Role of PDK1 in regulation of gastric acid secretion

Cellular Physiology and Biochemistry

Volumn 22, Issue 5-6, 2008, Pages 725-734

  Rotte, Anand ^a   Bhandaru, Madhuri ^a   Ackermann, Teresa F ^a   Boini, Krishna M ^a   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

H + secretion; K + recycling; K + H + ATPase; PI3 kinase; Stomach

Indexed keywords

AMMONIA; FORSKOLIN; GASTRIN; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; OMEPRAZOLE; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; POTASSIUM; PROTEIN KINASE C;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME ACTIVITY; FLUORESCENCE; GASTRIN BLOOD LEVEL; GENOTYPE; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; STOMACH ACID SECRETION; STOMACH GLAND; STOMACH PARIETAL CELL;

MUS;

EID: 57649192507     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000185556     Document Type: Article

References (41)

1. Hofer AM, Machen TE: K-induced alkalinization in all cell types of rabbit gastric glands: a novel K/H exchange mechanism. J Membr Biol 1992;126:245-256.
2. Hou W, Schubert ML: Gastric secretion. Curr Opin Gastroenterol 2006;22:593-598.
3. Lee HC, Breitbart H, Berman M, Forte JG: Potassium-stimulated ATPase activity and hydrogen transport in gastric microsomal vesicles. Biochim Biophys Acta 1979;553:107-131.
4. Yao X, Forte JG: Cell biology of acid secretion by the parietal cell. Annu Rev Physiol 2003;65:103-131.
5. Dedek K, Waldegger S: Colocalization of KCNQ1/KCNE channel subunits in the mouse gastrointestinal tract. Pflugers Arch 2001;442:896-902.
6. Heitzmann D, Grahammer F, von Hahn T, Schmitt-Graff A, Romeo E, Nitschke R, Gerlach U, Lang HJ, Verrey F, Barhanin J, Warth R: Heteromeric KCNE2/KCNQ1 potassium channels in the luminal membrane of gastric parietal cells. J Physiol 2004;561:547-557.
7. Heitzmann D, Koren V, Wagner M, Sterner C, Reichold M, Tegtmeier I, Volk T, Warth R: KCNE beta subunits determine pH sensitivity of KCNQ1 potassium channels. Cell Physiol Biochem 2007;19:21-32.
8. Vallon V, Grahammer F, Volkl H, Sandu CD, Richter K, Rexhepaj R, Gerlach U, Rong Q, Pfeifer K, Lang F: KCNQ1-dependent transport in renal and gastrointestinal epithelia. Proc Natl Acad Sci U S A 2005;102:17864-17869.
9. Ammar DA, Zhou R, Forte JG, Yao X: Syntaxin 3 is required for cAMP-induced acid secretion: streptolysin O-permeabilized gastric gland model. Am J Physiol Gastrointest Liver Physiol 2002;282:G23-G33.
10. Dong MQ, Lau CP, Gao Z, Tseng GN, Li GR: Characterization of recombinant human cardiac KCNQ1/KCNE1 channels (I (Ks)) stably expressed in HEK 293 cells. J Membr Biol 2006;210:183-192.
11. Kurokawa J, Chen L, Kass RS: Requirement of subunit expression for cAMP-mediated regulation of a heart potassium channel. Proc Natl Acad Sci U S A 2003;100:2122-2127.
12. Marx SO, Kurokawa J, Reiken S, Motoike H, D'Armiento J, Marks AR, Kass RS: Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science 2002;295:496-499.
13. Potet F, Scott JD, Mohammad-Panah R, Escande D, Baro I: AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex. Am J Physiol Heart Circ Physiol 2001;280:H2038-H2045.
14. Mettler SE, Ghayouri S, Christensen GP, Forte JG: Modulatory role of phosphoinositide 3-kinase in gastric acid secretion. Am J Physiol Gastrointest Liver Physiol 2007;293:G532-G543.
15. Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA: Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 1996;15:6541-6551.
16. Alessi DR, Cohen P: Mechanism of activation and function of protein kinase B. Curr Opin Genet Dev 1998;8:55-62.
17. Divecha N, Banfic H, Irvine RF: The polyphosphoinositide cycle exists in the nuclei of Swiss 3T3 cells under the control of a receptor (for IGF-I) in the plasma membrane, and stimulation of the cycle increases nuclear diacylglycerol and apparently induces translocation of protein kinase C to the nucleus. EMBO J 1991;10:3207-3214.
18. Gamper N, Fillon S, Huber SM, Feng Y, Kobayashi T, Cohen P, Lang F: IGF-1 upregulates K+ channels via PI3-kinase, PDK1 and SGK1. Pflugers Arch 2002;443:625-634.
19. Kobayashi T, Cohen P: Activation of serum-and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. Biochem J 1999;339:319-328.
20. Kotani K, Yonezawa K, Hara K, Ueda H, Kitamura Y, Sakaue H, Ando A, Chavanieu A, Calas B, Grigorescu F, .: Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling. EMBO J 1994;13:2313-2321.
