Poly (ε-caprolactone) microparticles containing Levobunolol HCl prepared by a multiple emulsion (W/O/W) solvent evaporation technique: Effects of some formulation parameters on microparticle characteristics

Journal of Microencapsulation

Volumn 26, Issue 1, 2009, Pages 63-74

  Karataş, Ayşegül ^a   Sonakin, O Ozlem ^a   Kili̧Carslan, Müge ^a   Baykara, Tamer ^a  

^a ANKARA UNIVERSITY   (Turkey)

Author keywords

Drug release; Levobunol HCl loaded microparticles; Multiple emulsion (W O W) solvent evaporation; Poly ( caprolactone); Polyvinylalcohol; Thermally reversible gel

Indexed keywords

LEVOBUNOLOL; POLYCAPROLACTONE; POLYVINYL ALCOHOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; MICROSPHERE; POLYESTER;

ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; EMULSION; EVAPORATION; GLAUCOMA; IONIZATION; PARTICLE SIZE; PH; PHYSICAL CHEMISTRY; SCANNING ELECTRON MICROSCOPY; ZETA POTENTIAL; CHEMISTRY; DELAYED RELEASE FORMULATION; KINETICS; METHODOLOGY;

ADRENERGIC BETA-ANTAGONISTS; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; EMULSIONS; GLAUCOMA; KINETICS; LEVOBUNOLOL; MICROSPHERES; POLYESTERS;

EID: 57949110780     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.1080/02652040802141039     Document Type: Article

References (52)

