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Volumn 15, Issue 1, 2009, Pages

l-dopa therapy for Parkinson's disease: Past, present, and future

Author keywords

Dopamine; Dyskinesia; l dopa; Parkinson's disease; Selegiline

Indexed keywords

ANTIPARKINSON AGENTS; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; LEVODOPA; PARKINSON DISEASE;

EID: 58149120928     PISSN: 13538020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1353-8020(09)70004-5     Document Type: Review
Times cited : (165)

References (65)
  • 2
    • 39049179635 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of Parkinson's disease: Neurotoxins, causative genes, and inflammatory cytokines
    • Nagatsu T., and Sawada M. Cellular and molecular mechanisms of Parkinson's disease: Neurotoxins, causative genes, and inflammatory cytokines. Cell Mol Neurobiology 26 (2006) 781-802
    • (2006) Cell Mol Neurobiology , vol.26 , pp. 781-802
    • Nagatsu, T.1    Sawada, M.2
  • 3
    • 9044252959 scopus 로고
    • Tyrosine hydroxylase: The initial step in norepinephrine biosynthesis
    • Nagatsu T., Levitt M., and Udenfriend S. Tyrosine hydroxylase: The initial step in norepinephrine biosynthesis. J Biol Chem 239 (1964) 2910-2917
    • (1964) J Biol Chem , vol.239 , pp. 2910-2917
    • Nagatsu, T.1    Levitt, M.2    Udenfriend, S.3
  • 4
    • 0030722720 scopus 로고    scopus 로고
    • Evidence of the indirect formation of the catecholic intermediate substrate responsible for the autoactivation kinetics of tyrosinase
    • Cooksey C.J., Garratt P.J., Land E.J., Pavel S., Ramsden C.A., Riley P.A., et al. Evidence of the indirect formation of the catecholic intermediate substrate responsible for the autoactivation kinetics of tyrosinase. J Biol Chem 272 (1997) 26226-26232
    • (1997) J Biol Chem , vol.272 , pp. 26226-26232
    • Cooksey, C.J.1    Garratt, P.J.2    Land, E.J.3    Pavel, S.4    Ramsden, C.A.5    Riley, P.A.6
  • 5
    • 0032480361 scopus 로고    scopus 로고
    • Does tyrosinase exist in neuromelanin-pigmented neurons in the human substantia nigra?
    • Ikemoto K., Nagatsu I., Ito S., King R.A., Nishimura A., and Nagatsu T. Does tyrosinase exist in neuromelanin-pigmented neurons in the human substantia nigra?. Neurosci Lett 253 (1998) 198-200
    • (1998) Neurosci Lett , vol.253 , pp. 198-200
    • Ikemoto, K.1    Nagatsu, I.2    Ito, S.3    King, R.A.4    Nishimura, A.5    Nagatsu, T.6
  • 7
    • 0011190688 scopus 로고
    • Precursors of adrenal epinephrine and norepinephrine in vivo
    • Udenfriend S., and Wyngaarden J.B. Precursors of adrenal epinephrine and norepinephrine in vivo. Biochim Biophys Acta 20 (1956) 48-52
    • (1956) Biochim Biophys Acta , vol.20 , pp. 48-52
    • Udenfriend, S.1    Wyngaarden, J.B.2
  • 9
    • 0000428532 scopus 로고
    • 3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists
    • Carlsson A., Lindqvist M., and Magnusson T. 3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists. Nature 180 (1957) 1200
    • (1957) Nature , vol.180 , pp. 1200
    • Carlsson, A.1    Lindqvist, M.2    Magnusson, T.3
  • 11
    • 0000015266 scopus 로고
    • The occurrence, distribution and physiological role of catecholamines in the nervous system
    • Carlsson A. The occurrence, distribution and physiological role of catecholamines in the nervous system. Pharmacol Rev 11 (1959) 490-493
    • (1959) Pharmacol Rev , vol.11 , pp. 490-493
    • Carlsson, A.1
  • 13
    • 0002747406 scopus 로고
    • Biochemistry of the extrapyramidal system
    • (Translated into English by Sano A. Parkinsonism Relat Disord 2000;6:303-6.)