21. Park J, Leong ML, Buse P, Maiyar AC, Firestone GL, Hemmings BA: Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J 1999;18:3024-3033.
22. Lawlor MA, Mora A, Ashby PR, Williams MR, Murray-Tait V, Malone L, Prescott AR, Lucocq JM, Alessi DR: Essential role of PDK1 in regulating cell size and development in mice. EMBO J 2002;21:3728-3738.
23. Waisbren SJ, Geibel J, Boron WF, Modlin IM: Luminal perfusion of isolated gastric glands. Am J Physiol 1994;266:C1013-C1027.
24. Roos A, Boron WF: Intracellular pH. Physiol Rev 1981;61:296-434.
25. Boyarsky G, Ganz MB, Sterzel RB, Boron WF: pH regulation in single glomerular mesangial cells. I. Acid extrusion in absence and presence of HCO3-. Am J Physiol 1988;255:C844-C856.
26. Rexhepaj R, Grahammer F, Volkl H, Remy C, Wagner CA, Sandulache D, Artunc F, Henke G, Nammi S, Capasso G, Alessi DR, Lang F: Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice. FASEB J 2006;20:2214-2222.
27. Lang F, Bohmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V: (Patho)physiological significance of the serum- and glucocorticoid-inducible kinase isoforms. Physiol Rev 2006;86:1151-1178.
28. Sandu C, Artunc F, Grahammer F, Rotte A, Boini KM, Friedrich B, Sandulache D, Metzger M, Just L, Mack A, Skutella T, Rexhepaj R, Risler T, Wulff P, Kuhl D, Lang F: Role of the serum and glucocorticoid inducible kinase SGK1 in glucocorticoid stimulation of gastric acid secretion. Pflugers Arch 2007;455:493-503.
29. Lang PA, Schniepp R, Kirchhoff P, Socrates T, Sidani SM, Geibel JP: PI3 kinase dependent stimulation of gastric acid secretion by dexamethasone. Cell Physiol Biochem 2007;20:527-534.
30. Luo JC, Lin HY, Lu CL, Wang LY, Chang FY, Lin HC, Huang YC, Ng KM, Chi CW, Lee SD: Dexamethasone inhibits basic fibroblast growth factor-stimulated gastric epithelial cell proliferation. Biochem Pharmacol 2008;76:841-849.
31. Yokota A, Taniguchi M, Takahira Y, Tanaka A, Takeuchi K: Dexamethasone damages the rat stomach but not small intestine during inhibition of COX-1. Dig Dis Sci 2007;52:1452-1461.
32. Wallace JL, Caliendo G, Santagada V, Cirino G, Fiorucci S: Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat. Gastroenterology 2007;132:261-271.
33. Wang GZ, Huang GP, Yin GL, Zhou G, Guo CJ, Xie CG, Jia BB, Wang JF: Aspirin can elicit the recurrence of gastric ulcer induced with acetic acid in rats. Cell Physiol Biochem 2007;20:205-212.
34. Grahammer F, Herling AW, Lang HJ, Schmitt-Graff A, Wittekindt OH, Nitschke R, Bleich M, Barhanin J, Warth R: The cardiac K+ channel KCNQ1 is essential for gastric acid secretion. Gastroenterology 2001;120:1363-1371.
35. Lee MP, Ravenel JD, Hu RJ, Lustig LR, Tomaselli G, Berger RD, Brandenburg SA, Litzi TJ, Bunton TE, Limb C, Francis H, Gorelikow M, Gu H, Washington K, Argani P, Goldenring JR, Coffey RJ, Feinberg AP: Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice. J Clin Invest 2000;106:1447-1455.
36. Busjahn A, Seebohm G, Maier G, Toliat MR, Nurnberg P, Aydin A, Luft FC, Lang F: Association of the serum and glucocorticoid regulated kinase (sgk1) gene with QT interval. Cell Physiol Biochem 2004;14:135-142.
37. Embark HM, Bohmer C, Vallon V, Luft F, Lang F: Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms. Pflugers Arch 2003;445:601-606.
38. Seebohm G, Strutz-Seebohm N, Birkin R, Dell G, Bucci C, Spinosa MR, Baltaev R, Mack AF, Korniychuk G, Choudhury A, Marks D, Pagano RE, Attali B, Pfeufer A, Kass RS, Sanguinetti MC, Tavare JM, Lang F: Regulation of endocytic recycling of KCNQ1/KCNE1 potassium channels. Circ Res 2007;100:686-692.
39. Kathofer S, Rockl K, Zhang W, Thomas D, Katus H, Kiehn J, Kreye V, Schoels W, Karle C: Human beta(3)-adrenoreceptors couple to KvLQT1/MinK potassium channels in Xenopus oocytes via protein kinase C phosphorylation of the KvLQT1 protein. Naunyn Schmiedebergs Arch Pharmacol 2003;368:119-126.
40. Lan WZ, Wang PY, Hill CE: Modulation of hepatocellular swelling-activated K+ currents by phosphoinositide pathway-dependent protein kinase C. Am J Physiol Cell Physiol 2006;291:C93-103.
41. Remy C, Kirchhoff P, Hafner P, Busque SM, Mueller MK, Geibel JP, Wagner CA: Stimulatory pathways of the Calcium-sensing receptor on acid secretion in freshly isolated human gastric glands. Cell Physiol Biochem 2007;19:33-42.