Differences between naive and memory T cell phenotype in Malawian and UK adolescents: A role for Cytomegalovirus?

BMC Infectious Diseases

Volumn 8, Issue , 2008, Pages

  Ben Smith, Anne ^a   Gorak Stolinska, Patricia ^a   Floyd, Sian ^a   Weir, Rosemary E ^a   Lalor, Maeve K ^a   Mvula, Hazzie ^b   Crampin, Amelia C ^b   Wallace, Diana ^c   Beverley, Peter C L ^d   Fine, Paul E M ^a   Dockrell, Hazel M ^a  

^a Department of Infectious and Tropical Diseases ^*  (United Kingdom)

^b KARONGA PREVENTION STUDY   (Malawi)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d NIHR Biomedical Researcg Centre   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD45RA ANTIGEN; CD45RO ANTIGEN; CHEMOKINE RECEPTOR CCR7; L SELECTIN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; CD3 ANTIGEN; CD45 ANTIGEN; VIRUS ANTIBODY;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE RESPONSE; MALAWI; MEMORY T LYMPHOCYTE; PHENOTYPE; SCHOOL CHILD; UMBILICAL CORD BLOOD; UNITED KINGDOM; VENOUS BLOOD; CHILD; COMPARATIVE STUDY; FEMALE; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; IMMUNOPHENOTYPING; MALE; NEWBORN; SERODIAGNOSIS; T LYMPHOCYTE SUBPOPULATION;

ADOLESCENT; ANTIBODIES, VIRAL; ANTIGENS, CD28; ANTIGENS, CD3; ANTIGENS, CD45; CHILD; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; FEMALE; FLOW CYTOMETRY; GREAT BRITAIN; HIV SERONEGATIVITY; HUMANS; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; INFANT, NEWBORN; MALAWI; MALE; T-LYMPHOCYTE SUBSETS; YOUNG ADULT;

EID: 57649235521     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-8-139     Document Type: Article

References (41)

