Synthesis and biological evaluation of some 4-(1H-indol-3-yl)-6-phenyl-1,2, 3,4-tetrahydropyrimidin-2-ones/thiones as potent anti-inflammatory agents

Acta Pharmaceutica

Volumn 58, Issue 4, 2008, Pages 467-477

  Amir, Mohammad ^a   Javed, Sadique Akhtar ^a   Kumar, Harish ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

Anti inflammatory activity; Lipid peroxidation; Pyrimidine derivatives; Ulcerogenicity

Indexed keywords

3 (1H INDOL 3 YL) 2 PROPEN 1 ONE DERIVATIVE; 4 (1H INDOL 3 YL) 6 (4 CHLOROPHENYL) 1,2,3,4 TETRAHYDROPYRIMIDIN 2 ONE; 4 (1H INDOL 3 YL) 6 (4 CHLOROPHENYL) 1,2,3,4 TETRAHYDROPYRIMIDINE 2 THIONE; 4 (1H INDOL 3 YL) 6 (4 METHYLPHENYL) 1,2,3,4 TETRAHYDROPYRIMIDIN 2 ONE; 4 (1H INDOL 3 YL) 6 (4 METHYLPHENYL) 1,2,3,4 TETRAHYDROPYRIMIDINE 2 THIONE; 4 (1H INDOL 3 YL) 6 PHENYL 1,2,3,4 TETRAHYDROPYRIMIDIN 2 ONE DERIVATIVE; 4 (1H INDOL 3 YL) 6 PHENYL 1,2,3,4 TETRAHYDROPYRIMIDINE 2 THIONE DERIVATIVE; IBUPROFEN; INDOLE DERIVATIVE; POTASSIUM HYDROXIDE; PYRIMIDINE DERIVATIVE; THIOUREA; UNCLASSIFIED DRUG; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EXPERIMENTAL MODEL; INFRARED SPECTROSCOPY; LIPID PEROXIDATION; MASS SPECTROMETRY; NONHUMAN; PAW EDEMA; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ANALYSIS; ULCEROGENESIS;

EID: 58149147299     PISSN: 13300075     EISSN: None     Source Type: Journal    
DOI: 10.2478/v10007-008-0028-x     Document Type: Article

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