Xenotransplantation of human umbilical cord blood mononuclear cells to rats with d-galactosamine-induced hepatitis

Cell Transplantation

Volumn 17, Issue 7, 2008, Pages 845-857

  Álvarez Mercado, Ana I ^a,b   Sáez Lara, María J ^a,b   García Mediavilla, María V ^c   Sánchez Campos, Sonia ^c   Abadía, Francisco ^d   Cabello Donayre, María ^a,b   Gil, Ángel ^a,b   González Gallego, Javier ^c   Fontana, Luis ^a,b,e  

^a Microbial Exopolysaccharide Research Group   (Spain)

^b Biomedical Research Center   (Spain)

^c UNIVERSITY OF LEÓN   (Spain)

^d UNIVERSITY OF GRANADA   (Spain)

^e Facultad de Farmacia   (Spain)

Author keywords

D Galactosamine; Experimental hepatitis; Human hematopoietic mononuclear cells; Umbilical cord blood; Xenotransplantation

Indexed keywords

ALBUMIN; ALKALINE PHOSPHATASE; ALPHA FETOPROTEIN; BILIRUBIN; BIOCHEMICAL MARKER; CD45 ANTIGEN; CYCLOSPORIN A; CYTOCHROME P450 3A4; CYTOKERATIN 18; GALACTOSAMINE; GAMMA GLUTAMYLTRANSFERASE; GANGLIOSIDE GM1 ANTIBODY; GLUTAMATE AMMONIA LIGASE; LACTATE DEHYDROGENASE; MESSENGER RNA; BIOLOGICAL MARKER;

ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BILIRUBIN BLOOD LEVEL; BLOOD; CELL DIFFERENTIATION; CELL REGENERATION; CELL TRANSPLANTATION; CONTROLLED STUDY; ENGRAFTMENT; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GRAFT REJECTION; HEMATOPOIETIC CELL; HEPATITIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER; LIVER CELL; LIVER DISEASE; LIVER FUNCTION; LIVER HISTOLOGY; LIVER INJURY; MALE; MONONUCLEAR CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REGENERATIVE MEDICINE; UMBILICAL CORD BLOOD; XENOTRANSPLANTATION; ANIMAL; CELL CULTURE; CYTOLOGY; EVALUATION; FETUS BLOOD; METABOLISM; PATHOLOGY; TOXIC HEPATITIS; TRANSPLANTATION; WISTAR RAT; XENOGRAFT;

ANIMALIA; RATTUS;

ANIMALS; BIOLOGICAL MARKERS; CELLS, CULTURED; FETAL BLOOD; GALACTOSAMINE; HEPATITIS, TOXIC; HUMANS; LEUKOCYTES, MONONUCLEAR; LIVER; MALE; RATS; RATS, WISTAR; TRANSPLANTATION, HETEROLOGOUS;

EID: 58149190484     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368908786516837     Document Type: Article

References (28)

