Advances in pediatric asthma in 2008: Where do we go now?

Journal of Allergy and Clinical Immunology

Volumn 123, Issue 1, 2009, Pages 28-34

  Szefler, Stanley J ^a  

^a DEPARTMENT OF MEDICINE   (United States)

Author keywords

Asthma; asthma control; asthma impairment; asthma risk; asthma severity; biomarkers; early intervention in asthma; genetics; therapeutics

Indexed keywords

ANTIRETROVIRUS AGENT; AZITHROMYCIN; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; CORTICOSTEROID; DIPHTHERIA PERTUSSIS TETANUS VACCINE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MONTELUKAST; SALBUTAMOL;

ARTICLE; ASTHMA; BRONCHOSPASM; CATARACT; DISEASE ASSOCIATION; DISEASE CONTROL; DISEASE COURSE; DISEASE EXACERBATION; DRUG EFFICACY; DRUG MEGADOSE; ENVIRONMENTAL IMPACT; EXERCISE INDUCED ASTHMA; FORCED EXPIRATORY VOLUME; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNIZATION; INTRAOCULAR PRESSURE; LONG TERM CARE; LOW DRUG DOSE; MANAGED CARE; OBESITY; OCCUPATIONAL ASTHMA; PRACTICE GUIDELINE; PRIORITY JOURNAL; RISK REDUCTION; SIDE EFFECT; SUICIDE ATTEMPT;

ADOLESCENT; ASTHMA, EXERCISE-INDUCED; CHILD; CHILD, PRESCHOOL; FEMALE; GUIDELINES AS TOPIC; HUMANS; MALE; NATIONAL HEALTH PROGRAMS; OBESITY; OCCUPATIONAL EXPOSURE; PATIENT EDUCATION AS TOPIC; PERIODICALS AS TOPIC; UNITED STATES;

EID: 58149127358     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2008.11.002     Document Type: Article

References (87)

