Allicin, a major component of garlic, inhibits apoptosis in vital organs in rats with trauma/hemorrhagic shock

Critical Care Medicine

Volumn 36, Issue 12, 2008, Pages 3226-3232

  Zhang, Yun ^a   Yao, Hang Ping ^b   Huang, Fang Fang ^a   Wu, Wei ^b   Gao, Yuan ^a   Chen, Zuo Bing ^a   Liang, Zhong Yan ^a   Liang, Ting Bo ^a  

^a BEIJING HOSPITAL   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Allicin; Apoptosis; Nuclear factor B; P38 mitogen activated protein kinase; Trauma hemorrhagic shock

Indexed keywords

ALLICIN; CASPASE 3; CASPASE 9; CREATININE; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTIC ACID; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; SULFINIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREATHING; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; FEMUR FRACTURE; GARLIC; HEMORRHAGIC SHOCK; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INTESTINE; INTESTINE INJURY; ISCHEMIA; KIDNEY; KIDNEY INJURY; LUNG; LUNG INJURY; MALE; NONHUMAN; ORGAN INJURY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION; SIGNAL TRANSDUCTION; TISSUE INJURY; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; ENDOTHELIUM CELL; METABOLISM; PATHOLOGY; REPERFUSION INJURY; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 9; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; FEMORAL FRACTURES; INTESTINES; KIDNEY; LUNG; MALE; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SHOCK, HEMORRHAGIC; SULFINIC ACIDS;

EID: 58149240651     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31818f2103     Document Type: Article

References (47)

