Endoscopic Therapy for Bleeding Ulcers: An Evidence-Based Approach Based on Meta-Analyses of Randomized Controlled Trials

Clinical Gastroenterology and Hepatology

Volumn 7, Issue 1, 2009, Pages 33-47

  Laine, Loren ^a   McQuaid, Kenneth R ^b,c  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ALCOHOL; FIBRIN GLUE; HISTAMINE H2 RECEPTOR ANTAGONIST; PLACEBO; POLIDOCANOL; PROTON PUMP INHIBITOR; SCLEROSING AGENT; THROMBIN;

ARGON PLASMA COAGULATION; ARTICLE; BLEEDING; BLEEDING TENDENCY; BLOOD CLOT; BLOOD VESSEL; BOLUS INJECTION; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; CLIP; CONTINUOUS INFUSION; DRUG EFFICACY; ELECTROCOAGULATION; ENDOSCOPIC THERAPY; EVIDENCE BASED PRACTICE; GASTROSCOPY; HEMOSTASIS; HUMAN; HYPERTHERMIC THERAPY; META ANALYSIS; OUTCOME ASSESSMENT; PEPTIC ULCER BLEEDING; PERFORATION; RANDOMIZED CONTROLLED TRIAL; RECURRENCE RISK; RECURRENT DISEASE; RETREATMENT; SYSTEMATIC REVIEW; THERAPY EFFECT;

COAGULANTS; ELECTROCOAGULATION; ENDOSCOPY, DIGESTIVE SYSTEM; EPINEPHRINE; HEMORRHAGE; HOT TEMPERATURE; HUMANS; PROTON PUMP INHIBITORS; SCLEROSING SOLUTIONS; SURGICAL INSTRUMENTS; TREATMENT OUTCOME; ULCER;

EID: 58049192926     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cgh.2008.08.016     Document Type: Article

References (126)

1. van Leerdam M., Vreeburg E., Rauws E., et al. Acute upper GI bleeding: did anything change?. Time trend analysis of incidence and outcome of acute upper GI bleeding between 1993/1994 and 2000. Am J Gastroenterol 98 (2003) 1494-1499
2. Thomopoulos K., Vagenas K., Vagianos C., et al. Changes in aetiology and clinical outcome of acute upper gastrointestinal bleeding during the last 15 years. Eur J Gastroenterol Hepatol 16 (2004) 177-182
3. Di Fiore F., Lecleire S., Merle V., et al. Changes in characteristics and outcome of acute upper gastrointestinal haemorrhage: a comparison of epidemiology and practices between 1996 and 2000 in a multicentre French study. Eur J Gastroenterol Hepatol 17 (2005) 641-647
4. Jensen D., Mawas I., Lousuebsakul V., et al. Changes in the prevalence of different diagnoses for UGI hemorrhage in the last two decades. Gastrointest Endosc 57 (2003) AB147
5. Enestvedt B., Gralnek I., Mattek N., et al. An evaluation of endoscopic indications and findings related to nonvariceal upper-GI hemorrhage in a large multicenter consortium. Gastrointest Endosc 67 (2008) 422-429
6. Laine L., and Peterson W. Bleeding peptic ulcers. N Engl J Med 331 (1994) 717-727
7. Jadad A., Moore R., and Carroll D. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Control Clin Trials 17 (1996) 1-12
8. Balanzó J., Sainz S., Such J., et al. Endoscopic hemostasis by local injection of epinephrine and polidocanol in bleeding ulcer. A prospective randomized trial. Endoscopy 20 (1988) 289-291
9. Berg P., Barina W., and Born P. Endoscopic injection of fibrin glue versus polidocanol in peptic ulcer hemorrhage: a pilot study. Endoscopy 26 (1994) 528-530
10. Bianco M., Rotondano G., Marmo R., et al. Combined epinephrine and bipolar probe coagulation vs. bipolar probe coagulation alone for bleeding peptic ulcer: a randomized, controlled trial. Gastrointest Endosc 60 (2004) 910-915
11. Brearley S., Hawker P., Dykes P., et al. Per-endoscopic bipolar diathermy coagulation of visible vessels using a 3.2 mm probe-a randomised clinical trial. Endoscopy 19 (1987) 160-163
12. Chau C., Siu W., Law B., et al. Randomized controlled trial comparing epinephrine injection plus heat probe coagulation versus epinephrine injection plus argon plasma coagulation for bleeding peptic ulcers. Gastrointest Endosc 57 (2003) 455-461
13. Choudari C., Rajgopal C., and Palmer K. Comparison of endoscopic injection therapy versus the heater probe in major peptic ulcer haemorrhage. Gut 33 (1992) 1159-1161
