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Volumn 579, Issue 15, 2005, Pages 3323-3329

The matrilins - Adaptor proteins in the extracellular matrix

Author keywords

Cartilage; Chondrodysplasia; Collagen; Extracellular matrix; Fibril; Matrilin

Indexed keywords

ADAPTOR PROTEIN; AGGRECAN; COLLAGEN; MATRILIN; MATRILIN 1; MATRILIN 2; MATRILIN 3; MATRILIN 4; MATRIX PROTEIN; MUTANT PROTEIN; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

EID: 20444376187     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.03.018     Document Type: Short Survey
Times cited : (96)

References (65)
  • 1
    • 0036796740 scopus 로고    scopus 로고
    • Distribution and evolution of von Willebrand/integrin a domains: Widely dispersed domains with roles in cell adhesion and elsewhere
    • C.A. Whittaker, and R.O. Hynes Distribution and evolution of von Willebrand/integrin A domains: Widely dispersed domains with roles in cell adhesion and elsewhere Mol. Biol. Cell 13 2002 3369 3387
    • (2002) Mol. Biol. Cell , vol.13 , pp. 3369-3387
    • Whittaker, C.A.1    Hynes, R.O.2
  • 3
    • 0040973727 scopus 로고    scopus 로고
    • The matrilins: A novel family of oligomeric extracellular matrix proteins
    • F. Deák, R. Wagener, I. Kiss, and M. Paulsson The matrilins: A novel family of oligomeric extracellular matrix proteins Matrix Biol. 18 1999 55 64
    • (1999) Matrix Biol. , vol.18 , pp. 55-64
    • Deák, F.1    Wagener, R.2    Kiss, I.3    Paulsson, M.4
  • 4
    • 14844296487 scopus 로고    scopus 로고
    • Zebrafish (Danio rerio) matrilins: Shared and divergent characteristics with their mammalian counterparts
    • Y.P. Ko, B. Kobbe, M. Paulsson, and R. Wagener Zebrafish (Danio rerio) matrilins: Shared and divergent characteristics with their mammalian counterparts Biochem. J. 386 2005 367 379
    • (2005) Biochem. J. , vol.386 , pp. 367-379
    • Ko, Y.P.1    Kobbe, B.2    Paulsson, M.3    Wagener, R.4
  • 7
    • 0035957096 scopus 로고    scopus 로고
    • The first epidermal growth factor-like domain of the low-density lipoprotein receptor contains a noncanonical calcium binding site
    • S. Malby, R. Pickering, S. Saha, R. Smallridge, S. Linse, and A.K. Downing The first epidermal growth factor-like domain of the low-density lipoprotein receptor contains a noncanonical calcium binding site Biochemistry 40 2001 2555 2563
    • (2001) Biochemistry , vol.40 , pp. 2555-2563
    • Malby, S.1    Pickering, R.2    Saha, S.3    Smallridge, R.4    Linse, S.5    Downing, A.K.6
  • 8
    • 0028104830 scopus 로고
    • Native cartilage matrix protein (CMP). a compact trimer of subunits assembled via a coiled-coil α-helix
    • N. Hauser, and M. Paulsson Native cartilage matrix protein (CMP). A compact trimer of subunits assembled via a coiled-coil α-helix J. Biol. Chem. 269 1994 25747 25753
    • (1994) J. Biol. Chem. , vol.269 , pp. 25747-25753
    • Hauser, N.1    Paulsson, M.2
  • 10
    • 0033531935 scopus 로고    scopus 로고
    • Matrilin-2, a large, oligomeric matrix protein, is expressed by a great variety of cells and forms fibrillar networks
    • D. Piecha, S. Muratoglu, M. Mörgelin, N. Hauser, D. Studer, I. Kiss, M. Paulsson, and F. Deák Matrilin-2, a large, oligomeric matrix protein, is expressed by a great variety of cells and forms fibrillar networks J. Biol. Chem. 274 1999 13353 13361
    • (1999) J. Biol. Chem. , vol.274 , pp. 13353-13361
    • Piecha, D.1    Muratoglu, S.2    Mörgelin, M.3    Hauser, N.4    Studer, D.5    Kiss, I.6    Paulsson, M.7    Deák, F.8
  • 11
