The penetratin sequence in the anticancer PNC-28 peptide causes tumor cell necrosis rather than apoptosis of human pancreatic cancer cells

Annals of Surgical Oncology

Volumn 15, Issue 12, 2008, Pages 3588-3600

  Bowne, Wilbur B ^a,b   Sookraj, Kelley A ^a,b   Vishnevetsky, Michael ^a   Adler, Victor ^b   Sarafraz Yazdi, Ehsan ^c   Lou, Sunming ^c   Koenke, Jesco ^d   Shteyler, Vadim ^a   Ikram, Kamran ^a,b   Harding, Michael ^b   Bluth, Martin H ^e   Ng, Mou ^a   Brandt Rauf, Paul W ^f   Hannan, Raqibul ^a   Bradu, Stephan ^a   Zenilman, Michael E ^a   Michl, Josef ^c   Pincus, Matthew R ^a,b  

^a SUNY Downstate Medical Center   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c SUNY DOWNSTATE MEDICAL CENTER   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e WAYNE STATE UNIVERSITY   (United States)

^f Columbia College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 7; LACTATE DEHYDROGENASE; LIPOCORTIN 5; PENETRATIN; PNC 28 PEPTIDE; PNC 29 PROTEIN; PROTEIN; PROTEIN P53; UNCLASSIFIED DRUG;

ACINAR CELL; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CHANNEL GATING; CONTROLLED STUDY; ELECTRON MICROSCOPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; PANCREAS CANCER; PLASMID; PROTEIN EXPRESSION; RAT; TUMOR CELL;

APOPTOSIS; CARRIER PROTEINS; CASPASES; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HUMANS; L-LACTATE DEHYDROGENASE; NECROSIS; PANCREATIC NEOPLASMS; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 58149293618     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-008-0147-0     Document Type: Article

References (16)

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