1. Alex, R. and Bodmeier, R. (1990) Encapsulation of water-soluble drugs by a modified solvent evaporation method. I. Effect of process and formulation variables on drug entrapment. J Microencapsulation, 7, pp. 347-355.
2. Allemann, E., Gurny, R. and Doelker, E. (1993) Drug loaded nanoparticles, preparation methods and drug targeting issues. Eur J Pharm Biopharm, 39, pp. 173-191.
3. Antunes, MCM and Felisberti, MI (2005) Blends of poly(hydroxybutyrate) and poly (ε-caprolactone) obtained from melting mixture. Polimeros, 15, pp. 134-138.
4. Bala, I., Bhardwaj, V., Hariharan, S., Sitterberg, J., Bakowsky, U. and Ravi Kumar, MNV (2005) Design of biodegradable nanoparticles: A novel approach to encapsulating poorly soluble phytochemical ellagic acid. Nanotechnology, 16, pp. 2819-2822.
5. Benoit, MA, Baras, B. and Gillard, J. (1999) Preparation and characterization of protein-loaded poly (ε-caprolactone) microparticles for oral vaccine delivery. Int J Pharm, 184, pp. 73-84.
6. Blanco, MD and Alonso, MJ (1997) Development and characrerization of protein-loaded poly(lactide-coglycolide) nanopheres. Eur J Pharm Biopharm, 43, pp. 287-294.
7. Bodmeier, R. and McGinity, JW (1987) Polylactic acid microspheres containing quinidine base and quinidine sulphate prepared by the solvent evaporation technique: II. Some process parameters influencing the preparation and properties of microcapsules. J Microencapsulation, 4, pp. 289-297.
8. Bodmeier, R. and McGinity, JW (1987) The preparation and evaluation of drug containing poly(D,L-Lactide) micropheres formed by the solvent evaporation method. Pharm Res, 4, pp. 465-471.
9. Bodmeier, R. and McGinity, JW (1988) Solvent selection in the preparation of poly (D,L-lactide) micropheres prepared by the solvent evaporation method. Int J Pharm, 43, pp. 179-186.
10. Boury, F., Ivanova, T., Panaiotov, I., Proust, JE, Bois, A. and Richou, J. (1995) Dynamic properties of poly(D,L-lactide) and polyvinyl alcohol monolayers at the air/water and dichloromethane/water interfaces. J Colloid Interface Sci, 169, pp. 380-392.
11. Cinotti, A., Cinotti, D., Grant, W., Jacobs, I., Galin, M., Silverstone, D., Shin, D., Esters, J., Lee, J. Bouchey, R. et al. (1985) Levobunolol vs timolol for open angle glaucoma and ocular hypertension. Am J Oftalmol, 99, pp. 11-17.
12. Costa, P. and Lobo, JMS (2001) Modeling and comparison of dissolution profiles. Eur J Pharm Sci, 13, pp. 123-133.
13. Couvreur, P., Barratt, G., Fattal, E., Legrand, P. and Vauthier, C. (2002) Nanocapsule technology: A review. Crit Rev Therapeut Drug Carrier Syst, 19, pp. 99-134.
14. Desai, SD and Blanchard, J. (2000) Pluronic® F127-based ocular delivery system containing biodegradable polyisobutylcyanoacrylate nanocapsules of pilocarpine. Drug Deliv, 7, pp. 201-207.
15. Dinarvand, R., Mirfattahi, S. and Atyabi, F. (2002) Preparation, characterization an in vitro drug release of isosorbide dinitrate micropheres. J Microencapsulation, 19, pp. 73-81.
16. Ding, S. (1998) Recent developments in ophthalmic drug delivery. Pharm Sci Tech Today, 1, pp. 328-335.
17. Elbahri, Z. and Taverdet, JL (2005) Optimization of an herbicide release from ethylcellulose micropheres. Polym Bull, 54, pp. 353-363.
18. El-Kamel, AH (2002) In vitro and in vivo evaluation of Pluronic F127-based ocular delivery systems for timolol maleate. Int J Pharm, 241, pp. 47-55.
19. Gonzalez, JP and Clissold, SP (1987) Ocular levobunolol: A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs, 34, pp. 648-661.
20. Govender, S., Lutchman, D., Pillay, V., Chetty, DJ and Govender, T. (2006) Enhancing drug incorporation into tetracycline-loaded chitosan microspheres for periodontal therapy. J Microencapsulation, 23, pp. 750-761.
21. Govender, T., Stolnik, S., Garnett, MC, Illum, L. and Davis, SS (1999) PLGA nanoparticles prepared by nanoprecipitation: Drug loading and release studies of a water soluble drug. J Contr Rel, 57, pp. 171-185.
22. Hoyng, PFJ and Beek, LMV (2000) Pharmacological therapy for glaucoma: A review. Drugs, 59, pp. 411-434.
23. Huatan, H., Collett, JH and Attwood, D. (1995) The microencapsulation of protein using a novel ternary blend based on poly (ε-caprolactone). J Microencapsulation, 12, pp. 557-567.
24. Guidline, ICH [Internet] 2005. Validation of analytical procedures: Text and methodology Q2(R1).
25. Jeong, JC, Lee, J. and Cho, K. (2003) effects of crystalline microstructure on drug release behaviour of poly (ε-caprolactone) micropheres. J Contr Rel, 92, pp. 249-258.
26. Jones, DS and Pearce, KJ (1995) An investigation of the effects of some process variables on the microencapsulation of propranolol hydrochloride by the solvent evaporation method. Int J Pharm, 118, pp. 199-205.
27. Le Bourlais, C, Acar, L., Zia, H., Sado, PA, Needham, T. and Leverge, R. (1998) Ophtalmic drug delivery systems-recent advances. Prog Retinal Eye Res, 17, pp. 33-58.
28. Lee, SC, Oh, JT, Jang, MH and Chung, SI (1999) Quantitative analysis of polyvinyl alcohol on the surface of poly (D,L-lactide-co-glycolide) microparticles prepared by solvent evaporation method: Effect of particle size and PVA concentration. J Contr Rel, 59, pp. 123-132.
29. Lionzo, MIZ, Ré, Mi, Guterres, SS and Pholmann, AR (2007) Microparticles prepared with poly(hydroxybutyrate-co-hydroxyvalerate) and poly (ε-caprolactone) blends to control the release of drug model. J Microencapsulation, 24, pp. 175-186.
