The Effect of Endoscopic Therapy in Patients Receiving Omeprazole for Bleeding Ulcers with Nonbleeding Visible Vessels or Adherent Clots: A Randomized Comparison

Annals of Internal Medicine

Volumn 139, Issue 4, 2003, Pages

  Sung, Joseph J Y ^a   Chan, Francis K L ^a   Lau, James Y W ^a   Yung, Man Yee ^a   Leung, Wai Keung ^a   Wu, Justin C Y ^a   Ng, Enders K W ^a   Chung, S C Sydney ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; CLARITHROMYCIN; OMEPRAZOLE; ANTIULCER AGENT; PROTON PUMP;

ADULT; AGED; ARTICLE; BLOOD CLOTTING; CLINICAL TRIAL; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIGESTIVE SYSTEM ULCER; DRUG INFUSION; DRUG MEGADOSE; ENDOSCOPIC THERAPY; EVALUATION; FEMALE; GASTROINTESTINAL HEMORRHAGE; HONG KONG; HOSPITAL DISCHARGE; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROBABILITY; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; SINGLE BLIND PROCEDURE; STATISTICAL ANALYSIS; SURGICAL ANATOMY; TREATMENT PLANNING; ULCER; ULCER PERFORATION; COMPARATIVE STUDY; DRUG ANTAGONISM; FOLLOW UP; GASTROINTESTINAL ENDOSCOPY; HEMOSTASIS; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; PATHOLOGY; STOMACH ULCER; TREATMENT OUTCOME;

ANTI-ULCER AGENTS; COMBINED MODALITY THERAPY; ENDOSCOPY, GASTROINTESTINAL; FEMALE; FOLLOW-UP STUDIES; GASTROINTESTINAL HEMORRHAGE; HEMOSTATIC TECHNIQUES; HUMANS; MALE; MIDDLE AGED; OMEPRAZOLE; PROTON PUMPS; RECURRENCE; SINGLE-BLIND METHOD; STOMACH ULCER; TREATMENT OUTCOME;

EID: 0141454746     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-139-4-200308190-00005     Document Type: Article

References (15)

1. Laine L, Freeman M, Cohen H. Lack of uniformity in evaluation of endoscopic prognostic features of bleeding ulcers. Gastrointest Endosc. 1994;40:411-7. [PMID: 7926529]
2. Lau JY, Sung JJ, Chan AC, Lai GW, Lau JT, Ng EK, et al. Stigmata of hemorrhage in bleeding peptic ulcers: an interobserver agreement study among international experts. Gastrointest Endosc. 1997;46:33-6. [PMID: 9260702]
3. Laine L, Stein C, Sharma V. A prospective outcome study of patients with clot in an ulcer and the effect of irrigation. Gastrointest Endosc. 1996;43:107-10. [PMID: 8635701]
4. Lin HJ, Wang K, Perng CL, Lee FY, Lee CH, Lee SD. Natural history of bleeding peptic ulcers with a tightly adherent blood clot: a prospective observation. Gastrointest Endosc. 1996;43:470-3. [PMID: 8726760]
5. Jensen DM, Kovacs TO, Jutabha R, Randall GM, Cheng S, Jensen ME, et al. Final results and cost assessment of endoscopic vs. medical therapies for prevention of recurrent ulcer hemorrhage from adherent clots in a randomized controlled trial [Abstract]. Gastrointest Endosc. 1995;41:AB279.
6. Bleau BL, Gostout CJ, Shaw MJ, Keate SR, Harford WV, Bracy W Jr, et al. Final results: rebleeding from peptic ulcer associated with adherent clots: a prospective randomized controlled study comparing endoscopic therapy with medical therapy [Abstract]. Gastrointest Endosc 1997;45:AB87.
7. Cook DJ, Guyatt GH, Salena BJ, Laine LA. Endoscopic therapy for acute nonvariceal upper gastrointestinal hemorrhage: a meta-analysis. Gastroenterology. 1992;102:139-48. [PMID: 1530782]
8. Khuroo MS, Yattoo GN, Javid G, Khan BA, Shah AA, Gulzar GM, et al. A comparison of omeprazole and placebo for bleeding peptic ulcer. N Engl J Med. 1997;336:1054-8. [PMID: 9091801]
9. Javid G, Masoodi I, Zargar SA, Khan BA, Yatoo GN, Shah AH, et al. Omeprazole as adjuvant therapy to endoscopic combination injection sclerotherapy for treating bleeding peptic ulcer. Am J Med. 2001;111:280-4. [PMID: 11566458]
10. Jensen DM, Kovacs TO, Jutabha R, Machicado GA, Gralnek IM, Savides TJ, et al. Randomized trial of medical or endoscopic therapy to prevent recurrent ulcer hemorrhage in patients with adherent clots. Gastroenterology. 2002;123:407-13. [PMID: 12145792]
11. Laine L. Management of ulcers with adherent clots [Editorial]. Gastroenterology. 2002;123:632-6. [PMID: 12145815]
12. Lau JY, Sung JJ, Lee KK, Yung MY, Wong SK, Wu JC, et al. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. N Engl J Med. 2000;343:310-6. [PMID: 10922420]
13. Consensus conference: Therapeutic endoscopy and bleeding ulcers. JAMA. 1989;262:1369-72. [PMID: 2668576]
14. Laine L, Peterson WL. Bleeding peptic ulcer. N Engl J Med. 1994;331:717-27. [PMID: 8058080]
15. Lau JY, Chung SC, Leung JW, Lo KK, Yung MY, Li AK. The evolution of stigmata of hemorrhage in bleeding peptic ulcers: a sequential endoscopic study. Endoscopy. 1998;30:513-8. [PMID: 9746158]