Identification of osteogenic purmophamine derivatives

Molecules and Cells

Volumn 26, Issue 4, 2008, Pages 380-386

  Lee, Sung Jin ^a   Lee, Hak Kyo ^b   Cho, Sung Yun ^c   Choi, Joong Kwon ^c   Shin, Hea Kyeong ^d   Kwak, Eun Jung ^e   Cho, Mi Ran ^e   Kim, Hye Ryun ^e   Kim, Seung Ryol ^e   Kim, Yong Min ^e   Park, Kyoung Jin ^e   Choi, Joong Kook ^e  

^a Kangwon National University   (South Korea)

^b Hankyong National University   (South Korea)

^c Korea Research Institute of Chemical Technology   (South Korea)

^d Dongguk University College of Medicine   (South Korea)

^e Chungbuk National University College of Medicine   (South Korea)

Author keywords

Alkaline phosphatase assay; C2C12 preosteoblasts; Osteogenesis; Pumorphamine; Sonic hedgehog

Indexed keywords

2 1 NAPHTHOXY 6 4 MORPHOLINOANILINO 9 CYCLOHEXYLPURIN; ALKALINE PHOSPHATASE; PURINE DERIVATIVE; PURMORPHAMINE DERIVATIVE; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; LACTATE DEHYDROGENASE; MORPHOLINE DERIVATIVE; PURMORPHAMINE;

ANIMAL CELL; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DNA MICROARRAY; DRUG DETERMINATION; DRUG SCREENING; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STEM CELL; ANIMAL; CELL DEATH; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM;

ERINACEIDAE;

