Functional analysis of multiple carotenogenic genes from Lycium barbarum and Gentiana lutea L. for their effects on β-carotene production in transgenic tobacco

Biotechnology Letters

Volumn 31, Issue 2, 2009, Pages 305-312

  Ji, Jing ^a   Wang, Gang ^a   Wang, Jiehua ^a   Wang, Ping ^b  

^a TIANJIN UNIVERSITY   (China)

^b HUAIHAI INSTITUTE OF TECHNOLOGY   (China)

Author keywords

carotene contents; Carotenoid biosynthesis; Gentiana lutea L.; Lycium barbarum; Transgenic tobacco

Indexed keywords

ANIMALS; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BIOSYNTHESIS; ENZYMES; GENE ENCODING; GENES; GENETIC ENGINEERING; PHOTOSYNTHESIS; PIGMENTS; PLANTS (BOTANY); TOBACCO;

BENEFICIAL EFFECTS; CAROTENE PRODUCTIONS; CAROTENOGENIC GENES; CAROTENOID BIOSYNTHESIS; CYCLASE; DESATURASE; DIETARY SOURCES; ENCODING PROTEINS; GENTIANA LUTEA L.; GERANYLGERANYL DIPHOSPHATE; GREEN LEAFY VEGETABLES; IN PLANTS; LYCIUM BARBARUM; LYCOPENE; NICOTIANA TABACUM; ORANGE FRUITS; ORANGE PIGMENTS; PHYTOENE SYNTHASE; PLANT SPECIES; SYNTHASE; TRANSGENES; TRANSGENIC TOBACCO; TRANSGENIC TOBACCO PLANTS;

AGRICULTURAL PRODUCTS;

BETA CAROTENE; VEGETABLE PROTEIN;

ARTICLE; BIOSYNTHESIS; GENETICS; GENTIAN; LYCIUM; METABOLISM; METHODOLOGY; PHYSIOLOGY; PROTEIN ENGINEERING; TOBACCO; TRANSGENIC PLANT;

BETA CAROTENE; GENTIANA; LYCIUM; PLANT PROTEINS; PLANTS, GENETICALLY MODIFIED; PROTEIN ENGINEERING; TOBACCO;

ANIMALIA; GENTIANA; GENTIANA LUTEA; LYCIUM; LYCIUM BARBARUM; NICOTIANA OBTUSIFOLIA; NICOTIANA TABACUM;

EID: 58149183848     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-008-9861-8     Document Type: Article

References (27)

1. S Al-Babili P Beyer 2005 Golden Rice-five years on the road-five years to go? Trends Plant Sci 10 565 573
2. P Bramley C Teulieres I Blain C Bird W Schuch 1992 Biochemical characterization of transgenic tomato plants in which carotenoid synthesis has been inhibited through the expression of antisense RNA to pTOM5 Plant J 2 343 349
3. FX Cunningham E Gantt 1998 Genes and enzymes of carotenoid biosynthesis in plants Annu Rev Plant Phys 49 557 583
4. FX Cunningham B Pogson Z Sun KA McDonald D DellaPenna E Gantt 1996 Functional analysis of the β and ε-lycopene cyclase enzymes of Arabidopsis reveals a mechanism for control of cyclic carotenoid formation Plant Cell 8 1613 1626
5. C D'Ambrosio G Giorio I Marino A Merendino A Petrozza L Salfi AL Stigliani F Cellini 2004 Virtually complete conversion of lycopene into beta-carotene in fruits of tomato plants transformed with the tomato lycopene beta-cyclase (tlcy-b) cDNA Plant Sci 166 207 214
6. D DellaPenna 1999 Nutritional genomics: manipulating plant micronutrients to improve human health Science 285 375 379
7. B Demmimg-Adam WW Adams 1996 The role of xanthophylls cycle carotenoids in the protection of photosynthesis Trends Plant Sci 1 21 26
8. G Forkmann S Martens 2001 Metabolic engineering and application of flavonoids Curr Opin Biotechnol 12 155 160
9. RG Fray A Wallace PD Fraser D Valero P Hedden PM Bramley D Grierson 1995 Constitutive expression of a fruit phytoene synthase gene in transgenic tomatoes causes dwarfism by redirecting metabolites from the gibberellin pathway Plant J 8 693 701
10. J Hirschberg 1999 Production of high-value compounds: carotenoids and vitamin E Curr Opin Biotechnol 10 186 191
11. J Hirschberg 2001 Carotenoid biosynthesis in flowering plants Curr Opin Plant Biol 4 210 218
12. ST Mayne 1996 Beta-carotene, carotenoids, and disease prevention in humans FESEB J 10 690 701
13. JA Paine CA Shipton S Chaggar RM Howells MJ Kennedy G Vernon SY Wright E Hinchliffe JL Adams AL Silverstone R Drake 2005 Improving the nutritional value of Golden Rice through increased pro-vitamin A content Nat Biotechnol 23 482 487
14. S Romer PD Fraser JW Kiano CA Shipton N Misawa W Schuch PM Bramley 2000 Elevation of the provitamin A content of transgenic tomato plants Nat Biotechnol 18 666 669
15. G Ronen M Cohen D Zamir J Hirschberg 1999 Regulation of carotenoid biosynthesis during tomato fruit development: expression of the gene for lycopene epsilon-cyclase is down-regulated during ripening and is elevated in the mutant Delta Plant J 17 341 351
16. C Rosati R Aquilani S Dharmapuri P Pallara C Marusic R Tavazza F Bouvier B Camara G Giuliano 2000 Metabolic engineering of beta-carotene and lycopene content in tomato fruit Plant J 24 413 419
17. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, USA
18. G Sandmann 2001 Carotenoid biosynthesis and biotechnological application Arch Biochem Biophys 385 4 12
19. C Schmidt-Dannert 2000 Engineering novel carotenoids in microorganisms Curr Opin Biotechnol 11 255 261
20. CK Shewmaker JA Sheehy M Daley S Colburn DY Ke 1999 Seed-specific overexpression of phytoene synthase: increase in carotenoids and other metabolic effects Plant J 20 401 412
21. CK Shewmaker JA Sheehy M Daley S Colburn DY Ke 1999 Seed-specific overexpression of phytoene synthase: increase in carotenoids and other metabolic effects Plant J 20 401 412
22. D Siefermann-Harms 1987 The light-harvesting and protective functions of carotenoids in photosynthetic membranes Physiol Planta 69 561 568
23. S Suzuki M Nishihara T Nakatsuka N Misawa I Ogiwara S Yamamura 2007 Flower color alteration in Lotus japonicus by modification of the carotenoid biosynthetic pathway Plant Cell Rep 26 951 959
24. Y Tanaka S Tsuda T Kusumi 1998 Metabolic engineering to modify flower color Plant Cell Physiol 39 1119 1126
25. H van den Berg R Faulks HF Granado J Hirschberg B Olmedilla G Sandmann S Southon W Stahl 2000 The potential for the improvement of carotenoid levels in foods and the likely systemic effects J Sci Food Agric 80 880 912
26. XD Ye S Al-Babili A Kloti J Zhang P Lucca P Beyer I Potrykus 2000 Engineering the provitamin A (beta-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm Science 287 303 305
27. S Zaripheh JW Erdman 2002 Factors that influence the bioavailablity of xanthophylls J Nutr 132 531 534