14. Chung S., Leung J., Sung J., et al. Injection or heat probe for bleeding ulcer. Gastroenterology 100 (1991) 33-37
15. Chung S., Leung J., Steele R., et al. Endoscopic injection of adrenaline for actively bleeding ulcers: a randomized trial. Br Med J (Clin Res Ed) 296 (1988) 1631-1633
16. Cipolletta L., Bianco M., Marmo R., et al. Endoclips versus heater probe in preventing early recurrent bleeding from peptic ulcer: a prospective and randomized trial. Gastrointest Endosc 53 (2001) 147-151
17. Cipolletta L., Bianco M., Rotondano G., et al. Prospective comparison of argon plasma coagulator and heater probe in the endoscopic treatment of major peptic ulcer bleeding. Gastrointest Endosc 48 (1998) 191-195
18. Fullarton G., Birnie G., Macdonald A., et al. Controlled trial of heater probe treatment in bleeding peptic ulcers. Br J Surg 76 (1989) 541-544
19. Gevers A., De Goede E., Simoens M., et al. A randomized trial comparing injection therapy with hemoclip and with injection combined with hemoclip for bleeding ulcers. Gastrointest Endosc 55 (2002) 466-469
20. Gralnek I., Jensen D., Gornbein J., et al. Clinical and economic outcomes of individuals with severe peptic ulcer hemorrhage and nonbleeding visible vessel: an analysis of two prospective clinical trials. Am J Gastroenterol 93 (1998) 2047-2056
21. Gralnek I., Jensen D., Kovacs T., et al. An economic analysis of patients with active arterial peptic ulcer hemorrhage treated with endoscopic heater probe, injection sclerosis, or surgery in a prospective, randomized trial. Gastrointest Endosc 46 (1997) 105-112
22. Hui W., Ng M., Lok A., et al. A randomized comparative study of laser photocoagulation, heater probe, and bipolar electrocoagulation in the treatment of actively bleeding ulcers. Gastrointest Endosc 37 (1991) 299-304
23. Jaramillo J., Carmona C., Gálvez C., et al. Efficacy of the heater probe in peptic ulcer with a non-bleeding visible vessel. A controlled, randomised study. Gut 34 (1993) 1502-1506
24. Juszkiewicz P., Wajda Z., Dobosz M., et al. The role of endoscopic thrombin injections in the treatment of gastroduodenal bleeding. S Afr J Surg 31 (1993) 98-102
25. Koyama T., Fujimoto K., Iwakiri R., et al. Prevention of recurrent bleeding from gastric ulcer with a nonbleeding visible vessel by endoscopic injection of absolute ethanol: a prospective, controlled trial. Gastrointest Endosc 42 (1995) 128-131
26. Laine L. Multipolar electrocoagulation versus injection therapy in the treatment of bleeding peptic ulcers. A prospective, randomized trial. Gastroenterology 99 (1990) 1303-1306
27. Laine L. Multipolar electrocoagulation in the treatment of peptic ulcers with nonbleeding visible vessels. A prospective, controlled trial. Ann Intern Med 110 (1989) 510-514
28. Laine L. Multipolar electrocoagulation in the treatment of active upper gastrointestinal tract hemorrhage. A prospective controlled trial. N Engl J Med 316 (1987) 1613-1617
29. Lin H., Perng C., Sun I., et al. Endoscopic haemoclip versus heater probe thermocoagulation plus hypertonic saline-epinephrine injection for peptic ulcer bleeding. Dig Liver Dis 35 (2003) 898-902
30. Lin H., Hsieh Y., Tseng G., et al. A prospective, randomized trial of endoscopic hemoclip versus heater probe thermocoagulation for peptic ulcer bleeding. Am J Gastroenterol 97 (2002) 2250-2254
31. Lin H., Hsieh Y., Tseng G., et al. Endoscopic injection with fibrin sealant versus epinephrine for arrest of peptic ulcer bleeding: a randomized, comparative trial. J Clin Gastroenterol 35 (2002) 218-221
32. Lin H., Wang K., Perng C., et al. Heater probe thermocoagulation and multipolar electrocoagulation for arrest of peptic ulcer bleeding. A prospective, randomized comparative trial. J Clin Gastroenterol 21 (1995) 99-102
