Mesenteritis precedes vasculitis in the rat mesentery after subacute administration of a phosphodiesterase type 4 inhibitor

Toxicology Letters

Volumn 163, Issue 1, 2006, Pages 54-64

  Mecklenburg, Lars ^a   Heuser, Anke ^a   Juengling, Tobias ^a   Kohler, Manfred ^a   Foell, Roman ^a   Ockert, Deborah ^a   Tuch, Klaus ^a   Bode, Gerd ^a  

^a ALTANA PHARMA AG   (Germany)

Author keywords

Arteritis; cAMP; Polyarteritis nodosa; Vasculitis

Indexed keywords

BYK 169171; FENOLDOPAM; PHOSPHODIESTERASE IV INHIBITOR;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTERITIS; ARTICLE; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE SEVERITY; DOSE RESPONSE; FIBROSIS; IMMUNOHISTOLOGY; INFLAMMATION; MESENTERITIS; MORPHOMETRICS; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PRIORITY JOURNAL; RAT; VASCULITIS;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ANIMALS; FIBROSIS; JEJUNUM; MALE; MESENTERY; PERITONITIS; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, WISTAR; VASCULITIS;

ANIMALIA;

EID: 33644824002     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2005.09.037     Document Type: Article

References (28)

1. M.S. Barnette Phosphodiesterase 4 (PDE4) inhibitors in asthma and chronic obstructive pulmonary disease (COPD) Progress. Drug. Res. 53 1999 195 229
2. J.J. Collins, M.R. Elwell, J.C. Lamb, A.G. Manus, J.E. Heath, and G.T. Makovec Subchronic toxicity of orally administered (gavage and dose-feed) theophylline in Fischer 344 rats and B6C3F1 mice Fundam. Appl. Toxicol. 11 1988 472 484
3. A.J. Duplantier, M.S. Bigers, R.J. Chambers, J.B. Cheng, K. Cooper, D.B. Damon, J.F. Eggler, K.G. Kraus, A. Marfat, H. Masamune, J.S. Pillar, J.T. Shirley, J.P. Umland, and J.W. Watson Biarylcarboxylic acids and amides: inhibition of phosphodiesterase type IV versus [3H]rolipram binding activity and their relationship to emetic behavior in the ferret J. Med. Chem. 39 1996 120 125
4. G. Hanton, J.L. LeNet, B. Ruty, and B. Leblanc Characterization of the arteritis induced by infusion of rats with UK-61,260, an inodilator, for 24 h Arch. Toxicol. 69 1995 698 704
5. Hess, R.A., Moore, B.J., 1993. Histological methods for evaluation of the testis. In: Chapin, B., Heindel, J. (Eds.), Methods in Toxicology. Academic press, London, pp. 52-85.
6. H. Ikegami, S. Kajikawa, K. Ito, H. Miura, A. Nii, H. Okamiya, H. Nakayama, and K. Doi Histopathological and immunohistochemical studies on fenoldopam-induced arteritis in rats Toxicol. Pathol. 31 Suppl. 2003 145
7. H. Ikegami, T. Shishido, K. Ishida, T. Hanada, H. Nakayama, and K. Doi Histopathological and immunohistochemical studies on arteritis induced by fenoldopam, a vasodilator, in rats Exp. Toxicol. Pathol. 53 2001 25 30
8. E.C. Joseph, J.A. Rees, and A.D. Dayan Mesenteric arteriopathy in the rat induced by phosphodiesterase III inhibitors: an investigation of morphological, ultrastructural, and hemodynamic changes Toxicol. Pathol. 24 1996 436 450
9. W.D. Kerns, E. Arena, R.A. Macia, P.J. Bugelski, W.D. Matthews, and D.G. Morgan Pathogenesis of arterial lesions induced by dopaminergic compounds in the rat Toxicol. Pathol. 17 1989 203 213
10. W.D. Kerns, E. Arena, and D.G. Morgan Role of dopaminergic and adrenergic receptors in the pathogenesis of arterial lesions induced by fenoldopam mesylate and dopamine in the rat Am. J. Pathol. 135 1989 339 349
