메뉴 건너뛰기




Volumn 35, Issue 4, 1996, Pages 429-434

The p53-MDM2 interaction in a cancer-prone family, and the identification of a novel therapeutic target

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CANCER; CONTROLLED STUDY; DRUG DEVELOPMENT; FAMILIAL DISEASE; FEMALE; HUMAN; HUMAN CELL; ONCOGENE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0030036517     PISSN: 0284186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/02841869609109917     Document Type: Article
Times cited : (28)

References (36)
  • 2
    • 0028124528 scopus 로고
    • p53 and human cancers
    • Lane DP. p53 and human cancers. Br Med Bull 1994; 50: 582-99.
    • (1994) Br Med Bull , vol.50 , pp. 582-599
    • Lane, D.P.1
  • 4
    • 0027983669 scopus 로고
    • Crystal structure of a p53 tumour suppressor-DNA complex: Understanding tumourigenic mutations
    • Cho Y, Gorina S, Jeffrey PD, Pavletich NP. Crystal structure of a p53 tumour suppressor-DNA complex: understanding tumourigenic mutations. Science 1994; 265: 346-55.
    • (1994) Science , vol.265 , pp. 346-355
    • Cho, Y.1    Gorina, S.2    Jeffrey, P.D.3    Pavletich, N.P.4
  • 5
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992; 69: 1237-45.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 6
    • 0027459198 scopus 로고
    • mdm2 expression is induced by wild type p53 activity
    • Barak Y, Juven T, Haffner R, Oren M. mdm2 expression is induced by wild type p53 activity. Embo J 1993; 12: 461-8.
    • (1993) Embo J , vol.12 , pp. 461-468
    • Barak, Y.1    Juven, T.2    Haffner, R.3    Oren, M.4
  • 8
  • 10
    • 0027232042 scopus 로고
    • p53 Mutation and MDM2 amplification in human soft tissue sarcomas
    • Leach FS, Tokino T, Meltzer P, et al. p53 Mutation and MDM2 amplification in human soft tissue sarcomas. Cancer Res 1993; 53: 2231-4.
    • (1993) Cancer Res , vol.53 , pp. 2231-2234
    • Leach, F.S.1    Tokino, T.2    Meltzer, P.3
  • 11
    • 0027196974 scopus 로고
    • Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations
    • Reifenberger G, Liu L, Ichimura K, Schmidt EE, Collins VP. Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res 1993; 53: 2736-9.
    • (1993) Cancer Res , vol.53 , pp. 2736-2739
    • Reifenberger, G.1    Liu, L.2    Ichimura, K.3    Schmidt, E.E.4    Collins, V.P.5
  • 12
    • 0028098165 scopus 로고
    • Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas
    • Cordon CC, Latres E, Drobnjak M, et al. Molecular abnormalities of mdm2 and p53 genes in adult soft tissue sarcomas. Cancer Res 1994; 54: 794-9.
    • (1994) Cancer Res , vol.54 , pp. 794-799
    • Cordon, C.C.1    Latres, E.2    Drobnjak, M.3
  • 13
    • 0027291285 scopus 로고
    • Upregulation of mdm-2 expression in Meth A tumor cells tolerating wild-type p53
    • Otto A, Deppert W. Upregulation of mdm-2 expression in Meth A tumor cells tolerating wild-type p53. Oncogene 1993; 8: 2591-603.
    • (1993) Oncogene , vol.8 , pp. 2591-2603
    • Otto, A.1    Deppert, W.2
  • 14
    • 0027956208 scopus 로고
    • Enhanced translation: A novel mechanism of mdm2 oncogene overex-pression identified in human tumor cells
    • Landers JE, Haines DS, Strauss B, George DL. Enhanced translation: a novel mechanism of mdm2 oncogene overex-pression identified in human tumor cells. Oncogene 1994; 9: 2745-50.