1. Szefler S.J. Advances in pediatric asthma in 2007. J Allergy Clin Immunol 121 (2008) 614-619
2. National Institutes of Health. National Heart, Lung, and Blood Institute. National Asthma Education and Prevention Program. Expert Panel Report 3: guidelines for the diagnosis and management of asthma. August 2007. NIH publication no. 07-4051. Available at: http://www.nhlbi.nih.gov/guidelines/asthma/index.htm. Accessed November, 10, 2008.
3. Expert Panel Report 3 (EPR-3): guidelines for the diagnosis and management of asthma-summary report 2007. J Allergy Clin Immunol 120 (2007) S94-S138
4. McIvor R.A., and Chapman K.R. The coming of age of asthma guidelines. Lancet 372 (2008) 1021-1022
5. Frey U., and Suki B. Complexity of chronic asthma and chronic obstructive pulmonary disease: implications for risk assessment and disease progression and control. Lancet 372 (2008) 1088-1099
6. Spahn J.D., and Covar R.A. Clinical assessment of asthma progression in children and adults. J Allergy Clin Immunol 121 (2008) 548-557
7. Anderson G.P. Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet 372 (2008) 1107-1119
8. Holt E.W., Cook E.F., Covar R.A., Spahn J.D., and Fuhlbrigge A.L. Identifying the components of asthma health status in children with mild to moderate asthma. J Allergy Clin Immunol 121 (2008) 1175-1180
9. Bender B., and Zhang L. Negative affect, medication adherence, and asthma control in children. J Allergy Clin Immunol 122 (2008) 490-495
10. Pelkonen A., Kari O., Selroos O., Nikander K., Haahtela T., and Turpeinen M. Ophthalmologic findings in children with asthma receiving inhaled budesonide. J Allergy Clin Immunol 122 (2008) 832-834
11. Holbrook J.T., and Harik-Khan R. Montelukast and emotional well-being as a marker for depression: results from three randomized double-masked clinical trials. J Allergy Clin Immunol 122 (2008) 828-829
12. Busse W.W., Pedersen S., Pauwels R.A., Tan W.C., Chen Y.Z., Lamm C.J., et al. START Investigators Group. The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthma. J Allergy Clin Immunol 121 (2008) 1167-1174
13. Zeiger R.S., Hay J.W., Contreras R., Chen W., Quinn V.P., Seal B., et al. Asthma costs and utilization in a managed care organization. J Allergy Clin Immunol 121 (2008) 885-892
14. Stingone J.A., and Claudio L. Disparities in allergy testing and health outcomes among urban children with asthma. J Allergy Clin Immunol 122 (2008) 748-753
15. Canino G., Vila D., Normand S.T., Acosta-Pérez E., Ramírez R., García P., et al. Reducing asthma health disparities in poor Puerto Rican children: the effectiveness of a culturally tailored family intervention. J Allergy Clin Immunol 121 (2008) 665-670
16. Reed C.E. What the 21st century does not know about asthma-yet. J Allergy Clin Immunol 121 (2008) 601-602
17. Pistiner M., Gold D.R., Abdulkerim H., Hoffman E., and Celedón J.C. Birth by cesarean section, allergic rhinitis, and allergic sensitization among children with a parental history of atopy. J Allergy Clin Immunol 122 (2008) 274-279
18. Kumar R., Yu Y., Story R.E., Pongracic J.A., Gupta R., Pearson C., et al. Prematurity, chorioamnionitis, and the development of recurrent wheezing: A prospective birth cohort study. J Allergy Clin Immunol 121 (2008) 878-884
19. McDonald K.L., Huq S.I., Lix L.M., Becker A.B., and Kozyrskyj A.L. Delay in diphtheria, pertussis, tetanus vaccination is associated with a reduced risk of childhood asthma. J Allergy Clin Immunol 121 (2008) 626-631
20. Kim J.S., Ouyang F., Pongracic J.A., Fang Y., Wang B., Liu X., et al. Dissociation between the prevalence of atopy and allergic disease in rural China among children and adults. J Allergy Clin Immunol 122 (2008) 929-935
21. Donohue K.M., Al-alem U., Perzanowski M.S., Chew G.L., Johnson A., Divjan A., et al. Anti-cockroach, mouse IgE is associated with early wheeze and atopy in an inner-city birth cohort. J Allergy Clin Immunol 122 (2008) 914-920
22. Foster S.B., McIntosh K., Thompson B., Lu M., Yin W., Rich K.C., et al. Increased incidence of asthma in HIV-infected children treated with highly active antiretroviral therapy in the National Institutes of Health Women and Infants Transmission Study. J Allergy Clin Immunol 122 (2008) 159-165