1. Merkenschlager M Terry L Edwards R Beverley PCL Limiting dilution analysis of proliferative responses in human lymphocyte populations defined by the monoclonal antibody UCHL1: Implications for differential CD45 expression in T cell memory formation European Journal of Immunology 1988, 18:1653-1661 10.1002/eji.1830181102 2974420
2. Merkenschlager M Beverley PCL Evidence for differential expression of CD45 isoforms by precursors for memory-dependent and independent cytotoxic responses: Human CD8 memory CTLp selectively express CD45RO (UCHL1) Int Immunol 1989, 1(4):450-459 10.1093/intimm/1.4.450 2562244
3. Butcher EC Picker LJ Lymphocyte homing and homeostasis Science 1996, 272:60-66 10.1126/science.272.5258.60 8600538
4. Banchereau J Steinman RM Dendritic cells and the control of immunity Nature 1998, 392:245-252 10.1038/32588 9521319
5. Mackay CR Homing of naive, memory and effector lymphocytes Current Opinion in Immunology 1993, 5:423-427 10.1016/0952-7915(93)90063-X 8347302
6. Dutton RW Bradley LM Swain SL T cell memory Annual Review of Immunology 1998, 16:201-223 10.1146/annurev.immunol.16.1.201 9597129
7. Sallusto F Lenig D Forster R Lipp M Lanzavecchia A Two subsets of memory T lymphocytes with distinct homing potentials and effector functions Nature 1999, 401(6754):708-712 10.1038/44385 10537110
8. Nikolich-Zugich J T cell aging: Naive but not young Journal of Experimental Medicine 2005, 201(6):837-840 2213096 15781575 10.1084/ jem.20050341
9. Nociari MM Telford W Russo C Post-thymic development of CD28-CD8+ T cell subset: Age-associated expansion and shift from memory to naive phenotype J Immunol 1999, 162(6):3327-3335 10092786
10. Looney RJ Falsey A Campbell D Torres A Kolassa J Brower C McCann R Menegus M McCormick K Frampton M Hall W Abraham GN Role of cytomegalovirus in the T cell changes seen in elderly individuals Clinical Immunology 1999, 90:213-219 10.1006/clim.1998.4638 10080833
11. Khan N Shariff N Cobbold M Bruton R Ainsworth JA Sinclair AJ Nayak L Moss PAH Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals J Immunol 2002, 169(4):1984-1992 12165524
12. Fletcher JM Vukmanovic-Stejic M Dunne PJ Birch KE Cook JE Jackson SE Salmon M Rustin MH Akbar AN Cytomegalovirus-specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion J Immunol 2005, 175(12):8218-8225 16339561
13. Ershler WB Tumors and aging: The influence of age-associated immune changes upon tumor growth and spread Adv Exp Med Biol 1993, 330:77-92 8368144
14. Gavazzi G Krause KH Ageing and infection The Lancet Infectious Diseases 2002, 2:659-666 10.1016/S1473-3099(02)00437-1 12409046
15. Messele T Abdulkadir M Fontanet AL Petros B Hamann D Koot M Roos MTL Schellekens PT Miedema F Rinke de Wit TF Reduced naive and increased activated CD4 and CD8 cells in healthy adult Ethiopians compared with their Dutch counterparts Clin Exp Immunol 1999, 115(3):443-450 10193416 10.1046/j.1365-2249.1999.00815.x 1905237
16. Kassu A Tsegaye A Petros B Wolday D Hailu E Tilahun T Hailu B Roos MT Fontanet AL Hamann D De Wit TF Distribution of lymphocyte subsets in healthy human immunodeficiency virus-negative adult Ethiopians from two geographic locales Clin Diagn Lab Immunol 2001, 8(6):1171-1176 96245 11687459 10.1128/CDLI.8.6.1171-1176.2001
17. Sutherland I Springett VH Effectiveness of BCG vaccination in England and Wales in 1983 Tubercle 1987, 68(2):81-92 10.1016/ 0041-3879(87)90023-7 3660468
18. Karonga Prevention Trial Group Randomised controlled trial of single BCG, repeated BCG, or combined BCG and killed Mycobacterium leprae vaccine for prevention of leprosy and tuberculosis in Malawi. Karonga Prevention Trial Group Lancet 1996, 348(9019):17-24 10.1016/ S0140-6736(96)02166-6 8691924
19. Fine PEM Variation in protection by BCG: Implications of and for heterologous immunity Lancet 1995, 346:1339-1345 10.1016/ S0140-6736(95)92348-9 7475776
20. Black GF Weir RE Floyd S Bliss L Warndorff DK Crampin AC Ngwira B Sichali L Nazareth B Blackwell JM Branson K Chaguluka SD Donovan L Jarman E King E Fine PE Dockrell HM BCG-induced increase in interferon-gamma response to mycobacterial antigens and efficacy of BCG vaccination in Malawi and the UK: Two randomised controlled studies Lancet 2002, 359:9315-1393 1401 10.1016/S0140-6736(02)08353-8 11978337
21. Dunne PJ Faint JM Gudgeon NH Fletcher JM Plunkett FJ Soares MVD Hislop AD Annels NE Rickinson AB Salmon M Akbar AN Epstein-Barr virus-specific CD8+ T cells that re-express CD45RA are apoptosis-resistant memory cells that retain replicative potential Blood 2002, 100:933-940 10.1182/ blood-2002-01-0160 12130505
22. Faint JM Annels NE Curnow SJ Shields P Pilling D Hislop AD Wu L Akbar AN Buckley CD Moss PAH Adams DH Rickinson AB Salmon M Memory T cells constitute a subset of the human CD8+CD45RA+ pool with distinct phenotypic and migratory characteristics J Immunol 2001, 167(1):212-220 11418651
