CD8+ T cells that express CD4 on their surface (CD4 dimCD8bright T cells) recognize an antigen-specific target, are detected in vivo, and can be productively infected by T-tropic HIV

Blood

Volumn 102, Issue 6, 2003, Pages 2156-2164

  Zloza, Andrew ^b   Sullivan, Yvonne B ^b   Connick, Elizabeth ^b   Landay, Alan L ^b   Al Harthi, Lena ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BETA CHEMOKINE; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4;

ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 0141567584     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-07-1972     Document Type: Article

References (40)

1. bright T cells constitute an activated phenotype of CD8+ T cells. Immunology. 2001;103:270-280.
2. Flamand L, Crowley RW, Lusso P, Colombini-Hatch S, Margolis DM, Gallo RC. Activation of CD8+ T lymphocytes through the T cell receptor turns on CD4 gene expression: implications for HIV pathogenesis. Proc Natl Acad Sci U S A. 1998;95:3111-3116
3. Kitchen SG, Korin YD, Roth MD, Landay A, Zack JA. Costimulation of naive CD8(+) lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection. J Virol. 1998;72:9054-9060.
4. Yang LP, Riley JL, Carroll RG, et al. Productive infection of neonatal CD8+ T lymphocytes by HIV-1. J Exp Med. 1998;187:1139-1144.
5. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999;401:708-712.
6. Champagne P, Ogg GS, King AS, et al. Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature. 2001;410:106-111.
7. Wherry EJ, Teichgraber V, Becker TC, et al. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat Immunol. 2003;4:225-234.
8. Sallusto F, Lanzavecchia A. Exploring pathways for memory T cell generation. J Clin Invest. 2001;108:805-806.
9. Aandahl EM, Sandberg JK, Beckerman KP, Tasken K, Moretto WJ, Nixon DF. CD7 is a differentiation marker that identifies multiple CD8 T cell effector subsets. J Immunol. 2003;170:2349-2355.
10. Semenzato G, Agostini C, Ometto L, et al. CD8+ T lymphocytes in the lung of acquired immunodeficiency syndrome patients harbor human immunodeficiency virus type 1. Blood. 1995;85:2308-2314.
11. Constantin CM, Bonney EE, Altman JD, Strickland OL. Major histocompatibility complex (MHC) tetramer technology: an evaluation. Biol Res Nurs. 2002;4:115-127.
12. Coligan J, Kruisbeek A, Margulis D, Shevach E, Strober W, Coico R. Current protocols in Immunology. New York: John Wiley and Sons; 1994.
13. Altman JD, Moss PA, Goulder PJ, et al. Phenotypic analysis of antigen-specific T lymphocytes. Science. 1996;274:94-96.
14. Darden JM, Polonis VR, deSouza MS, et al. A flow cytometric method for measuring neutralization of HIV-1 subtype B and E primary isolates. Cytometry. 2000;40:141-150.
15. Al-Harthi L, Landay A. Alternative targets of productive HIV infection: role of CD4 up-regulation on susceptibility of cells to HIV infection. AIDS Rev. 2001;3:67-74.
16. Blue ML, Daley JF, Levine H, Schlossman SF. Coexpression of T4 and T8 on peripheral blood T cells demonstrated by two-color fluorescence flow cytometry. J Immunol. 1985;134:2281-2286.
17. Schlesinger I, Rabinowitz R, Brenner T, Abramsky O, Schlesinger M. Changes in lymphocyte subsets in myasthenia gravis: correlation with level of antibodies to acetylcholine receptor and age of patient. Neurology. 1992;42:2153-2157.
18. Ortolani C, Forti E, Radin E, Cibin R, Cossarizza A. Cytofluorimetric identification of two populations of double positive (CD4+, CD8+) T lymphocytes in human peripheral blood. Biochem Biophys Res Commun. 1993;191:601-609.
19. Sala P, Tonutti E, Feruglio C, Florian F, Colombatti A. Persistent expansions of CD4+ CD8+ peripheral blood T cells. Blood. 1993;82:1546-1552.
20. Bergstedt-Lindqvist S, Moon HB, Persson U, Moller G, Heusser C, Severinson E. Interleukin 4 instructs uncommitted B lymphocytes to switch to IgG1 and IgE. Eur J Immunol. 1988;18:1073-1077.