23. Burgess J.A., Dharmage S.C., Byrnes G.B., Matheson M.C., Gurrin L.C., Wharton C.L., et al. Childhood eczema and asthma incidence and persistence: a cohort study from childhood to middle age. J Allergy Clin Immunol 122 (2008) 280-285
24. Shaaban R., Zureik M., Soussan D., Neukirch C., Heinrich J., Sunyer J., et al. Rhinitis and onset of asthma: a longitudinal population-based study. Lancet 372 (2008) 1049-1057
25. Lowe A.J., Carlin J.B., Bennett C.M., Hosking C.S., Abramson M.J., Hill D.J., et al. Do boys do the atopic march while girls dawdle?. J Allergy Clin Immunol 121 (2008) 1190-1195
26. Beasley R., Clayton T., Crane J., von Mutius E., Lai C.K.W., Montefort S., et al., ISAAC Phase Three Study Group. Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years: Analysis from Phase Three of the ISAAC programme. Lancet 372 (2008) 1039-1048
27. Tepper R.S., Llapur C.J., Jones M.H., Tiller C., Coates C., Kimmel R., et al. Expired nitric oxide and airway reactivity in infants at risk for asthma. J Allergy Clin Immunol 122 (2008) 760-765
28. Elliott L., Henderson J., Northstone K., Chiu G.Y., Dunson D., and London S.J. Prospective study of breast-feeding in relation to wheeze, atopy, and bronchial responsiveness in the Avon Longitudinal Study of Parents and Children (ASPAC). J Allergy Clin Immunol 122 (2008) 49-54
29. Sicherer S.H., and Burks A.W. Maternal and infant diets for prevention of allergic diseases: understanding menu changes in 2008. J Allergy Clin Immunol 122 (2008) 29-33
30. Stern D.A., Morgan W.J., Halonen M., Wright A.L., and Martinez F.D. Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study. Lancet 372 (2008) 1058-1064
31. Sly P.D., Boner A.L., Bjorksten B., Bush A., Custovic A., Eigenmann P.A., et al. Early identification of atopy in the prediction of persistent asthma in children. Lancet 372 (2008) 1100-1106
32. Nicolaou N.C., Simpson A., Lowe L.A., Murray C.S., Woodcock A., and Custovic A. Day-care attendance, position in sibship, and early childhood wheezing: a population-based birth cohort study. J Allergy Clin Immunol 122 (2008) 500-506
33. Guilbert T.W., Morgan W.J., Zeiger R.S., Mauger D.T., Boehmer S.J., Szefler S.J., et al. Two year inhaled corticosteroid treatment on subsequent asthma in high-risk toddlers. N Engl J Med 354 (2006) 1985-1997
34. Litonjua A.A., and Gold D.R. Asthma and obesity: common early-life influences in the inception of disease. J Allergy Clin Immunol 121 (2008) 1075-1084
35. Shore S.A. Obesity and asthma: possible mechanisms. J Allergy Clin Immunol 121 (2008) 1087-1093
36. Mehra R., and Redline S. Sleep apnea: a proinflammatory disorder that coaggregates with obesity. J Allergy Clin Immunol 121 (2008) 1096-1102
37. Mosen D.M., Schatz M., Magid D.J., and Camargo C.A. The relationship between obesity and asthma severity and control in adults. J Allergy Clin Immunol 122 (2008) 507-511
38. Taveras E.M., Rifas-Shiman S.L., Camargo C.A., Gold D.R., Litonjua A.A., Oken E., et al. Higher adiposity in infancy associated with recurrent wheeze in a prospective cohort of children. J Allergy Clin Immunol 121 (2008) 1161-1166
39. Szefler S.J. Asthma exacerbations: putting a lid on the volcano. J Allergy Clin Immunol 122 (2008) 697-699
40. Sears M.R. Epidemiology of asthma exacerbations. J Allergy Clin Immunol 122 (2008) 662-668
41. Sykes A., and Johnston S.L. Etiology of asthma exacerbations. J Allergy Clin Immunol 122 (2008) 685-688
42. Kelly J.T., and Busse W.W. Host immune responses to rhinovirus: mechanisms in asthma. J Allergy Clin Immunol 122 (2008) 671-682
43. Covar R.A., Szefler S.J., Zeiger R.S., Sorkness C.A., Moss M., Mauger D.T., et al., Childhood Asthma Research and Education Network. Factors associated with asthma exacerbations during a long-term clinical trial of controller medications in children. J Allergy Clin Immunol 122 (2008) 741-747
44. Sorkness C.A., Lemanske R.F., Mauger D.T., Boehmer S.J., Chinchilli V.M., Martinez F.D., et al., Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute. Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial. J Allergy Clin Immunol 119 (2007) 64-72
