RP DeMatteo CR Antonescu 2007 Pathologic and molecular heterogeneity in imatinib-stable or imatinib-responsive gastrointestinal stromal tumors Clin Cancer Res 13 170 181
3. P Bergh LG Kindblom B Gunterberg F Remotti W Ryd JM Meis-Kindblom 2000 Prognostic factors in chordoma of the sacrum and mobile spine: a study of 39 patients Cancer 88 2122 2134
4. Bertoni F, Bacchini P, Hogendoorn P (2002) Chondrosarcoma. IARC Press, Lyon
5. W Bi JM Deng Z Zhang RR Behringer B de Crombrugghe 1999 Sox9 is required for cartilage formation Nat Genet 22 85 89
6. J Bjornsson RA McLeod KK Unni DM Ilstrup DJ Pritchard 1998 Primary chondrosarcoma of long bones and limb girdles Cancer 83 2105 2119
7. JA Block SE Inerot S Gitelis JH Kimura 1991 The effects of long term monolayer culture on the proteoglycan phenotype of a clonal population of mature human malignant chondrocytes Connect Tissue Res 26 295 313
8. TJ Bos P Margiotta L Bush W Wasilenko 1999 Enhanced cell motility and invasion of chicken embryo fibroblasts in response to Jun over-expression Int J Cancer 81 404 410
9. MR Campoli CC Chang T Kageshita X Wang JB McCarthy S Ferrone 2004 Human high molecular weight-melanoma-associated antigen (HMW-MAA): a melanoma cell surface chondroitin sulfate proteoglycan (MSCP) with biological and clinical significance Crit Rev Immunol 24 267 296
10. E de Bri FP Reinholt D Heinegard S Mengarelli-Widholm M Norgard O Svensson 1996 Bone sialoprotein and osteopontin distribution at the osteocartilaginous interface Clin Orthop Relat Res 330 251 260
11. K Demircan S Hirohata K Nishida OF Hatipoglu T Oohashi T Yonezawa SS Apte Y Ninomiya 2005 ADAMTS-9 is synergistically induced by interleukin-1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes Arthritis Rheum 52 1451 1460
12. DR Eyre JJ Wu RJ Fernandes TA Pietka MA Weis 2002 Recent developments in cartilage research: matrix biology of the collagen II/IX/XI heterofibril network Biochem Soc Trans 30 893 899
13. B Fuchs ID Dickey MJ Yaszemski CY Inwards FH Sim 2005 Operative management of sacral chordoma J Bone Joint Surg Am 87 2211 2216
14. S Gitelis F Bertoni P Picci M Campanacci 1981 Chondrosarcoma of bone. The experience at the Istituto Ortopedico Rizzoli J Bone Joint Surg Am 63 1248 1257
15. D Gottschalk M Fehn S Patt W Saeger T Kirchner T Aigner 2001 Matrix gene expression analysis and cellular phenotyping in chordoma reveals focal differentiation pattern of neoplastic cells mimicking nucleus pulposus development Am J Pathol 158 1571 1578
16. Healey JH, Lane JM (1986) Chondrosarcoma. Clin Orthop Relat Res:119-129
17. JH Healey JM Lane 1989 Chordoma: a critical review of diagnosis and treatment Orthop Clin North Am 20 417 426
18. SR Henderson D Guiliano N Presneau S McLean R Frow S Vujovic J Anderson N Sebire J Whelan N Athanasou AM Flanagan C Boshoff 2005 A molecular map of mesenchymal tumors Genome Biol 6 R76
19. T Ishida HD Dorfman 1994 Chondroid chordoma versus low-grade chondrosarcoma of the base of the skull: can immunohistochemistry resolve the controversy? J Neurooncol 18 199 206
20. M Kusama T Kageshita ZJ Chen S Ferrone 1989 Characterization of syngeneic antiidiotypic monoclonal antibodies to murine anti-human high molecular weight melanoma-associated antigen monoclonal antibodies J Immunol 143 3844 3852
21. V Lefebvre W Huang VR Harley PN Goodfellow B de Crombrugghe 1997 SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene Mol Cell Biol 17 2336 2346
22. W Luo E Ko JC Hsu X Wang S Ferrone 2006 Targeting melanoma cells with human high molecular weight-melanoma associated antigen-specific antibodies elicited by a peptide mimotope: functional effects J Immunol 176 6046 6054
23. Mirra J, Rocca C, Nelson S, Mertens F (2002) Notochordal tumours. IARC Press, Lyon
24. A Mittelman ZJ Chen H Yang GY Wong S Ferrone 1992 Human high molecular weight melanoma-associated antigen (HMW-MAA) mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: induction of humoral anti-HMW-MAA immunity and prolongation of survival in patients with stage IV melanoma Proc Natl Acad Sci USA 89 466 470
