Bone marrow or foetal liver cells fail to induce islet regeneration in diabetic Akita mice

Diabetes/Metabolism Research and Reviews

Volumn 24, Issue 7, 2008, Pages 585-590

  Akashi, Tomoyuki ^a   Shigematsu, Hirokazu ^a   Hamamoto, Yoshiyuki ^a   Iwasaki, Hiromi ^a   Yatoh, Shigeru ^a   Bonner Weir, Susan ^a   Akashi, Koichi ^a   Weir, Gordon C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

cells; Bone marrow; Diabetes; Foetal liver; Islets; Regeneration

Indexed keywords

CD45 ANTIGEN; GREEN FLUORESCENT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW TRANSPLANTATION; C57BL 6 MOUSE; CELL DIFFERENTIATION; CELL REGENERATION; CHIMERA; CONTROLLED STUDY; DIABETES MELLITUS; FETUS CELL; FETUS LIVER; GLUCOSE BLOOD LEVEL; HEPATOCYTE TRANSPLANTATION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; TRANSGENIC MOUSE; TREATMENT FAILURE; ANIMAL; CELL TRANSPLANTATION; CYTOLOGY; DISEASE MODEL; EXPERIMENTAL DIABETES MELLITUS; INSULIN DEPENDENT DIABETES MELLITUS; LIVER; PANCREAS ISLET; PHYSIOLOGY; PRENATAL DEVELOPMENT; REGENERATION;

ANIMALS; BONE MARROW TRANSPLANTATION; CELL TRANSPLANTATION; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; ISLETS OF LANGERHANS; LIVER; MICE; REGENERATION;

EID: 58149159612     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.884     Document Type: Article

References (37)