30. Luan, X., Skupin, M., Siepman, J. and Bodmeier, R. (2006) Key parameters affecting the initial release (burst) and encapsulation efficiency of peptide-containing poly(lactide-co-glycolide) microparticles. Int J Pharm, 324, pp. 168-175.
31. Mainardes, RM and Evangelista, RC (2005) PLGA nanoparticles containing praziquantel: Effect of formulation variables on size distribution. Int J Pharm, 290, pp. 137-144.
32. Marchal-Heussler, L., Fessi, H., Devissaguet, JP, Hoffman, M. and Maincent, P. (1992) Colloidal drug delivery systems for the eye a comparison of the efficacy of three different polymers: Polyisobutylcyanoacrylate, polylactic-co-glycolic acid, poly-epsilon-caprolacton. STP Pharma Sci, 2, pp. 98-104.
33. Meng, FT, Ma, GH, Liu, YD, Qiu, W. and Su, ZG (2004) Microencapsulation of bovine haemoglobin with high bio-activity and high entrapment efficiency using a W/O/W double emulsion technique. Colloids Surf B Biointerfaces, 33, pp. 177-183.
34. Miyazaki, S., Hashiguchi, N., Hou, W-M, Yokouchi, C. and Takada, M. (1986) Preparation and evaluation in vitro and in vivo of fibrinogen microspheres containing adriamycin. Chem Pharm Bull, 34, pp. 3384-3393.
35. Niwa, T., Takeuchi, H., Hino, T., Kunou, N. and Kawashima, Y. (1993) Preparation of biodegradable nanopheres of water-soluble and insoluble drugs with D,L-lactide/glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behaviour. J Contr Rel, 25, pp. 89-98.
36. Parikh, RH, Parikh, JR, Dubey, RR, Soni, HN and Kapadia, KN (2003) Poly(D,L-lactide-co-glycolide) micropheres containing 5-fluorouracil: Optimization of process parameters. AAPS PharmSciTech [serial online]; 4(2), Article 13.
37. Peltonen, L., Aitta, J., Hyvonen, S., Karjalainen, M. and Hirvonen, J. (2004) Improved entrapment efficiency of hydrophilic drug substance during nanoprecipitation of poly(l)lactide nanoparticles. AAPS. Pharm Sci Tech 5(1), 16, pp. 1-6.
38. Pérez, MH, Zinnuti, C., Lamprecht, A., Ubrich, N., Astier, A., Hoffman, M., Bodmeier, R. and Maincent, P. (2000) The preparation and the evaluation of poly (ε-caprolactone) microparticles containing both a lipophilic and hydrophilic drug. J Contr Rel, 65, pp. 429-438.
39. Pignatello, R., Bucolo, C., Ferrra, P., Maltese, A., Puleo, A. and Puglisi, G. (2002) Eudrogit RS100® nanosuspansion for the ophthalmic controlled delivery of ibuprofen. Eur J Pharm Sci, 16, pp. 53-61.
40. Quintanar-Guerrero, D., Fessi, H., Alleman, E. and Doelker, E. (1996) Influence of stabilizing agents and preparative variables on the formation of poly(D,L-lactic acid) nanoparticles by an emulsification-diffusion technique. Int J Pharm, 143, pp. 133-141.
41. Rafati, H., Coombes, AGA, Adler, J., Holland, J. and Davis, SS (1997) Protein loaded poly(Dl-lactide-co-gylcolide) microparticles for oral administration: Formulation, structural and release characteristics. J Contr Rel, 43, pp. 89-102.
42. Schugens, C., Laruelle, N., Nihant, N., Grandfils, C., Jerome, R. and Teyssie, P. (1994) Effects of the emulsion stability on the morphology and porosity of semicrystalline poly l-lactide microparticles prepared by W/O/W double emulsion-evaporation. J Contr Rel, 32, pp. 161-176.
43. Shin, IG, Kim, SY, Lee, YM, Cho, CS and Sung, KY (1998) Methoxy poly (ethylene glycol) ε-caprolactone amphiphilic block copolymeric micelle containing indomethacin. I. preparation and characterization. J Contr Rel, 51, pp. 1-11.
44. Singh, M., Briones, M., Ott, G. and O'Hagan, D. (2000) Cationic microparticles: A potent delivery systems for DNA vaccines. Proc Natl Acad Sci USA, 97, pp. 811-816.
45. Sintzel, MB, Bernatchez, SF, Tabatabay, C. and Gurny, R. (1996) Biomaterials in ophthalmic drug delivery. Eur J Pharm Biopharm, 42, pp. 358-374.
46. Song, CX, Labhasetwar, V., Murphy, H., Qu, X., Humphrey, WR, Shebuski, RJ and Levy, RJ (1997) Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery. J Contr Rel, 43, pp. 197-212.
47. Ubrich, N., Bouillot, P., Pellerin, C., Hoffman, M. and Maincent, P. (2004) Preparation and characterization of propranolol hydrochloride nanoparticles: A comparative study. J Contr Rel, 97, pp. 291-300.
48. Walters, RT, Maloney, S., Slater, D., Liss, C., Wilson, H. and Hartenbaum, D. (1998) Efficacy and tolerability of 0.5% timolol maleate ophthalmic gel-forming solution QD compared with 0.5% levobunolol hydrochloride BID in patients with open-angle glaucoma or ocular hypertension. Clin Therapeut, 20, pp. 1170-1178.
49. Yang, YY, Chung, TS, Bai, XL and Chan, WK (2000) Effects of preparation conditions on morphology and release profiles of biodegradable polymeric microspheres containing protein fabricated by double emulsion method. Chem Eng Sci, 55, pp. 2223-2236.
50. Zambaux, MF, Bonneaux, F., Gref, R., Maincent, P., Dellacherie, E., Alonso, MJ, Labrude, P. and Vigneron, C. (1998) Influence of experimental parameters on the characteristics of poly(lactic acid) nanoparticles prepared by a double emulsion method. J Contr Rel, 50, pp. 31-40.
51. Zidan, AS, Sammour, OA, Hammad, MA, Megrab, NA, Hussain, MD, Khan, MA and Habib, MJ (2006) Formulation of anastrozole microparticles as biodegradable anticancer drug carriers. AAPS PharmSciTech [serial online], 7:3
52. Zimmer, AK and Kreuter, J. (1995) Micropheres and nanoparticles used in ocular delivery systems. Adv Drug Deliv Rev, 16, pp. 61-73.