Role of the hypothalamic PVN in the reflex reduction in mesenteric blood flow elicited by hyperthermia

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 295, Issue 6, 2008, Pages

  Chen, Feng ^a   Dworak, Melissa ^a   Wang, Yuliang ^b   Joo, Lee Cham ^a   Badoer, Emilio ^a  

^a RMIT UNIVERSITY   (Australia)

^b WEIFANG MEDICAL UNIVERSITY   (China)

Author keywords

Increased core body temperature; Reflex mesenteric blood flow

Indexed keywords

MUSCIMOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD VESSEL REACTIVITY; BRAIN REGION; CONDUCTANCE; CONTROLLED STUDY; CORE TEMPERATURE; HEART RATE; HYPERTHERMIA; HYPOTHALAMUS; MALE; MESENTERY BLOOD FLOW; NONHUMAN; PRIORITY JOURNAL; RAT; THALAMUS MIDLINE NUCLEUS; VASOCONSTRICTION; VASOMOTOR REFLEX;

ANIMALS; BLOOD PRESSURE; BODY TEMPERATURE; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FEVER; GABA AGONISTS; HEART RATE; MALE; MICROINJECTIONS; MUSCIMOL; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; REFLEX; REGIONAL BLOOD FLOW; SPLANCHNIC CIRCULATION; TIME FACTORS; VASOCONSTRICTION;

EID: 57749093379     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.90384.2008     Document Type: Article

References (48)

