Persistent oligoclonal CD4dimCD8+T cells in peripheral blood

Cytometry Part B - Clinical Cytometry

Volumn 66, Issue 1, 2005, Pages 10-17

  Lambert, Claude ^a,b   Iobagiu, Cristina ^a   Genin, Christian ^a  

^a UNIVERSITY HOSPITAL OF SAINT ETIENNE   (France)

^b SERVICE DE NEUROLOGIE   (France)

Author keywords

CD4dimCD8+ T cells; Double positive T cells; T cell subsets; Unconventional T cells

Indexed keywords

CD4 ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR;

ADULT; AGED; ARTICLE; BLOOD; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DEFICIENCY; INFECTION; KIDNEY TRANSPLANTATION; LYMPHOPROLIFERATIVE DISEASE; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS INFECTION; ADOLESCENT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHEMISTRY; COMPARATIVE STUDY; IMMUNOLOGY; IMMUNOPHENOTYPING; MIDDLE AGED; T LYMPHOCYTE SUBPOPULATION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD4; ANTIGENS, CD8; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HIV INFECTIONS; HUMANS; IMMUNOPHENOTYPING; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTE SUBSETS;

EID: 20544469253     PISSN: 15524949     EISSN: None     Source Type: Journal    
DOI: 10.1002/cyto.b.20047     Document Type: Article

References (20)

1. Sala P, Tonutti E, Feruglio C, et al. Persistent expansions of CD4+ CD8+ peripheral blood T cells. Blood 1993;82:1546-1552.
2. Prince HE, Golding J, York J. Characterization of circulating CD4+ CD8+ lymphocytes in healthy individuals prompted by identification of a blood donor with a markedly elevated level of CD4+ CD8+ lymphocytes. Clin Diagn Lab Immunol 1994;1:597-605.
3. Ortolani C, Forti E, Radin E, et al. Cytofluorimetric identification of two populations of double positive (CD4+,CD8+) T lymphocytes in human peripheral blood. Biochem Biophys Res Commun 1993;191:601-609.
4. Warrington KJ, Takemura S, Goronzy JJ, Weyand CM. CD4+CD28-T cells in rheumatoid arthritis patients combine features of the innate and adaptive immune systems. Arthritis Rheum 2001;44:13-20.
5. Airo P, Rossi G, Facchetti F, et al. Monoclonal expansion of large granular lymphocytes with a CD4+ CD8dim+/- phenotype associated with hairy cell leukemia. Haematologica 1995;80: 146-149.
6. Richards SJ, Sivakumaran M, Parapia LA, et al. A distinct large granular lymphocyte (LGL)/NK-associated (NKa) abnormality characterized by membrane CD4 and CD8 coexpression. The Yorkshire Leukaemia Group. Br J Haematol 1992;82:494-501.
7. Zuckermann FA. Extrathymic CD4/CD8 double positive T cells. Vet Immunol Immunopathol 1999;72:55-66.
8. Weiss L, Roux A, Garcia S, et al. Persistent expansion, in a human immunodeficiency virus-infected person, of V beta-restricted CD4+CD8+ T lymphocytes that express cytotoxicity-associated molecules and are committed to produce interferon-gamma and tumor necrosis factor-alpha. J Infect Dis 1998;178:1158-1162.
9. Suni MA, Ghanekar SA, Houck DW, et al. CD4(+)CD8(dim) T lymphocytes exhibit enhanced cytokine expression, proliferation and cytotoxic activity in response to HCMV and HIV-1 antigens. Eur J Immunol 2001;31:2512-2520.
10. Bagot M, Echchakir H, Mami-Chouaib F, et al. Isolation of tumor-specific cytotoxic CD4+ and CD4dimCD8++ T-cell clones infiltrating a cutaneous T-cell lymphoma. Blood 1998;91:4331-434l.
11. Tonutti E, Sala P, Feruglio C, et al. Phenotypic heterogeneity of persistent expansions of CD4+ CD8+ T cells. Clin Immunol Immunopathol 1994;73:312-320.
12. Mackall CL, Fleisher TA, Brown MR, et al. Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy. N Engl J Med 1995;332:143-149.
13. Imlach S, McBreen S, Shirafuji T, et al. Activated peripheral CD8 lymphocytes express CD4 in vivo and are targets for infection by human immunodeficiency virus type 1. J Virol 2001;75:11555-1164.
14. Sullivan YB, Landay AL, Zack JA, et al. Upregulation of CD4 on CD8+ T cells: CD4dimCD8bright T cells constitute an activated phenotype of CD8+ T cells. Immunology 2001;103:270-280.
15. Luhtala M, Lassila O, Toivanen P, Vainio O. A novel peripheral CD4+ CD8+ T cell population: inheritance of CD8alpha expression on CD4+ T cells. Eur J Immunol 1997;27:189-193.
16. Zloza A, Sullivan YB, Connick E, et al. CD8+ T cells that express CD4 on their surface (CD4dimCD8bright T cells) recognize an antigen-specific target, are detected in vivo, and can be productively infected by T-tropic HIV Blood 2003;102:2156-2l64.
17. Yamada K, Kimura Y, Nishimura H, et al. Characterization of CD4+ CD8alphaalpha+ and CD4-CD8alphaalpha+ intestinal intraepithelial lymphocytes in rats. Int Immunol 1999;11:21-28.
18. Pittet MJ, Speiser DE, Valmori D, et al. Cytolytic effector function in human circulating CD8+ T cells closely correlates with CD56 surface expression. J Immunol 2000;164:1148-1152.
19. Callan MF, Fazou C, Yang H, et al. CD8(+) T-cell selection, function, and death in the primary immune response in vivo. J Clin Invest 2000;106:1251-126l.
20. Matsui M, Fukuyama H, Akiguchi I, Kameyama M. Circulating CD4+CD8+ cells in myasthenia gravis: supplementary immunological parameter for long-term prognosis. J Neurol 1989;236:329-335.