ANIMALS; CELL DEATH; CELL DIFFERENTIATION; CELL LINE; GENE EXPRESSION REGULATION; L-LACTATE DEHYDROGENASE; MICE; MORPHOLINES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOBLASTS; OSTEOGENESIS; PURINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 58049193701     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Akiyama, H., Chaboissier, M.C., Martin, J.F., Schedl, A., and de Crombrugghe, B. (2002). The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 16, 2813-2828.
2. Beloti, M.M., Bellesini, L.S., and Rosa, A.L. (2005). Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Cell Biol. Int. 29, 537-541.
3. Cancedda, R., Castagnola, P., Cancedda, F.D., Dozin, B., and Quarto, R. (2000). Developmental control of chondrogenesis and osteogenesis. Int. J. Dev. Biol. 44, 707-714.
4. Chen, S., Zhang, Q., Wu, X., Schultz, P.G., and Ding, S. (2004). Dedifferentiation of lineage-committed cells by a small molecule. J. Am. Chem. Soc. 126, 410-411
5. Cohen, M.M. Jr. (2006). The new bone biology: Pathologic, molecular, and clinical correlates. Am. J. Med. Genet. A 140, 2646-2706.
6. Eames, B.F., de la, F.L., and Helms, J.A. (2003). Molecular ontogeny of the skeleton. Birth Defects Res. C. Embryo. Today 69, 93-101.
7. Fanganiello, R.D., Sertie, A.L., Reis, E.M., Yeh, E., Oliveira, N.A., Bueno, D.F., Kerkis, I., Alonso, N., Cavalheiro, S., Matsushita, H., et al. (2007). Apert p.Ser252Trp mutation in FGFR2 alters osteogenic potential and gene expression of cranial periosteal cells. Mol. Med. 13, 422-442.
8. Gibert, S.F. (2006). Intramembranous ossification. Dev. Biol. 8th eds., 420-421.
9. Hall, B.K., and Miyake, T. (1992). The membranous skeleton: the role of cell condensations in vertebrate skeletogenesis. Anat. Embryol. 186, 107-124.
10. Hammerschmidt, M., Brook, A., and McMahon, A.P. (1997). The world according to hedgehog. Trends Genet. 13, 14-21.
11. Harris, S.E., Guo, D., Harris, M.A., Krishnaswamy, A., and Lichtler, A. (2003). Transcriptional regulation of BMP-2 activated genes in osteoblasts using gene expression microarray analysis: role of Dlx2 and Dlx5 transcription factors. Front Biosci. 8, S1249-1265.
12. Iwamoto, M., Enomoto-Iwamoto, M., and Kurisu, K. (1999). Actions of hedgehog proteins on skeletal cells. Crit. Rev. Oral. Biol. Med. 10, 477-486.
13. James, C.G., Appleton, C.T., Ulici, V., Underhill, T.M., and Beier, F. (2005). Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy. Mol. Biol. Cell 16, 5316-5333.
14. Karsenty, G., and Wagner, E.F. (2002). Reaching a genetic and molecular understanding of skeletal development. Dev. Cell 2, 389-406.
15. Kronenberg, H.M. (2003). Developmental regulation of the growth plate. Nature 423, 332-336.
16. Lee, J.S., Thomas, D.M., Gutierrez, G., Carty, S.A., Yanagawa, S., and Hinds, P.W. (2006). HES1 cooperates with pRb to activate RUNX2-dependent transcription. J. Bone Miner. Res. 21, 921-933.
17. Lee, S.K., Lee, Z.H., Lee, S.J., Ahn, B.D., Kim, Y.J., Lee, S.H., and Kim, J.W. (2008). DLX3 mutation in a new family and its phenotypic variations. J. Dent. Res. 87, 354-357.
18. Lengner, C.J., Steinman, H.A., Gagnon, J., Smith, T.W., Henderson, J.E., Kream, B.E., Stein, G.S., Lian, J.B., and Jones, S.N. (2006). Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling. J. Cell Biol. 172, 909-921.
19. Matsuo, N., Tanaka, S., Gordon, M.K., Koch, M., Yoshioka, H., and Ramirez, F. (2006). CREB-AP1 protein complexes regulate transcription of the collagen XXIV gene (Col24a1) in osteoblasts. J. Biol. Chem. 281, 5445-5452.
20. Merlo, G.R., Zerega, B., Paleari, L., Trombino, S., Mantero, S., and Levi, G. (2000). Multiple functions of Dlx genes. Int. J. Dev. Biol. 44, 619-626.
21. Perrimon, N. (1995). Hedgehog and beyond. Cell 80, 517-520.
22. Sapkota, G., Alarcon, C., Spagnoli, F.M., Brivanlou, A.H., and Massague, J. (2007). Balancing BMP signaling through integrated inputs into the Smad1 linker. Mol. Cell 25, 441-454.
23. Shum, L., and Nuckolls, G. (2002). The life cycle of chondrocytes in the developing skeleton. Arthritis Res. 4, 94-106.
24. Sinha, S., and Chen, J.K. (2006). Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat. Chem. Biol. 2, 29-30.
25. Spinella-Jaegle, S., Rawadi, G., Kawai, S., Gallea, S., Faucheu, C., Mollat, P., Courtois, B., Bergaud, B., Ramez, V., Blanchet, A.M., et al. (2001). Sonic hedgehog increases the com-mitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation. J. Cell. Sci. 114, 2085-2094.
26. Suh, J.H., Lee, H.W., Lee, J.W., and Kim, J.B. (2008). Hes1 stimulates transcriptional activity of Runx2 by increasing protein stabilization during osteoblast differentiation. Biochem. Biophys. Res. Commun. 367, 97-102.
27. Tataria, M., Quarto, N., Longaker, M.T., and Sylvester, K.G. (2006). Absence of the p53 tumor suppressor gene promotes osteogenesis in mesenchymal stem cells. J. Pediatr. Surg. 41, 624-632.
28. Wu, X., Ding, S., Ding, Q., Gray, N.S., and Schultz, P.G. (2002). A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. J. Am. Chem. Soc. 124, 14520-14521.
29. Wu, X., Itoh, N., Taniguchi, T., Nakanishi, T., Tatsu, Y., Yumoto, N., and Tanaka, K. (2003). Zinc-induced sodium-dependent vitamin C transporter 2 expression: potent roles in osteoblast differenttiation. Arch. Biochem. Biophys. 420, 114-120.
30. Wu, X., Walker, J., Zhang, J., Ding, S., and Schultz, P.G. (2004). Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Chem. Biol. 11, 1229-1238.
31. Yamamoto, N., Akiyama, S., Katagiri, T., Namiki, M., Kurokawa, T., and Suda, T. (1997). Smad1 and smad5 act downstream of intracellular signalings of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts. Biochem. Biophys. Res. Commun. 238, 574-580.