A comparison of omeprazole and placebo for bleeding peptic ulcer

New England Journal of Medicine

Volumn 336, Issue 15, 1997, Pages 1054-1058

  Khuroo, Mohammad Sultan ^a,b   Yattoo, Ghulam Nabi ^a   Javid, Gul ^a   Khan, Bashir Ahmad ^a   Shah, Altaf Ahmad ^a   Gulzar, Ghulam Mohammad ^a   Sodi, Jaswinder Singh ^a  

^a SHER I KASHMIR INSTITUTE OF MEDICAL SCIENCES   (India)

^b KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTACID AGENT; DIGENE; OMEPRAZOLE; PLACEBO; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BLOOD CLOTTING; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG POTENCY; FEMALE; GASTROINTESTINAL HEMORRHAGE; HUMAN; MAJOR CLINICAL STUDY; MALE; ORAL DRUG ADMINISTRATION; PEPTIC ULCER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; AGED; ANTI-ULCER AGENTS; DOUBLE-BLIND METHOD; DUODENAL ULCER; ENDOSCOPY, GASTROINTESTINAL; FEMALE; HUMANS; MALE; MIDDLE AGED; OMEPRAZOLE; PEPTIC ULCER HEMORRHAGE; PLACEBOS; RECURRENCE; STOMACH ULCER; TREATMENT OUTCOME;

EID: 0030941533     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199704103361503     Document Type: Article

References (28)

1. Gilbert DA. Epidemiology of upper gastrointestinal bleeding. Gastrointest Endosc 1990;36:Suppl:S8-S13.
2. Krejs GJ, Little KH, Westergaard H, Hamilton JK, Spady DK, Polter DE. Laser photocoagulation for the treatment of acute peptic-ulcer bleeding. N Engl J Med 1987;316:1618-21.
3. Laine L. Multipolar electrocoagulation in the treatment of peptic ulcers with nonbleeding visible vessels: a prospective, controlled trial. Ann Intern Med 1989;110:510-4.
4. Jensen DM. Heat probe for hemostasis of bleeding peptic ulcers: techniques and results of randomized controlled trials. Gastrointest Endosc 1990;36:Suppl:S42-S49.
5. Oxner RBG, Simmonds NJ, Gertner DJ, Nightingale JMD, Burnham WR. Controlled trial of endoscopic injection treatment for bleeding from peptic ulcers with visible vessels. Lancet 1992;339:966-8.
6. Therapeutic endoscopy and bleeding ulcers. JAMA 1989;262:1369-72.
7. Fleischer DE. Endoscopic control of upper gastrointestinal bleeding. J Clin Gastroenterol 1990;12:Suppl 2:S41-S47.
8. Barer D, Ogilvie A, Henry D, et al. Cimetidine and tranexamic acid in the treatment of acute upper gastrointestinal-tract bleeding. N Engl J Med 1983;308:1571-5.
9. Zuckerman G, Welch R, Douglas A, et al. Controlled trial of medical therapy for active upper gastrointestinal bleeding and prevention of rebleeding. Am J Med 1984;76:361-6.
10. Christiansen J, Ottenjann R, Von Arx F. Placebo-controlled trial with the somatostatin analogue SMS 201-995 in peptic ulcer bleeding. Gastroenterology 1989;97:568-74.
11. Walt RP, Cottrell J, Mann SG, Freemantle NP, Langman MJS. Continuous intravenous famotidine for haemorrhage from peptic ulcer. Lancet 1992;340:1058-62.
12. Barkham P, Tocantins LM. Action of human gastric juice on human blood clots. J Appl Physiol 1953;6:1-7.
13. Han P, Ardlie NG. The influence of pH, temperature, and calcium on platelet aggregation: maintenance of environmental pH and platelet function for in vitro studies in plasma stored at 37 degrees C. Br J Haematol 1974;26:373-89.
14. Patchett SE, Enright H, Afdhal N, O'Connell W, O'Donoghue DP. Clot lysis by gastric juice: an in vitro study. Gut 1989;30:1704-7.
15. 2 antagonists in acute upper gastrointestinal hemorrhage: implications of randomized trials. N Engl J Med 1985;313:660-6.
16. Langman MJS. Problems in assessing pharmacologic treatment of acute upper gastrointestinal bleeding. Hepatogastroenterology 1990;37: Suppl 1:29-30.
17. Forrest JAH, Finlayson NDC, Shearman DJ. Endoscopy in gastrointestinal bleeding. Lancet 1974;2:394-7.
18. Griffiths WJ, Neumann DA, Welsh JD. The visible vessel as an indicator of uncontrolled or recurrent gastrointestinal hemorrhage. N Engl J Med 1979;300:1411-3.
19. Johnston JH. Endoscopic risk factors for bleeding peptic ulcer. Gastrointest Endosc 1990;36:Suppl:S16-S20.
20. Branicki FJ, Boey J, Fok PJ, et al. Bleeding duodenal ulcer: a prospective evaluation of risk factors for rebleeding and death. Ann Surg 1990; 211:411-8.
21. Campbell MJ, Machin D. Medical statistics: a common sense approach. Chichester, England: John Wiley, 1992.
22. Fleiss JL. Confidence intervals for the odds ratio in case-control studies: the state of the art. J Chronic Dis 1979;32:69-77.
23. Lanas A, Artal A, Blas JM, Arroyo MT, Lopez-Zaborras J, Sainz R. Effect of parenteral omeprazole and ranitidine on gastric pH and the outcome of bleeding peptic ulcer. J Clin Gastroenterol 1995;21:103-6.
24. Khuroo MS, Verma SL. Gastric secretory pattern in normal subjects and duodenal ulcer patients in Kashmir. J Ind Med Assoc 1974;63:185-7.
25. Ahmed SZ, Khuroo MS, Ismail SM. Minimal dose of histamine acid phosphate (H.A.P.) for maximal gastric acid secretion in subjects from Kashmir. J Assoc Phys Ind 1975;23:321-5.
26. Daneshmend TK, Hawkey CJ, Langmann MJS, Logan RFA, Long RG, Walt RP. Omeprazole versus placebo for acute upper gastrointestinal bleeding: randomised double blind controlled trial. BMJ 1992;304:143-7.
27. Schaffalitzky de Muckadell OB, Havelund T, Harling H, et al. Omeprazole improves outcome in peptic ulcer bleeding. Gastroenterology 1995; 108:Suppl:A212. abstract.
28. Lind T, Aadland E, Eriksson S, Fernstrom P, Hasselgren G, Lundell L. Beneficial effects of I.V. omeprazole (OME) in patients with peptic ulcer bleeding (PUB). Gastroenterology 1995;108:Suppl:A150. abstract.