The role of alpha-helical structure in p53 peptides as a determinant for their mechanism of cell death: Necrosis versus apoptosis

Advanced Drug Delivery Reviews

Volumn 57, Issue 4 SPEC.ISS., 2005, Pages 653-660

  Rosal, Ramon ^a   Brandt Rauf, Paul ^a   Pincus, Matthew R ^b   Wang, Hsin ^c   Mao, Yuehua ^d   Li, Yin ^d   Fine, Robert L ^d  

^a Columbia University ^*  (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c CITY UNIVERSITY OF NEW YORK   (United States)

^d Columbia Univ Coll Phys Surgs ^*  (United States)

Author keywords

Alpha helical; Apoptosis; Necrosis; NMR solution structure; p53; Peptides

Indexed keywords

CELL MEMBRANES; POLYPEPTIDES; PORE SIZE; SOLUTIONS; TUMORS;

CYTOTOXIC EFFECTS; EXTRACELLULAR MATRIX; HUMAN CANCER CELLS; MEMBRANE TRANSDUCTION;

PROTEINS;

ANTENNAPEDIA PROTEIN; FAS ANTIGEN; GLYCYLSERYLARGINYLALANYLHISTIDYLSERYLSERYLHISTIDYLLEUCYLLYSYLSERYLLYSYL LYSYLGLYCYLGLUTAMINYLSERYLTHREONYLSERYLARGINYLHISTIDINE; HELIX LOOP HELIX PROTEIN; PROLYLPROLYLLEUCYLSERYLGLUTAMINYLGLUTAMYLTHREONYLPHENYLALANYLSERYLASPARTYL LEUCYLTRYPTOPHYLLYSYLLEUCYLLEUCINE; PROTEIN P53; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; AQUEOUS SOLUTION; ARTICLE; CANCER CELL; CANCER CELL DESTRUCTION; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CELL MEMBRANE; CELL MEMBRANE TRANSPORT; CHANNEL GATING; CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG PENETRATION; DRUG SELECTIVITY; DRUG STRUCTURE; EXTRACELLULAR MATRIX; NECROSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

EID: 13844255513     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.addr.2004.10.008     Document Type: Review

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