    • Sano I. Biochemistry of the extrapyramidal system. Shinkei Kenkyu No Shinnpo (Adv Neurol Sci) 5 (1960) 42-48 (Translated into English by Sano A. Parkinsonism Relat Disord 2000;6:303-6.)
    • (1960) Shinkei Kenkyu No Shinnpo (Adv Neurol Sci) , vol.5 , pp. 42-48
    • Sano, I.1
  • 14
    • 34250928307 scopus 로고
    • Verteilung von Noradrenalin und Dopamin (3-Hydroxytyramin) im Gehirn des Menschen und ihr Verhalten bei Erkrankungen des Extrapyramidaren Systems
    • (In German)
    • Ehringer H., and Hornykiewicz O. Verteilung von Noradrenalin und Dopamin (3-Hydroxytyramin) im Gehirn des Menschen und ihr Verhalten bei Erkrankungen des Extrapyramidaren Systems. Klin Wochenschr 38 (1960) 1236-1239 (In German)
    • (1960) Klin Wochenschr , vol.38 , pp. 1236-1239
    • Ehringer, H.1    Hornykiewicz, O.2
  • 16
    • 73049129373 scopus 로고
    • Der l-Dihydrophenylalanin (DOPA) - Effekt bei der Parkinson-akinese
    • Birkmayer W., and Hornykiewicz O. Der l-Dihydrophenylalanin (DOPA) - Effekt bei der Parkinson-akinese. Wien Klin Wochenschr 73 (1961) 787-788
    • (1961) Wien Klin Wochenschr , vol.73 , pp. 787-788
    • Birkmayer, W.1    Hornykiewicz, O.2
  • 17
    • 33749281221 scopus 로고
    • Excretion of dopamine in diseases of basal ganglia
    • Barbeau A., Murphy G.F., and Sourkes T.L. Excretion of dopamine in diseases of basal ganglia. Science 133 (1961) 1706-1707
    • (1961) Science , vol.133 , pp. 1706-1707
    • Barbeau, A.1    Murphy, G.F.2    Sourkes, T.L.3
  • 18
    • 0014673226 scopus 로고
    • Modification of parkinsonism: Chronic treatment with l-DOPA
    • Cotzias G.C., Papavasiliou P.S., and Gellene R. Modification of parkinsonism: Chronic treatment with l-DOPA. New Engl J Med 280 (1969) 337-345
    • (1969) New Engl J Med , vol.280 , pp. 337-345
    • Cotzias, G.C.1    Papavasiliou, P.S.2    Gellene, R.3
  • 19
    • 0014572531 scopus 로고
    • The metabolism of orally administered l-DOPA in Parkinsonism
    • Calne D.B., Karoum F., Ruthven C.R.J., and Sandler M. The metabolism of orally administered l-DOPA in Parkinsonism. Br J Pharmacol 37 (1969) 57-68
    • (1969) Br J Pharmacol , vol.37 , pp. 57-68
    • Calne, D.B.1    Karoum, F.2    Ruthven, C.R.J.3    Sandler, M.4
  • 20
    • 0014210962 scopus 로고
    • Increase of cerebral catecholamines caused by 3,4-dihydroxyphenylalanine after inhibition of peripheral decarboxylase
    • Bartholini G., Burkard W.P., Pletscher A., and Bates H.M. Increase of cerebral catecholamines caused by 3,4-dihydroxyphenylalanine after inhibition of peripheral decarboxylase. Nature 215 (1967) 852-853
    • (1967) Nature , vol.215 , pp. 852-853
    • Bartholini, G.1    Burkard, W.P.2    Pletscher, A.3    Bates, H.M.4
  • 21
    • 0001077883 scopus 로고
    • O-methylation of epinephrine and other catecholamines in vitro and in vivo
    • Axelrod J. O-methylation of epinephrine and other catecholamines in vitro and in vivo. Science 126 (1957) 400-401
    • (1957) Science , vol.126 , pp. 400-401
    • Axelrod, J.1
  • 22
  • 23
    • 0022369108 scopus 로고
    • Catecholamine metabolism: basic aspects and clinical significance
    • Kopin I.J. Catecholamine metabolism: basic aspects and clinical significance. Pharmacol Rev 37 (1985) 333-364
