Attenuation of edema and infarct volume following focal cerebral ischemia by early but not delayed administration of a novel small molecule KDR kinase inhibitor

Neuroscience Research

Volumn 63, Issue 1, 2009, Pages 10-16

  Foster, Kelley A ^a   Regan, Hillary K ^a   Danziger, Andrew P ^a   Detwiler, Theodore ^a   Kwon, Nancy ^a   Rickert, Keith ^a   Lynch, Joseph J ^a   Regan, Christopher P ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Brain infarction; Edema; Ischemic stroke; KDR kinase; Middle cerebral artery occlusion; VEGF

Indexed keywords

DIZOCILPINE; PHOSPHOTRANSFERASE INHIBITOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; BRAIN EDEMA; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG RECEPTOR BINDING; MALE; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; PROTEIN STRUCTURE; RAT; RECEPTOR BLOCKING; REPERFUSION; STROKE;

ANIMALS; BRAIN; BRAIN EDEMA; CEREBRAL INFARCTION; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; ENZYME INHIBITORS; HYPOXIA-ISCHEMIA, BRAIN; INDOLES; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MOLECULAR WEIGHT; PIPERAZINES; RATS; TIME FACTORS; TREATMENT OUTCOME; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 57649178833     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neures.2008.09.007     Document Type: Article

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