1. Baue AE: Multiple organ failure, multiple organ dysfunction syndrome, and the systemic inflammatory response syndrome-where do we stand? Shock 1994; 2:385-397
2. Deitch EA: Multiple organ failure. Patho-physiology and potential future therapy. Ann Surg 1992; 216:117-134
3. Anderson BO, Harken AH: Multiple organ failure: Inflammatory priming and activation sequences promote autologous tissue injury. J Trauma 1990; 30:s44-s49
4. Genesca M, Sola A, Miquel R, et al: Role of changes in tissular nucleotides on the development of apoptosis during ischemia/ reperfusion in rat small bowel. Am J Pathol 2002; 161:1839-1847
5. Wang X, Zhou Y, Kim HP, et al: Hepatocyte growth factor protects against hypoxia/ reoxygenation-induced apoptosis in endothe-lial cells. J Biol Chem 2004; 279:5237-5243
6. Jiang DJ, Jia SJ, Dai Z, et al: Asymmetric dimethylarginine induces apoptosis via p38 MAPK/caspase-3-dependent signaling pathway in endothelial cells. J Mol Cell Cardiol 2006; 40:529-539
7. de Nigris F, Lerman A, Ignarro LJ, et al: Oxidation-sensitive mechanisms, vascular apoptosis and atherosclerosis. Trends Mol Med 2003; 9:351-359
8. Hoefen RJ, Berk BC: The role of MAP kinases in endothelial activation. Vascul Pharmacol 2002; 38:271-273
9. Jiang C, Kim KH, Wang Z, et al: Methyl selenium-induced vascular endothelial apoptosis is executed by caspases and principally mediated by p38 MAPK pathway. Nutr Cancer 2004; 49:174-183
10. Osone S, Hosoi H, Kuwahara Y, et al: Fen-retinide induces sustained-activation of JNK/ p38 MAPK and apoptosis in a reactive oxygen species-dependent manner in neuroblastoma cells. Int J Cancer 2004; 112:219-224
11. Pearl-Yafe M, Halperin D, Scheuerman O, et al: The p38 pathway partially mediates caspase-3 activation induced by reactive oxygen species in Fanconi anemia C cells. Biochem Pharmacol 2004; 67:539-546
12. Porter AG, Jänicke RU: Emerging roles of caspase-3 in apoptosis. Cell Death Differ 1999; 6:99-104
13. Kim HJ, Lee HS, Chong YH, et al: p38 mitogen-activated protein kinase up-regulates LPS-induced NF-kappa B activation in the development of lung injury and RAW 264.7 macrophages. Toxicology 2006; 225:36-47
14. Wang H, Wang Z, Chen J, et al: Apoptosis induced by NO via phosphorylation of p38 MAPK that stimulates NF-kappaB, p53 and caspase-3 activation in rabbit articular chondrocytes. Cell Biol Int 2007; 31:1027-1035
15. Cutler RR, Wilson P: Antibacterial activity of a new, stable, aqueous extract of allicin against methicillin-resistant Staphylococcus aureus. Br J Biomed Sci 2004; 61:71-74
16. Cañizares P, Gracia I, Gómez LA, et al: Thermal degradation of allicin in garlic extracts and its implication on the inhibition of the in-vitro growth of Helicobacter pylori. Biotechnol Prog 2004; 20:32-37
17. Park SY, Cho SJ, Kwon HC, et al: Caspase-independent cell death by allicin in human epithelial carcinoma cells: involvement of PKA. Cancer Lett 2005; 224:123-132
18. Oommen S, Anto RJ, Srinivas G, et al: Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells. Eur J Pharmacol 2004; 485:97-103
19. Patya M, Zahalka MA, Vanichkin A, et al: Allicin stimulates lymphocytes and elicits an antitumor effect: A possible role of p21ras. Int Immunol 2004; 16:275-281
20. Borek C: Antioxidant health effects of aged garlic extract. J Nutr 2001; 131:1010s-1015s
21. Hodge G, Hodge S, Han P: Allium sativum (garlic) suppresses leukocyte inflammatory cytokine production in vitro: Potential therapeutic use in the treatment of inflammatory bowel disease. Cytometry 2002; 48:209-215
22. Lang A, Lahav M, Sakhnini E, et al: Allicin inhibits spontaneous and TNF-alpha induced secretion of proinflammatory cytokines and chemokines from intestinal epithelial cells. Clin Nutr 2004; 23:1199-1208
23. Chiang YH, Jen LN, Su HY, et al: Effects of garlic oil and two of its major organosulfur compounds, diallyl disulfide and diallyl trisulfide, on intestinal damage in rats injected with endotoxin. Toxicol Appl Pharmacol 2006; 213:46-54
24. Azuara D, Sola A, Hotter G, et al: Apoptosis inhibition plays a greater role than necrosis inhibition in decreasing bacterial translocation in experimental intestinal transplantation. Surgery 2005; 137:85-91
25. Kabasakal L, Sehirli O, Cetinel S, et al: Protective effect of aqueous garlic extract against renal ischemia/reperfusion injury in rats. J Med Food 2005; 8:319-326
26. Numagami Y, Sato S, Ohnishi ST: Attenuation of rat ischemic brain damage by aged garlic extracts: A possible protecting mechanism as antioxidants. Neurochem Int 1996; 29:135-143
27. Fallon MB, Abrams GA, Abdel-Razek TT, et al: Garlic prevents hypoxic pulmonary hypertension in rats. Am J Physiol 1998; 275: L283-L287
28. Cho SJ, Rhee DK, Pyo S: Allicin, a major component of garlic, inhibits apoptosis of macrophage in a depleted nutritional state. Nutrition 2006; 22:1177-1184
29. Fujimi S, Kawasaki T, Lederer JA, et al: Trauma-hemorrhage induces depressed splenic dendritic cell functions in mice. J Immunol 2006; 177:4514-4520
30. Zhou YQ, He C, Chen YQ, et al: Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: Generation of different splicing variants and their oncogenic potential. Oncogene 2003; 22:186-197
31. Deb S, Martin B, Sun L, et al: Resuscitation with lactated Ringer's solution in rats with hemorrhagic shock induces immediate apoptosis. J Trauma 1999; 46:582-588
32. Deb S, Sun L, Martin B, et al: Lactated ringer's solution and hetastarch but not plasma resuscitation after rat hemorrhagic shock is associated with immediate lung apoptosis by the up-regulation of the Bax protein. J Trauma 2000; 49:47-53
33. Ikeda H, Suzuki Y, Suzuki M, et al: Apoptosis is a major mode of cell death caused by ischaemia and ischaemia/reperfusion injury to the rat intestinal epithelium. Gut 1998; 42:530-537
34. Ng CS, Wan S, Yim AP: Pulmonary ischaemia-reperfusion injury: Role of apoptosis. Eur Respir J 2005; 25:356-363
35. De Broe ME: Apoptosis in acute renal failure. Nephrol Dial Transplant 2001; 16:23-26
36. Sun L, Wang X: Effects of allicin on both telomerase activity and apoptosis in gastric cancer SGC-7901 cells. World J Gastroenterol 2003; 9:1930-1934
37. Hirsch K, Danilenko M, Giat J, et al: Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation. Nutr Cancer 2000; 38:245-254
38. Zhang ZM, Yang XY, Deng SH, et al: Antitumor effects of polybutylcyanoacrylate nanoparticles of diallyl trisulfide on orthotopic transplantation tumor model of hepatocellular carcinoma in BALB/c nude mice. Chin Med J (Engl) 2007; 120:1336-1342
39. Miron T, Mironchik M, Mirelman D, et al: Inhibition of tumor growth by a novel approach: In situ allicin generation using targeted alliinase delivery. Mol Cancer Ther 2003; 2:1295-1301
40. Kaye AD, De Witt BJ, Anwar M, et al: Analysis of responses of garlic derivatives in the pulmonary vascular bed of the rat. J Appl Physiol 2000; 89:353-358
41. Batirel HF, Naka Y, Kayano K, et al: Intravenous allicin improves pulmonary blood flow after ischemia-reperfusion injury in rats. J Cardiovasc Surg (Torino) 2002; 43:175-179
42. Matot I, Weiniger CF, Zeira E, et al: A3 adenosine receptors and mitogen-activated protein kinases in lung injury following in vivo reperfusion. Crit Care 2006; 10:R65
43. Lai EW, Toledo-Pereyra LH, Walsh J, et al: The role of MAP kinases in trauma and ischemia-reperfusion. J Invest Surg 2004; 17: 45-53
44. Khan TA, Bianchi C, Ruel M, et al: Mitogen-activated protein kinase pathways and cardiac surgery. J Thorac Cardiovasc Surg 2004; 127:806-811
45. Toledo-Pereyra LH, Toledo AH, Walsh J, et al: Molecular signaling pathways in ischemia/ reperfusion. Exp Clin Transplant 2004; 2:174-177
46. Khan TA, Bianchi C, Araujo EG, et al: Activation of pulmonary mitogen-activated protein kinases during cardiopulmonary bypass. J Surg Res 2003; 115:56-62
47. Yue TL, Wang C, Gu JL, et al: Inhibition of extracellular signal-regulated kinase enhances Ischemia/reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart. Circ Res 2000; 86:692-699