    • 0034635355 scopus 로고    scopus 로고
    • Molecular structure and tissue distribution of matrilin-3, a filament-forming extracellular matrix protein expressed during skeletal development
    • A.R. Klatt, D.P. Nitsche, B. Kobbe, M. Mörgelin, M. Paulsson, and R. Wagener Molecular structure and tissue distribution of matrilin-3, a filament-forming extracellular matrix protein expressed during skeletal development J. Biol. Chem. 275 2000 3999 4006
    • (2000) J. Biol. Chem. , vol.275 , pp. 3999-4006
    • Klatt, A.R.1    Nitsche, D.P.2    Kobbe, B.3    Mörgelin, M.4    Paulsson, M.5    Wagener, R.6
  • 14
    • 0032504216 scopus 로고    scopus 로고
    • Matrilin-3 forms disulfide-linked oligomers with matrilin-1 in bovine epiphyseal cartilage
    • J.J. Wu, and D.R. Eyre Matrilin-3 forms disulfide-linked oligomers with matrilin-1 in bovine epiphyseal cartilage J. Biol. Chem. 273 1998 17433 17438
    • (1998) J. Biol. Chem. , vol.273 , pp. 17433-17438
    • Wu, J.J.1    Eyre, D.R.2
  • 15
    • 0019605257 scopus 로고
    • Purification and structural characterization of a cartilage matrix protein
    • M. Paulsson, and D. Heinegård Purification and structural characterization of a cartilage matrix protein Biochem. J. 197 1981 367 375
    • (1981) Biochem. J. , vol.197 , pp. 367-375
    • Paulsson, M.1    Heinegård, D.2
  • 17
    • 0030852250 scopus 로고    scopus 로고
    • Primary structure of matrilin-3, a new member of a family of extracellular matrix proteins related to cartilage matrix protein (matrilin-1) and von Willebrand factor
    • R. Wagener, B. Kobbe, and M. Paulsson Primary structure of matrilin-3, a new member of a family of extracellular matrix proteins related to cartilage matrix protein (matrilin-1) and von Willebrand factor FEBS Lett. 413 1997 129 134
    • (1997) FEBS Lett. , vol.413 , pp. 129-134
    • Wagener, R.1    Kobbe, B.2    Paulsson, M.3
  • 18
    • 0032566539 scopus 로고    scopus 로고
    • Matrilin-4, a new member of the matrilin family of extracellular matrix proteins
    • R. Wagener, B. Kobbe, and M. Paulsson Matrilin-4, a new member of the matrilin family of extracellular matrix proteins FEBS Lett. 436 1998 123 127
    • (1998) FEBS Lett. , vol.436 , pp. 123-127
    • Wagener, R.1    Kobbe, B.2    Paulsson, M.3
  • 20
    • 0036257418 scopus 로고    scopus 로고
    • Expression of matrilins during maturation of mouse skeletal tissues
    • A.R. Klatt, M. Paulsson, and R. Wagener Expression of matrilins during maturation of mouse skeletal tissues Matrix Biol. 21 2002 289 296
    • (2002) Matrix Biol. , vol.21 , pp. 289-296
    • Klatt, A.R.1    Paulsson, M.2    Wagener, R.3
  • 21
    • 0029881980 scopus 로고    scopus 로고
    • Cloning, sequencing and expression analysis of mouse cartilage matrix protein cDNA
    • A. Aszódi, N. Hauser, D. Studer, M. Paulsson, L. Hiripi, and Z. Bösze Cloning, sequencing and expression analysis of mouse cartilage matrix protein cDNA Eur. J. Biochem. 236 1996 970 977
    • (1996) Eur. J. Biochem. , vol.236 , pp. 970-977
    • Aszódi, A.1    Hauser, N.2    Studer, D.3    Paulsson, M.4    Hiripi, L.5    Bösze, Z.6
  • 22
    • 0028324219 scopus 로고
    • Developmental expression of human cartilage matrix protein
    • S. Mundlos, and B. Zabel Developmental expression of human cartilage matrix protein Dev. Dyn. 199 1994 241 252
    • (1994) Dev. Dyn. , vol.199 , pp. 241-252
    • Mundlos, S.1    Zabel, B.2
  • 23
    • 0024455899 scopus 로고
    • Gene regulation during cartilage differentiation: Temporal and spatial expression of link protein and cartilage matrix protein in the developing limb
