Proportion of HIV-1 infected CD8+CD4-T lymphocytes in vivo

Current HIV Research

Volumn 6, Issue 6, 2008, Pages 585-596

  Gulzar, Naveed ^a,b   Diker, Bilge ^a   Mihowich, Jennifer ^a   Deschatelets, Jose ^a   Arsenault, Mary Ellen ^c   Lamoureux, Nancy ^c   Cameron, Donald W ^c   Kim, John E ^a   Copeland, Karen F T ^a  

^a PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

CD8+ T cell; HIV 1; Infection; Viral load

Indexed keywords

ABACAVIR; ANTIRETROVIRUS AGENT; ATAZANAVIR; EFAVIRENZ; GAG PROTEIN; INDINIVIR; LAMIVUDINE; LAMIVUDINE PLUS ZIDOVUDINE; LOPINAVIR; LOPINAVIR PLUS RITONAVIR; RITONAVIR; SAQUINAVIR; STAVUDINE; UNCLASSIFIED DRUG; ZIDOVUDINE; VIRUS PROTEIN; VIRUS RNA;

ADULT; CD4 CD8 RATIO; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CD8 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CELL ISOLATION; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE REDUCTION; EX VIVO STUDY; FLOW CYTOMETRY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOPATHOGENESIS; IN VIVO STUDY; LYMPHOCYTE COUNT; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; VIRUS LOAD; VIRUS TITRATION; ARTICLE; BIOSYNTHESIS; IMMUNOLOGY; ISOLATION AND PURIFICATION; MIDDLE AGED; VIROLOGY;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FLOW CYTOMETRY; HIV INFECTIONS; HIV-1; HUMANS; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; VIRAL PROTEINS;

EID: 58149260507     PISSN: 1570162X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157016208786501544     Document Type: Review

References (45)