23. Posnett D Sinha R Kabak S Russo C Clonal expansions of T cells in normal elderly humans: The T cell equivalent to 'benign monoclonal gammopathy' Journal of Experimental Medicine 1994, 179:609-618 2191374 8294871 10.1084/jem.179.2.609
24. Vallejo AN Nestel AR Schirmer M Weyand CM Goronzy JJ Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene-specific nuclear factor binding activity Journal of Biological Chemistry 1998, 273(14):8119-8129 10.1074/jbc.273.14.8119 9525915
25. Azuma M Phillips JH Lanier LL CD28- T lymphocytes. Antigenic and functional properties J Immunol 1993, 150(4):1147-1159 8381831
26. Fagnoni FF Vescovini R Mazzola M Bologna G Nigro E Lavagetto G Franceschi C Passeri M Sansoni P Expansion of cytotoxic CD8+CD28- T cells in healthy ageing people, including centenarians Immunology 1996, 88(4):501-507 1456634 8881749 10.1046/j.1365-2567.1996.d01-689.x
27. Olsson J Wikby A Johansson B Lofgren S Nilsson BO Ferguson FG Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: The Swedish longitudinal OCTO immune study Mech Ageing Dev 2000, 121(1-3):187-201 11164473 10.1016/ S0047-6374(00)00210-4
28. Tsegaye A Wolday D Otto S Petros B Assefa T Alebachew T Hailu E Adugna F Measho W Dorigo W Fontanet AL van Baarle D Miedema F Immunophenotyping of blood lymphocytes at birth, during childhood, and during adulthood in HIV-1-uninfected Ethiopians Clinical Immunology 2003, 109:338-346 10.1016/j.clim.2003.08.008 14697749
29. Boucher N Defeu-Duchesne T Vicaut E Farge D Effros RB Schachter F CD28 expression in T cell ageing and human longevity Experimental Gerontology 1998, 33(3):267-282 10.1016/S0531-5565(97)00132-0 9615924
30. Fagnoni F Vescovini R Passeri G Bologna G Pedrazzoni M Lavagetto G Casti A Franceschi C Passeri M Sansoni P Shortage of circulating naive CD8 T cells provides new insights on immunodeficiency in aging Blood 2000, 95(9):2860-2868 10779432
31. Kassu A Tsegaye A Wolday D Petros B Aklilu M Sanders EJ Fontanet AL van Baarle D Hamann D De Wit TF Role of incidental and/or cured intestinal parasitic infections on profile of CD4+ and CD8+ T cell subsets and activation status in HIV-1 infected and uninfected adult Ethiopians Clin Exp Immunol 2003, 132(1):113-119 1808681 12653845 10.1046/ j.1365-2249.2003.02106.x
32. Elias D Akuffo H Britton S Helminthes could influence the outcome of vaccines against TB in the tropics Parasite Immunol 2006, 28(10):507-513 10.1111/j.1365-3024.2006.00854.x 16965286
33. Gupta S Bi R Su K Yel L Chiplunkar S Gollapudi S Characterization of naive, memory and effector CD8+ T cells: Effect of age Exp Gerontol 2004, 39(4):545-550 10.1016/j.exger.2003.08.013 15050289
34. Shimizu Y van Seventer GA Ennis E Newman W Horgan KJ Shaw S Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion J Exp Med 1992, 175(2):577-582 2119108 1370688 10.1084/ jem.175.2.577
35. Champagne P Ogg GS King AS Knabenhans C Ellefsen K Nobile M Appay V Rizzardi GP Fleury S Lipp M Forster R Rowland-Jones S Sekaly RP McMichael AJ Pantaleo G Skewed maturation of memory HIV-specific CD8 T lymphocytes Nature 2001, 410(6824):106-111 10.1038/35065118 11242051
36. Miles DJ Sande van der M Jeffries D Kaye S Ismaili J Ojuola O Sanneh M Touray ES Waight P Rowland-Jones S Whittle H Marchant A Cytomegalovirus infection in Gambian infants leads to profound CD8 T-cell differentiation J Virol 2007, 81(11):5766-5776 1900274 17376923 10.1128/ JVI.00052-07
37. Sallusto F Lanzavecchia A Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression Immunological Reviews 2000, 177:134-144 10.1034/j.1600-065X.2000.17717.x 11138771
38. Wang EC Moss PA Frodsham P Lehner PJ Bell JI Borysiewicz LK CD8high CD57+ T lymphocytes in normal, healthy individuals are oligoclonal and respond to human CMV J Immunol 1995, 155(10):5046-56 7594513
39. Sylwester AW Mitchell BL Edgar JB Taormina C Pelte C Ruchti F Sleath PR Grabstein KH Hosken NA Kern F Nelson JA Picker LJ Broadly targeted human cytomegalovirus-specific CD4(+) and CD8(+) T-cells dominate the memory compartments of exposed subjects Journal of Experimental Medicine 2005, 202(9):673 2212883 16147978 10.1084/jem.20050882
40. Brenchley JM Karandikar NJ Betts MR Ambrozak DR Hill BJ Crotty LE Casazza JP Kuruppu J Migueles SA Connors M Roederer M Douek DC Koup RA Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells Blood 2003, 101:2711-2720 10.1182/ blood-2002-07-2103 12433688
41. Effros RB Allsopp R Chiu CP Hausner MA Hirji K Wang L Harley CB Villeponteau B West MD Giorgi JV ρShortened telomeres in the expanded CD28-CD8+ subset in HIV disease implicate replicative senescence in HIV pathogenesis AIDS 1996, 10:F17-F22 10.1097/ 00002030-199607000-00001 8828735