    • (1985) Pharmacol Rev , vol.37 , pp. 333-364
    • Kopin, I.J.1
  • 24
    • 34748819354 scopus 로고    scopus 로고
    • Catechol-O-methyltransferase and its inhibitors in Parkinson's disease
    • Bonifácio M.J., Plama P.N., Almeida L., and Soares-da-Silva P. Catechol-O-methyltransferase and its inhibitors in Parkinson's disease. CNS Drug Rev 13 (2007) 352-379
    • (2007) CNS Drug Rev , vol.13 , pp. 352-379
    • Bonifácio, M.J.1    Plama, P.N.2    Almeida, L.3    Soares-da-Silva, P.4
  • 26
    • 38449091547 scopus 로고    scopus 로고
    • Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects
    • Nagatsu T., and Sawada M. Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects. J Neural Transm Suppl 72 (2007) 113-120
    • (2007) J Neural Transm , Issue.SUPPL. 72 , pp. 113-120
    • Nagatsu, T.1    Sawada, M.2
  • 27
    • 34249791777 scopus 로고    scopus 로고
    • Dopaminergic neurons intrinsic to the striatum
    • Huot P., and Parent A. Dopaminergic neurons intrinsic to the striatum. J Neurochem 101 (2007) 1441-1447
    • (2007) J Neurochem , vol.101 , pp. 1441-1447
    • Huot, P.1    Parent, A.2
  • 28
    • 34548150970 scopus 로고    scopus 로고
    • Localization of l-DOPA uptake and decarboxylating neuronal structures in the cat brain using dopamine immunohistochemistry
    • Kitahama K., Geffard M., Araneda S., Arai R., Ogawa K., Nagatsu I., et al. Localization of l-DOPA uptake and decarboxylating neuronal structures in the cat brain using dopamine immunohistochemistry. Brain Res 1167 (2007) 56-70
    • (2007) Brain Res , vol.1167 , pp. 56-70
    • Kitahama, K.1    Geffard, M.2    Araneda, S.3    Arai, R.4    Ogawa, K.5    Nagatsu, I.6
  • 29
    • 34548024827 scopus 로고    scopus 로고
    • Immunohistochemical detection of l-DOPA-derived dopamine within serotonergic fibers in the striatum and the substantia nigra pars reticulata in Parkinsonian model rats
    • Yamada H., Aimi Y., Nagatsu I., Taki K., Kudo M., and Arai R. Immunohistochemical detection of l-DOPA-derived dopamine within serotonergic fibers in the striatum and the substantia nigra pars reticulata in Parkinsonian model rats. Neurosci Res 59 (2007) 1-7
    • (2007) Neurosci Res , vol.59 , pp. 1-7
    • Yamada, H.1    Aimi, Y.2    Nagatsu, I.3    Taki, K.4    Kudo, M.5    Arai, R.6
  • 30
  • 31
    • 33646076457 scopus 로고    scopus 로고
    • Practice parameter: Treatment of Parkinson disease with motor fluctuations and dyskinesia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology
    • Pahwa R., Factor S.A., Lyons K.E., Ondo W.G., Gronseth G., Bronte-Stewart H., et al. Practice parameter: Treatment of Parkinson disease with motor fluctuations and dyskinesia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 66 (2006) 983-995
    • (2006) Neurology , vol.66 , pp. 983-995
    • Pahwa, R.1    Factor, S.A.2    Lyons, K.E.3    Ondo, W.G.4    Gronseth, G.5    Bronte-Stewart, H.6
  • 33
    • 36549085132 scopus 로고    scopus 로고
    • Systemic administration of an mgluR5 antagonist, but not unilateral subthalamic lesion, counteracts l-DOPA-induced dyskinesia in a rodent model of Parkinson's disease
