An increased regional blood flow precedes mesenteric inflammation in rats treated by a phosphodiesterase 4 inhibitor

Toxicological Sciences

Volumn 107, Issue 1, 2009, Pages 298-305

  Korkmaz, Sevil ^a   Maupoil, Véronique ^a   Sobry, Cécile ^b   Brunet, Chloé ^a   Chevalier, Stephan ^b   Freslon, Jean Luis ^a  

^a UNIVERSITÉ DE TOURS   (France)

^b PFIZER INC   (United States)

Author keywords

Drug induced vascular injury; Mesenteric artery; Mesenteric blood flow; PDE4 inhibitor; Vasoreactivity

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; CI 1044; PHOSPHODIESTERASE IV INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOWMETRY; BLOOD PRESSURE MEASUREMENT; BLOOD VESSEL INJURY; CONCENTRATION RESPONSE; CONTROLLED STUDY; HEART OUTPUT; INTESTINE BLOOD FLOW; MACROPHAGE; MALE; MESENTERITIS; MESENTERY BLOOD FLOW; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PATHOLOGICAL ANATOMY; RAT; VASCULAR RESISTANCE; VASODILATATION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANALYSIS OF VARIANCE; ANIMALS; AZEPINES; BLOOD PRESSURE; CARDIAC OUTPUT; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DUODENUM; HEART; HEMODYNAMICS; ILEUM; INFLAMMATION; JEJUNUM; MALE; MESENTERIC ARTERIES; MUSCLE, SKELETAL; NECROSIS; NIACINAMIDE; NOREPINEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; SPLANCHNIC CIRCULATION;

ANIMALIA; RATTUS;

EID: 58049211930     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn218     Document Type: Article

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