1. Brunstein, C. Q.; Setubal, D. C.; Wagner, J. E. Expanding the role of umbilical cord blood transplantation. Br. J. Haematol. 13:20-35; 2007.
2. Grompe, M.; Lindstedt, S.; al-Dhalimy, M.; Kennaway, N. G.; Papaconstantinou, J.; Torres-Ramos, C. A.; Ou, C. N.; Finegold, M. Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I. Nat. Genet. 10:453-460; 1995.
3. Guengerich, F. P. Cytochrome P-450 3A4: Regulation and role in drug metabolism. Annu. Rev. Pharmacol. Toxicol. 39:1-17; 1999.
4. Habu, S.; Fukui, H.; Shimamura, K.; Kasai, M.; Nagai, Y.; Okumura, K.; Tamaoki, N. In vivo effects of antiasialo GM1.1. Reduction of NK activity and enhancement of transplanted tumor growth in nude mice. J. Immunol. 127:34-38; 1981.
5. Ishikawa, F.; Drake, C. J.; Yang, S.; Fleming, P.; Minamiguchi, H.; Visconti, R. P.; Crosby, C. V.; Argraves, W. S.; Harada, M.; Key, Jr., L. L.; Livingston, A. G.; Wingard, J. R.; Ogawa, M. Transplanted human cord blood cells give rise to hepatocytes in engrafted mice. Ann. NY Acad. Sci. 996:174-185; 2003.
6. Jochheim, A.; Hillemann, T.; Kania, G.; Scharf, J.; Attaran, M.; Manns, M. P.; Wobus, A. M.; Ott, M. Quantitative gene expression profiling reveals a fetal hepatic phenotype of murine ES-derived hepatocytes. Int. J. Dev. Biol. 48:23-29; 2004.
7. Kakinuma, S.; Tanaka, Y.; Chinzei, R.; Watanabe, M.; Shimizu-Saito, K.; Hara, Y.; Teramoto, K.; Arii, S.; Sato, C.; Takase, K.; Yasuzimu, T.; Teraoka, H. Human umbilical cord blood as a source of transplantable hepatic progenitor cells. Stem Cells 21:217-227; 2003.
8. Kasai, M.; Iwamori, M.; Nagai, Y.; Okumura, K.; Tada, T. A glycolipid on the surface of mouse natural killer cells. Eur. J. Immunol. 10:175-180; 1980.
9. Keppler, D.; Lesch, R.; Reutter, W.; Decker, K. Experimental hepatitis induced by D-galactosamine. Exp. Mol. Pathol. 9:279-290; 1968.
10. Livak, K. J.; Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402-408; 2001.
11. Mayani, H.; Lansdoip, P. M. Biology of human umbilical cord blood-derived hematopoietic stem/progenitor cells. Stem Cells 16:153-165; 1998.
12. Musina, R. A.; Bekchanova, E. S.; Belyavskii, A. V.; Grinenko, T. S.; Sukhikh, G. T. Umbilical cord blood mesenchymal stem cells. Bull. Exp. Biol. Med. 143:127-131; 2007.
13. Newcomb, J. D.; Sanberg, P. R.; Klasko, S. K.; Willing, A. E. Umbilical cord blood research: Current and future perspectives. Cell Transplant. 16:151-158; 2007.
14. Newsome, P. N.; Johannessen, I.; Boyle, S.; Dalakas, E.; McAulay, K. A.; Samuel, K.; Rae, F.; Forrester, L.; Turner, M. L.; Hayes, P. C.; Harrison, D. J.; Bickmore, W. A.; Plevris, J. N. Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion. Gastroenterology 124:1891-1900; 2003.
15. Nonome, K.; Li, X. K.; Takahara, T.; Kitazawa, Y.; Funeshima, N.; Yata, Y.; Xue, F.; Kanayama, M.; Shinno, E.; Kuwae, C.; Saito, S.; Watanabe, A.; Sugiyama, T. Human umbilical cord blood-derived cells differentiate into hepatocyte-like cells in the Fas-mediated liver injury model. Am. J. Physiol. Gastrointest. Liver Physiol. 289: G1091-1099; 2005.
16. Noort, W. A.; Wilpshaar, J.; Hertogh, C. D.; Rad, M.; Lurvink, E. G.; van Luxemburg-Heijs, S. A.; Zwinderman, K.; Verwey, R. A.; Willemze, R.; Falkenburg, J. H. Similar myeloid recovery despite superior overall engraftment in NOD/SCID mice after transplantation of human CD34(+) cells from umbilical cord blood as compared to adult sources. Bone Marrow Transplant. 28:163-171; 2001.