    • N.S. Stirpe, and P.F. Goetinck Gene regulation during cartilage differentiation: Temporal and spatial expression of link protein and cartilage matrix protein in the developing limb Development 107 1989 23 33
    • (1989) Development , vol.107 , pp. 23-33
    • Stirpe, N.S.1    Goetinck, P.F.2
  • 24
    • 0031590314 scopus 로고    scopus 로고
    • Matrilin-3 from chicken cartilage
    • D. Belluoccio, and B. Trueb Matrilin-3 from chicken cartilage FEBS Lett. 415 1997 212 216
    • (1997) FEBS Lett. , vol.415 , pp. 212-216
    • Belluoccio, D.1    Trueb, B.2
  • 25
    • 0025349267 scopus 로고
    • Identification of positive and negative regulatory regions controlling expression of the cartilage matrix protein gene
    • I. Kiss, Z. Bösze, P. Szabó, R. Altanchimeg, E. Barta, and F. Deák Identification of positive and negative regulatory regions controlling expression of the cartilage matrix protein gene Mol. Cell. Biol. 10 1990 2432 2436
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 2432-2436
    • Kiss, I.1    Bösze, Z.2    Szabó, P.3    Altanchimeg, R.4    Barta, E.5    Deák, F.6
  • 27
    • 1942451841 scopus 로고    scopus 로고
    • Functional analysis of the regulatory regions of the matrilin-1 gene in transgenic mice reveals modular arrangement of tissue-specific control elements
    • I. Karcagi, T. Rauch, L. Hiripi, O. Rentsendorj, A. Nagy, Z. Bösze, and I. Kiss Functional analysis of the regulatory regions of the matrilin-1 gene in transgenic mice reveals modular arrangement of tissue-specific control elements Matrix Biol. 22 2004 605 618
    • (2004) Matrix Biol. , vol.22 , pp. 605-618
    • Karcagi, I.1    Rauch, T.2    Hiripi, L.3    Rentsendorj, O.4    Nagy, A.5    Bösze, Z.6    Kiss, I.7
  • 28
    • 0018597773 scopus 로고
    • Matrix proteins bound to associatively prepared proteoglycans from bovine cartilage
    • M. Paulsson, and D. Heinegård Matrix proteins bound to associatively prepared proteoglycans from bovine cartilage Biochem. J. 183 1979 539 545
    • (1979) Biochem. J. , vol.183 , pp. 539-545
    • Paulsson, M.1    Heinegård, D.2
  • 29
    • 0029752015 scopus 로고    scopus 로고
    • Interaction of cartilage matrix protein with aggrecan. Increased covalent cross-linking with tissue maturation
    • N. Hauser, M. Paulsson, D. Heinegård, and M. Mörgelin Interaction of cartilage matrix protein with aggrecan. Increased covalent cross-linking with tissue maturation J. Biol. Chem. 271 1996 32247 32252
    • (1996) J. Biol. Chem. , vol.271 , pp. 32247-32252
    • Hauser, N.1    Paulsson, M.2    Heinegård, D.3    Mörgelin, M.4
  • 31
    • 0028846691 scopus 로고
    • Cartilage matrix protein forms a type II collagen-independent filamentous network: Analysis in primary cell cultures with a retrovirus expression system
    • Q. Chen, D.M. Johnson, D.R. Haudenschild, M.M. Tondravi, and P.F. Goetinck Cartilage matrix protein forms a type II collagen-independent filamentous network: Analysis in primary cell cultures with a retrovirus expression system Mol. Biol. Cell 6 1995 1743 1753
    • (1995) Mol. Biol. Cell , vol.6 , pp. 1743-1753
    • Chen, Q.1    Johnson, D.M.2    Haudenschild, D.R.3    Tondravi, M.M.4    Goetinck, P.F.5
  • 32
    • 2942597560 scopus 로고    scopus 로고
    • Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias
    • H.H. Mann, S. Özbek, J. Engel, M. Paulsson, and R. Wagener Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias J. Biol. Chem. 279 2004 25294 25298
