Intragastric pH With Oral vs Intravenous Bolus Plus Infusion Proton-Pump Inhibitor Therapy in Patients With Bleeding Ulcers

Gastroenterology

Volumn 134, Issue 7, 2008, Pages 1836-1841

  Laine, Loren ^a   Shah, Abbid ^a   Bemanian, Shahrooz ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LANSOPRAZOLE; PROTON PUMP INHIBITOR;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG INFUSION; DUODENAL ULCER BLEEDING; FEMALE; GASTRIC PH MONITORING; GASTRIC ULCER BLEEDING; GASTROSCOPY; HUMAN; HUMAN TISSUE; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; PEPTIC ULCER BLEEDING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

EID: 44649155825     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.03.006     Document Type: Article

References (16)

1. Laine L., and Peterson W. Bleeding peptic ulcers. N Engl J Med 331 (1994) 717-727
2. Cook D.J., Salena B., Guyatt G.H., et al. Endoscopic therapy for acute non-variceal upper gastrointestinal hemorrhage-a meta-analysis. Gastroenterology 102 (1992) 139-148
3. Barkun A., Bardou M., and Marshall J.K. Nonvariceal Upper GI Bleeding Consensus Conference Group. Consensus recommendations for managing patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med 139 (2003) 843-857
4. Sung J.J.Y., Chan F.K.L., Lau J.Y.W., et al. The effect of endoscopic therapy in patients receiving omeprazole for bleeding ulcers with nonbleeding visible vessels or adherent clots. A randomized comparison. Ann Intern Med 139 (2003) 237-243
5. Lau J.Y.W., Sung J.J.Y., Lee K.K.C., et al. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. N Engl J Med 343 (2000) 310-316
6. Chaimhoff C., Creter D., and Djaldetti M. The effect of pH on platelet and coagualtion factor activities. Am J Surg 136 (1978) 257-259
7. Green F.W., Kaplan M.M., Curtis L.E., et al. Effect of acid and pepsin on blood coagulation and platelet aggregation. Gastroenterology 74 (1978) 38-43
8. Labenz J., Peitz U., Leusing C., et al. Efficacy of primed infusions with high-dose ranitidine and omeprazole to maintain high intragastric pH in patients with peptic ulcer bleeding: a prospective randomised controlled study. Gut 40 (1997) 36-41
9. Freston J.W., Pilmer B.L., Chiu Y.L., et al. Evaluation of the pharmacokinetics and pharmacodynamics of intravenous lansoprazole. Aliment Pharmacol Ther 19 (2004) 1111-1122
10. Pais S.A., Nathwani R., Dhar V., et al. Effect of frequent dosing of an oral proton pump inhibitor on intragastric pH. Aliment Pharmacol Ther 23 (2006) 1607-1611
11. Metz D.C., Amer F., Hunt B., et al. Lansoprazole regimens that sustain intragastric pH >6.0: an evaluation of intermittent oral and continuous intravenous infusion dosages. Aliment Pharmacol Ther 23 (2006) 985-995
12. Howden C.W., Metz D.C., Hunt B., et al. Dose-response evaluation of the antisecretory effect of continuous infusion intravenous lansoprazole regimens over 48 hours. Aliment Pharmacol Ther 23 (2006) 975-984
13. Van Rensberg C.J., Hartmann M., Thorpe A., et al. Intragastric pH during continuous infusion with pantoprazole in patients with bleeding peptic ulcer. Am J Gastroenterol 98 (2003) 2685-2691
14. Patchett S.E., Euright H., Afdhal N., et al. Clot lysis by gastric juice: an in vitro study. Gut 30 (1989) 1704-1707
15. Pilotto A., Franceschi M., and Paris F. Recent advances in the treatment of GERD in the elderly: focus on proton pump inhibitors. Int J Clin Pract 59 (2005) 1204-1209
16. Klotz U. Pharmacokinetic considerations in the eradication of Helicobacter pylori. Clin Pharmacokinetics 38 (2000) 243-270