17. Noort, W. A.; Willemze, R.; Falkenburg, J. H. Comparison of repopulating ability of hematopoietic progenitor cells isolated from human umbilical cord blood or bone marrow cells in NOD/SCID mice. Bone Marrow Transplant. 22(Suppl. l):S58-60; 1998.
18. Porada, G. A.; Porada, C.; Zanjani, E. D. The fetal sheep: A unique model system for assessing the full differentia-five potential of human stem cells. Yonsei Med. J. 45(Suppl.):7-14; 2004.
19. Saez-Lara, M. J.; Frecha, C.; Martin, F.; Abadia, F.; Toscano, M.; Gil, A.; Fontana, L. Transplantation of human CD34+ stem cells from umbilical cord blood to rats with thioacetamide-induced liver cirrhosis. Xenotransplantation 13:529-535; 2006.
20. Snykers, S.; Vanhaecke, T.; Papeleu, P.; Luttun, A.; Jiang, Y.; Vander Heyden, Y.; Verfaillie, C.; Rogiers, V. Sequential exposure to cytokines reflecting embryogenesis: The key for in vitro differentiation of adult bone marrow stem cells into functional hepatocyte-like cells. Toxicol. Sci. 94:330-341; 2006.
21. Sun, Y.; Xiao, D.; Zhang, R. S.; Cui, G. H.; Wang, X. H.; Chen, X. G. Formation of human hepatocyte-like cells with different cellular phenotypes by human umbilical cord blood-derived cells in the human-rat chimeras. Biochem. Biophys. Res. Commun. 324:711-718; 2007.
22. Tanabe, Y.; Tajima, F.; Nakamura, Y.; Shibasaki, E.; Wakejima, M.; Shimomura, T.; Murai, R.; Murawaki, Y.; Hashiguchi, K.; Kanbe, T.; Saeki, T.; Ichiba, M.; Yoshida, Y.; Mitsunari, M.; Yoshida, S.; Miake, J.; Yamamoto, Y.; Nagata, N.; Harada, T.; Kurimasa, A.; Hisatome, I.; Terakawa, N.; Murawaki, Y.; Shiota, G. Analyses to clarify rich fractions in hepatic progenitor cells from human umbilical cord blood and cell fusion. Biochem. Biophys. Res. Commun. 324:711-718; 2004.
23. Theise, N. D.; Nimmakayalu, M.; Gardner, R.; Illei, P. B.; Morgan, G.; Teperman, L.; Henegariu, O.; Krause, D. S. Liver from bone marrow in humans. Hepatology 32:11-16; 2000.
24. Thorgeirsson, S. S.; Grisham, J. W. Hematopoietic cells as hepatocyte stem cells: A critical review of the evidence. Hepatology 43:2-8; 2006.
25. Tunon, M. J.; Sanchez-Campos, S.; Gutierrez, B.; Culebras, J. M.; Gonzalez-Gallego, J. Effects of FK506 and rapamycin on generation of reactive oxygen species, nitric oxide production and nuclear factor kappa B activation in rat hepatocytes. Biochem. Pharmacol. 66:439-445; 2003.
26. Weber-Nordt, R. M.; Schott, E.; Finke, J.; Henschler, R.; Schulz, G.; Mertelsmann, R. Umbilical cord blood: An alternative to the transplantation of bone marrow stem cells. Cancer Treat. Rev. 22:381-391; 1996.
27. Yoshida, Y.; Shimomura, T.; Sakabe, T.; Ishii, K.; Gonda, K.; Matsuoka, S.; Watanabe, Y.; Takubo, K.; Tsuchiya, H.; Hoshikawa, Y.; Kurimasa, A.; Hisatome, I.; Uyama, T.; Terai, M.; Umezawa, A.; Shiota, G. A role of Wnt/ beta-catenin signals in hepatic fate specification of human umbilical cord blood-derived mesenchymal stem cells. Am. J. Physiol. Gastrointest. Liver Physiol. 293:G1089-1098; 2007.
28. Zeng, F.; Chen, M. J.; Baldwin, D. A.; Gong, Z. J.; Yan, J. B.; Qian, H.; Wang, J.; Jiang, X.; Ren, Z. R.; Sun, D.; Huang, S. Z. Multiorgan engraftment and differentiation of human cord blood CD34+ Lin- cells in goats assessed by gene expression profiling. Proc. Natl. Acad. Sci. USA 103:7801-7806; 2006.