Antitubercular activities of novel benzothiazolo naphthyridone carboxylic acid derivatives endowed with high activity toward multi-drug resistant tuberculosis

Biomedicine and Pharmacotherapy

Volumn 63, Issue 1, 2009, Pages 11-18

  Dinakaran, Murugesan ^a   Senthilkumar, Palaniappan ^a   Yogeeswari, Perumal ^a   Sriram, Dharmarajan ^a  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

Antimycobacterial activity; Antitubercular activity; Benzothiazolonaphthyridones; Naphthyridones; Tuberculosis

Indexed keywords

2 (1,4 DIOXA 8 AZASPIRO[4.5]DEC 8 YL) 3 NITRO 5,12 DIHYDRO 5 OXOBENZOTHIAZOLO[3,2 A] 1,8 NAPHTHYRIDINE 6 CARBOXYLIC ACID; 2 (2,6 DIMETHYLMORPHOLINO) 3 NITRO 5,12 DIHYDRO 5 OXOBENZOTHIAZOLO[3,2 A] 1,8 NAPHTHYRIDINE 6 CARBOXYLIC ACID; 2 (4,4 DIMETHYLOXAZOLIDIN 3 YL) 3 NITRO 5,12 DIHYDRO 5 OXOBENZOTHIAZOLO[3,2 A] 1,8 NAPHTHYRIDINE 6 CARBOXYLIC ACID; 2 [1 (TERT BUTYLCARBAMOYL) 3,4 DIHYDROISOQUINOLIN 2(1H) YL] 3 NITRO 5,12 DIHYDRO 5 OXOBENZOTHIAZOLO[3,2 A] 1,8 NAPHTHYRIDINE 6 CARBOXYLIC ACID; 2 [2 CARBOXY 5,6 DIHYDROIMIDAZO[1,2 A]PYRAZIN 7(8H) YL] 3 NITRO 5,12 DIHYDRO 5 OXOBENZOTHIAZOLO[3,2 A] 1,8 NAPHTHYRIDINE 6 CARBOXYLIC ACID; 2 [3 (DIETHYLCARBAMOYL)PIPERIDIN 1 YL] 3 NITRO 5,12 DIHYDRO 5 OXOBENZOTHIAZOLO[3,2 A] 1,8 NAPHTHYRIDINE 6 CARBOXYLIC ACID; 2 [4 (2 FUROYL)PIPERAZIN 1 YL] 3 NITRO 5,12 DIHYDRO 5 OXOBENZOTHIAZOLO[3,2 A] 1,8 NAPHTHYRIDINE 6 CARBOXYLIC ACID; 2 [4 (4 CHLOROPHENYL) 4 HYDROXYPIPERIDIN 1 YL] 3 NITRO 5,12 DIHYDRO 5 OXOBENZOTHIAZOLO[3,2 A] 1,8 NAPHTHYRIDINE 6 CARBOXYLIC ACID; 2 [4 (6 CHLORO 1,2 DIHYDRO 2 OXOBENZO[D]IMIDAZOL 3 YL)PIPERIDIN 1 YL] 3 NITRO 5,12 DIHYDRO 5 OXOBENZOTHIAZOLO[3,2 A] 1,8 NAPHTHYRIDINE 6 CARBOXYLIC ACID; 2 [4 [(BENZO[D][1,3]DIOXOL 6 YL)METHYL]PIPERAZIN 1 YL] 3 NITRO 5,12 DIHYDRO 5 OXOBENZOTHIAZOLOL[3,2 A] 1,8 NAPHTHYRIDINE 6 CARBOXYLIC ACID; 2 [4 [3 (2,6 DIFLUOROPHENYL) 5 METHYLISOXAZOL 4 OYL](PIPERAZIN 1 YL)] 3 NITRO 5,12 DIHYDRO 5 OXOBENZOTHIAZOLO[3,2 A] 1,8 NAPHTHYRIDINE 6 CARBOXYLIC ACID; 2 [8 (4 METHOXYBENZYL) 3,4,5,6,7,8 HEXAHYDROISOQUINOLIN 2(1H) YL] 3 NITRO 5,12 DIHYDRO 5 OXOBENZOTHIAZOLO[3,2 A] 1,8 NAPHTHYRIDINE 6 CARBOXYLIC ACID; 2 AMINOTHIOPHENOL DERIVATIVE; 2 METHOXY 3 NITRO 5,12 DIHYDRO 5 OXOBENZOTHIAZOLO[3,2 A] 1,8 NAPHTHYRIDINE 6 CARBOXYLIC ACID; 2,6 DIMETHOXY 5 NITROPYRIDINE 3 CARBONYL CHLORIDE; 2,6 DIMETHOXY 5 NITROPYRIDINE 3 CARBOXYLIC ACID; 2,6 DIMETHOXYNICOTINIC ACID DERIVATIVE; 3 NITRO 2 (4 METHYL 3 PHENYLPIPERAZIN 1 YL) 5,12 DIHYDRO 5 OXOBENZOTHIAZOLOL[3,2 A] 1,8 NAPHTHYRIDINE 6 CARBOXYLIC ACID; 3 NITRO 2 (THIOMORPHOLINO 1 YL) 5,12 DIHYDRO 5 OXOBENZOTHIAZOLO[3,2 A] 1,8 NAPHTHYRIDINE 6 CARBOXYLIC ACID; 3 NITRO 2 [4 (PIPERIDIN 1 YL)PIPERIDIN 1 YL] 5,12 DIHYDRO 5 OXOBENZOTHIAZOLO[3,2 A] 1,8 NAPHTHYRIDINE 6 CARBOXYLIC ACID; 3 NITRO 5,12 DIHYDRO 5 OXOBENZOTHIAZOLO[3,2 A] 1,8 NAPHTHYRIDINE 6 CARBOXYLIC ACID; 5,12 DIHYDRO 5 OXOBENZOTHIAZOLO[3,2 A] 1,8 NAPHTHYRIDINE 6 CARBOXYLIC ACID; BENZOTHIAZOLONAPHTHYRIDONE CARBOXYLIC ACID DERIVATIVE; ETHYL 2 (BENZOTHIAZOL 2 YL) 3 (2,6 DIMETHOXY 5 NITROPYRIDIN 3 YL) 3 OXOPROPANOATE; ETHYL 2 (BENZOTHIAZOL 2 YL)ACETATE; ETHYL 2 METHOXY 3 NITRO 5,12 DIHYDRO 5 OXOBENZOTHIAZOLO[3,2 A] 1,8 NAPHTHYRIDINE 6 CARBOXYLIC ACID; GATIFLOXACIN; ISONIAZID; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL COUNT; BACTERIAL STRAIN; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LUNG PARENCHYMA; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MULTIDRUG RESISTANT TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SPLEEN; TUBERCULOSIS;

ANIMALS; ANTITUBERCULAR AGENTS; CARBOXYLIC ACIDS; CERCOPITHECUS AETHIOPS; FEMALE; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS, MULTIDRUG-RESISTANT; VERO CELLS;

EID: 58049169788     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2007.10.009     Document Type: Article

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