1. Akine A, Montanaro M, Allen AM. Hypothalamic paraventricular nucleus inhibition decreases renal sympathetic nerve activity in hypertensive and normotensive rats. Auton Neurosci 108: 17-21, 2003.
2. American Physiological Society. Guiding principles for research involving animals and human beings. Am J Physiol Regul Integr Comp Physiol 283: R281-R283, 2002.
3. Bachtell RK, Tsivkovskaia NO, Ryabinin AE. Identification of temperature-sensitive neural circuits in mice using c-Fos expression mapping. Brain Res 960: 157-164, 2003.
4. Badoer E. Cardiovascular role of parvocellular neurons in the paraventricular nucleus of the hypothalamus. News Physiol Sci 11: 43-47, 1996.
5. Badoer E, McKinley MJ, Oldfield BJ, McAllen RM. A comparison of hypotensive and non-hypotensive hemorrhage on Fos expression in spinal projecting neurons of the paraventricular nucleus and rostral ventrolateral medulla. Brain Res 610: 216-223, 1993.
6. Badoer E, Merolli J. Neurons in the hypothalamic paraventricular nucleus that project to the rostral ventrolateral medulla are activated by haemorrhage. Brain Res 791: 317-320, 1998.
7. Bratincsak A, Palkovits M. Activation of brain areas in rat following warm and cold ambient exposure. Neuroscience 127: 385-397, 2004.
8. Cechetto DF, Saper CB. Neurochemical organization of the hypothalamic projection to the spinal cord in the rat. J Comp Neurol 272: 579-604, 1988.
9. Cham JL, Badoer E. Exposure to a hot environment can activate rostral ventrolateral medulla-projecting neurones in the hypothalamic paraventricular nucleus in conscious rats. Exp Physiol 93: 64-74, 2008.
10. Cham JL, Badoer E. Hypothalamic paraventricular nucleus is critical for renal vasoconstriction elicited by elevations in body temperature. Am J Physiol Renal Physiol 294: F309-F315, 2008.
11. Cham JL, Klein R, Owens NC, Mathai M, McKinley M, Badoer E. Activation of spinally projecting and nitrergic neurons in the PVN following heat exposure. Am J Physiol Regul Integr Comp Physiol 291: R91-R101, 2006.
12. De Novellis V, Stotz-Potter EH, Morin SM, Rossi F, DiMicco JA. Hypothalamic sites mediating cardiovascular effects of microinjected bicuculline and EAAs in rats. Am J Physiol Regul Integr Comp Physiol 269: R131-R140, 1995.
13. Deering J, Coote JH. Paraventricular neurons elicit a volume expansion-like change in sympathetic nerves to the heart and kidney in the rabbit. Exp Physiol 85: 177-186, 2000.
14. Duan YF, Winters R, Mccabe PM, Green EJ, Huang Y, Schneiderman N. Cardiorespiratory components of defense reaction elicited from paraventricular nucleus. Physiol Behav 61: 325-330, 1997.
15. 1 and glutamatergic receptors in the paraventricular nucleus support blood pressure during water deprivation. Am J Physiol Regul Integr Comp Physiol 292: R1675-R1682, 2007.
16. Harikai N, Tomogane K, Sugawara T, Tashiro S. Differences in hypothalamic Fos expressions between two heat stress conditions in conscious mice. Brain Res Bull 61: 617-626, 2003.
17. Haselton JR, Vari RC. Neuronal cell bodies in paraventricular nucleus affect renal hemodynamics and excretion via the renal nerves. Am J Physiol Regul Integr Comp Physiol 275: R1334-R1342, 1998.
18. Hubschle T, Mathai M, McKinley MJ, Oldfield BJ. Multisynaptic neuronal pathways from the submandibular and sublingual glands to the lamina terminalis in the rat: a model for the role of the lamina terminalis in the control of osmo- and thermoregulatory behaviour. Clin Exp Pharmacol Physiol 28: 558-569, 2001.
19. Inenaga K, Osaka T, Yamashita H. Thermosensitivity of neurons in the paraventricular nucleus of the rat slice preparation. Brain Res 424: 126-132, 1987.
20. Kannan H, Hayashida Y, Yamashita H. Increase in sympathetic outflow by paraventricular nucleus stimulation in awake rats. Am J Physiol Regul Integr Comp Physiol 256: R1325-R1330, 1989.
21. Kanosue K, Yanase-Fujiwara M, Hosono T. Hypothalamic network for thermoregulatory vasomotor control. Am J Physiol Regul Integr Comp Physiol 267: R283-R288, 1994.
22. Kantzides A, Badoer E. Fos, RVLM-projecting neurons, and spinally projecting neurons in the PVN following hypertonic saline infusion. Am J Physiol Regul Integr Comp Physiol 284: R945-R953, 2003.
23. Kantzides A, Owens NC, De Matteo R, Badoer E. Right atrial stretch activates neurons in autonomic brain regions that project to the rostral ventrolateral medulla in the rat. Neuroscience 133: 775-786, 2005.
24. Kazuyuki K, Hosono T, Zhang YH, Chen XM. Neuronal networks controlling thermoregulatory effectors. Prog Brain Res 115: 49-62, 1998.