    • (1994) Oncogene , vol.9 , pp. 2745-2750
    • Landers, J.E.1    Haines, D.S.2    Strauss, B.3    George, D.L.4
  • 15
    • 0027498314 scopus 로고
    • The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth
    • Finlay CA. The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth. Mol Cell Biol 1993; 13: 301-6.
    • (1993) Mol Cell Biol , vol.13 , pp. 301-306
    • Finlay, C.A.1
  • 16
    • 0026632997 scopus 로고
    • Abnormal expression of wild type p53 protein in normal cells of a cancer family patient
    • Barnes DM, Hanby AM, Gillett CE, et al. Abnormal expression of wild type p53 protein in normal cells of a cancer family patient. Lancet 1992; 340: 259-63.
    • (1992) Lancet , vol.340 , pp. 259-263
    • Barnes, D.M.1    Hanby, A.M.2    Gillett, C.E.3
  • 18
    • 0027359827 scopus 로고
    • WAF-1, a potential mediator of p53 tumour suppression
    • El-Deiry WS, Tokino T, Velculescu VE, et al. WAF-1, a potential mediator of p53 tumour suppression. Cell 1994; 75: 817-25.
    • (1994) Cell , vol.75 , pp. 817-825
    • El-Deiry, W.S.1    Tokino, T.2    Velculescu, V.E.3
  • 19
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1994; 75: 805-16.
    • (1994) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 20
    • 0028342664 scopus 로고
    • Cloning of a senescent cell-derived inhibitor of DNA sythesis using an expression screen
    • Noda A, Ning Y, Venable SF,Piera-Smith OM, Smith JR. Cloning of a senescent cell-derived inhibitor of DNA sythesis using an expression screen. Exper.Cell.Res 1994; 211: 90-98.
    • (1994) Exper.Cell.Res , vol.211 , pp. 90-98
    • Noda, A.1    Ning, Y.2    Venable, S.F.3    Piera-Smith, O.M.4    Smith, J.R.5
  • 21
    • 0026569616 scopus 로고
    • Analysis of p53 expression in human tumours: An antibody raised against human p53 expressed in Escherichia coli
    • Midgley CA, Fisher CJ, Bartek J, Vojtesek B, Lane D, Barnes DM. Analysis of p53 expression in human tumours: an antibody raised against human p53 expressed in Escherichia coli. J Cell Sci 1992; 101: 183-9.
    • (1992) J Cell Sci , vol.101 , pp. 183-189
    • Midgley, C.A.1    Fisher, C.J.2    Bartek, J.3    Vojtesek, B.4    Lane, D.5    Barnes, D.M.6
  • 22
    • 0026769713 scopus 로고
    • An immunochemical analysis of the human nuclear phosphoprotein p53. New monoclonal antibodies and epitope mapping using recombinant p53
    • Vojtesek B, Bartek J, Midgley CA, Lane DP. An immunochemical analysis of the human nuclear phosphoprotein p53. New monoclonal antibodies and epitope mapping using recombinant p53. J Immunol Methods 1992; 151: 237-44.
    • (1992) J Immunol Methods , vol.151 , pp. 237-244
    • Vojtesek, B.1    Bartek, J.2    Midgley, C.A.3    Lane, D.P.4
  • 23
    • 0027964904 scopus 로고
    • Immunochemical analysis of the interaction of p53 with MDM2; - Fine mapping of the MDM2 binding site on p53 using synthetic peptides
    • Picksley SM, Vojtesek B, Sparks A, Lane DP. Immunochemical analysis of the interaction of p53 with MDM2; - fine mapping of the MDM2 binding site on p53 using synthetic peptides. Oncogene 1994; 9: 2523-9.
    • (1994) Oncogene , vol.9 , pp. 2523-2529
    • Picksley, S.M.1    Vojtesek, B.2    Sparks, A.3    Lane, D.P.4
  • 25
    • 0026561121 scopus 로고
    • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
    • Donehower LA, Harvey M, Slagle BL, et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 1992; 356: 215-21.