    • Levandis G., Bazzini E., Armentero M.T., Nappi G., and Blandini F. Systemic administration of an mgluR5 antagonist, but not unilateral subthalamic lesion, counteracts l-DOPA-induced dyskinesia in a rodent model of Parkinson's disease. Neurobiol Dis 29 (2008) 161-168
    • (2008) Neurobiol Dis , vol.29 , pp. 161-168
    • Levandis, G.1    Bazzini, E.2    Armentero, M.T.3    Nappi, G.4    Blandini, F.5
  • 34
    • 35348938494 scopus 로고    scopus 로고
    • Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: Role of CB(1) and TRPV1 receptors
    • Morgese M.G., Cassano T., Cuomo V., and Giuffrida A. Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: Role of CB(1) and TRPV1 receptors. Exp Neurol 208 (2007) 110-119
    • (2007) Exp Neurol , vol.208 , pp. 110-119
    • Morgese, M.G.1    Cassano, T.2    Cuomo, V.3    Giuffrida, A.4
  • 35
    • 33747061265 scopus 로고    scopus 로고
    • A role for vanilloid receptor 1 (TRPV1) and endocarnnabinoid signaling of spontaneous and l-dopa induced locomotion in normal and reserpine-treated rats
    • Lee J., Di Marzo V., and Brotchie J.M. A role for vanilloid receptor 1 (TRPV1) and endocarnnabinoid signaling of spontaneous and l-dopa induced locomotion in normal and reserpine-treated rats. Neuropharmacology 51 (2006) 557-565
    • (2006) Neuropharmacology , vol.51 , pp. 557-565
    • Lee, J.1    Di Marzo, V.2    Brotchie, J.M.3
  • 36
    • 33745605176 scopus 로고    scopus 로고
    • Drug insight: Continuous dopaminergic stimulation in the treatment of Parkinson's disease
    • Olanow C.W., Obeso J.A., and Stocchi F. Drug insight: Continuous dopaminergic stimulation in the treatment of Parkinson's disease. Nature Clin Pract Neurol 2 (2006) 382-392
    • (2006) Nature Clin Pract Neurol , vol.2 , pp. 382-392
    • Olanow, C.W.1    Obeso, J.A.2    Stocchi, F.3
  • 37
    • 20844454214 scopus 로고    scopus 로고
    • Intermittent versus continuous levodopa administration in patients with advanced Parkinson disease: a clinical and pharmacokinetic study
    • Stocchi F., Vacca L., Ruggieri S., and Olanow C.W. Intermittent versus continuous levodopa administration in patients with advanced Parkinson disease: a clinical and pharmacokinetic study. Arch Neurol 62 (2005) 905-910
    • (2005) Arch Neurol , vol.62 , pp. 905-910
    • Stocchi, F.1    Vacca, L.2    Ruggieri, S.3    Olanow, C.W.4
  • 38
    • 34447627504 scopus 로고    scopus 로고
    • Dopamine released from 5-HT terminals is the cause of l-DOPA-induced dyskinesia in parkinsonian rats
    • Carta M., Carlsson T., Kirik D., and Björklund A. Dopamine released from 5-HT terminals is the cause of l-DOPA-induced dyskinesia in parkinsonian rats. Brain 130 (2007) 1819-1833
    • (2007) Brain , vol.130 , pp. 1819-1833
    • Carta, M.1    Carlsson, T.2    Kirik, D.3    Björklund, A.4
  • 39
    • 34547484764 scopus 로고    scopus 로고
    • Serotonin neuron transplants exacerbate l-DOPA-induced dyskinesia in a rat model of Parkinson's disease
    • Carlsson T., Carta M., Winkler C., Björklund A., and Kirik D. Serotonin neuron transplants exacerbate l-DOPA-induced dyskinesia in a rat model of Parkinson's disease. J Neurosci 27 (2007) 8011-8022
    • (2007) J Neurosci , vol.27 , pp. 8011-8022
    • Carlsson, T.1    Carta, M.2    Winkler, C.3    Björklund, A.4    Kirik, D.5
