Troglitazone induced cytosolic acidification via extracellular signal-response kinase activation and mitochondrial depolarization: Complex I proton pumping regulates ammoniagenesis in proximal tubule-like LLC-PK 1 cells

Cellular Physiology and Biochemistry

Volumn 22, Issue 5-6, 2008, Pages 475-486

  Oliver III, Robert ^a   Friday, Ellen ^b   Turturro, Francesco ^b   Welbourne, Tomas ^a,b  

^a LSUHSC

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

5 (N ethyl N isopropyl) amiloride; Acid production; Cytosolic pH; EIPA; Glutamine metabolism; Mitogen activated protein kinase kinase extracellular signal regulated kinase (MEKK ERK) inhibitors; PPAR agonists; Sodium hydrogen ion exchanger (NHE)

Indexed keywords

5 (N ETHYL N ISOPROPYL)AMILORIDE; ACID; GLUTAMINE; MITOGEN ACTIVATED PROTEIN KINASE; PROTON; ROTENONE; SODIUM ION; SODIUM PROTON EXCHANGE PROTEIN; TROGLITAZONE;

ACIDIFICATION; ACIDOSIS; AMMONIA FORMATION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOSOL; DEPOLARIZATION; DOSE RESPONSE; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; SWINE;

SUIDAE;

EID: 57649181367     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000185496     Document Type: Article

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