25. Kenney MJ, Barney CC, Hirai T, Gisolfi CV. Sympathetic nerve responses to hyperthermia in the anaesthetized rat. J Appl Physiol 78: 881-889, 1995.
26. Kenney MJ, Fels RJ. Forebrain and brain stem neural circuits contribute to altered sympathetic responses to heating in senescent rats. J Appl Physiol 95: 1986-1993, 2003.
27. Kenney MJ, Musch TI. Senescence alters blood flow responses to acute heat stress. Am J Physiol Heart Circ Physiol 286: H1480-H1485, 2004.
28. Kenney MJ, Pickar JG, Weiss ML, Saindon CS, Fels RJ. Effects of midbrain and spinal cord transections on sympathetic nerve responses to heating. Am J Physiol Regul Integr Comp Physiol 278: R1329-R1338, 2000.
29. Kiyohara T, Miyata S, Nakamura T, Shido O, Nakashima T, Shibata M. Differences in Fos expression in the rat brains between cold and warm ambient exposures. Brain Res Bull 38: 193-201, 1995.
30. Kregel KC, Wall PT, Gisolfi CV. Peripheral vascular responses to hyperthermia in the rat. J Appl Physiol 64: 2582-2588, 1988.
31. Kubarko AI, Tsaiuk VV. Effect of phosphatidylcholine on body temperature and activity of posterior hypothalamus neurons in animals. Bull Exp Biol Med 101: 652-654, 1986.
32. Li DP, Pan HL. Role of γ-aminobutyric acid (GABA) A and GABA B receptors in the paraventricular nucleus in control of sympathetic vasomotor tone in hypertension. J Pharmacol Exp Ther 320: 615-626, 2007.
33. Li Q, Thornhill J. Thermoresponsiveness of posterior hypothalamic (PH) neurons of rats to scrotal and abdominal thermal stimulation. Brain Res 794: 80-87, 1998.
34. Martin DS, Haywood JR. Reduced GABA inhibition of sympathetic function in renal-wrapped hypertensive rats. Am J Physiol Regul Integr Comp Physiol 275: R1523-R1529, 1998.
35. Morin SM, Stotz-Potter EH, DiMicco JA. Injection of muscimol in dorsomedial hypothalamus and stress-induced Fos expression in paraventricular nucleus. Am J Physiol Regul Integr Comp Physiol 280: R1276-R1284, 2001.
36. Morrison SF. RVLM and raphe differentially regulate sympathetic outflows to splanchnic and brown adipose tissue. Am J Physiol Regul Integr Comp Physiol 276: R962-R973, 1999.
37. Nagashima K, Nakai S, Tanaka M, Kanosue K. Neuronal circuitries involved in thermoregulation. Auton Neurosci 85: 18-25, 2000.
38. Ng CW, De Matteo R, Badoer E. Effect of muscimol and L-NAME in the PVN on the RSNA response to volume expansion in conscious rabbits. Am J Physiol Renal Physiol 287: F739-F746, 2004.
39. Oldfield BJ, Giles ME, Watson A, Anderson C, Colvill LM, McKinley MJ. The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat. Neuroscience 110: 515-526, 2002.
40. Shafton AD, Ryan A, Badoer E. Neurons in the hypothalamic paraventricular nucleus send collaterals to the spinal cord and to the rostal ventrolateral medulla in the rat. Brain Res 801: 239-243, 1998.
41. Silva AQ, Santos RA, Fontes MA. Blockade of endogenous angiotensin-(1-7) in the hypothalamic paraventricular nucleus reduces renal sympathetic tone. Hypertension 46: 341-348, 2005.
42. Smith JE, Jansen AS, Gilbey MP, Loewy AD. CNS cell groups projecting to sympathetic outflow of tail artery: neural circuits involved in heat loss in the rat. Brain Res 786: 153-164, 1998.
43. Stocker SD, Hunwick KJ, Toney GM. Hypothalamic paraventricular nucleus differentially supports lumbar and renal sympathetic nerve outflow in water-deprived rats. J Physiol 563: 249-263, 2005.
44. Stocker SD, Keith KJ, Toney GM. Acute inhibition of the hypothalamic paraventricular nucleus decreases renal sympathetic nerve activity and arterial blood pressure in water-deprived rats. Am J Physiol Regul Integr Comp Physiol 286: R719-R725, 2004.
45. Stotz-Potter EH, Morin SM, DiMicco JA. Effect of microinjection of muscimol into the dorsomedial or paraventricular hypothalamic nucleus on air stress-induced neuroendocrine and cardiovascular changes in rats. Brain Res 742: 219-224, 1996.
46. Stotz-Potter EH, Willis LR, DiMicco JA. Muscimol acts in dorsomedial but not paraventricular hypothalamic nucleus to suppress cardiovascular effects of stress. J Neurosci 16: 1173-1179, 1996.
47. Swanson LW, Sawchenko PE. Hypothalamic integration: organization of the paraventricular and supraoptic nuclei. Ann Rev Neurosci 6: 269-324, 1983.
48. Swanson LW, Sawchenko PE, Wiegand SJ, Price JL. Separate neurons in the paraventricular nucleus project to the median eminence and to the medulla or spinal cord. Brain Res 198: 190-195, 1980.