  • 41
    • 58149137635 scopus 로고    scopus 로고
    • DOPA as a neurotransmitter candidate
    • Misu Y., and Goshima Y. (Eds), CRC Taylor & Francis, Boca Raton
    • Misu Y., and Goshima Y. DOPA as a neurotransmitter candidate. In: Misu Y., and Goshima Y. (Eds). Neurobiology of DOPA as a neurotransmitter (2006), CRC Taylor & Francis, Boca Raton 23-34
    • (2006) Neurobiology of DOPA as a neurotransmitter , pp. 23-34
    • Misu, Y.1    Goshima, Y.2
  • 42
    • 34447628675 scopus 로고    scopus 로고
    • In vivo evidence of D-3 dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesias
    • Sanchez-Pernaute R., Jenkins B.G., Choi J.K., Chen Y., and Isacson O. In vivo evidence of D-3 dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesias. Neurobiol Disease 27 (2007) 220-227
    • (2007) Neurobiol Disease , vol.27 , pp. 220-227
    • Sanchez-Pernaute, R.1    Jenkins, B.G.2    Choi, J.K.3    Chen, Y.4    Isacson, O.5
  • 43
    • 0035434121 scopus 로고    scopus 로고
    • Pathophysiology of levodopa-induced dyskinesia: potential or new therapies
    • Bezard E., Brotchie J.M., and Gross C.E. Pathophysiology of levodopa-induced dyskinesia: potential or new therapies. Nature Rev Neurosci 2 (2001) 577-588
    • (2001) Nature Rev Neurosci , vol.2 , pp. 577-588
    • Bezard, E.1    Brotchie, J.M.2    Gross, C.E.3
  • 44
    • 19944427055 scopus 로고    scopus 로고
    • Increased D1 dopamine receptor signaling in levodopa-induced dyskinesia
    • Aubert I., Guigoni C., Hakansson K., Li Q., Dovero S., Barthe N., et al. Increased D1 dopamine receptor signaling in levodopa-induced dyskinesia. Ann Neurol 57 (2005) 17-26
    • (2005) Ann Neurol , vol.57 , pp. 17-26
    • Aubert, I.1    Guigoni, C.2    Hakansson, K.3    Li, Q.4    Dovero, S.5    Barthe, N.6
  • 45
    • 19944428022 scopus 로고    scopus 로고
    • Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum
    • Valjent E., Pascoli V., Svenningsson P., Paul S., Enslen H., Corvol J.C., et al. Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum. Proc Natl Acad Sci USA 102 (2005) 491-496
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 491-496
    • Valjent, E.1    Pascoli, V.2    Svenningsson, P.3    Paul, S.4    Enslen, H.5    Corvol, J.C.6
  • 46
    • 34347357671 scopus 로고    scopus 로고
    • Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in l-DOPA-induced dyskinesia
    • Santini E., Valjent E., Usiello A., Carta M., Borgkvist A., Girault J.-A., et al. Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in l-DOPA-induced dyskinesia. J Neurosci 27 (2007) 6695-7005
    • (2007) J Neurosci , vol.27 , pp. 6695-7005
    • Santini, E.1    Valjent, E.2    Usiello, A.3    Carta, M.4    Borgkvist, A.5    Girault, J.-A.6
  • 47
    • 34447295080 scopus 로고    scopus 로고
    • Dopamine depletion and subsequent treatment with l-DOPA, but not the long-lived dopamine agonist pergolide, enhances activity of the Akt pathway in the rat striatum
    • Bychkov E., Ahmed M.R., Dalbyk N., and Gurevich E.V. Dopamine depletion and subsequent treatment with l-DOPA, but not the long-lived dopamine agonist pergolide, enhances activity of the Akt pathway in the rat striatum. J Neurochem 102 (2007) 699-711
    • (2007) J Neurochem , vol.102 , pp. 699-711