45. Sorkness R.L., Gonzalez-Fernandez G., Billmeyer E.E., Evans M.D., Gern J.E., and Jarjour N.N. The asthma index: a continuous variable to characterize exacerbations of asthma. J Allergy Clin Immunol 122 (2008) 838-840
46. Fitch K.D., Sue-Chu M., Anderson S.D., Boulet L.P., Hancox R.J., McKenzie D.C., et al. Asthma and the elite athlete: summary of the International Olympic Committee's Consensus Conference, Lausanne, Switzerland, January 22-24, 2008. J Allergy Clin Immunol 122 (2008) 254-260
47. Anderson S.D., and Kippelen P. Airway injury as a mechanism for exercise-induced bronchoconstriction in elite athletes. J Allergy Clin Immunol 122 (2008) 225-235
48. Pedersen L., Lund T.K., Barnes P.J., Kharitonov S.A., and Backer V. Airway responsiveness and inflammation in adolescent elite swimmers. J Allergy Clin Immunol 122 (2008) 322-327
49. Rundell K.W., and Slee J.B. Exercise and other indirect challenges to demonstrate asthma or exercise-induced bronchoconstriction in athletes. J Allergy Clin Immunol 122 (2008) 238-246
50. Weinberger M. Long-acting β-agonists and exercise. J Allergy Clin Immunol 122 (2008) 251-253
51. Sharma S., Litonjua A.A., Tantisira K.G., Fuhlbrigge A.L., Szefler S.J., Strunk R.C., et al., CAMP Research Group. Clinical predictors and outcomes of consistent bronchodilator response in the Childhood Asthma Management Program. J Allergy Clin Immunol 122 (2008) 921-928
52. Goleva E., Hauk P.J., Hall C.F., Liu A.H., Riches D.W.H., Martin R.J., et al. Corticosteroid-resistant asthma is associated with classic antimicrobial activation of airway macrophages. J Allergy Clin Immunol 122 (2008) 550-559
53. Szefler S.J. Asthma progression: can we and should we measure it?. J Allergy Clin Immunol 121 (2008) 598-600
54. Panettieri R.A., Covar R.A., Grant E., Hillyer E.V., and Bacharier L. Natural history of asthma: persistence versus progression-does the beginning predict the end?. J Allergy Clin Immunol 121 (2008) 607-613
55. Broide D.H. Immunologic and inflammatory mechanisms that drive asthma progression to remodeling. J Allergy Clin Immunol 121 (2008) 560-570
56. Holloway J.W., Yang I.A., and Holgate S.T. Interpatient variability in rates of asthma progression: can genetics provide an answer?. J Allergy Clin Immunol 121 (2008) 573-579
57. Leigh R., Oyelusi W., Wiehler S., Koetzler R., Zaheer R.S., Newton R., et al. Human rhinovirus infection enhances airway epithelial cell production of growth factors involved in airway remodeling. J Allergy Clin Immunol 121 (2008) 1238-1245
58. Sackesen C., Ercan H., Dizdar E., Soyer O., Gumus P., Nursal Tosun B., et al. A comprehensive evaluation of the enzymatic and nonenzymatic antioxidant systems in childhood asthma. J Allergy Clin Immunol 122 (2008) 78-85
59. Fitzpatrick A.M., Holguin F., Teague W.G., and Brown L.A.S. Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma. J Allergy Clin Immunol 121 (2008) 1372-1378
60. Bush R.K., and Peden D. Advances in environmental and occupational respiratory disease in 2007. J Allergy Clin Immunol 121 (2008) 1359-1362
61. Gupta R.S., Zhang X., Sharp L.K., Shannon J.J., and Weiss K.B. Geographic variability in childhood asthma prevalence in Chicago. J Allergy Clin Immunol 121 (2008) 639-645
62. O'Connor G.T., Neas L., Vaughn B., Kattan M., Mitchell H., Crain E.F., et al. Acute respiratory health effects of air pollution on children with asthma in US inner cities. J Allergy Clin Immunol 121 (2008) 1133-1139
63. Tovey E.R., Almqvist C., Li Q., Crisafulli D., and Marks G.B. Nonlinear relationship of mite allergen exposure to mite sensitization and asthma in a birth cohort. J Allergy Clin Immunol 122 (2008) 114-118
64. Kumar R., Curtis L.M., Khiani S., Moy J., Shalowitz M.U., Sharp L., et al. A community-based study of tobacco smoke exposure among inner city children with asthma in Chicago. J Allergy Clin Immunol 122 (2008) 754-759
65. 4-related albuterol usage and response to montelukast. J Allergy Clin Immunol 121 (2008) 1365-1371
66. Rayens M.K., Burkhart P.V., Zhang M., Lee S., Moser D.K., Mannino D., et al. Reduction in asthma-related emergency department visits after implementation of a smoke-free law. J Allergy Clin Immunol 122 (2008) 537-541