    • (2004) J. Biol. Chem. , vol.279 , pp. 25294-25298
    • Mann, H.H.1    Özbek, S.2    Engel, J.3    Paulsson, M.4    Wagener, R.5
  • 34
    • 0141621124 scopus 로고    scopus 로고
    • Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan
    • C. Wiberg, A.R. Klatt, R. Wagener, M. Paulsson, J.F. Bateman, D. Heinegård, and M. Mörgelin Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan J. Biol. Chem. 278 2003 37698 37704
    • (2003) J. Biol. Chem. , vol.278 , pp. 37698-37704
    • Wiberg, C.1    Klatt, A.R.2    Wagener, R.3    Paulsson, M.4    Bateman, J.F.5    Heinegård, D.6    Mörgelin, M.7
  • 35
    • 0034933884 scopus 로고    scopus 로고
    • Mutations in the region encoding the von Willebrand factor a domain of matrilin-3 are associated with multiple epiphyseal dysplasia
    • K.L. Chapman, G.R. Mortier, K. Chapman, J. Loughlin, M.E. Grant, and M.D. Briggs Mutations in the region encoding the von Willebrand factor A domain of matrilin-3 are associated with multiple epiphyseal dysplasia Nat. Genet. 28 2001 393 396
    • (2001) Nat. Genet. , vol.28 , pp. 393-396
    • Chapman, K.L.1    Mortier, G.R.2    Chapman, K.3    Loughlin, J.4    Grant, M.E.5    Briggs, M.D.6
  • 38
    • 0042324183 scopus 로고    scopus 로고
    • Familial multiple epiphyseal dysplasia due to a matrilin-3 mutation: Further delineation of the phenotype including 40 years follow-up
    • A.K. Mostert, P.F. Dijkstra, B.R. Jansen, J.R. van Horn, B. de Graaf, P. Heutink, and D. Lindhout Familial multiple epiphyseal dysplasia due to a matrilin-3 mutation: Further delineation of the phenotype including 40 years follow-up Am. J. Med. Genet. A 120 2003 490 497
    • (2003) Am. J. Med. Genet. a , vol.120 , pp. 490-497
    • Mostert, A.K.1    Dijkstra, P.F.2    Jansen, B.R.3    Van Horn, J.R.4    De Graaf, B.5    Heutink, P.6    Lindhout, D.7
  • 41
    • 0030069658 scopus 로고    scopus 로고
    • A mutation in the gene encoding the α2 chain of the fibril-associated collagen IX, COL9A2, causes multiple epiphyseal dysplasia (EDM2)
    • Y. Muragaki, E.C. Mariman, S.E. van Beersum, M. Perala, J.B. van Mourik, M.L. Warman, B.R. Olsen, and B.C. Hamel A mutation in the gene encoding the α2 chain of the fibril-associated collagen IX, COL9A2, causes multiple epiphyseal dysplasia (EDM2) Nat. Genet. 12 1996 103 105
    • (1996) Nat. Genet. , vol.12 , pp. 103-105
    • Muragaki, Y.1    Mariman, E.C.2    Van Beersum, S.E.3    Perala, M.4    Van Mourik, J.B.5    Warman, M.L.6    Olsen, B.R.7    Hamel, B.C.8
  • 43
    • 2342577420 scopus 로고    scopus 로고
    • Spondylo-epi-metaphyseal dysplasia (SEMD) matrilin 3 type: Homozygote matrilin 3 mutation in a novel form of SEMD
    • Z.U. Borochowitz, D. Scheffer, V. Adir, N. Dagoneau, A. Munnich, and V. Cormier-Daire Spondylo-epi-metaphyseal dysplasia (SEMD) matrilin 3 type: Homozygote matrilin 3 mutation in a novel form of SEMD J. Med. Genet. 41 2004 366 372
    • (2004) J. Med. Genet. , vol.41 , pp. 366-372
    • Borochowitz, Z.U.1    Scheffer, D.2    Adir, V.3    Dagoneau, N.4    Munnich, A.5    Cormier-Daire, V.6
  • 45
    • 26944490699 scopus 로고    scopus 로고
    • Matrilin-3 mutations that cause chondrodysplasias interfere with protein trafficking while a mutation associated with hand osteoarthritis does not
    • in press
    • Otten, C., Wagener, R., Paulsson, M. and Zaucke, F. (in press) Matrilin-3 mutations that cause chondrodysplasias interfere with protein trafficking while a mutation associated with hand osteoarthritis does not. J. Med. Genet
    • J. Med. Genet.