33. Lin H., Wang K., Perng C., et al. Octreotide and heater probe thermocoagulation for arrest of peptic ulcer hemorrhage. A prospective, randomized, controlled trial. J Clin Gastroenterol 21 (1995) 95-98
34. Lin H., Lee F., Kang W., et al. Heat probe thermocoagulation and pure alcohol injection in massive peptic ulcer haemorrhage: a prospective, randomised controlled trial. Gut 21 (1990) 753-757
35. Lin H., Lee F., Kang W., et al. A controlled study of therapeutic endoscopy for peptic ulcer with non-bleeding visible vessel. Gastrointest Endosc 36 (1990) 241-246
36. Lin H., Tsai Y., Lee S., et al. A prospectively randomized trial of heat probe thermocoagulation versus pure alcohol injection in nonvariceal peptic ulcer hemorrhage. Am J Gastroenterol 83 (1988) 283-286
37. Llach J., Bordas J., Salmerón J., et al. A prospective randomized trial of heater probe thermocoagulation versus injection therapy in peptic ulcer hemorrhage. Gastrointest Endosc 43 (1996) 117-120
38. Lo C., Hsu P., Lo G., et al. Comparison of hemostatic efficacy for epinephrine injection alone and injection combined with hemoclip therapy in treating high-risk bleeding ulcers. Gastrointest Endosc 63 (2006) 767-773
39. Matthewson K., Swain C., Bland M., et al. Randomized comparison of Nd YAG laser, heater probe, and no endoscopic therapy for bleeding peptic ulcers. Gastroenterology 98 (1990) 1239-1244
40. Moretó M., Zaballa M., Suárez M., et al. Endoscopic local injection of ethanolamine oleate and thrombin as an effective treatment for bleeding duodenal ulcer: a controlled trial. Gut 33 (1992) 456-459
41. O'Brien J., Day S., and Burnham W. Controlled trial of small bipolar probe in bleeding peptic ulcers. Lancet 1 (1986) 464-467
42. Panés J., Viver J., Forné M., et al. Controlled trial of endoscopic sclerosis in bleeding peptic ulcers. Lancet 2 (1987) 1292-1294
43. Rutgeerts P., Rauws E., Wara P., et al. Randomised trial of single and repeated fibrin glue compared with injection of polidocanol in treatment of bleeding peptic ulcer. Lancet 350 (1997) 692-696
44. Rutgeerts P., Gevers A., Hiele M., et al. Endoscopic injection therapy to prevent rebleeding from peptic ulcers with a protruding vessel: a controlled comparative trial. Gut 34 (1993) 348-350
45. Rutgeerts P., Vantrappen G., Broeckaert L., et al. Comparison of endoscopic polidocanol injection and YAG laser therapy for bleeding peptic ulcers. Lancet 1 (1989) 1164-1167
46. Saltzman J., Strate L., Di Sena V., et al. Prospective trial of endoscopic clips versus combination therapy in upper GI bleeding (PROTECCT-UGI bleeding). Am J Gastroenterol 100 (2005) 1503-1508
47. Shimoda R., Iwakiri R., Sakata H., et al. Evaluation of endoscopic hemostasis with metallic hemoclips for bleeding gastric ulcer: comparison with endoscopic injection of absolute ethanol in a prospective, randomized study. Am J Gastroenterol 98 (2003) 2198-2202
48. Skok P., Krizman I., and Skok M. Argon plasma coagulation versus injection sclerotherapy in peptic ulcer hemorrhage-a prospective, controlled study. Hepatogastroenterology 51 (2004) 165-170
49. Sofia C., Portela F., Gregório C., et al. Endoscopic injection therapy vs. multipolar electrocoagulation vs. laser vs. injection + octreotide vs. injection + omeprazole in the treatment of bleeding peptic ulcers. A prospective randomized study. Hepatogastroenterology 47 (2000) 1332-1336
50. Song S., Chung J., Moon Y., et al. Comparison of the hemostatic effect of endoscopic injection with fibrin glue and hypertonic saline-epinephrine for peptic ulcer bleeding: a prospective randomized trial. Endoscopy 29 (1997) 827-833
51. Waring J., Sanowski R., Sawyer R., et al. A randomized comparison of multipolar electrocoagulation and injection sclerosis for the treatment of bleeding peptic ulcer. Gastrointest Endosc 37 (1991) 295-298