1. Maddon PJ, Dalgleish AG, McDougal JS, Clapham PR, Weiss RA, Axel R. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 1986; 47: 333-48.
2. Clapham PR, McKnight A. Cell surface receptors, virus entry and tropism of primate lentiviruses. J Gen Virol 2002; 83: 1809-29.
3. Kaiser P, Joos B, Niederost B, Weber R, Gunthard HF, Fischer M. Productive Human Immunodeficiency Virus type 1 infection in peripheral blood predominantly takes place in CD4/CD8 double-negative T lymphocytes. J Virol 2007; 81: 9693-706.
4. Hughes GJ, Willey SJ, Cochrane A, Leen C, Bell JE, Simmonds P. Virus immunocapture provides evidence of CD8 lymphocyte-derived HIV-1 in vivo. AIDS (London, England) 2007; 21: 1507-13.
5. Cochrane A, Imlach S, Leen C, Scott G, Kennedy D, Simmonds P. High levels of human immunodeficiency virus infection of CD8 lymphocytes expressing CD4 in vivo. J Virol 2004; 78: 9862-71.
6. De Maria A, Pantaleo G, Schnittman SM, et al. Infection of CD8+ T lymphocytes with HIV. Requirement for interaction with infected CD4+ cells and induction of infectious virus from chronically infected CD8+ cells. J Immunol 1991; 146: 2220-6.
7. Potter SJ, Dwyer DE, Saksena NK. Differential cellular distribution of HIV-1 drug resistance in vivo: evidence for infection of CD8+ T cells during HAART. Virol 2003; 305: 339-52.
8. Finzi D, Hermankova M, Pierson T, et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 1997; 278: 1295-300.
9. Semenzato G, Agostini C, Ometto L, et al. CD8+ T lymphocytes in the lung of acquired immunodeficiency syndrome patients harbor human immunodeficiency virus type 1. Blood 1995; 85: 2308-14.
10. McBreen S, Imlach S, Shirafuji T, et al. Infection of the CD45RA+ (naive) subset of peripheral CD8+ lymphocytes by human immunodeficiency virus type 1 in vivo. J Virol 2001; 75: 4091-102.
11. Livingstone WJ, Moore M, Innes D, Bell JE, Simmonds P. Frequent infection of peripheral blood CD8-positive T-lymphocytes with HIV-1. Edinburgh Heterosexual Transmission Study Group. Lancet 1996; 348: 649-54.
12. Lee S, Goldstein H, Baseler M, Adelsberger J, Golding H. Human immunodeficiency virus type 1 infection of mature CD3hiCD8+ thymocytes. J Virol 1997; 71: 6671-6.
13. Saha K, Zhang J, Zerhouni B. Evidence of productively infected CD8+ T cells in patients with AIDS: implications for HIV-1 pathogenesis. J AIDS 2001; 26: 199-207.
14. Brenchley JM, Hill BJ, Ambrozak DR, et al. T-cell subsets that harbor human immunodeficiency virus (HIV) in vivo: implications for HIV pathogenesis. J Virol 2004; 78: 1160-8.
15. Saha K, Zhang J, Gupta A, Dave R, Yimen M, Zerhouni B. Isolation of primary HIV-1 that target CD8+ T lymphocytes using CD8 as a receptor. Nat Med 2001; 7: 65-72.
16. Yang LP, Riley JL, Carroll RG, et al. Productive infection of neonatal CD8+ T lymphocytes by HIV-1. J Exp Med 1998; 187: 1139-44.
17. Tsubota H, Ringler DJ, Kannagi M, et al. CD8+CD4- lymphocyte lines can harbor the AIDS virus in vitro. J Immunol 1989; 143: 858-63.
18. Zerhouni B, Nelson JA, Saha K. Isolation of CD4-independent primary human immunodeficiency virus type 1 isolates that are syncytium inducing and acutely cytopathic for CD8+ lymphocytes. J Virol 2004; 78: 1243-55.
19. Mercure L, Phaneuf D, Wainberg MA. Detection of unintegrated human immunodeficiency virus type 1 DNA in persistently infected CD8+ cells. J Gen Virol 1993; 74: 2077-83.
20. Trapani JA, Sutton VR, Smyth MJ. CTL granules: evolution of vesicles essential for combating virus infections. Immunol Today 1999; 20: 351-6.
21. Hoffenbach A, Langlade-Demoyen P, Dadaglio G, et al. Unusually high frequencies of HIV-specific cytotoxic T lymphocytes in humans. J Immunol 1989; 142: 452-62.
22. Klein MR, van Baalen CA, Holwerda AM, et al. Kinetics of Gagspecific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics. J Exp Med 1995; 181: 1365-72.
23. Rinaldo C, Huang XL, Fan ZF, et al. High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic Tlymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors. J Virol 1995; 69: 5838-42.