    • Otten, C.1    Wagener, R.2    Paulsson, M.3    Zaucke, F.4
  • 47
    • 0036238236 scopus 로고    scopus 로고
    • Pseudoachondroplasia and multiple epiphyseal dysplasia: Mutation review, molecular interactions, and genotype to phenotype correlations
    • M.D. Briggs, and K.L. Chapman Pseudoachondroplasia and multiple epiphyseal dysplasia: Mutation review, molecular interactions, and genotype to phenotype correlations Hum. Mutat. 19 2002 465 478
    • (2002) Hum. Mutat. , vol.19 , pp. 465-478
    • Briggs, M.D.1    Chapman, K.L.2
  • 48
    • 0028124911 scopus 로고
    • Exclusion of the cartilage link protein and the cartilage matrix protein genes as the mutant loci in several heritable chondrodysplasias
    • J. Loughlin, C. Irven, and B. Sykes Exclusion of the cartilage link protein and the cartilage matrix protein genes as the mutant loci in several heritable chondrodysplasias Hum. Genet. 94 1994 698 700
    • (1994) Hum. Genet. , vol.94 , pp. 698-700
    • Loughlin, J.1    Irven, C.2    Sykes, B.3
  • 50
    • 0034084296 scopus 로고    scopus 로고
    • Analysis of the association of the matrillin-1 gene (CRTM) with osteoarthritis: Comment on the article by Meulenbelt et al
    • J. Loughlin, B. Dowling, Z. Mustafa, A. Smith, B. Sykes, and K. Chapman Analysis of the association of the matrillin-1 gene (CRTM) with osteoarthritis: Comment on the article by Meulenbelt et al Arthritis Rheum. 43 2000 1423 1425
    • (2000) Arthritis Rheum. , vol.43 , pp. 1423-1425
    • Loughlin, J.1    Dowling, B.2    Mustafa, Z.3    Smith, A.4    Sykes, B.5    Chapman, K.6
  • 52
    • 0033857843 scopus 로고    scopus 로고
    • Autoreactivity against matrilin-1 in a patient with relapsing polychondritis
    • J.H. Buckner, J.J. Wu, R.A. Reife, K. Terato, and D.R. Eyre Autoreactivity against matrilin-1 in a patient with relapsing polychondritis Arthritis Rheum. 43 2000 939 943
    • (2000) Arthritis Rheum. , vol.43 , pp. 939-943
    • Buckner, J.H.1    Wu, J.J.2    Reife, R.A.3    Terato, K.4    Eyre, D.R.5
  • 53
    • 0034768570 scopus 로고    scopus 로고
    • The occurrence of autoantibodies to matrilin 1 reflects a tissue-specific response to cartilage of the respiratory tract in patients with relapsing polychondritis
    • A.S. Hansson, D. Heinegård, J.C. Piette, H. Burkhardt, and R. Holmdahl The occurrence of autoantibodies to matrilin 1 reflects a tissue-specific response to cartilage of the respiratory tract in patients with relapsing polychondritis Arthritis Rheum. 44 2001 2402 2412
    • (2001) Arthritis Rheum. , vol.44 , pp. 2402-2412
    • Hansson, A.S.1    Heinegård, D.2    Piette, J.C.3    Burkhardt, H.4    Holmdahl, R.5
  • 54
    • 0344146514 scopus 로고    scopus 로고
    • A new animal model for relapsing polychondritis, induced by cartilage matrix protein (matrilin-1)
    • A.S. Hansson, D. Heinegård, and R. Holmdahl A new animal model for relapsing polychondritis, induced by cartilage matrix protein (matrilin-1) J. Clin. Invest. 104 1999 589 598
    • (1999) J. Clin. Invest. , vol.104 , pp. 589-598
    • Hansson, A.S.1    Heinegård, D.2    Holmdahl, R.3
  • 55
