A Non-Leaky Artemis-Deficient Mouse That Accurately Models the Human Severe Combined Immune Deficiency Phenotype, Including Resistance to Hematopoietic Stem Cell Transplantation

Biology of Blood and Marrow Transplantation

Volumn 15, Issue 1, 2009, Pages 1-11

  Xiao, Zheng ^a   Dunn, Elizabeth ^a   Singh, Kanal ^a   Khan, Imran S ^b   Yannone, Steven M ^b   Cowan, Morton J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Artemis deficiency; Athabascan; Hematopoietic stem cell transplantation; Knockout mouse; Severe combined immune deficiency

Indexed keywords

ACCURACY; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACKCROSSING; C57BL 6 MOUSE; CD4+ T LYMPHOCYTE; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; DISEASE MODEL; DNA REPAIR; ENGRAFTMENT; FEMALE; GENE DOSAGE; GENE MUTATION; GENE THERAPY; GENOTYPE; IMMUNE RESPONSE; IONIZING RADIATION; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN DEFICIENCY; RADIOSENSITIVITY; SCID MOUSE; THERAPY RESISTANCE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; DNA REPAIR; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNE SYSTEM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NUCLEAR PROTEINS; PHENOTYPE; SEVERE COMBINED IMMUNODEFICIENCY;

EID: 58149183672     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2008.10.026     Document Type: Article

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