52. Balanzó J., Villanueva C., Sainz S., et al. Injection therapy of bleeding peptic ulcer. A prospective, randomized trial using epinephrine and thrombin. Endoscopy 22 (1990) 157-159
53. Choudari C., and Palmer K. Endoscopic injection therapy for bleeding peptic ulcer; a comparison of adrenaline alone with adrenaline plus ethanolamine oleate. Gut 35 (1994) 608-610
54. Chung I., Ham J., Kim H., et al. Comparison of the hemostatic efficacy of the endoscopic hemoclip method with hypertonic saline-epinephrine injection and a combination of the two for the management of bleeding peptic ulcers. Gastrointest Endosc 49 (1999) 13-18
55. Chung S., Leong H., Chan A., et al. Epinephrine or epinephrine plus alcohol for injection of bleeding ulcers: a prospective randomized trial. Gastrointest Endosc 43 (1996) 591-595
56. Chung S., Leung J., Leong H., et al. Adding a sclerosant to endoscopic epinephrine injection in actively bleeding ulcers: a randomized trial. Gastrointest Endosc 39 (1993) 611-615
57. Chung S., Lau J., Sung J., et al. Randomised comparison between adrenaline injection alone and adrenaline injection plus heat probe treatment for actively bleeding ulcers. BMJ 314 (1997) 1307-1311
58. Garrido Serrano A., Guerrero Igea F., Perianes Hernández C., et al. Local therapeutic injection in bleeding peptic ulcer: a comparison of adrenaline to adrenaline plus a sclerosing agent. Rev Esp Enferm Dig 94 (2002) 395-405
59. Kubba A., Murphy W., and Palmer K. Endoscopic injection for bleeding peptic ulcer: a comparison of adrenaline alone with adrenaline plus human thrombin. Gastroenterology 111 (1996) 623-628
60. Lin H., Tseng G., Perng C., et al. Comparison of adrenaline injection and bipolar electrocoagulation for the arrest of peptic ulcer bleeding. Gut 44 (1999) 715-719
61. Lin H., Perng C., and Lee S. Is sclerosant injection mandatory after an epinephrine injection for arrest of peptic ulcer haemorrhage?. A prospective, randomised, comparative study. Gut 34 (1993) 1182-1185
62. Pescatore P., Jornod P., Borovicka J., et al. Epinephrine versus epinephrine plus fibrin glue injection in peptic ulcer bleeding: a prospective randomized trial. Gastrointest Endosc 55 (2002) 348-353
63. Sollano J., Ang V., and Moreno J. Endoscopic hemostasis of bleeding peptic ulcers: 1:10000 adrenalin injection vs. 1:10000 adrenalin +1% aethoxysclerol injection vs. heater probe. Gastroenterol Jpn 26 (1991) 83-85
64. Villanueva C., Balanzó J., Espinós J., et al. Endoscopic injection therapy of bleeding ulcer: a prospective and randomized comparison of adrenaline alone or with polidocanol. J Clin Gastroenterol 17 (1993) 195-200
65. Bleau B., Gostout C., Sherman K., et al. Recurrent bleeding from peptic ulcer associated with adherent clot: a randomized study comparing endoscopic treatment with medical therapy. Gastrointest Endosc 56 (2002) 1-6
66. Bour B., Pariente E., Hamelin B., et al. Orally administered omeprazole versus injection therapy in the prevention of rebleeding from peptic ulcer with visible vessel. A multicenter randomized study. Gastroenterol Clin Biol 17 (1993) 329-333
67. Grosso C., Rossi A., Gambitta P., et al. Non-bleeding visible vessel treatment: perendoscopic injection therapy versus omeprazole infusion. Scand J Gastroenterol 30 (1995) 872-875
68. Hung W., Li V., Chung C., et al. Randomized trial comparing pantoprazole infusion, bolus and no treatment on gastric pH and recurrent bleeding in peptic ulcers. Aust N Z J Surg 77 (2007) 677-681
69. Javid G., Masoodi I., Zargar S., et al. Omeprazole as adjuvant therapy to endoscopic combination injection sclerotherapy for treating bleeding peptic ulcer. Am J Med 111 (2001) 280-284
70. Jensen D., Pace S., Soffer E., et al. Continuous infusion of pantoprazole versus ranitidine for prevention of ulcer rebleeding: a U.S. multicenter randomized, double-blind study. Am J Gastroenterol 101 (2006) 1991-1999