21. Brod SA, Purvee M, Benjamin D, Hafler DA. Frequency analysis of CD4+CD8+ T cells cloned with IL-4. Cell Immunol. 1990;125:426-436.
22. Hori T, Paliard X, de Waal Malefijt R, Ranes M, Spits H. Comparative analysis of CD8 expressed on mature CD4+ CD8+ T cell clones cultured with IL-4 and that on CD8+ T cell clones: implication for functional significance of CD8 beta. Int Immunol. 1991;3:737-741.
23. Paliard X, Malefijt RW, de Vries JE, Spits H. Interleukin-4 mediates CD8 induction on human CD4+ T-cell clones. Nature. 1988;335:642-644.
24. Kitchen SG, LaForge S, Patel VP, Kitchen CM, Miceli MC, Zack JA. Activation of CD8 T cells induces expression of CD4, which functions as a chemotactic receptor. Blood. 2002;99:207-212.
25. Livingstone WJ, Moore M, Innes D, Bell JE, Simmonds P. Frequent infection of peripheral blood CD8-positive T-lymphocytes with HIV-1. Edinburgh Heterosexual Transmission Study Group. Lancet. 1996;348:649-654.
26. Imlach S, McBreen S, Shirafuji T, Leen C, Bell JE, Simmonds P. Activated peripheral CD8 lymphocytes express CD4 in vivo and are targets for infection by human immunodeficiency virus type 1. J Virol. 2001;75:11555-11564.
27. Mercure L, Phaneuf D, Wainberg MA. Detection of unintegrated human immunodeficiency virus type 1 DNA in persistently infected CD8+ cells. J Gen Virol. 1993;74:2077-2083.
28. Saha K, Zhang J, Zerhouni B. Evidence of productively infected CD8+ T cells in patients with AIDS: implications for HIV-1 pathogenesis. J Acquir Immune Defic Syndr. 2001;26:199-207.
29. Macchi B, Graziani G, Zhang J, Mastino A. Emergence of double-positive CD4/CD8 cells from adult peripheral blood mononuclear cells infected with human T cell leukemia virus type I (HTLV-I). Cell Immunol. 1993;149:376-389.
30. Creson JR, Lin AA, Li Q, Broad DF, Roberts MR, Anderson SJ. The mode and duration of anti-CD28 costimulation determine resistance to infection by macrophage-tropic strains of human immunodeficiency virus type 1 in vitro. J Virol. 1999;73:9337-9347.
31. Platt EJ, Wehrly K, Kuhmann SE, Chesebro B, Kabat D. Effects of CCR5 and CD4 cell surface concentrations on infections by macrophage-tropic isolates of human immunodeficiency virus type 1. J Virol. 1998;72:2855-2864.
32. Al-Harthi L, Siegel J, Spritzler J, Pottage J, Agnoli M, Landay A. Maximum suppression of HIV replication leads to the restoration of HIV-specific responses in early HIV disease. AIDS. 2000;14:761-770.
33. Valdez H, Al-Harthi L, Landay A, Lederman MM. Rationale for immune-based therapies for HIV-1 infection. J Lab Clin Med. 1998;131:197-206.
34. Kelleher AD, Al-Harthi L, Landay AL. Immunological effects of antiretroviral and immune therapies for HIV. AIDS. 1997;11:S149-S155.
35. Mizuki M, Tagawa S, Machii T, et al. Phenotypical heterogeneity of CD4+CD8+ double-positive chronic T lymphoid leukemia. Leukemia. 1998;12:499-504.
36. Aziz KE, McCluskey PJ, Wakefield D. Phenotypic and functional abnormalities in the peripheral blood T-cells of patients with primary Sjogren's syndrome. Cytometry. 1994;18:35-41.
37. Matsui M, Fukuyama H, Akiguchi I, Kameyama M. Circulating CD4+CD8+ cells in myasthenia gravis: supplementary immunological parameter for long-term prognosis. J Neurol. 1989;236:329-335.
38. Munschauer FE, Stewart C, Jacobs L, et al. Circulating CD3+ CD4+ CD8+ T lymphocytes in multiple sclerosis. J Clin Immunol. 1993;13:113-118.
39. Mizutani H, Katagiri S, Uejima K, et al. T-cell abnormalities in patients with idiopathic thrombocytopenic purpura: the presence of OKT4+8+ cells. Scand J Haematol. 1985;35:233-239.
40. Valesini G, Pivetti-Pezzi P, Mastrandrea F, Moncada A, Cuomo M, Natali PG. Evaluation of T cell subsets in Behcet's syndrome using anti-T cell monoclonal antibodies. Clin Exp Immunol. 1985;60:55-60.