Etiology of common childhood acute lymphoblastic leukemia: The adrenal hypothesis

Leukemia

Volumn 22, Issue 12, 2008, Pages 2137-2141

  Schmiegelow, K ^a,b   Vestergaard, T ^a   Nielsen, S M ^a   Hjalgrim, H ^c  

^a International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c STATENS SERUM INSTITUT   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANTILEUKEMIC AGENT; ANTINEOPLASTIC ANTIMETABOLITE; CORTICOTROPIN; CYTOKINE; GLUCOCORTICOID; HYDROCORTISONE; MIXED LINEAGE LEUKEMIA PROTEIN; PREDNISOLONE; PREDNISONE; VINCRISTINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; CANCER GROWTH; CANCER INCIDENCE; CANCER MORTALITY; CANCER RISK; CELL PROLIFERATION; CELL STRESS; CELLULAR IMMUNITY; CHILD; CHILDHOOD LEUKEMIA; CHILDHOOD MORTALITY; DISEASE COURSE; DISEASE SEVERITY; DRUG ABSORPTION; DRUG EFFECT; DRUG EFFICACY; DRUG METABOLISM; DRUG RESPONSE; GENE MUTATION; GENE REARRANGEMENT; GENETIC RISK; GEOGRAPHIC DISTRIBUTION; HUMAN; HUMORAL IMMUNITY; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE DEFICIENCY; INFECTION; INFLAMMATION; LEUKEMIA CELL; LEUKEMIA REMISSION; LEUKEMOGENESIS; LYMPHOCYTE PROLIFERATION; MALNUTRITION; MOLECULAR CLONING; MONOTHERAPY; PRECANCER; PREVALENCE; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; RISK FACTOR; RISK REDUCTION; SINGLE DRUG DOSE; TH1 CELL; TH2 CELL;

EID: 57849157777     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2008.212     Document Type: Review

References (50)