    • (1992) Nature , vol.356 , pp. 215-221
    • Donehower, L.A.1    Harvey, M.2    Slagle, B.L.3
  • 26
    • 0028172939 scopus 로고
    • Linkage studies in a Li-Fraumeni family with increased expression of p53 protein but no germline mutation in p53
    • Birch JM, Heighway J, Teare MD, et al. Linkage studies in a Li-Fraumeni family with increased expression of p53 protein but no germline mutation in p53. Br J Cancer 1994; 70: 1176-81.
    • (1994) Br J Cancer , vol.70 , pp. 1176-1181
    • Birch, J.M.1    Heighway, J.2    Teare, M.D.3
  • 27
    • 0027728787 scopus 로고
    • Mapping of amplification units in the q13-14 region of chromosome 12 in human sarcomas: Some amplica do not include MDM2
    • Forus A, Florenes VA, Maelandsmo GM, et al. Mapping of amplification units in the q13-14 region of chromosome 12 in human sarcomas: some amplica do not include MDM2. Cell Growth Differ 1993; 4: 1065-70.
    • (1993) Cell Growth Differ , vol.4 , pp. 1065-1070
    • Forus, A.1    Florenes, V.A.2    Maelandsmo, G.M.3
  • 29
    • 0027222956 scopus 로고
    • Mapping of the p53 and mdm-2 interaction domains
    • Chen J, Marechal V, Levine AJ. Mapping of the p53 and mdm-2 interaction domains. Mol Cell Biol 1993; 13: 4107-14.
    • (1993) Mol Cell Biol , vol.13 , pp. 4107-4114
    • Chen, J.1    Marechal, V.2    Levine, A.J.3
  • 30
    • 0027980357 scopus 로고
    • Interaction of p53 with MDM2 is independent of E6 and does not mediate wild type transformation suppressor function
    • Marston NJ, Crook T, Vousden KH. Interaction of p53 with MDM2 is independent of E6 and does not mediate wild type transformation suppressor function. Oncogene 1994; 9: 2707-16.
    • (1994) Oncogene , vol.9 , pp. 2707-2716
    • Marston, N.J.1    Crook, T.2    Vousden, K.H.3
  • 31
    • 0028303752 scopus 로고
    • Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional actviation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
    • Lin J, Chen J, Elenbaas B, Levine AJ. Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional actviation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein. Genes Dev 1994; 8. 1235-46.
    • (1994) Genes Dev , vol.8 , pp. 1235-1246
    • Lin, J.1    Chen, J.2    Elenbaas, B.3    Levine, A.J.4
  • 33
    • 0028235196 scopus 로고
    • Linear antigenic sites defined by the B-cell response to human p53 are localized predominantly in the amino and carboxy-termini of the protein
    • Legros Y, Lafon C, Soussi T. Linear antigenic sites defined by the B-cell response to human p53 are localized predominantly in the amino and carboxy-termini of the protein. Oncogene 1994; 9: 2071-6.
    • (1994) Oncogene , vol.9 , pp. 2071-2076
    • Legros, Y.1    Lafon, C.2    Soussi, T.3
  • 34
    • 0028915250 scopus 로고
    • Characterisation of epi-topes on human p53 using phage-displayed peptide libraries: Insights into antibody-peptide interactions
    • Stephen CW, Helmenin P, Lane DP. characterisation of epi-topes on human p53 using phage-displayed peptide libraries: insights into antibody-peptide interactions. J Mol Biol 1995; 248: 58-78.
    • (1995) J Mol Biol , vol.248 , pp. 58-78
    • Stephen, C.W.1    Helmenin, P.2    Lane, D.P.3
  • 35
    • 0027109075 scopus 로고
    • Cancer. p53, guardian of the genome
    • Lane DP Cancer. p53, guardian of the genome. Nature 1992; 358: 15-6.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 36
    • 0028323294 scopus 로고
    • Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells
    • Lowe SW, Jacks T, Housman DE, Ruley HE. Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. Proc Natl Acad Sci USA 1994; 91: 2026-30.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 2026-2030
    • Lowe, S.W.1    Jacks, T.2    Housman, D.E.3    Ruley, H.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.