67. Ginde A.A., Espinola J.A., and Camargo C.A. Improved overall trends but persistent racial disparities in emergency department visits for acute asthma, 1993-2005. J Allergy Clin Immunol 122 (2008) 313-318
68. Strunk R.C., Bacharier L.B., Phillips B.R., Szefler S.J., Zeiger R.S., Chinchilli V.M., et al., Childhood Asthma Research and Education Network of the National Heart, Lung and Blood Institute. Azithromycin or montelukast as inhaled corticosteroid-sparing agents in moderate to severe childhood asthma study. J Allergy Clin Immunol 122 (2008) 1138-1144
69. Bacharier L.B., Phillips B.R., Zeiger R.S., Szefler S.J., Martinez F.D., Lemanske R.F., et al., Childhood Asthma Research and Education Network of the National Heart, Lung and Blood Institute. Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing. J Allergy Clin Immunol 122 (2008) 1127-1135
70. Moeller A., Diefenbacher C., Lehmann A., Rochat M., Brooks-Wildhaber J., Hall G.L., et al. Exhaled nitric oxide distinguishes between subgroups of preschool children with respiratory symptoms. J Allergy Clin Immunol 121 (2008) 705-709
71. Szefler S.J., Mitchell H., Sorkness C.A., Gergen P.J., O'Connor G.T., Morgan W.J., et al. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomized controlled trial. Lancet 372 (2008) 1065-1072
72. Ono E., Mita H., Taniguchi M., Higashi N., Tsuburai T., Hasegawa M., et al. Increase in inflammatory mediator concentrations in exhaled breath condensate after allergen inhalation. J Allergy Clin Immunol 122 (2008) 768-773
73. Romieu I., Barraza-Villarreal A., Escamilla-Nuñez C., Almstrand A.C., Diaz-Sanchez D., Sly P.D., et al. Exhaled breath malondialdehyde as a marker of effect of exposure to air pollution in children with asthma. J Allergy Clin Immunol 121 (2008) 903-909
74. Steinke J.W., Rich S.S., and Borish L. Genetics of allergic disease. J Allergy Clin Immunol 121 (2008) S384-S387
75. Vercelli D. Advances in asthma and allergy genetics in 2007. J Allergy Clin Immunol 122 (2008) 267-271
76. Chatterjee R., Batra J., Das S., Kumar Sharma S., and Ghosh B. Genetic association of acidic mammalian chitinase with atopic asthma and serum total IgE levels. J Allergy Clin Immunol 122 (2008) 202-208
77. Tavendale R., Macgregor D.F., Mukhopadhyay S., and Palmer C.N.A. A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications. J Allergy Clin Immunol 121 (2008) 860-863
78. Ueda T., Niimi A., Matsumoto H., Takemura M., Yamaguchi M., Matsuoka H., et al. TGFB1 promoter polymorphism C-509T and pathophysiology of asthma. J Allergy Clin Immunol 121 (2008) 659-664
79. Kormann M.S.D., Depner M., Hartl D., Klopp N., Illig T., Adamski J., et al. Toll-like receptor heterodimer variants protect from childhood asthma. J Allergy Clin Immunol 122 (2008) 86-92
80. Hunninghake G.M., Soto-Quirós M.E., Lasky-Su J., Avila L., Ly N.P., Liang C., et al. Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations. J Allergy Clin Immunol 122 (2008) 93-98
81. Weidinger S., O'Sullivan M., Illig T., Baurecht H., Depner M., Rodriguez E., et al. Filaggrin mutations, atopic eczema, hay fever, and asthma in children. J Allergy Clin Immunol 121 (2008) 1203-1209
82. Bouzigon E., Corda E., Aschard H., Dizier M.-H., Boland A., Bousquet J., et al. Effect of 17q21 variants and smoking exposure in early-onset asthma. N Engl J Med 359 (2008) 1985-1994
83. Adcock I.M., Caramori G., and Chung K.F. New targets for drug development in asthma. Lancet 372 (2008) 1073-1087
84. Casale T.B., and Stokes J.R. Immunomodulators for allergic respiratory disorders. J Allergy Clin Immunol 121 (2008) 288-296
85. Cousins D.J., McDonald J., and Lee T.H. Therapeutic approaches for control of transcription factors in allergic disease. J Allergy Clin Immunol 121 (2008) 803-809
86. Bhavsar P., Ahmad T., and Adcock I.M. The role of histone deacetylases in asthma and allergic diseases. J Allergy Clin Immunol 121 (2008) 580-584
87. Chatila T.A., Li N., Garcia-Lloret M., Kim H.J., and Nel A.E. T-cell effector pathways in allergic diseases: transcriptional mechanisms and therapeutic targets. J Allergy Clin Immunol 121 (2008) 812-823