71. Jensen D., Kovacs T., Jutabha R., et al. Randomized trial of medical or endoscopic therapy to prevent recurrent ulcer hemorrhage in patients with adherent clots. Gastroenterology 123 (2002) 407-413
72. Jung H., Son H., Jung S., et al. Comparison of oral omeprazole and endoscopic ethanol injection therapy for prevention of recurrent bleeding from peptic ulcers with nonbleeding visible vessels or fresh adherent clots. Am J Gastroenterol 97 (2002) 1736-1740
73. Kaviani M., Hashemi M., Kazemifar A., et al. Effect of oral omeprazole in reducing re-bleeding in bleeding peptic ulcers: a prospective, double-blind, randomized, clinical trial. Aliment Pharmacol Ther 17 (2003) 211-216
74. Lau J., Sung J., Lee K., et al. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. N Engl J Med 343 (2000) 310-316
75. Lin H., Lo W., Lee F., et al. A prospective randomized comparative trial showing that omeprazole prevents rebleeding in patients with bleeding peptic ulcer after successful endoscopic therapy. Arch Intern Med 158 (1998) 54-58
76. Lin H., Lo W., Cheng Y., et al. Role of intravenous omeprazole in patients with high-risk peptic ulcer bleeding after successful endoscopic epinephrine injection: a prospective randomized comparative trial. Am J Gastroenterol 101 (2006) 500-505
77. Lin H., Lo W., Perng C., et al. Can optimal acid suppression prevent rebleeding in peptic ulcer patients with a non-bleeding visible vessel: a preliminary report of a randomized comparative study. Hepatogastroenterology 44 (1997) 1495-1499
78. Sung J., Chan F., Lau J., et al. The effect of endoscopic therapy in patients receiving omeprazole for bleeding ulcers with nonbleeding visible vessels or adherent clots: a randomized comparison. Ann Intern Med 139 (2003) 237-243
79. Villanueva C., Balanzó J., Torras X., et al. Omeprazole versus ranitidine as adjunct therapy to endoscopic injection in actively bleeding ulcers: a prospective and randomized study. Endoscopy 27 (1995) 308-312
80. Wei K., Tung S., Sheen C., et al. Effect of oral esomeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. J Gastroenterol Hepatol 22 (2007) 43-46
81. Zargar S., Javid G., Khan B., et al. Pantoprazole infusion as adjuvant therapy to endoscopic treatment in patients with peptic ulcer bleeding: prospective randomized controlled trial. J Gastroenterol Hepatol 21 (2006) 716-721
82. Church N., Dallal H., Masson J., et al. A randomized trial comparing heater probe plus thrombin with heater probe plus placebo for bleeding peptic ulcer. Gastroenterology 125 (2003) 396-403
83. Kernohan R., Anderson J., McKelvey S., et al. A controlled trial of bipolar electrocoagulation in patients with upper gastrointestinal bleeding. Br J Surg 71 (1984) 889-891
84. Rajgopal C., and Palmer K. Endoscopic injection sclerosis: effective treatment for bleeding peptic ulcer. Gut 32 (1991) 727-729
85. Oxner R., Simmonds N., Gertner D., et al. Controlled trial of endoscopic injection treatment for bleeding from peptic ulcers with visible vessels. Lancet 339 (1992) 966-968
86. Goh P., and Tekant Y. Endoscopic hemostasis of bleeding peptic ulcers. Dig Dis 11 (1993) 216-227
87. Tekant Y., Goh P., Alexander D., et al. Combination therapy using adrenaline and heater probe to reduce rebleeding in patients with peptic ulcer haemorrhage: a prospective randomized trial. Br J Surg 82 (1995) 223-226
88. Chou Y., Hsu P., Lai K., et al. A prospective, randomized trial of endoscopic hemoclip placement and distilled water injection for treatment of high-risk bleeding ulcers. Gastrointest Endosc 57 (2003) 324-328
89. Jubicic L.N., Supanc V., and Vrsalovic M. Efficacy of endoscopic clipping for actively bleeding peptic ulcer: comparison with polidocanol injection therapy. Hepatogastroenterology 51 (2004) 408-412