1. Hjalgrim LL, Rostgaard K, Schmiegelow K, Soderhall S, Kolmannskog S, Vettenranta K et al. Age- and sex-specific incidence of childhood leukemia by immunophenotype in the Nordic countries. J Natl Cancer Inst 2003; 95: 1539-1544.
2. Schmiegelow K, Hjalgrim H. Is the risk of acute lymphoblastic leukemia reduced in siblings to children with the disease? A novel hypothesis explored by international collaboration. Leukemia 2006; 20: 1206-1208.
3. Stiller CA, Parkin DM. Geographic and ethnic variations in the incidence of childhood cancer. Br Med Bull 1996; 52: 682-703.
4. IARC. International Incidence of Childhood Cancer. IARC Scientific Publications: Lyon, 1998, 1-391.
5. Edgar K, Morgan A. Does infections cause or prevent childhood leukemia? 2008, 1-43.
6. Pieters R, Schrappe M, De LP, Hann I, De RG, Felice M et al. A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): An observational study and a multicentre randomised trial. Lancet 2007; 370: 240-250.
7. Forestier E, Schmiegelow K. The incidence peaks of the childhood acute leukemias reflect specific cytogenetic aberrations. J Pediatr Hematol Oncol 2006; 28: 486-495.
8. Murray CJ, Laakso T, Shibuya K, Hill K, Lopez AD. Can we achieve millennium development goal 4? New analysis of country trends and forecasts of under-5 mortality to 2015. Lancet 2007; 370: 1040-1054.
9. Rajalekshmy KR, Abitha AR, Pramila R, Gnanasagar T, Shanta V. Immunophenotypic analysis of T-cell acute lymphoblastic leukaemia in Madras, India. Leuk Res 1997; 21: 119-124.
10. Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 2007; 446: 758-764.
11. Wiemels JL, Cazzaniga G, Daniotti M, Eden OB, Addison GM, Masera G et al. Prenatal origin of acute lymphoblastic leukaemia in children. Lancet 1999; 354: 1499-1503.
12. Wiemels JL, Ford AM, van Wering ER, Postma A, Greaves M. Protracted and variable latency of acute lymphoblastic leukemia after TEL-AML1 gene fusion in utero. Blood 1999; 94: 1057-1062.
13. Hjalgrim LL, Madsen HO, Melbye M, Jorgensen P, Christiansen M, Andersen MT et al. Presence of clone specific markers at birth in children with acute lymphoblastic leukemia. Br J Cancer 2002; 97: 994-999.
14. McHale CM, Wiemels JL, Zhang L, Ma X, Buffler PA, Guo W et al. Prenatal origin of TEL-AML1-positive acute lymphoblastic leukemia in children born in California. Genes Chromosomes Cancer 2003; 37 36-43.
15. Zuna J, Muzikova K, Ford AM, Maia AT, Krejci O, Tousovska K et al. Pre-natal, clonal origin of acute lymphoblastic leukaemia in triplets. Leuk Lymphoma 2003; 44: 2099-2102.
16. Maia AT, Tussiwand R, Cazzaniga G, Rebulla P, Colman S, Biondi A et al. Identification of preleukemic precursors of hyperdiploid acute lymphoblastic leukemia in cord blood. Genes Chromosomes Cancer 2004; 40: 38-43.
17. Mori H, Colman SM, Xiao Z, Ford AM, Healy LE, Donaldson C et al. Chromosome translocations and covert leukemic clones are generated during normal fetal development. Proc Natl Acad Sci USA 2002; 99: 8242-8247.
18. Olsen M, Madsen HO, Hjalgrim H, Gregers J, Rostgaard K, Schmiegelow K. Preleukemic TEL-AML1-positive clones at cell level of 10(-3) to 10(-4) do not persist into adulthood. J Pediatr Hematol Oncol 2006; 28 734-740.
19. Wiemels JL, Leonard BC, Wang Y, Segal MR, Hunger SP, Smith MT et al Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia. Proc Natl Acad Sci USA 2002; 99: 15101-15106.
20. Fischer S, Mann G, Konrad M, Metzler M, Ebetsberger G, Jones N et al Screening for leukemia- and clone-specific markers at birth in children with T-cell precursor ALL suggests a predominantly postnatal origin. Blood 2007; 110: 3036-3038.
21. Eguchi-Ishimae M, Eguchi M, Kempski H, Greaves M. NOTCH1 mutation can be an early, prenatal genetic event in T-ALL. Blood 2008; 111: 376-378.
22. Gaynon PS, Carrel AL. Glucocorticosteroid therapy in childhood acute lymphoblastic leukemia. Adv Exp Med Biol 1999; 457: 593-605.
23. Distelhorst CW. Recent insights into the mechanism of glucocorti- costeroid-induced apoptosis. Cell Death Differ 2002; 9: 6-19.
24. Nyvold C, Madsen HO, Ryder LP, Seyfarth J, Svejgaard A, Clausen N et al. Precise quantification of minimal residual disease at day 29 allows identification of children with acute lymphoblastic leukemia and an excellent outcome. Blood 2002; 99: 1253-1258.
25. Rosenthal MC, Saunders RH, Schwartz LI, Zannos L, Perez SE, DameShek W. The use of adrenocorticotropic hormone and cortisone in the treatment of leukemia and leukosarcoma. Blood 1951; 6: 804-823.