25. A Mittelman ZJ Chen CC Liu S Hirai S Ferrone 1994 Kinetics of the immune response and regression of metastatic lesions following development of humoral anti-high molecular weight-melanoma associated antigen immunity in three patients with advanced malignant melanoma immunized with mouse antiidiotypic monoclonal antibody MK2-23 Cancer Res 54 415 421
26. T Naka C Boltze D Kuester TO Schulz A Samii C Herold H Ostertag A Roessner 2004 Expression of matrix metalloproteinase (MMP)-1, MMP-2, MMP-9, cathepsin B, and urokinase plasminogen activator in non-skull base chordoma Am J Clin Pathol 122 926 930
27. E Ostroumov CJ Hunter 2007 The role of extracellular factors in human metastatic chordoma cell growth in vitro Spine 32 2957 2964
28. CM Overall O Kleifeld 2006 Tumour microenvironment-opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy Nat Rev Cancer 6 227 239
29. T Ozaki A Hillmann W Winkelmann 1997 Surgical treatment of sacrococcygeal chordoma J Surg Oncol 64 274 279
30. BW Ozanne HJ Spence LC McGarry RF Hennigan 2007 Transcription factors control invasion: AP-1 the first among equals Oncogene 26 1 10
31. C Palena DE Polev KY Tsang RI Fernando M Litzinger LL Krukovskaya AV Baranova AP Kozlov J Schlom 2007 The human T-box mesodermal transcription factor Brachyury is a candidate target for T-cell-mediated cancer immunotherapy Clin Cancer Res 13 2471 2478
32. Y Pei A Harvey XP Yu S Chandrasekhar K Thirunavukkarasu 2006 Differential regulation of cytokine-induced MMP-1 and MMP-13 expression by p38 kinase inhibitors in human chondrosarcoma cells: potential role of Runx2 in mediating p38 effects Osteoarthritis Cartilage 14 749 758
33. M Polette B Nawrocki-Raby C Gilles C Clavel P Birembaut 2004 Tumour invasion and matrix metalloproteinases Crit Rev Oncol Hematol 49 179 186
34. ME Pring KL Weber KK Unni FH Sim 2001 Chondrosarcoma of the pelvis A review of sixty-four cases. J Bone Joint Surg Am 83-A 1630 1642
35. AE Rosenberg GA Brown AK Bhan JM Lee 1994 Chondroid chordoma-a variant of chordoma. A morphologic and immunohistochemical study Am J Clin Pathol 101 36 41
36. LA Scott JK Vass EK Parkinson DA Gillespie JN Winnie BW Ozanne 2004 Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53 Mol Cell Biol 24 1540 1559
37. NH Segal P Pavlidis CR Antonescu RG Maki WS Noble D DeSantis JM Woodruff JJ Lewis MF Brennan AN Houghton C Cordon-Cardo 2003 Classification and subtype prediction of adult soft tissue sarcoma by functional genomics Am J Pathol 163 691 700
38. I Sekiya K Tsuji P Koopman H Watanabe Y Yamada K Shinomiya A Nifuji M Noda 2000 SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6 J Biol Chem 275 10738 10744
39. N Sundaresan JH Galicich FC Chu AG Huvos 1979 Spinal chordomas J Neurosurg 50 312 319
40. M Temponi T Kageshita F Perosa R Ono H Okada S Ferrone 1989 Purification of murine IgG monoclonal antibodies by precipitation with caprylic acid: comparison with other methods of purification Hybridoma 8 85 95
41. R Tirabosco DC Mangham AE Rosenberg S Vujovic K Bousdras S Pizzolitto G De Maglio MA den Bakker L Di Francesco RK Kalil NA Athanasou P O'Donnell EF McCarthy AM Flanagan 2008 Brachyury expression in extra-axial skeletal and soft tissue chordomas: a marker that distinguishes chordoma from mixed tumor/myoepithelioma/parachordoma in soft tissue Am J Surg Pathol 32 4 572 580
42. JA Uria M Balbin JM Lopez J Alvarez F Vizoso M Takigawa C Lopez-Otin 1998 Collagenase-3 (MMP-13) expression in chondrosarcoma cells and its regulation by basic fibroblast growth factor Am J Pathol 153 91 101
43. S Vujovic S Henderson N Presneau E Odell TS Jacques R Tirabosco C Boshoff AM Flanagan 2006 Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas J Pathol 209 157 165
44. R Wagener HW Ehlen YP Ko B Kobbe HH Mann G Sengle M Paulsson 2005 The matrilins-adaptor proteins in the extracellular matrix FEBS Lett 579 3323 3329
45. WF Xie X Zhang S Sakano V Lefebvre LJ Sandell 1999 Trans-activation of the mouse cartilage-derived retinoic acid-sensitive protein gene by Sox9 J Bone Miner Res 14 757 763
46. A Zharkikh WH Li 1995 Estimation of confidence in phylogeny: the complete-and-partial bootstrap technique Mol Phylogenet Evol 4 44 63