90. Park C., Joo Y., Kim H., et al. A prospective, randomized trial comparing mechanical methods of hemostasis plus epinephrine injection to epinephrine injection alone for bleeding peptic ulcer. Gastrointest Endosc 60 (2004) 173-179
91. Sacks H., Chalmers T., Blum A., et al. Endoscopic hemostasis. An effective therapy for bleeding peptic ulcers. JAMA 264 (1990) 494-499
92. Chua R., Lin H., Wang K., et al. Intravenous omeprazole prevents rebleeding in peptic ulcer patients with a non-bleeding visible vessel: a preliminary report of a randomized controlled study. Zhonghua Yi Xue Za Zhi (Taipei) 57 (1996) 139-145
93. Cardi M., Muttillo I., Amadori L., et al. [Intravenous omeprazole versus ranitidine in the treatment of hemorrhagic duodenal ulcer: a prospective randomized study]. Ann Chir 51 (1997) 136-139
94. Hsu P., Lo G., Lo C., et al. Intravenous pantoprazole versus ranitidine for prevention of rebleeding after endoscopic hemostasis of bleeding peptic ulcers. World J Gastroenterol 10 (2004) 3666-3669
95. Hasselgren G., Lind T., Lundell L., et al. Continuous intravenous infusion of omeprazole in elderly patients with peptic ulcer bleeding. Results of a placebo-controlled multicenter study. Scand J Gastroenterol 32 (1997) 328-333
96. Khoshbaten M., Fattahi E., Naderi N., et al. A comparison of oral omeprazole and intravenous cimetidine in reducing complications of duodenal peptic ulcer. BMC Gastroenterol 6 (2006) 2
97. Schaffalitzky de Muckadell O., Havelund T., et al. Effect of omeprazole on the outcome of endoscopically treated bleeding peptic ulcers. Randomized double-blind placebo-controlled multicentre study. Scand J Gastroenterol 32 (1997) 320-327
98. Michel P., Duhamel C., Bazin B., et al. Lansoprazole versus ranitidine in the prevention of early recurrences of digestive hemorrhages from gastroduodenal ulcers. Randomized double-blind multicenter study. Gastroenterol Clin Biol 18 (1994) 1102-1105
99. Pérez Flores R., García Molinero M., Herrero Quirós C., et al. The treatment of upper digestive hemorrhage of peptic origin: intravenous ranitidine versus intravenous omeprazole. Rev Esp Enferm Dig 86 (1994) 637-641
100. Cook D., Salena B., Guyatt G., et al. Endoscopic therapy for acute non-variceal upper gastrointestinal hemorrhage-a meta-analysis. Gastroenterology 102 (1992) 139-148
101. Kahi C., Jensen D., Sung J., et al. Endoscopic therapy versus medical therapy for bleeding peptic ulcer with adherent clot: a meta-analysis. Gastroenterology 129 (2005) 855-862
102. Sung J., Tsoi K., Lai L., et al. Endoscopic clipping versus injection and thermo-coagulation in the treatment of non-variceal upper gastrointestinal bleeding: a meta-analysis. Gut 56 (2007) 1364-1373
103. Vergara M., Calvet X., and Gisbert J. Epinephrine injection versus epinephrine injection and a second endoscopic method in high risk bleeding ulcers. Cochrane Database Syst Rev (2007)
104. Andriulli A., Annese V., Caruso N., et al. Proton-pump inhibitors and outcome of endoscopic hemostasis in bleeding peptic ulcers: a series of meta-analyses. Am J Gastroenterol 100 (2005) 207-219
105. Bardou M., Toubouti Y., Benhaberou-Brun D., et al. Meta-analysis: proton-pump inhibition in high-risk patients with acute peptic ulcer bleeding. Aliment Pharmacol Ther 21 (2005) 677-686
106. Gisbert J., González L., Calvet X., et al. Proton pump inhibitors versus H2-receptor antagonists: a meta-analysis of their efficacy in treating bleeding peptic ulcer. Aliment Pharmacol Ther 15 (2001) 917-926
107. Marmo R., Rotondano G., Piscopo R., et al. Dual therapy versus monotherapy in the endoscopic treatment of high-risk bleeding ulcers: a meta-analysis of controlled trials. Am J Gastroenterol 102 (2007) 279-289
108. Khuroo M., Khuroo M., Farahat K., et al. Treatment with proton pump inhibitors in acute non-variceal upper gastrointestinal bleeding: a meta-analysis. J Gastroenterol Hepatol 20 (2005) 11-25