    • 1242271332 scopus 로고    scopus 로고
    • Relapsing polychondritis, induced in mice with matrilin 1, is an antibody- and complement-dependent disease
    • A.S. Hansson, M. Johannesson, L. Svensson, K.S. Nandakumar, D. Heinegård, and R. Holmdahl Relapsing polychondritis, induced in mice with matrilin 1, is an antibody- and complement-dependent disease Am. J. Pathol. 164 2004 959 966
    • (2004) Am. J. Pathol. , vol.164 , pp. 959-966
    • Hansson, A.S.1    Johannesson, M.2    Svensson, L.3    Nandakumar, K.S.4    Heinegård, D.5    Holmdahl, R.6
  • 56
    • 20444373563 scopus 로고    scopus 로고
    • Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice
    • A.S. Hansson, A.C. Johansson, and R. Holmdahl Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice Arthritis Res. Ther. 6 2004 R484 R491
    • (2004) Arthritis Res. Ther. , vol.6
    • Hansson, A.S.1    Johansson, A.C.2    Holmdahl, R.3
  • 58
    • 0024449973 scopus 로고
    • Involvement of nonarticular cartilage, as demonstrated by release of a cartilage-specific protein, in rheumatoid arthritis
    • T. Saxne, and D. Heinegård Involvement of nonarticular cartilage, as demonstrated by release of a cartilage-specific protein, in rheumatoid arthritis Arthritis Rheum. 32 1989 1080 1086
    • (1989) Arthritis Rheum. , vol.32 , pp. 1080-1086
    • Saxne, T.1    Heinegård, D.2
  • 62
    • 3843080738 scopus 로고    scopus 로고
    • Mice lacking the extracellular matrix adaptor protein matrilin-2 develop without obvious abnormalities
    • L. Mátés, C. Nicolae, M. Mörgelin, F. Deák, I. Kiss, and A. Aszódi Mice lacking the extracellular matrix adaptor protein matrilin-2 develop without obvious abnormalities Matrix Biol. 23 2004 195 204
    • (2004) Matrix Biol. , vol.23 , pp. 195-204
    • Mátés, L.1    Nicolae, C.2    Mörgelin, M.3    Deák, F.4    Kiss, I.5    Aszódi, A.6
  • 64
    • 0032713596 scopus 로고    scopus 로고
    • Mice lacking matrilin-1 (cartilage matrix protein) have alterations in type II collagen fibrillogenesis and fibril organization
    • X. Huang, D.E. Birk, and P.F. Goetinck Mice lacking matrilin-1 (cartilage matrix protein) have alterations in type II collagen fibrillogenesis and fibril organization Dev. Dyn. 216 1999 434 441
    • (1999) Dev. Dyn. , vol.216 , pp. 434-441
    • Huang, X.1    Birk, D.E.2    Goetinck, P.F.3
  • 65
    • 0033574437 scopus 로고    scopus 로고
    • Enhancement of cell adhesion and spreading by a cartilage-specific noncollagenous protein, cartilage matrix protein (CMP/Matrilin-1), via integrin α1β1
    • S. Makihira, W. Yan, S. Ohno, T. Kawamoto, K. Fujimoto, A. Okimura, E. Yoshida, M. Noshiro, T. Hamada, and Y. Kato Enhancement of cell adhesion and spreading by a cartilage-specific noncollagenous protein, cartilage matrix protein (CMP/Matrilin-1), via integrin α1β1 J. Biol. Chem. 274 1999 11417 11423
    • (1999) J. Biol. Chem. , vol.274 , pp. 11417-11423
    • Makihira, S.1    Yan, W.2    Ohno, S.3    Kawamoto, T.4    Fujimoto, K.5    Okimura, A.6    Yoshida, E.7    Noshiro, M.8    Hamada, T.9    Kato, Y.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.