11. W.D Kerns, L. Schwartz, K. Blanchard, S. Burchiel, D. Essayan, E. Fung, R. Johnson, M. Lawton, C. Louden, J. MacGregor, F. Miller, P. Nagarkatti, D. Robertson, P. Snyder, H. Thomas, B. Wagner, A. Ward, and J. Zhang Drug-induced vascular injury - a quest for biomarkers Toxicol. Appl. Pharmacol. 203 2005 62 87
12. V. Kumar, A.K. Abbas, and N. Fausto Robbins and Cotran Pathologic Basis of Disease 7th ed. 2004 WB Saunders Company Philadelphia pp. 4-144
13. J.L. Larson, M.V. Pino, L.E. Geiger, and C.R. Simeone The toxicity of repeated exposures to rolipram, a type IV phosphodiesterase inhibitor, in rats Pharmacol. Toxicol. 78 1996 44 49
14. A. Nyska, R.A. Herbert, P.C. Chan, J.K. Haseman, and J.R. Hailey Theophylline-induced mesenteric periarteritis in F344/N rats Arch. Toxicol. 72 1991 731 737
15. D.H. Percy, and S.W. Barthold Pathology of laboratory rodents and rabbits 2001 Iowa State Press Ames p. 153
16. D.G. Robertson, M.D. Reily, M. Albassam, and L.A. Dethloff Metabonomic assessment of vasculitis in rats Cardiovasc. Toxicol. 1 2001 7 19
17. A. Robichaud, F.D. Tattersall, I. Choudhury, and I.W. Rodger Emesis induced by inhibitors of type 4 cyclic nucleotide phosphodiesterase (PDE IV) in the ferret Neuropharmacology 38 1999 289 297
18. G.E. Sandusky, R.B. Franklin, and J.R. Means Acute, subchronic, and chronic toxicity of the cardiotonic isomazole in rats Fundam. Appl. Toxicol. 13 1989 409 417
19. G.E. Sandusky, and J.R. Means Acute and subchronic toxicology of LY-195115 in rats and dogs Toxicol. Lett. 38 1987 177 186
20. R.M. Slim, D.G. Robertson, M. Albassam, M.D. Reily, M.D. Robosky, and L.A. Dethloff Effect of dexamethasone on the metabonomics profile associated with phosphodiesterase inhibitor-induced vascular lesions in rats Toxicol. Appl. Pharmacol. 183 2002 108 116
21. R.M. Slim, Y. Song, M. Albassam, and L.A. Dethloff Apoptosis and nitrative stress associated with phosphodiesterase inhibitor-induced mesenteric vasculitis in rats Toxicol. Pathol. 31 2003 638 645
22. T.J. Torphy, M.S. Barnette, D.C. Underwood, D.E. Griswold, S.B. Christensen, R.D. Murdoch, R.B. Nieman, and C.H. Compton Ariflo (SB 207499), a second generation phosphodiesterase 4 inhibitor for the treatment of asthma and COPD: from concept to clinic Pulm. Pharmacol. Ther. 12 1999 131 135
23. T.J. Torphy, B.J. Undem, L.B. Cieslinski, M.A. Luttmann, M.L. Reeves, and D.W. Hay Identification, characterization and functional role of phosphodiesterase isoenzymes in human airway smooth muscle J. Pharmacol. Exp. Ther. 265 1993 1213 1223
24. T.J. Torphy, and B.J. Undem Phosphodiesterase inhibitors: new opportunities for the treatment of asthma Thorax 46 1991 512 523
25. F.R. Westwood, T.J. Iswaran, and P. Greaves Long-term effects of an inotropic phosphodiesterase inhibitor (ICI 153, 110) on the rat salivary gland, harderian gland, and intestinal mucosa Toxicol. Pathol. 19 1991 214 223
26. F.R. Westwood, T.J. Iswaran, and P. Greaves Pathologic changes in blood vessels following administration of an inotropic vasodilator (ICI 153, 110) to the rat Fundam. Appl. Toxicol. 14 1990 797 809
27. E.M. Yuhas, D.G. Morgan, E. Arena, R.P. Kupp, L.Z. Saunders, and H.B. Lewis Arterial medial necrosis and hemorrhage induced in rats by intravenous infusion of fenoldopam mesylate, a dopaminergic vasodilator Am. J. Pathol. 119 1985 83 91
28. J. Zhang, E.H. Herman, A. Knapton, D.P. Chadwick, V.E. Whitehurst, J.E. Koerner, T. Papoian, V.J. Ferrans, and F.D. Sistare SK&F95654-induced acute cardiovascular toxicity in Sprague-Dawley rats - histopathologic, elecron microscopic, and immunohistochemical studies Toxicol. Pathol. 30 2002 28 40