G-CSF modulates cytokine profile of dendritic cells and decreases acute graft-versus-host disease through effects on the donor rather than the recipient

Transplantation

Volumn 69, Issue 4, 2000, Pages 691-693

  Reddy, Vijay ^a,b   Hill, Geoffrey R ^a   Pan, Luying ^a   Gerbitz, Armin ^a   Teshima, Takanori ^c   Brinson, Yani ^a   Ferrara, James L M ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GRANULOCYTE COLONY STIMULATING FACTOR; HLA ANTIGEN; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DISEASE SEVERITY; GRAFT SURVIVAL; GRAFT VERSUS HOST REACTION; MOUSE; NONHUMAN; ORGAN DONOR; PERIPHERAL BLOOD STEM CELL; PRIORITY JOURNAL; RECIPIENT; SPLEEN CELL; STEM CELL TRANSPLANTATION; T LYMPHOCYTE SUBPOPULATION;

EID: 0034053751     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200002270-00041     Document Type: Article

References (10)

1. Hill GR, Krenger W, Ferrara JLM. The role of cytokines in acute graft-vs-host disease. Cell Mol Ther 1997; 3: 257.
2. Storek J, Gooley T, Siadak M, et al. Allogeneic peripheral blood stem cell transplantation may be associated with a high risk of chronic graft-versus-host disease. Blood 1997; 90: 4705
3. Bensinger W, Clift R, Martin P, Appelabaum FR, et al. Allogeneic peripheral blood stem cell transplantation in patients with advanced hematologic malignancies: a retrospective comparison with marrow transplantation. Blood 1996; 88: 2794.
4. Pan L, Delmonte J, Jalonen CK, et al. Pretreatment of donors with granulocyte colony-stimulating factor polarizes donor T lymphocytes toward type 2 cytokine production and reduces severity of experimental graft versus host disease. Blood 1995; 86: 4422.
5. Mielcarek M, Martin PJ, Torok-Storb B. Suppression of alloantigen-induced T-cell proliferation by CD14+ cells derived from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells. Blood 1997; 89: 1629.
6. Cooke KR, Hill GR, Crawford JM, et al. Tumor necrosis factor α production to lipopolysaccharide stimulation by donor cells predicts the severity of experimental acute graft-versus-host disease. J Clin Invest 1998; 102: 1882.
7. Liu L, Rich BE, Inobe J, Chen W, Weiner HL. A potential pathway of Th2 development during the primary immune response: IL-10 pretreated dendritic cells prime naive CD4+ T cells to secrete IL-4. Adv Exp Med Biol 1997; 417: 375.
8. Gorgen I, Hartung T, Leist M, et al. Granulocytic colony stimulating factor protects rodents against lipopolysaccharide induced toxicity via suppression of systemic tumor necrosis factor α. J Immunol 1992; 149: 918.
9. Rissoan M-C, Soumelis V, Kadowaki N, et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science 1999; 283: 1183.
10. Arpinati M, Loken M, Anasetti C. G-CSF mobilizes type 2-dendritic cells rather than type 1-dendritic cells. Blood 1998; 92: 453.