HAT cofactor TRRAP mediates β-catenin ubiquitination on the chromatin and the regulation of the canonical Wnt pathway

Cell Cycle

Volumn 7, Issue 24, 2008, Pages 3908-3914

  Finkbeiner, Martin G ^a   Sawan, Carla ^a   Ouzounova, Maria ^a   Murr, Rabih ^a   Herceg, Zdenko ^a  

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

Chromatin; TRRAP; Ubiquitination; Wnt pathway; catenin

Indexed keywords

BETA CATENIN; HISTONE ACETYLTRANSFERASE; WNT PROTEIN;

ARTICLE; CHROMATIN; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; REGULATORY MECHANISM; UBIQUITINATION;

EID: 58049202113     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.7.24.7354     Document Type: Article

References (20)

1. Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005; 434:843-50.
2. Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006; 127:469-80.
3. Polakis P. Wnt signaling and cancer. Genes Dev 2000; 14:1837-51.
4. Bienz M, Clevers H. Armadillo/beta-catenin signals in the nucleus - proof beyond a reasonable doubt? Nat Cell Biol 2003; 5:179-82.
5. Aberle H, Bauer A, Stappert J, Kispert A, Kemler R. beta-catenin is a target for the ubiquitin-proteasome pathway. Embo J 1997; 16:3797-804.
6. Matsuzawa SI, Reed JC. Siah-1, SIP and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. Mol Cell 2001; 7:915-26.
7. Liu J, Stevens J, Rote CA, Yost HJ, Hu Y, Neufeld KL, White RL, Matsunami N. Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol Cell 2001; 7:927-36.
8. Rosin-Arbesfeld R, Cliffe A, Brabletz T, Bienz M. Nuclear export of the APC tumor suppressor controls beta-catenin function in transcription. Embo J 2003; 22:1101-13.
9. Cong F, Varmus H. Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin. Proc Natl Acad Sci USA 2004; 101:2882-7.
10. Sierra J, Yoshida T, Joazeiro CA, Jones KA. The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. Genes Dev 2006; 20:586-600.
11. Murr R, Loizou JI, Yang YG, Cuenin C, Li H, Wang ZQ, Herceg Z. Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks. Nat Cell Biol 2006; 8:91-9.
12. Lee JH, Paull TT. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science 2004; 304:93-6.
13. Mendez J, Stillman B. Chromatin association of human origin recognition complex, cdc6 and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. Mol Cell Biol 2000; 20:8602-12.
14. Li H, Cuenin C, Murr R, Wang ZQ, Herceg Z. HAT cofactor Trrap regulates the mitotic checkpoint by modulation of Mad1 and Mad2 expression. Embo J 2004; 23:4824-34.
15. Ashraf SI, Ip YT. Transcriptional control: repression by local chromatin modification. Curr Biol 1998; 8:683-6.
16. Murr R, Vaissiere T, Sawan C, Shukla V, Herceg Z. Orchestration of chromatin-based processes: mind the TRRAP. Oncogene 2007; 26:5358-72.
17. McMahon SB, Van Buskirk HA, Dugan KA, Copeland TD, Cole MD. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell 1998; 94:363-74.
18. Feng Y, Lee N, Fearon ER. TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling. Cancer Res 2003; 63:8726-34.
19. -/- colon carcinoma. Science 1997; 275:1784-7.
20. Hecht A, Vleminckx K, Stemmler MP, van Roy F, Kemler R. The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates. Embo J 2000; 19:1839-50.