    • Bychkov, E.1    Ahmed, M.R.2    Dalbyk, N.3    Gurevich, E.V.4
  • 48
    • 1842787936 scopus 로고    scopus 로고
    • Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade
    • Beaulieu J.M., Sotnikova T.D., Yao W.D., Kockeritz L., Woodgett J.R., Gainetdinov R.R., et al. Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade. Proc Nat Acad Sci USA 101 (2004) 5099-5104
    • (2004) Proc Nat Acad Sci USA , vol.101 , pp. 5099-5104
    • Beaulieu, J.M.1    Sotnikova, T.D.2    Yao, W.D.3    Kockeritz, L.4    Woodgett, J.R.5    Gainetdinov, R.R.6
  • 49
    • 22744449073 scopus 로고    scopus 로고
    • An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
    • Beaulieu J.M., Sotnikova T.D., Marion S., Lefkowitz R.J., Gainetdinov R.R., and Caron M.G. An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 122 (2005) 261-273
    • (2005) Cell , vol.122 , pp. 261-273
    • Beaulieu, J.M.1    Sotnikova, T.D.2    Marion, S.3    Lefkowitz, R.J.4    Gainetdinov, R.R.5    Caron, M.G.6
  • 50
    • 0029775677 scopus 로고    scopus 로고
    • Is levodopa toxic?
    • Fahn S. Is levodopa toxic?. Neurology 47 Suppl 3 (1996) S184-S195
    • (1996) Neurology , vol.47 , Issue.SUPPL. 3
    • Fahn, S.1
  • 51
    • 0031899713 scopus 로고    scopus 로고
    • Levodopa: is toxicity a myth?
    • Agid Y. Levodopa: is toxicity a myth?. Neurology 50 (1998) 858-863
    • (1998) Neurology , vol.50 , pp. 858-863
    • Agid, Y.1
  • 52
    • 33749002240 scopus 로고    scopus 로고
    • Levodopár toxic or neuroprotective?
    • Weiner W.J. Levodopár toxic or neuroprotective?. Nature Clin Pract Neurol 2 (2006) 518-519
    • (2006) Nature Clin Pract Neurol , vol.2 , pp. 518-519
    • Weiner, W.J.1
  • 53
    • 0042868558 scopus 로고    scopus 로고
    • Autosomal dominant guanosine triphosphate cyclohydrolase I deficiency (Segawa disease)
    • Segawa M., Nomura Y., and Nishiyama N. Autosomal dominant guanosine triphosphate cyclohydrolase I deficiency (Segawa disease). Ann Neurol 54 Suppl 6 (2003) S32-S45
    • (2003) Ann Neurol , vol.54 , Issue.SUPPL. 6
    • Segawa, M.1    Nomura, Y.2    Nishiyama, N.3
  • 54
    • 0028151448 scopus 로고
    • Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene
    • Ichinose H., Ohye T., Takahashi E., Seki N., Hori T., Segawa M., et al. Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene. Nature Genet 8 (1994) 236-242
    • (1994) Nature Genet , vol.8 , pp. 236-242
    • Ichinose, H.1    Ohye, T.2    Takahashi, E.3    Seki, N.4    Hori, T.5    Segawa, M.6
  • 55
    • 19744378296 scopus 로고    scopus 로고
    • Levodopa and the progression of Parkinson's disease
    • The Parkinson Study Group. Levodopa and the progression of Parkinson's disease. New Engl J Med 351 (2004) 2498-2508
    • (2004) New Engl J Med , vol.351 , pp. 2498-2508
    • The Parkinson Study Group1
  • 56
    • 33745786419 scopus 로고    scopus 로고
    • Disease progression and pharmacodynamics in Parkinson Diseasér vidence for functional protection with levodopa and other treatments
    • Holford N.H.G., Chan P.L.S., Nutt J.G., Kieburtz K., Shoulson I., and Parkinson Study Group. Disease progression and pharmacodynamics in Parkinson Diseasér vidence for functional protection with levodopa and other treatments. J Pharmacokinet Pharmacodyn 33 (2006) 281-311