1. Moriscot C, de Fraipont F, Richard MJ, et al. Human bone marrow mesenchymal stem cells can express insulin and key transcription factors of the endocrine pancreas developmental pathway upon genetic and/or microenvironmental manipulation in vitro. Stem Cells 2005; 23: 594-603.
2. Li Y, Zhang R, Qiao H, et al. Generation of insulin-producing cells from PDX-1 gene-modified human mesenchymal stem cells. J Cell Physiol 2007; 211: 36-44.
3. Schwartz RE, Reyes M, Koodie L, et al. Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest 2002; 109: 1291-1302.
4. Kucia M, Reca R, Campbell FR, et al. A population of very small embryonic-like (VSEL) CXCR4(+)SSEA-1(+)Oct-4+ stem cells identified in adult bone marrow. Leukemia 2006; 20: 857-869.
5. Oh SH, Muzzonigro TM, Bae SH, LaPlante JM, Hatch HM, Petersen BE. Adult bone marrow-derived cells transdifferentiating into insulin-producing cells for the treatment of type I diabetes. Lab Invest 2004; 84: 607-617.
6. Tang DQ, Cao LZ, Burkhardt BR, et al. In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow. Diabetes 2004; 53: 1721-1732.
7. Ianus A, Holz GG, Theise ND, Hussain MA. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest 2003; 111: 843-850.
8. Kodama S, Kuhtreiber W, Fujimura S, Dale EA, Faustman DL. Islet regeneration during the reversal of autoimmune diabetes in NOD mice. Science 2003; 302: 1223-1227.
9. Lee RH, Seo MJ, Reger RL, et al. Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Proc Natl Acad Sci U S A 2006; 103: 17438-17443.
10. Choi JB, Uchino H, AzumaK, et al. Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells. Diabetologia 2003; 46: 1366-1374.
11. Lechner A, Yang YG, Blacken RA, Wang L, Nolan AL, Habener JF. No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo. Diabetes 2004; 53: 616-623.
12. Taneera J, Rosengren A, Renstrom E, et al. Failure of transplanted bone marrow cells to adopt a pancreatic beta-cell fate. Diabetes 2006; 55: 290-296.
13. Hess D, Li L, Martin M, et al. Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotechnol 2003; 21: 763-770.
14. Mathews V, Hanson PT, Ford E, Fujita J, Polonsky KS, Graubert TA. Recruitment of bone marrow-derived endothelial cells to sites of pancreatic beta-cell injury. Diabetes 2004; 53: 91-98.
15. Hasegawa Y, Ogihara T, Yamada T, et al. Bone Marrow (BM) transplantation promotes βcell regeneration after acute injury through BM cell mobilization. Endocrinology 2007; 148: 2006-2015.
16. Nishio J, Gaglia JL, Turvey SE, Campbell C, Benoist C, Mathis D. Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution. Science 2005; 311: 1775-1778.
17. Zalzman M, Gupta S, Giri RK, et al. Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells. Proc Natl Acad Sci U S A 2003; 100: 7253-7258.
18. Banerjee M, Kumar A, Bhonde RR. Reversal of experimental diabetes by multiple bone marrow transplantation. Biochem Biophys Res Commun 2005; 328: 318-325.
19. Izumida Y, Aoki T, Yasuda D, et al. Hepatocyte growth factor is constitutively produced by donor-derived bone marrow cells and promotes regeneration of pancreatic beta-cells. Biochem Biophys Res Commun 2005; 333: 273-282.
20. Li FX, Zhu JW, Tessem JS, et al. The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss. Proc Natl Acad Sci U S A 2003; 100: 12935-12940.
21. Than S, Ishida H, Inaba M, et al. Bone marrow transplantation as a strategy for treatment of non-insulin-dependent diabetes mellitus in KK-Ay mice. J Exp Med 1992; 176: 1233-1238.
22. Yoshioka M, Kayo T, Ikeda T, Koizumi A. A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/ 6 (Akita) mutant mice. Diabetes 1997; 46: 887-894.
23. Wang J, Takeuchi T, Tanaka S, et al. A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse. J Clin Invest 1999; 103: 27-37.
24. Oyadomari S, Koizumi A, Takeda K, et al. Targeted disruption ofthe Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest 2002; 109: 525-532.
25. Nozaki J, Kubota H, Yoshida H, et al. The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells. Genes Cells 2004; 9: 261-270.
26. Hara M, Wang X, Kawamura T, et al. Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells. Am J Physiol Endocrinol Metab 2003; 284: E177-E183.
27. Like AA, Appel MC, Williams RM, Rossini AA. Streptozotocin-induced pancreatic insulitis in mice. Lab Invest 1978; 38: 470-486.
28. Like AA, Rossini AA. Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science 1976; 193: 415-417.
29. Hardikar AA, Karandikar MS, Bhonde RR. Effect of partial pancreatectomy on diabetic status in BALB/c mice. J Endocrinol 1999; 162: 189-195.
30. Leroux L, Desbois P, Lamotte L, et al. Compensatory responses in mice carrying a null mutation for Ins1 or Ins2. Diabetes 2001; 50(Suppl. 1): S150-S153.
31. Devaskar SU, Singh BS, Carnaghi LR, Rajakumar PA, Giddings SJ. Insulin II gene expression in rat central nervous system. Regul Pept 1993; 48: 55-63.
32. Hanahan D. Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity. Curr Opin Immunol 1998; 10: 656-662.
33. Devaskar SU, Giddings SJ, Rajakumar PA, Carnaghi LR, Menon RK, Zahm DS. Insulin gene expression and insulin synthesis in mammalian neuronal cells. J Biol Chem 1994; 269: 8445-8454.
34. Alarcon C, Serna J, Perez-Villamil B, de Pablo F. Synthesis and differentially regulated processing of proinsulin in developing chick pancreas, liver and neuroretina. FEBS Lett 1998; 436: 361-366.
35. Suzuki A, Zheng YW, Kaneko S, et al. Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver. J Cell Biol 2002; 156: 173-184.
36. Morrison SJ, Hemmati HD, Wandycz AM, Weissman IL. The purification and characterization of fetal liver hematopoietic stem cells. Proc Natl Acad Sci U S A 1995; 92: 10302-10306.
37. Sordi V, Malosio ML, Marchesi F, et al. Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets. Blood 2005; 106: 419-427.