24. Lewis DE, Tang DS, Adu-Oppong A, Schober W, Rodgers JR. Anergy and apoptosis in CD8+ T cells from HIV-infected persons. J Immunol 1994; 153: 412-20.
25. De Maria A, Colombini S, Schnittman SM, Moretta L. CD8+ cytolytic T lymphocytes become infected in vitro in the process of killing HIV-1-infected target cells. Eur J Immunol 1994; 24: 531-6.
26. Sullivan YB, Landay AL, Zack JA, Kitchen SG, Al-Harthi L. Upregulation of CD4 on CD8+ T cells: CD4dimCD8bright T cells constitute an activated phenotype of CD8+ T cells. Immunol 2001; 103: 270-80.
27. Flamand L, Crowley RW, Lusso P, Colombini-Hatch S, Margolis DM, Gallo RC. Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: implications for HIV pathogenesis. Proc Natl Acad Sci USA 1998; 95: 3111-6.
28. Imlach S, McBreen S, Shirafuji T, Leen C, Bell JE, Simmonds P. Activated peripheral CD8 lymphocytes express CD4 in vivo and are targets for infection by human immunodeficiency virus type 1. J Virol 2001; 75: 11555-64.
29. Kitchen SG, LaForge S, Patel VP, Kitchen CM, Miceli MC, Zack JA. Activation of CD8 T cells induces expression of CD4, which functions as a chemotactic receptor. Blood 2002; 99: 207-12.
30. Zloza A, Sullivan YB, Connick E, Landay AL, Al-Harthi L. CD8+ T cells that express CD4 on their surface (CD4dimCD8bright T cells) recognize an antigen-specific target, are detected in vivo, and can be productively infected by T-tropic HIV. Blood 2003; 102: 2156-64.
31. Kitchen SG, Korin YD, Roth MD, Landay A, Zack JA. Costimulation of naive CD8(+) lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection. J Virol 1998; 72: 9054-60.
32. Lambert C, Iobagiu C, Genin C. Persistent oligoclonal CD4dim CD8+T cells in peripheral blood. Cytometry 2005; 66: 10-7.
33. Lusso P, De Maria A, Malnati M, et al. Induction of CD4 and susceptibility to HIV-1 infection in human CD8+ T lymphocytes by human herpesvirus 6. Nature 1991; 349: 533-5.
34. Semenzato G, Agostini C, Chieco-Bianchi L, De Rossi A. HIV load in highly purified CD8+ T cells retrieved from pulmonary and blood compartments. J Leukoc Biol 1998; 64: 298-301.
35. Blue ML, Daley JF, Levine H, Schlossman SF. Coexpression of T4 and T8 on peripheral blood T cells demonstrated by two-color fluorescence flow cytometry. J Immunol 1985; 134: 2281-6.
36. Giorgi JV, Detels R. T-cell subset alterations in HIV-infected homosexual men: NIAID Multicenter AIDS cohort study. Clin Immunol Immunopathol 1989; 52: 10-8.
37. Salazar-Gonzalez JF, Moody DJ, Giorgi JV, Martinez-Maza O, Mitsuyasu RT, Fahey JL. Reduced ecto-5′-nucleotidase activity and enhanced OKT10 and HLA-DR expression on CD8 (T suppressor/cytotoxic) lymphocytes in the acquired immune deficiency syndrome: evidence of CD8 cell immaturity. J Immunol 1985; 135: 1778-85.
38. Gea-Banacloche JC, Migueles SA, Martino L, et al. Maintenance of large numbers of virus-specific CD8+ T cells in HIV-infected progressors and long-term nonprogressors. J Immunol 2000; 165: 1082-92.
39. Addo MM, Yu XG, Rosenberg ES, Walker BD, Altfeld M. Cytotoxic T-lymphocyte (CTL) responses directed against regulatory and accessory proteins in HIV-1 infection. DNA Cell Biol 2002; 21: 671-8.
40. Littman DR. Chemokine receptors: keys to AIDS pathogenesis? Cell 1998; 93: 677-80.
41. Cook DG, Fantini J, Spitalnik SL, Gonzalez-Scarano F. Binding of human immunodeficiency virus type I (HIV-1) gp120 to galactosylceramide (GalCer): relationship to the V3 loop. Virology 1994; 201: 206-14.
42. Bhat S, Spitalnik SL, Gonzalez-Scarano F, Silberberg DH. Galactosyl ceramide or a derivative is an essential component of the neural receptor for human immunodeficiency virus type 1 envelope glycoprotein gp120. Proc Natl Acad Sci USA 1991; 88: 7131-4.
43. Harouse JM, Bhat S, Spitalnik SL, et al. Inhibition of entry of HIV-1 in neural cell lines by antibodies against galactosyl ceramide. Science 1991; 253: 320-3.
44. Pang S, Yu D, An DS, et al. Human immunodeficiency virus Envindependent infection of human CD4(-) cells. J Virol 2000; 74: 10994-1000.
45. Pantaleo G, Graziosi C, Butini L, et al. Lymphoid organs function as major reservoirs for human immunodeficiency virus. Proc Natl Acad Sci USA 1991; 88: 9838-42.