    • (2006) J Pharmacokinet Pharmacodyn , vol.33 , pp. 281-311
    • Holford, N.H.G.1    Chan, P.L.S.2    Nutt, J.G.3    Kieburtz, K.4    Shoulson, I.5    Parkinson Study Group6
  • 57
    • 33947105151 scopus 로고    scopus 로고
    • Levodopa slows progression of Parkinson's disease. External validation by clinical trial simulation
    • Chan P.L.S., Nutt J.G., and Hoford N.H.G. Levodopa slows progression of Parkinson's disease. External validation by clinical trial simulation. Pharmaceutical Res 24 (2007) 791-802
    • (2007) Pharmaceutical Res , vol.24 , pp. 791-802
    • Chan, P.L.S.1    Nutt, J.G.2    Hoford, N.H.G.3
  • 58
    • 34248550990 scopus 로고    scopus 로고
    • Neuroprotection for Parkinson's disease
    • LeWitt P.A. Neuroprotection for Parkinson's disease. J Neural Transm Suppl 71 (2006) 113-122
    • (2006) J Neural Transm , Issue.SUPPL. 71 , pp. 113-122
    • LeWitt, P.A.1
  • 59
    • 34248524384 scopus 로고    scopus 로고
    • Molecular mechanism of the relation of monoamine oxidase B and its inhibitors to Parkinson's disease: possible implications of glial cells
    • Nagatsu T., and Sawada M. Molecular mechanism of the relation of monoamine oxidase B and its inhibitors to Parkinson's disease: possible implications of glial cells. J Neural Transm Suppl 71 (2006) 53-65
    • (2006) J Neural Transm , Issue.SUPPL. 71 , pp. 53-65
    • Nagatsu, T.1    Sawada, M.2
  • 60
    • 33645307953 scopus 로고    scopus 로고
    • The therapeutic potential of monoamine oxidase inhibitors
    • Youdim M.B.H., Edmondson D., and Tipton K.F. The therapeutic potential of monoamine oxidase inhibitors. Nature Rev Neurosci 7 (2006) 295-303
    • (2006) Nature Rev Neurosci , vol.7 , pp. 295-303
    • Youdim, M.B.H.1    Edmondson, D.2    Tipton, K.F.3
  • 62
    • 0026600902 scopus 로고
    • Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic l-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesis
    • Sumi-Ichinose C., Ichinose H., Takahashi E., Hori T., and Nagatsu T. Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic l-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesis. Biochemistry 31 (1992) 2229-2238
    • (1992) Biochemistry , vol.31 , pp. 2229-2238
    • Sumi-Ichinose, C.1    Ichinose, H.2    Takahashi, E.3    Hori, T.4    Nagatsu, T.5
  • 63
    • 0036210202 scopus 로고    scopus 로고
    • Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes
    • Muramatsu S., Fujimoto K., Ikeguchi K., Shimizu N., Kawasaki K., Ono F., et al. Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes. Human Gene Therapy 13 (2002) 345-354
    • (2002) Human Gene Therapy , vol.13 , pp. 345-354
    • Muramatsu, S.1    Fujimoto, K.2    Ikeguchi, K.3    Shimizu, N.4    Kawasaki, K.5    Ono, F.6
  • 64
    • 37549059628 scopus 로고    scopus 로고
    • Current status of gene therapy trials for Parkinson's disease
    • Fiandaca M., Forsayeth J., and Bankiewicz K.S. Current status of gene therapy trials for Parkinson's disease. Exp Neurol 209 (2008) 51-57
    • (2008) Exp Neurol , vol.209 , pp. 51-57
    • Fiandaca, M.1    Forsayeth, J.2    Bankiewicz, K.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.