26. Phillips RS, Enwonwu CO, Okolo S, Hassan A. Metabolic effects of acute measles in chronically malnourished Nigerian children. J Nutr Biochem 2004; 15: 281-288.
27. Manary MJ, Muglia LJ, Vogt SK, Yarasheski KE. Cortisol and its action on the glucocorticoid receptor in malnutrition and acute infection. Metabolism 2006; 55: 550-554.
28. Pinto RA, Arredondo SM, Bono MR, Gaggero AA, Diaz PV. T helper 1/T helper 2 cytokine imbalance in respiratory syncytial virus infection is associated with increased endogenous plasma cortisol. Pediatrics 2006; 117: E878-e886.
29. Singhi SC, Bansal A. Serum cortisol levels in children with acute bacterial and aseptic meningitis. Pediatr Crit Care Med 2006; 7 74-78.
30. Nickels DA, Moore DC. Serum cortisol responses in febrile children. Pediatr Infect Dis J 1989; 8: 16-20.
31. Ho JT, Al-Musalhi H, Chapman MJ, Quach T, Thomas PD, Bagley CJ et al Septic shock and sepsis: A comparison of total and free plasma cortisol levels. J Clin Endocrinol Metab 2006; 91: 105-114.
32. Petersen KB, Jusko WJ, Rasmussen M, Schmiegelow K. Population pharmacokinetics of prednisolone in children with acute lymphoblastic leukemia. Cancer Chemother Pharmacol 2003; 51: 465-473.
33. Van den BG, de ZF, Bouillon R. Clinical review 95: Acute and prolonged critical illness as different neuroendocrine paradigms. J Clin Endocrinol Metab 1998; 83: 1827-1834.
34. Bierman HR, Crile DM, Dod KS, Kelly KH, Petrakis NL, White LP et al Remissions in leukemia of childhood following acute infectious disease: Staphylococcus and streptococcus, varicella, and feline panleukopenia. Cancer 1953; 6: 591-605.
35. Pelner L, Fowler GA, Nauts HC. Effects of concurrent infections and their toxins on the course of leukemia. Acta Med Scand Suppl 1958; 338: 1-47.
36. Diamond LK, luhby LA. Pattern of 'spontaneous' remissions in leukemia of childhood, observed in 26 of 300 cases. Am J Med 1951; 10: 238-239.
37. Kamper-Jorgensen M, Wohlfahrt J, Simonsen J, Gronbaek M, Benn CS. Population-based study of the impact of childcare attendance on hospitalizations for acute respiratory infections. Pediatrics 2006; 118: 1439-1446.
38. Kamper-Jørgensen M, Woodward A, Wohlfahrt J, Benn CS, Simonsen J, Hjalgrim H et al. Childcare in the first two years of life reduces the risk of childhood acute lymphoblastic leukemia. Leukemia 2007; 22: 189-193.
39. Gilham C, Peto J, Simpson J, Roman E, Eden TO, Greaves MF et al. Day care in infancy and risk of childhood acute lymphoblastic leukaemia: findings from UK case-control study. BMJ 2005; 330: 1294.
40. Roman E, Simpson J, Ansell P, Kinsey S, Mitchell CD, McKinney PA et al. Childhood acute lymphoblastic leukemia and infections in the first year of life: A report from the United Kingdom Childhood Cancer Study. Am J Epidemiol 2007; 165: 496-504.
41. Sherman B, Wysham C, Pfohl B. Age-related changes in the circadian rhythm of plasma cortisol in man. J Clin Endocrinol Metab 1985; 61: 439-443.
42. Lewis M, Ramsay DS. Developmental change in infants' responses to stress. Child Dev 1995; 66: 657-670.
43. Kinlen LJ. Infective cause of childhood leukaemia. Lancet 1989; 1: 378-379.
44. Greaves M. Infection, immune responses and the aetiology of childhood leukaemia. Nat Rev Cancer 2006; 6: 193-203.
45. Rook GA. Glucocorticoids and immune function. Baillieres Best Pract Res Clin Endocrinol Metab 1999; 13: 567-581.
46. Gasparoni A, Ciardelli L, Avanzini A, Castellazzi AM, Carini R, Rondini G et al. Age-related changes in intracellular TH1/TH2 cytokine production, immunoproliferative T lymphocyte response and natural killer cell activity in newborns, children and adults. Biol Neonate 2003; 84: 297-303.
47. Dunne DW, Cooke A. A worm's eye view of the immune system: Consequences for evolution of human autoimmune disease. Nat Rev Immunol 2005; 5: 420-426.
48. Sapolsky RM, Romero LM, Munck AU. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev 2000; 21: 55-89.
49. Blotta. MH, DeKruyff RH, Umetsu DT. Corticosteroids inhibit IL-12 production in human monocytes and enhance their capacity to induce IL-4 synthesis in CD4+ lymphocytes. J Immunol 1997; 158: 5589-5595.
50. Shanks N, Windle RJ, Perks PA, Harbuz MS, Jessop IDS, Ingram CD et al Early-life exposure to endotoxin alters hypothalamic-pituitary-adrenal function and predisposition to inflammation. Proc Natl Acad Sci USA 2000; 97: 5645-5650.