109. Leontiadis G., Sharma V., and Howden C. Proton pump inhibitor therapy for peptic ulcer bleeding: Cochrane collaboration meta-analysis of randomized controlled trials. Mayo Clin Proc 82 (2007) 286-296
110. Leontiadis G., Sharma V., and Howden C. Systematic review and meta-analysis of proton pump inhibitor therapy in peptic ulcer bleeding. BMJ 330 (2005) 568-574
111. Leontiadis G., Sharma V., and Howden C. Systematic review and meta-analysis: proton-pump inhibitor treatment for ulcer bleeding reduces transfusion requirements and hospital stay-results from the Cochrane Collaboration. Aliment Pharmacol Ther 22 (2005) 169-174
112. Leontiadis G., Sharma V., and Howden C. Systematic review and meta-analysis: enhanced efficacy of proton-pump inhibitor therapy for peptic ulcer bleeding in Asia-a post hoc analysis from the Cochrane Collaboration. Aliment Pharmacol Ther 21 (2005) 1055-1061
113. Selby N., Kubba A., and Hawkey C. Acid suppression in peptic ulcer haemorrhage: a 'meta-analysis'. Aliment Pharmacol Ther 14 (2000) 1119-1126
114. Zed P., Loewen P., Slavik R., et al. Meta-analysis of proton pump inhibitors in treatment of bleeding peptic ulcers. Ann Pharmacother 35 (2001) 1528-1534
115. Sheu B., Chi C., Huang C., et al. Impact of intravenous omeprazole on Helicobacter pylori eradication by triple therapy in patients with peptic ulcer bleeding. Aliment Pharmacol Ther 16 (2002) 137-143
116. Prassler R., Hendrich H., Barnert J., et al. Is medication with proton pump inhibitors more effective than H2-receptor antagonists after endoscopic hemostasis of ulcer bleeding?. Z Gastroenterol 33 (1995) 431-434
117. Van Rensburg C.J., Racz I., Bailey R.J., et al. >Prevention of peptic ulcer rebleeding using continuous infusion of pantoprazole (pan) vs. ranitidine (ran): a multicenter, multinational, randomized, double-blind, parallel-group comparison. Can J Gastroenterol 18 Suppl A (2004) 149
118. Sung J., Mossner J., Barkun A., et al. Intravenous esomeprazole for prevention of peptic ulcer rebleeding: rationale/design of Peptic Ulcer Bleeding study. Aliment Pharmacol Ther 27 (2008) 666-677
119. Sung J.J.Y., Barkun A., Kuipers E.J., et al. Intravenous esomeprazole for prevention of peptic ulcer re-bleeding: a multinational, randomized, placebo-controlled study. Scand J Gastroenterol 43 Suppl 244 (2008) 38
120. Freston J., Pilmer B., Chiu Y., et al. Evaluation of the pharmacokinetics and pharmacodynamics of intravenous lansoprazole. Aliment Pharmacol Ther 19 (2004) 1111-1122
121. Khuroo M., Yattoo G., Javid G., et al. A comparison of omeprazole and placebo for bleeding peptic ulcer. N Engl J Med 336 (1997) 1054-1058
122. Levine J., Leontiadis G., Sharma V., et al. Meta-analysis: the efficacy of intravenous H2-receptor antagonists in bleeding peptic ulcer. Aliment Pharmacol Ther 16 (2002) 1137-1142
123. Laine L., Shah A., and Bemanian S. Intragastric pH with oral vs intravenous bolus + infusion proton pump inhibitor therapy in patients with bleeding ulcers. Gastroenterology 134 (2008) 1836-1841
124. Andriulli A., Loperfido S., Focareta R., et al. Bolus versus continuous high-dose omeprazole infusion combined with endoscopic hemostasis in peptic ulcer bleeding. A randomized, multicenter, Italian study. Gastrointest Endosc 65 (2007) AB120
125. Jang J., Dong S., Jung J., et al. High-dose oral proton pump inhibitor is effective as intravenous administration in the aspect of increasing intragastric pH and reducing rebleeding after endoscopic treatment of bleeding peptic ulcers. Gastroenterology 130 (2006) A467
126. Kim H.I., Kim J.S., Cho Y.S., et al. Effect of high dose oral rabeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers: a preliminary report. Gastrointest Endosc 67 (2008) AB257